Clinical trials: Memory, Short-Term
Attention Deficit Hyperactivity Disorder
Study of the Effects of Osmotic-Release Oral System (OROS) Methylphenidate (Concerta) on Attention and Memory
This study investigates whether OROS-methylphenidate improves performance on different aspects of attention and memory in children with Attention-Deficit Hyperactivity Disorder (ADHD).
- Trial name
- CHOP (NCT00530257)
- Testing
- OROS-methylphenidate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Philadelphia
Impulsive Behavior, Mental Disorders
Cognitive Control Training for Urgency in a Naturalistic Clinical Setting
This study is designed to test whether computer-based cognitive exercises are helpful for reducing a specific type of impulsivity.
- Trial name
- NCT03527550
- Testing
- Cognitive Control Training
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Mclean Hospital
Schizophrenia
A Pilot Trial of Acute N-Acetylcysteine Effects on Working Memory and Other Cognitive Functions in Schizophrenia
The purpose of this study is to evaluate the effects of the amino acid supplement N-Acetylcysteine versus placebo on working memory and other cognitive functions in persons with a diagnosis of schizophrenia.
- Trial name
- NAC (NCT01232790)
- Testing
- N-Acetylcysteine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Yale University
Schizophrenia
Effects of Galantamine on Cognition
Schizophrenia is a chronic disorder with onset of psychosis occurring in late teen early twenties, with cognitive impairments and negative symptoms frequently emerging much earlier.
- Trial name
- NCT01100775
- Testing
- Galantamine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Maryland, Baltimore
Memory
Individualized Closed Loop TMS for Working Memory Enhancement
The study is investigating working memory brain states by using transcranial magnetic stimulation (TMS) in combination with functional magnetic resonance imaging (fMRI).
- Trial name
- NCT04402294
- Testing
- Functional Magnetic Resonance Imaging (fMRI), Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hearing Loss
Evaluation of Cogmed Working Memory Training for Adult Hearing Aid Users
A double-blind randomised active-controlled trial aims to assess whether Cogmed (adaptive) working memory training results in improvements in untrained measures of cognition, speech perception and self-reported hearing abilities…
- Trial name
- TEACH2 (NCT01892007)
- Testing
- Cogmed RM - Online adaptive working memory training
- Where
- United Kingdom
- Volunteers
- 57 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Attention Deficit Disorder
Neurofeedback and Working Memory Training for Children and Adolescents With ADHD
The purpose of this study is to investigate if neurofeedback and working memory training improves core symptoms of ADHD in children and adolescents.
- Trial name
- KITE (NCT01841151)
- Testing
- SCP training, Live Z-score training, WM training
- Where
- Sweden
- Volunteers
- 202 people
- Sponsor
- Karolinska Institutet
Cognitive Aging
The Effects of Mixed Working Memory Training on Subsequent Training Gains Among Older Adults
While an intellectually active and socially integrated lifestyle shows promise for promoting cognitive resilience, the mechanisms underlying any such effects are not well understood.
- Trial name
- MixedWM (NCT05672771)
- Testing
- Different Mixed Condition (DM), Different Single Condition (DS), Same Task (ST) Practice Control
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
HIV
Improving Memory Performance by Applying Cognitive Training
The proposed study will test the efficacy of a cognitive training program to improve working memory in a sample of HIV-infected persons.
- Trial name
- IMPACT (NCT02216591)
- Testing
- Active Cognitive Training (ACT), Control (CON)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Duke University
Tobacco Use Disorder
Working Memory Training Combined With Transcranial Magnetic Stimulation in Smokers
Smoking remains the leading cause of preventable death in the United States, and current first-line treatments leave the majority of tobacco dependent individuals unable to quit.
