Clinical trials: Memory Problems
Healthy
A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine
The main objective of this trail is to investigate if and to what extent BI 409306, BI 425809 and lamotrigine attenuate ketamine induced cognitive deficits.
- Trial name
- NCT04602221
- Testing
- Lamotrigine, BI 409306, BI 425809
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Boehringer Ingelheim
Mild Cognitive Impairment, Dementia
A 3 Year Study to Evaluate the Safety and Efficacy of Low Dose Ladostigil in Patients With Mild Cognitive Impairment
The purpose of this study is to determine whether treatment with the investigational drug ladostigil will delay the onset of Alzheimer's disease(AD) in patients with Mild Cognitive Impairment (MCI).
- Trial name
- NCT01429623
- Testing
- ladostigil hemitartrate
- Where
- 12 sites in Austria, Germany and 1 more
- Volunteers
- 210 people
- Sponsor
- Avraham Pharmaceuticals Ltd
Mild Cognitive Impairment, Cognitive Impairment
Study of Nasal Insulin to Fight Forgetfulness - Device Study
The SNIFF Device study will involve using a device to administer insulin through each participant's nose or intra-nasally. Insulin is a hormone that is produced in the body.
- Trial name
- NCT03857321
- Testing
- Insulin, intranasal nebulizer-like device
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Cognitive Impairment
Phenytoin for Memory Impairment Secondary to Megestrol
This study is designed to test if megestrol acetate induces changes in declarative memory in healthy controls and if pre-administration of phenytoin can ameliorate any induced cognitive impairments.
- Trial name
- NCT02595723
- Testing
- Phenytoin 200 mg capsule, Megestrol 800 mg liquid
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Delirium, Postoperative Cognitive Dysfunction
Rivastigmine in the Treatment of Postoperative Delirium: a Pilot Clinical Trial
The purpose of this study is to determine whether preoperative administration of Rivastigmine prevents the incidence of postoperative delirium in patients undergoing major surgery as well as postoperative cognitive dysfunction.
- Trial name
- NCT00835159
- Testing
- Rivastigmine Patch
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Alzheimer Disease (AD)
A Study of LY3303560 in Participants With Early Symptomatic Alzheimer's Disease
The purpose of this study is to evaluate the safety and efficacy of a study drug that targets an abnormal protein in the brain found in people with Alzheimer's Disease (AD).
- Trial name
- NCT03518073
- Testing
- Zagotenemab
- Where
- 60 sites in United States, Canada and 1 more
- Volunteers
- 360 people
- Sponsor
- Eli Lilly and Company
Hypertension, Mild Cognitive Impairment
Brain Connections and Blood Pressure
This pilot randomized controlled study evaluates Mindfulness and DASH Diet resting state network and blood pressure in 36 (n=12 intervention; n=12 attention control; n = 12 control) Black and African American older adults with…
- Trial name
- NCT03736434
- Testing
- Mindfulness and DASH Diet Education, Education group
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Ohio State University
Age-Related Memory Disorders
Study of LX6171 in Elderly Volunteers With Age Associated Memory Impairment
The purpose of the study is to determine the safety, tolerability, and effectiveness of 2 dose levels of LX6171 given over 28 days in patients with Age Associated Memory Impairment (AAMI).
- Trial name
- NCT00691808
- Testing
- LX6171 High Dose, LX6171 Low Dose
- Where
- 2 sites in Netherlands
- Volunteers
- 103 people
- Sponsor
- Lexicon Pharmaceuticals
Memory Disorders, Multiple Sclerosis
Recall Enhancement Through Treatment With Atomoxetine in MS (RETAIN-MS)
The purpose of this crossover trial is to investigate whether atomoxetine (versus placebo) improves memory function in persons with memory deficits due to multiple sclerosis.
- Trial name
- NCT03091400
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Menopause
Estrogen and Serotonin on Changing Brain Chemistry
The aim of this study is to examine the effects of estrogen and serotonin on cognition, emotional processing, and brain activation.
