Clinical trials: Memory
Memory, Sleep
Autonomic Mechanisms of Sleep-dependent Memory Consolidation
The goal of the proposed project is to identify the impact vagal activity during sleep for memory formation. Nearly 100 years of research contends that sleep plays a critical role in memory consolidation (i.e.
- Trial name
- MemS (NCT04021797)
- Testing
- transcutaneous vagal nerve stimulation
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Working Memory
Traveling-wave Transcranial Electric Stimulation
This study will assess the impact of traveling wave transcranial alternating current stimulation (tACS) on working memory performance in adults.
- Trial name
- TravelingTES (NCT05399381)
- Testing
- Transcranial alternating current stimulation (tACS)
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Intrusive Memories of Traumatic Event(s)
A Brief Cognitive Task Intervention for NHS Staff Affected by COVID-19 Trauma (GAINS-2 Study)
Frontline healthcare staff are frequently exposed to traumatic events at work (e.g., witnessing patients die), amplified by the COVID-19 pandemic.
- Trial name
- GAINS-2 (NCT05616676)
- Testing
- Brief digital imagery-competing task, Brief digital music-listening task, Treatment As Usual
- Where
- United Kingdom
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- P1vital Products Limited
HIV Infections, Memory
Prevalence and Predictors of Neurocognitive Impairment Among HIV-infected Patients
Despite the advent of highly active antiretroviral therapy (HAART), the prevalence of neurocognitive impairment among HIV-infected patients continues to be an important issue.
- Trial name
- NCT00893815
- Where
- 3 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Healthy Adults With Subjective Memory Complaints
Effects of HX106 on Improvement in Cognitive-Bio-Markers of Memory Function
The objectives of the current study are to evaluate the efficacy and safety of HX106 in healthy adults with subjective memory complaints for improving cognitive and neurobiolgoical markers of memory.
- Trial name
- NCT01956097
- Testing
- HX106 590mg, HX106 1180mg
- Where
- South Korea
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University
Memory
Individualized Closed Loop TMS for Working Memory Enhancement
The study is investigating working memory brain states by using transcranial magnetic stimulation (TMS) in combination with functional magnetic resonance imaging (fMRI).
- Trial name
- NCT04402294
- Testing
- Functional Magnetic Resonance Imaging (fMRI), Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Intrusive Memories of Traumatic Event(s)
A Brief GAmeplay Intervention for NHS ICU Staff Affected by COVID-19 Trauma (GAINS Study)
Intensive care unit (ICU) staff are frequently exposed to traumatic events at work (e.g., witnessing patients die), amplified by the COVID-19 pandemic.
- Trial name
- GAINS (NCT04992390)
- Testing
- Brief digital imagery-competing task intervention
- Where
- United Kingdom
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- P1vital Products Limited
Memory Consolidation
The Impact of Reactivation During Sleep on the Consolidation of Abstract Information in Humans
In any given cognitive domain, representations of individual elements are not independent but are organized by means of structured relations.
- Trial name
- NCT05746299
- Testing
- Congruent vs. Incongruent, Immediate vs. Awake vs. Asleep, Targeted memory reactivation (TMR)
- Where
- United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Memory Disorders, Postmenopausal Symptoms
The Effect of a Multivitamin in the Treatment of Memory Loss in Postmenopausal Women
Complaints about memory loss are very common in women in the menopausal transition period. The effectiveness of estrogen replacement therapy in cognitive improvement is controversial.
- Trial name
- NCT03835325
- Testing
- Cogmax®
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Eurofarma Laboratorios S.A.
Transcranial Alternating Current Stimulation, Aging
Effects of Gamma-tACS on Memory and Sleep
The purpose of this clinical trial is to investigate the feasibility and efficacy of non-invasive transcranial alternating current stimulation (tACS) at gamma frequency in enhancing memory recall and modulating sleep network…
- Conditions
- Transcranial Alternating Current Stimulation, Aging, Cognitive Decline, Memory
- Trial name
- NCT05907707
- Testing
- Gamma transcranial alternating current stimulation, Control transcranial alternating current stimulation, EEG headband
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Memory
The Effect of Cannabidiol in Learning and Memory of Adults
The main objectives of this study were to test if a singular dose of Cannabidiol (1) enhances the learning and memory of healthy human subjects, (2) test if Cannabidiol has negative effects on Retroactive and Proactive…
- Trial name
- NCT06074172
- Testing
- Cannabidiol (246mg press pill)
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder
Network Control TMS fMRI
This study uses different types of functional magnetic resonance imagining (fMRI) to generate individual transcranial magnetic stimulation (TMS) targets.
