Clinical trials: Memory Dysfunction, open to volunteers
Cognitive Dysfunction, Cognition Disorder
Nutrition-based Interventions to Prevent Cognitive Decline
This study intends to evaluate the feasibility and the effectiveness of an innovative and integrated nutrition-based intervention addressing key modifiable risk factors for dementia while meeting participants' preferences for…
- Conditions
- Cognitive Dysfunction, Cognition Disorder, Memory Disorders, Cognitive Impairment
- Trial name
- NUTRIMIND (NCT06853405)
- Testing
- Nutrition-related lifestyle group sessions, Cognitive training, Clinical nutrition consultations
- Where
- 2 sites in Portugal
- Volunteers
- 120 people
- Sponsor
- Instituto de Saude Publica da Universidade do Porto
Alzheimer Disease, Dementia, Mild
Paper-Based and Smartphone-Based Memory Supports
Alzheimer's disease and related dementias lead to marked declines in daily functioning, independence, and quality of life. One of the earliest cognitive changes in these conditions is impairment in prospective memory, or the…
- Conditions
- Alzheimer Disease, Dementia, Mild, Mild Cognitive Impairment
- Trial name
- NCT06444841
- Testing
- Digital - Google Calendar, Paper-based - Memory Support System
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Baylor University
Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Amnestic
Deep Brain Stimulation Guided by Brain Mapping to Treat Cognitive Impairment
This trial is a 12-month safety and feasibility study, enrolling up to six participants. These participants will serve as their own controls, structured in multiple parts that follow an initial short-term stereo…
- Conditions
- Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Amnestic, Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, Memory Deficit
- Trial name
- NCT07887737
- Testing
- Abbott St Jude Medical Infinity™
- Volunteers
- 6 people
- Sponsor
- University of Texas Southwestern Medical Center
Eldery People, Cognitive Decline
Optimizing CNS DHA Delivery in Elderly Adults at Risk for Dementia
The purpose of this placebo-controlled trial is to compare the effects of 24-weeks supplementation with LPC-DHA and TAG-DHA on cerebrospinal fluid and blood DHA levels, as well as biomarkers of central neurodegenerative and…
- Conditions
- Eldery People, Cognitive Decline, Memory Decline, DHA CNS Delivery
- Trial name
- NCT06933095
- Testing
- LPC-EPA+DHA capsules containing omega-3 fatty acids EPA and DHA esterified to lysophosphatidylcholine (LPC-EPA+DHA)(Trade name: Lysoveta)
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- University of Cincinnati
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
A Physical Activity Program Compared to Health Education for Improving Memory and Attention in Hispanic Women With Newly-Diagnosed Stage I-IIIa Breast Cancer, MAMA Trial
This clinical trial compares a physical activity program to a health education program for improving memory and attention in Hispanic women who are 50 years of age or older and are newly-diagnosed with stage I-IIIa breast cancer.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Cancer-related Cognitive Dysfunction
- Trial name
- NCT07331077
- Testing
- Accelerometry, Aerobic Exercise, Electronic Health Record Review
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Mild Cognitive Impairment
LifeBio Memory: Development of a Reminiscence Therapy Online Platform With Machine Learning to Increase Engagement
LifeBioMEMORY (LBM) is a reminiscence therapy (RT) mobile application that captures older adults' life stories in their own voices to promote social engagement and psychosocial well-being.
- Trial name
- LifeBio Memory (NCT07685067)
- Testing
- LifeBio Memory (LBM) digital reminiscence intervention
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- George Mason University
Dementia, Mild Cognitive Impairment (MCI)
Early-Stage Partner in Care Living Alone Plus
EPICLA+ (Early-Stage Partners in Care Living Alone Plus) is a research project designed to assist people with early-stage memory loss who live alone in the community by providing early-stage related education and skill-training…
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Alzheimer Disease
- Trial name
- EPICLA+ (NCT06962111)
- Testing
- Psychoeducational skills training intervention
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Arizona State University
Alzheimer Disease
Georgia Memory Net Anti-Amyloid Monoclonal Antibody Registry
The purpose of this registry is to compile information on patients who are receiving FDA-approved anti-amyloid mAbs in the course of their clinic visits in the Emory Cognitive Neurology Clinic and in Georgia Memory Net Memory…
- Trial name
- NCT05999084
- Testing
- Anti-amyloid Monoclonal Antibodies (mAbs), Standard of Care
- Where
- 8 sites in United States
- Volunteers
- 735 people
- Sponsor
- Emory University
Alzheimer Disease, Hearing Loss
Early Age-Related Hearing Loss Investigation (EARHLI)
Early Age-Related Hearing Loss Investigation (EARHLI) is a single site study that will randomize late middle age adults to either a hearing intervention (including hearing aids) or a health education intervention.