- Trial name
- NCT01208324
- Testing
- estrogen patch, Amino acids
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Caregivers of Alzheimer's Disease or Memory Problem Patients
Caring for the Caregiver Network
The prevalence of family caregivers is projected to increase in concert with the projected increase in number of AD patients. The focus of the study is to gather systematic data on the acceptability and efficacy of a unique…
- Trial name
- NCT03049501
- Testing
- Caregiving condition, Nutrition condition
- Where
- United States
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- University of Miami
Alzheimer's Disease
Resveratrol for Alzheimer's Disease
Resveratrol is derived from plants and is found in highest levels in red wine and the skin of red grapes. A recent study reported that monthly and weekly consumption of red wine is associated with a lower risk of dementia.
- Trial name
- NCT01504854
- Testing
- Resveratrol
- Where
- 26 sites in United States
- Volunteers
- 119 people
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Mild Cognitive Impairment, Alzheimer's Disease
Reducing Risk for Alzheimer's Disease in High-Risk Women Through Yogic Meditation Training
The purpose of this pilot study will be to test whether Kundalini yoga (KY) and Kirtan Kriya (KK) yogic meditation is superior to Memory Enhancement Training (MET) for improving cognitive functioning, health (including…
- Trial name
- NCT03503669
- Testing
- Memory Training, Kundalini yoga and meditation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Los Angeles
Mild Cognitive Impairment, Cognitive Impairment
SNIFF - Combo INI+EMPA Trial
The proposed pilot study will provide safety and efficacy preliminary data regarding singular and combined effects of two therapeutic approaches, intranasal insulin and treatment with the sodium-glucose cotransporter type 2…
- Conditions
- Mild Cognitive Impairment, Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT05081219
- Testing
- Insulin (Humulin® R U-100), Empagliflozin 10 MG, Aptar Pharma CPS Intranasal Delivery Device
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Mild Cognitive Impairment
Water-based Activity to Enhance Recall in Veterans
This two-year study will evaluate the feasibility of an exercise training augmentation for cognitive training intervention to improve memory performance in Veterans with a diagnosis of amnestic Mild Cognitive Impairment (aMCI).
- Trial name
- WATER-VET (NCT02614092)
- Testing
- Water-based Activity + Cognitive Training
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Mild Cognitive Impairment
Memory Training Versus Yogic Meditation Training in Older Adults With Mild Cognitive Impairment
The purpose of this pilot study is to test whether 6 months of supervised weekly Kundalini yoga classes and a brief daily meditation homework assignment can improve memory and thinking in older adults with mild memory complaints…
- Trial name
- NCT01983930
- Testing
- Kundalini yoga and meditation, Memory Training
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of California, Los Angeles
Bipolar Disorder
Research Study of Bipolar Mood Symptoms and Cognitive Problems
This is a sixteen week, randomized, double-blind add-on study of valacyclovir versus placebo in approximately 60 outpatients meeting diagnostic criteria according to the Diagnostic and Statistical Manual of Mental Disorders (DSM)…
- Trial name
- NCT00428298
- Testing
- Valacyclovir
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Memory Impairment
Vilazodone for Corticosteroid-Induced Memory Impairment
The purpose of this study is to examine whether vilazodone attenuates the memory and mood effects of corticosteroids on the human hippocampus in 24 healthy controls.
- Trial name
- NCT01828515
- Testing
- Vilazodone, Hydrocortisone
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Traumatic Brain Injury
Brain Training to Enhance Frontal Lobe Reasoning
This study is being done to improve the ability to diagnose and to achieve higher-levels of functional recovery in soldiers and civilians who have suffered either mild Traumatic Brain Injury (TBIs) or moderate-to-severe TBIs at…
- Trial name
- NCT01552473
- Testing
- Brain Training Program 1, Brain Training Program 2
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- The University of Texas at Dallas
Mild Cognitive Impairment
Network-guided TMS in Early Alzheimer's Disease
The proposed research will test a novel network-based neurostimulation approach using MRI-derived measures of brain connectivity to establish target sites for neurostimulation and test for the enhancement of memory function…
- Trial name
- NetTMS (NCT04549155)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Duke University