Clinical trials: Memory Dysfunction
Epilepsy, Cognitive Decline
Influence of Non-invasive Neurostimulation (Transcutaneous Vagus Nerve Stimulation) on 1. the Noradrenergic Release in the Brain and 2. a Neuropsychological Memory Task
The goal of this study is to investigate the influence of transcutaneous vagus nerve stimulation 1. on the noradrenergic system in the brain and 2. on memory, in healthy volunteers.
- Trial name
- NCT02409069
- Testing
- Transcutaneous vagus nerve stimulation (Nemos®, Cerbomed GmbH)
- Where
- Belgium
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Subjective Cognitive Complaints, Mild Cognitive Impairment
Electronic Memory and Management Aid
This study will evaluate the effectiveness of a personalized, web-based training intervention that was developed to teach use of an Electronic Memory and Management Aid (EMMA) application.
- Trial name
- EMMA (NCT05696756)
- Testing
- Personalized Web-based training for EMMA app, Motivational Interviewing: Clinician Support
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Washington State University
Alzheimer Disease, Mild Cognitive Impairment
Memory Enhancement Using Transcranial Alternating Current Stimulation
The 32 million Alzheimer's disease (AD) and 69 million prodromal AD patients worldwide contribute to a large economic burden. Effective and safe therapies that slow or prevent the progression from mild cognitive impairment (MCI)…
- Trial name
- Memento (NCT06202872)
- Testing
- Gamma (40 Hz) tACS at the precuneus region
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- Amsterdam UMC, location VUmc
Traumatic Brain Injury
PC-Based Cognitive Rehabilitation for Traumatic Brain Injury (TBI)
The investigators evaluated whether it was possible to improve the measurement of memory, attention, and executive function in patients who have suffered traumatic brain injury through the use of computer-based testing.
- Trial name
- NCT00927576
- Testing
- Digit span testing, Spatial span testing, Finger tapping
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Parkinson's Disease, Cognitive Impairment
Memantine for Treatment of Cognitive Impairment in Patients With Parkinson's Disease and Dementia
The purpose of this research is to evaluate the usefulness of memantine, compared to placebo (sugar pill), for the treatment of cognitive impairment in patients with idiopathic Parkinson's disease (PD) and dementia.
- Conditions
- Parkinson's Disease, Cognitive Impairment, Dementia
- Trial name
- NCT00294554
- Testing
- Memantine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Alzheimer's Disease
Study of Magnetic Fields to Treat Alzheimer's Disease
To determine if low level magnetic fields can help to improve memory in patients diagnosed with Alzheimer's disease.
- Trial name
- NCT01313806
- Testing
- Resonator
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- pico-tesla Magnetic Therapies, LLC
Dementia, Mild Cognitive Impairment
Case-Finding for Neurocognitive Disorders in Pavia
Dementia is a global public health challenge with a heavy caregiving burden, impacting families, communities, and healthcare systems. It is a priority in healthcare planning, with focus on early diagnosis and ongoing support.
- Trial name
- C-FiND Pavia (NCT06983119)
- Testing
- Case-finding for Neurocognitive Disorders
- Where
- Italy
- Volunteers
- 490 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Older Adults (60 - 85 Years Old), Mild Cognitive Impairment (MCI)
Non-invasive Stimulation of Deep Brain Structures to Modulate Working Memory
A study investigating the effects of non-invasive electrical stimulation of deep brain structures on working memory, attention, and executive functions involved in everyday activities.
- Trial name
- DEEPBRAIN (NCT07560904)
- Testing
- Non-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (20 Hz), Control striatal stimulation, Non-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (60 Hz)
- Where
- Czechia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Memory Dysfunction, Mood Disorders
To Access the Effect of Brain Pill™ on Working Memory Capacity and Mood Behaviour.
Brain Pill™ is a mental health enhancing and successfully marketed dietary supplement.
- Trial name
- NCT03198936
- Testing
- Cognizin® SynapsaTM
- Where
- India
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Mild Cognitive Impairment
Real-time fMRI Neurofeedback in Patients With MCI
Increased activity in the hippocampus (i.e., hyperactivity) during a fMRI memory task was found in patients with Mild Cognitive Impairment due to Alzheimer's disease (MCI).