- Conditions
- Alzheimer Disease, Hearing Loss, Cognitive Impairment
- Trial name
- EARHLI (NCT06174038)
- Testing
- Hearing Intervention, Health Education Intervention
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Columbia University
Mild Cognitive Impairment (MCI)
Enhancing Attention in Elderly Using a Brain-Computer-Interface
Cognitive reserve refers to the brain's ability to maintain cognitive performance despite age-related changes or neuropathology.
- Trial name
- NCT07441122
- Testing
- transcranial electrical stimulation, Mindfulness Meditation
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Dementia, Memory Loss
Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia
This project aims to examine the efficacy of remote, caregiver-led tES/brain stimulation intervention targeted to improve memory, mobility, and executive functioning among older adults with mild cognitive impairment or mild…
- Conditions
- Dementia, Memory Loss, Alzheimer Disease, Executive Dysfunction
- Trial name
- ACDCStim (NCT05661084)
- Testing
- Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (active)
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Hebrew SeniorLife
Older Adults (60 - 85 Years Old), Mild Cognitive Impairment (MCI)
Non-invasive Stimulation of Deep Brain Structures to Modulate Working Memory
A study investigating the effects of non-invasive electrical stimulation of deep brain structures on working memory, attention, and executive functions involved in everyday activities.
- Trial name
- DEEPBRAIN (NCT07560904)
- Testing
- Non-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (20 Hz), Control striatal stimulation, Non-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (60 Hz)
- Where
- Czechia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Mild Cognitive Impairment
Spatial Memory Training and Cognitive Function
Mild cognitive impairment (MCI) is often considered a transitional stage between normal aging and dementia, particularly Alzheimer's disease (AD).
- Trial name
- NCT07002996
- Testing
- SMIP, No intervention
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Douglas Mental Health University Institute
Mild Cognitive Impairment (MCI), Subjective Memory Complaint
Validation of a Digital Intervention to Rehabilitate Cognitive Resources
The goal of this clinical trial is to learn if the use of a digital cognitive rehabilitation system named RICORDO, that is flexible and capable of adapting the rehabilitation pathway according to the needs and capacity of the…
- Conditions
- Mild Cognitive Impairment (MCI), Subjective Memory Complaint, Dementia Alzheimer Type
- Trial name
- MI-RICORDO (NCT07064226)
- Testing
- RICORDO, Treatment as Usual (TAU)
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Cognitive Decline
ADL+2.0: Intervention for Prevention of Cognitive Decline in Community-dwelling Older Adults
Singapore's rising dementia incidence with an ageing population presents an urgent need for effective interventions that delay or prevent cognitive decline.
- Trial name
- ADL+ 2 (NCT07141160)
- Testing
- Combined: Mobile app + 6WELLS, Remote mobile based app
- Where
- Singapore
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Mild Cognitive Impairment (MCI)
Memory Support System for Older Chinese Americans With Mild Cognitive Impairment
The Memory Support System (MSS) from the Healthy Action to Benefit Independence \& Thinking® (HABIT) Program is an evidence-based, non-pharmacological intervention for mild cognitive impairment (MCI).
- Trial name
- NCT07142499
- Testing
- Memory Support System, Brain Health Education
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Mild Cognitive Impairment (MCI), Memory
Percepta for Cognitive Optimization
This Phase 1, randomized, double-blind, placebo-controlled trial evaluates the cognitive and neurophysiological effects of a dietary supplement containing cat's claw (Uncaria tomentosa) bark extract and oolong tea extract, in…
- Trial name
- PFCO (NCT07612449)
- Testing
- Percepta
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Cerebrum DAO Association
Mild Cognitive Impairment, Alzheimer's Disease
Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia
Bio-Hermes-002 is a 120-day cross-sectional study that will result in a blood, CSF, retinal, digital, MRI, and PET brain imaging biomarker database that can be used to determine the primary objective.
- Conditions
- Mild Cognitive Impairment, Alzheimer's Disease, Alzheimer's Disease, Early Onset, Memory Loss
- Trial name
- Bio-Hermes-002 (NCT06584357)
- Testing
- Biomarker Data Collection, MK6240
- Where
- 26 sites in United States, Canada and 1 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- GAP Innovations, PBC
Alzheimer Disease, Mild Cognitive Impairment
Biodistribution of [11C]PIB in Patients With Risk Factors for Alzheimer's Disease
Participants enrolled at the Alzheimer's Disease Research Center (ADRC) at Wake Forest School of Medicine will be invited to take part in this study.
- Trial name
- NCT03089827
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pain, Chronic, Dementia, Mild
Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia
The purpose of this study is to develop an exercise treatment program for knee osteoarthritis that works well for people with memory problems. This study will include two parts.
- Conditions
- Pain, Chronic, Dementia, Mild, Mobility Limitation, Physical Disability
- Trial name
- NCT06264362
- Testing
- Tailored Physical Activity Program
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Drexel University