- Trial name
- NCT03337113
- Testing
- Working Memory Training, repetitive Transcranial Magnetic Stimulation
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kent State University
Young Adults
Oscillatory Contributions to Working Memory and Attention
The objectives are articulated in the proposal's specific aims: Aim 1: To test the hypothesis that the cognitive control of unattended memory items (UMI) is implemented by the same frontoparietal mechanisms that control spatial…
- Trial name
- NCT03787134
- Testing
- working memory and attention
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Healthy Adults
Characterizing the Synergistic Effects of Physical and Cognitive Training on Attention and Working Memory
The primary goal of this project is to evidence potential synergistic benefits on cognitive control processes using a video game ("Body-Brain Trainer", or BBT) that integrates cognitive and physical challenges in a complimentary…
- Trial name
- BBT (NCT03032796)
- Testing
- Body-Brain Trainer, Body Trainer, Brain Trainer
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Schizophrenia
Pharmacologically-augmented Cognitive Therapies (PACTs) for Schizophrenia.
This application seeks renewed support for MH59803, "Dopaminergic substrates of startle gating across species," to extend a clear path of "bench-to-bedside" progress towards a critical paradigm shift in therapeutic models for…
- Trial name
- NCT02634684
- Testing
- Dextroamphetamine
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
ADHD
Genetic Modulation of Working Memory in Attention Deficit Hyperactivity Disorder (ADHD)
In this study the investigators will measure the functional brain activity of adult Attention Deficit Hyperactivity Disorder (ADHD) patients, genotyped according to the COMT genotype, during a Working Memory Paradigm, before and…
- Trial name
- BEAS (NCT01351272)
- Testing
- Methylphenidate, non-retard
- Where
- Germany
- Volunteers
- 41 people
- Sponsor
- Wuerzburg University Hospital
Executive Function
Theta Connectivity in Working Memory
The participants will perform a cognitive control task. During the task, rhythmic trains of transcranial magnetic stimulation will be delivered to the prefrontal cortex and parietal cortex.
- Trial name
- STAR (NCT05204381)
- Testing
- Theta-frequency near-zero phase lag stimulation, Theta-frequency anti-synchrony stimulation, Arrhythmic near-zero phase lag stimulation
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Schizophrenia, Schizoaffective Disorder
Remediation of Working Memory in Schizophrenia
The primary aim of the study is to test the efficacy of a novel cognitive remediation intervention that targets working memory-related functions.
- Trial name
- NCT00995553
- Testing
- Cognitive Remediation, Computer Skills
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- VA Office of Research and Development
NMDA Receptor Function
The Effects of Ketamine and Guanfacine on Working Memory in Healthy Subjects
The purpose of the study is 1. To establish the feasibility of fMRI studies of the interaction of guanfacine and ketamine. 2. To explore the possibility that guanfacine can ameliorate the negative effects of ketamine on…
- Trial name
- GuaKet (NCT01600885)
- Testing
- Guanfacine
- Where
- 3 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Yale University
Multiple Sclerosis, Neurological Disorder
Cognitive Remediation Augmented With Transcranial Direct Current Stimulation (tDCS)
The proposed study will test the feasibility and tolerability of transcranial direct current stimulation (tDCS) added to a cognitive remediation program in n=100 adults.
- Trial name
- NCT03049969
- Testing
- tDCS stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- NYU Langone Health
Schizophrenia, Psychosis
Non-Invasive Direct Current Stimulation for Cognition in Schizophrenia
This study proposes to assess the effect of trans-cranial direct current stimulation (tDCS) on cognitive control, working memory, functional, clinical, and cognitive outcomes in schizophrenia patients.
- Trial name
- NCT02739347
- Testing
- Active Trans-cranial direct-current stimulation
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Baylor College of Medicine
Schizophrenia
Neurocognitive Effects of Ziprasidone: Relationship to Working Memory and Dopamine Blockade
Ziprasidone is a newer drug intended for the treatment of the symptoms of schizophrenia. This new drug may have an added benefit of being able to help with some of the difficulties in problem solving and memory that many patients…
- Trial name
- NCT00225498
- Testing
- ziprasidone vs risperidone or olanzapine
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Northwell Health