- Trial name
- NCT04020744
- Testing
- real-time fMRI based neurofeedback from the hippocampus, real-time fMRI based neurofeedback from another brain area
- Where
- 2 sites in Switzerland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Bern
Schizophrenia, Schizoaffective Disorder
Guanfacine Adjunctive Treatment to Atypical Antipsychotics for Cognitive Dysfunction in Schizophrenia
Our overall aim is to determine if the administration of guanfacine in combination with aripiprazole, olanzapine, quetiapine, and/or risperidone is significantly more effective than any of those medications alone in treating some…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Cognitive Impairment
- Trial name
- Guanfacine (NCT00469664)
- Testing
- Guanfacine/Tenex
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Parkinson's Disease, Mild Cognitive Impairment
Cognitive Rehab for Parkinson's
This study will examine the feasibility of an at-home cognitive training program that incorporates both memory training and online computerized cognitive training (CCT) software.
- Trial name
- NCT03836963
- Testing
- cognitive training, active control cognitive training, memory strategy training
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- VA Office of Research and Development
Memory Deficits, Aging
The Effect of Tai Chi and Therapy by Dance and Movement on Blood Irisin Levels in Older Adults Over 65 Years of Age.
The aim of this project is to estimate the effects of therapy with dance and movement and Tai Chi on irisin plasma levels, a myokine with proven neuroprotective effects, in the context of baseline levels of cognitive function and…
- Conditions
- Memory Deficits, Aging, Cognitive Impairment, Physical Activity
- Trial name
- NCT05363228
- Testing
- Therapy by Dance and Movement, Tai Chi
- Where
- 2 sites in Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Mild Cognitive Impairment
Rosiglitazone Effects on Cognition for Adults in Later Life
The purpose of this study is to determine the effects of the insulin-sensitizing medication rosiglitazone on attention and memory skills in older adults with mild cognitive impairment (MCI).
- Trial name
- RECALL (NCT00242593)
- Testing
- Rosiglitazone
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Washington
Mild Cognitive Impairment, Subjective Memory Impairment
The Cognitive Ageing Nutrition and Neurogenesis (CANN) Trial
There is a dearth of research which takes a multi-compound approach to dietary interventions, in humans, aimed at improving outcome measures of cognition.
- Trial name
- CANN (NCT02525198)
- Testing
- fatty acid/flavonoid blend
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Stroke, Cognitive Deficit
Transcranial Direct Current Stimulation (tDCS) in Post-Stroke Working Memory Deficits
The purpose of this study is to test the effects of tDCS (Transcranial Direct Current Stimulation) on stroke patients with working memory problems.
- Conditions
- Stroke, Cognitive Deficit, Cognitive Impairment, Short-Term Memory Impairment
- Trial name
- TDCS-PSMWD (NCT03034109)
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Stony Brook University
Mild Cognitive Impairment (MCI)
Levetiracetam and Memory Function in Amnestic Mild Cognitive Impairment (MCI)
This research is being done to find out if daily use of the drug levetiracetam can improve memory function in individuals with memory problems like those associated with Mild Cognitive Impairment (MCI) and Alzheimer's disease…
- Trial name
- NCT01044758
- Testing
- Levetiracetam 62.5mg, Levetiracetam 125mg, Levetiracetam 250mg
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Mild Cognitive Impairment, Memory Impairment
Diminishing Accelerated Long-term Forgetting in Mild Cognitive Impairment
This study is designed as a prospective, double-blind, placebo-controlled, randomized parallel-group study that will be completed at the clinical research facility at St. James' Hospital and at Trinity College Dublin, Ireland.
- Conditions
- Mild Cognitive Impairment, Memory Impairment, Memory Disorders in Old Age
- Trial name
- NCT05289804
- Testing
- NITESGON, Lidocaine / Prilocaine Topical Cream, C5/C6 stimulation
- Where
- Ireland
- Volunteers
- 80 people
- Sponsor
- University of Dublin, Trinity College
Mild Cognitive Impairment, Alzheimer Disease
Using Exercise and Electrical Brain Stimulation to Improve Memory in Dementia
Mild cognitive impairment and Alzheimer's disease are conditions that involve memory difficulties. Transcranial direct current stimulation is a type of brain stimulation. It may help improve these memory difficulties.
- Trial name
- EXACT (NCT03670615)
- Testing
- tDCS, Exercise, Exercise Education
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Memory Disorders, Mild Cognitive Impairment
Physical Exercise for Prevention of Dementia
The principal aim of this study is to verify whether a program of supervised, multimodal physical exercise improves cognitive function and/or reduces the rate of cognitive decline in older adults
- Conditions
- Memory Disorders, Mild Cognitive Impairment, Aging
- Trial name
- EPD (NCT02236416)
- Testing
- Intervention group, Control group
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Molise