- Conditions
- Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder, Working Memory
- Trial name
- NCT05736458
- Testing
- Transcranial Magnetic Stimulation (TMS), High controllability TMS target
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alzheimer Disease, Mild Cognitive Impairment
Evaluation of a Computerized Complex Instrumental Activities of Daily Living Marker (NMI)
The proposed study is designed to evaluate the performance of the ALTOIDA™ System as a tool to assist physicians in diagnosing Alzheimer's Disease (AD) in real-world clinical settings.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Memory Disorders, Cognitive Impairment
- Trial name
- AltoidaML (NCT02843529)
- Testing
- Altoida: neuropsychological, MRI, EEG and CSF biomarkers
- Volunteers
- 548 people, healthy volunteers welcome
- Sponsor
- Altoida
Dementia, Alzheimer Disease
The Healthy Patterns Sleep Study
The Healthy Patterns Study intervention is a home-based activity intervention designed to improve symptoms of circadian rhythm disorders (CRD) and quality of life (QOL) in home-dwelling persons with dementia.
- Conditions
- Dementia, Alzheimer Disease, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder
- Trial name
- NCT03682185
- Testing
- Attention-Control Condition, Timed Activity Intervention
- Where
- United States
- Volunteers
- 421 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Memory Impairment
Better Memory With Literacy Acquisition Later in Life
This study aims to discover whether acquiring basic-literacy in adulthood can improve episodic memory and brain structural and functional connectivity.
- Trial name
- NCT04473235
- Testing
- Literacy training, Non-Literacy training
- Where
- Brazil
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Epilepsy
fMRI Guided TMS Enhancement of Associative Memory Networks
This is a randomized, single-blinded, controlled phase 1 study to demonstrate feasibility and explore the neurophysiologic and clinical effects of repetitive transcranial magnetic stimulation (TMS) interventions in epilepsy…
- Trial name
- NCT02749422
- Testing
- MagStim RapidStim2
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Effect of tDCS on Memory in Older and Younger Adults
Effect of Noninvasive Electrical Brain Stimulation on Memory at Different Times of Day in Younger and Older Adults
This study will investigate the extent to which tDCS to dorsolateral prefrontal cortex (or dlPFC) impacts memory performance as a function of time-of-day in younger and older adults.
- Trial name
- NCT03723850
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Mild Cognitive Impairment
Water-based Activity to Enhance Recall in Veterans
This two-year study will evaluate the feasibility of an exercise training augmentation for cognitive training intervention to improve memory performance in Veterans with a diagnosis of amnestic Mild Cognitive Impairment (aMCI).
- Trial name
- WATER-VET (NCT02614092)
- Testing
- Water-based Activity + Cognitive Training
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Brain Diseases, Memory Disorders
Low Intensity Focused Ultrasound for Learning and Memory and Emotion Regulation
The goal of this clinical trial is to investigate the impact of low intensity focused ultrasound pulsation (LIFUP) to two different brain regions, the amygdala and entorhinal cortex, in older adults.
- Conditions
- Brain Diseases, Memory Disorders, Learning Disabilities, Cognitive Impairment
- Trial name
- LIFUPMEMEMOT (NCT03717922)
- Testing
- Low Intensity Focused Ultrasound Pulsation to Amygdala, Low Intensity Focused Ultrasound Pulsation to Entorhinal Cortex
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Associative Memory in Healthy Subjects
Investigating Transcranial Direct Current Stimulation (tDCS) in Accelerating Learning in a Healthy Older Population
The overall objective of this study is to explore whether transcranial Direct Current Stimulation (tDCS) can accelerate associative learning and boost associative memory in healthy subjects.
- Trial name
- NCT03467698
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas