Clinical trials: Memory Functions
Behavior, Health
Train Your Brain: A Pilot Project to Improve Memory and Decision Making
The goal of this clinical trial is to pilot a computer-based working memory training program to improve delay discounting (DD) and prevent substance use among at-risk adolescents in a traditionally underserved area.
- Trial name
- NCT05879198
- Testing
- Computer-based Intervention
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Henry Ford Health System
Mild Cognitive Impairment, Alzheimer's Disease
Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI)
Memory deficits are common after traumatic brain injuries (TBI) and are characteristic of various forms of dementia, such as Alzheimer's disease and its common precursor mild cognitive impairment (MCI).
- Conditions
- Mild Cognitive Impairment, Alzheimer's Disease, Traumatic Brain Injury
- Trial name
- NCT00714571
- Testing
- Mnemonic strategy training (MST), Repeated exposure (XP), Subtracting Cues training
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Memory Impairment
The Efficacy of Phosphatidylserine-Omega3 in Elderly Subjects With Memory Impairment
The primary objective of this trial is to assess the ability of Phosphatidylserine-Omega3 to improve cognitive performance in elderly subjects with memory impairment.
- Trial name
- NCT00736034
- Testing
- Phosphatidylserine-Omega3 (SharpPS™-Gold)
- Where
- Israel
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Enzymotec
Cocaine Addiction, Cocaine-related Disorder
Prefrontal Cortex Stimulation as Treatment for Crack-cocaine Addiction
The use of crack-cocaine is growing at alarming rate in our country and it is absolutely worrisome the fast establishment of addiction to it.
- Conditions
- Cocaine Addiction, Cocaine-related Disorder, Executive Dysfunction
- Trial name
- NCT01337297
- Testing
- transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Espirito Santo
Stress Disorders, Post-Traumatic, Affect
Examining Effects of a Therapeutic Focus on Positive Memories on Post-Trauma Health
Posttraumatic stress disorder (PTSD) has devastating health consequences. Evidence-based PTSD interventions address the substantial burden of PTSD on the health of individuals and societies; however, several individuals receiving…
- Conditions
- Stress Disorders, Post-Traumatic, Affect, Memory
- Trial name
- NCT05523453
- Testing
- Processing of Positive Memories Technique (PPMT), Supportive Counseling (SC)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of North Texas, Denton, TX
Normal Physiology
Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory
Background: Transcranial magnetic stimulation (TMS) of the brain has been used to change the activity and connections in the brain to improve memory.
- Trial name
- NCT04694131
- Testing
- TMS
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Brain Injuries
CDP-Choline and Working Memory After TBI: A Neuroimaging Study
The purpose of this study is to determine whether an investigational drug, called "CDP-Choline", improves memory in people with traumatic brain injury (TBI).
- Trial name
- NCT00727246
- Testing
- CDP-Choline
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Patricia M. Arenth
Influenza
Innate and Acquired Immunity to Influenza Infection and Immunization (SLVP029)
The purpose of the study is to get a better understanding of the natural and adaptive immune response to the flu virus and to compare the immune cell responses to FDA-licensed flu vaccines in nasal mucosal cells and in blood.
- Trial name
- NCT03028974
- Testing
- Fluzone®, FluMist®
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Stanford University
Mild Cognitive Impairment
Olfactory Deficits in MCI as Predictor of Improved Cognition on Donepezil
Odor identification deficits, which are a result of early Alzheimer's Disease (AD) pathology in the olfactory bulb and tract as well as olfactory projection areas in the medial temporal lobe (entorhinal and piriform cortex and…
- Trial name
- NCT01845636
- Testing
- Donepezil, Atropine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- New York State Psychiatric Institute
Chronic Pain, Mild Cognitive Impairment
Managing Pain and Cognitions in Older Adults With Mild Cognitive Impairment or Memory Related Problems and Chronic Pain
We aim to conduct a pilot randomized controlled trial comparing 2 symptom management programs for older adults with self-reported memory problems and chronic pain, Active Brains 1 and Active Brains 2.
- Conditions
- Chronic Pain, Mild Cognitive Impairment, Older Adults, Physical Activity
- Trial name
- NCT04044183
- Testing
- Active Brains 1, Active Brains 2
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Healthy Adults
Investigating Memory in Healthy Subjects Using Transcranial Direct Current Stimulation
The purpose of this study is to investigate whether we can improve associative memory performance in healthy subjects, by applying transcranial Direct Current Stimulation (tDCS) during a verbal paired-associate learning task
- Trial name
- NCT03564353
- Testing
- tDCS
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Effect of tDCS on Memory in Older and Younger Adults
Effect of Noninvasive Electrical Brain Stimulation on Memory at Different Times of Day in Younger and Older Adults
This study will investigate the extent to which tDCS to dorsolateral prefrontal cortex (or dlPFC) impacts memory performance as a function of time-of-day in younger and older adults.
- Trial name
- NCT03723850
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Posttraumatic Stress Disorders
Eszopiclone for the Treatment of Posttraumatic Stress Disorder
The purpose of this study is to determine if eszopiclone relative to placebo (sugar pill) is effective and tolerable for people with posttraumatic stress disorder (PTSD)-related sleep disturbance.
- Trial name
- NCT01605253
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Rush University Medical Center
Mild Cognitive Impairment, Cognitive Decline
Exercise in Adults With Mild Memory Problems
This study evaluates the effects of physical exercise on cognition, functional status, brain atrophy and blood flow, and cerebrospinal fluid biomarkers of Alzheimer's disease in adults with a mild memory impairment.
- Conditions
- Mild Cognitive Impairment, Cognitive Decline, Memory Impairment
- Trial name
- EXERT (NCT02814526)
- Testing
- Aerobic exercise, Stretching/balance/range of motion exercise
- Where
- 14 sites in United States
- Volunteers
- 296 people
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Alcohol Dependence, PTSD
Neuromodulation of Trauma Memories in PTSD & Alcohol Dependence
The purpose of this study is to examine the effect of propranolol versus placebo on craving, distress and cue reactivity to trauma and alcohol cues.
- Trial name
- NCT01055171
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Alzheimer Disease, Dementia
Moving Together: An Online Group Movement Program for People Living With Memory Loss and Caregivers
To determine whether Moving Together improves quality of life in people with memory loss (PWML) and caregivers (CG) by performing a randomized, controlled trial (RCT) with a waitlist control group in 224 dyads.
- Trial name
- NCT04621448
- Testing
- Moving Together
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- University of California, San Francisco
Anxiety and Fear
Memory and Fear Study (Fear of Memory Loss Study)
This study is a randomized control study to determine the impact of a tailored, web-based mindfulness program to reduce anxiety and increase the quality of life in older adults experiencing dementia-related fears, relative to a…
- Trial name
- NCT04821960
- Testing
- Tailored Mindfulness Program for Fear of Memory Loss, Conventional Mindfulness Program
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Northwestern University
HIV
Improving Memory Performance by Applying Cognitive Training
The proposed study will test the efficacy of a cognitive training program to improve working memory in a sample of HIV-infected persons.
- Trial name
- IMPACT (NCT02216591)
- Testing
- Active Cognitive Training (ACT), Control (CON)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Duke University
Insomnia, Sleep Initiation and Maintenance Disorders
Modafinil Treatment for Sleep/Wake Disturbances in Older Adults
Modafinil, trade named Provigil, is a medication approved by the Food and Drug Administration for the treatment of narcolepsy, obstructive sleep apnea/hypopnea syndrome, and shift work sleep disorder.
- Conditions
- Insomnia, Sleep Initiation and Maintenance Disorders, Alzheimer Disease
- Trial name
- NCT00626210
- Testing
- modafinil
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- VA Palo Alto Health Care System
Very Premature Baby
Attention Control Training (ACT) and Very Preterm Infants
Infants' attention control, defined as the ability to select what to pay attention to, is a fundamental building block for developing learning abilities and behaviour self-regulation.
- Trial name
- ACT (NCT03896490)
- Testing
- Attention Control Training, Control
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast