Clinical trials: Meningitis/Encephalitis
Meningococcal Disease, Meningococcal Meningitis
A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults
This study compares the safety and immunogenicity profile of several travel vaccines given alone or concomitantly with MenACWY-CRM to healthy adults.
- Conditions
- Meningococcal Disease, Meningococcal Meningitis, Typhoid, Yellow Fever
- Trial name
- NCT01466387
- Testing
- Typhoid Vi Polysaccharide Vaccine, Yellow Fever Vaccine, Japanese Encephalitis Vaccine
- Where
- 5 sites in Czechia, Germany
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- Novartis
Meningitis, Encephalitis Infection
Clinical Performance of QIAstat-Dx® Meningitis/Encephalitis (ME) Panel Plus
Performance evaluation of QIAstat-Dx® ME Panel Plus using the QIAstat-Dx® Analyzer to demonstrate that the QIAstat-Dx® ME Panel Plus achieves its intended performance during normal conditions of use by the intended user in the…
- Trial name
- NCT06820060
- Where
- United Kingdom
- Volunteers
- 1,500 people
- Sponsor
- QIAGEN Gaithersburg, Inc
Meningitis, Encephalitic Infection
Prediction of Infectious Agents in the Biofire® FilmArray bioMérieux Meningitis/Encephalitis Panel Based on Clinical Syndrome and Cerebrospinal Fluid Parameters: a Diagnostic Stewardship Proposal.
Background: Infections of the central nervous system (CNS) are associated with high morbidity, mortality, and high resource consumption.
- Conditions
- Meningitis, Encephalitic Infection, Encephalitis, Meningitis, Fungal
- Trial name
- NCT07432113
- Testing
- Biofire FilmArray Meningitis/Encephalitis Panel
- Where
- Brazil
- Volunteers
- 182 people
- Sponsor
- Federal University of Health Science of Porto Alegre
West Nile Virus Infection
Expanded Access to MGAWN1 in Subjects With Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection; or Substantial Accidental Exposure
This study will test an experimental drug called MGAWN1 for the treatment of West Nile infections.
- Trial name
- NCT01206504
- Testing
- MGAWN1
- Sponsor
- MacroGenics
Aseptic Meningitis
Aseptic Meningoencephalitis in Slovenia
The main objective of this study is: to establish etiology of acute aseptic meningitis/meningoencephalitis in Slovenia to assess the clinical course and outcome of tick-borne encephalitis and Lyme neuroborreliosis to characterize…
- Trial name
- NCT02328469
- Testing
- symptomatic therapy, Ceftriaxone or Doxycycline, questionnaire
- Where
- 2 sites in Slovenia
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Trauma Injury, Brain Injuries
The Effect of Supraglottic and Oropharyngeal Decontamination on the Incidence of Ventilator-associated Pneumonia
Oropharynx is the main source of pathogen microorganisms for the ventilator - associated pneumoniae. As known bacteriophages can eliminate different pathogen microorganisms or reduce a degree of a pathogen's colonization.
- Conditions
- Trauma Injury, Brain Injuries, Abdominal Sepsis, Pancreatitis
- Trial name
- SGDC-VAP (NCT04325685)
- Testing
- Control, Antiseptic Solution, Bacteriophage
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Northern State Medical University
Coma, Disorders of Consciousness
Recovery Trajectory for Coma and Disorders of Consciousness
This study aims to better understand recovery after coma caused by serious neurologic illness or injury. Patients who are unconscious (in a coma or disorder of consciousness) due to conditions such as stroke, cardiac arrest…
- Conditions
- Coma, Disorders of Consciousness, Cardiac Arrest (CA), Traumatic Brain Injuries
- Trial name
- Coma Cohort (NCT07614074)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of California, San Francisco
Encephalitis, Myelitis
Neurologic Manifestations of the Arbovirus Infection in Colombia
This is a multi-center case-control study that aims to define the association between the exposure to an arbovirus infection and the development of a neurological syndrome in patients from Colombia.
- Conditions
- Encephalitis, Myelitis, Guillain-Barre Syndrome, Cranial Nerve Palsies
- Trial name
- NCT03206541
- Where
- 8 sites in Colombia
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Lupus Erythematosus, Cutaneous, Lupus Erythematosus, Discoid
Phase Ib Study of SC Milatuzumab in SLE
Milatuzumab will be given subcutaneously at different dose levels once (depending on the dose level) for 4 weeks to determine if milatuzumab helps to control lupus (SLE).
- Conditions
- Lupus Erythematosus, Cutaneous, Lupus Erythematosus, Discoid, Lupus Erythematosus, Systemic, Lupus Vasculitis, Central Nervous System
- Trial name
- NCT01845740
- Testing
- milatuzumab
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Gilead Sciences
Systemic Lupus Erythematosus (SLE), Lupus Nephritis
Lupus Landmark Study: A Prospective Registry and Biorepository
The purpose of the registry and biorepository is to provide a mechanism to store clinical data, linked biospecimens and molecular data to support the conduct of future research on Systemic Lupus Erythematosus (SLE), including…
- Conditions
- Systemic Lupus Erythematosus (SLE), Lupus Nephritis, Neuropsychiatric Systemic Lupus Erythematosus
- Trial name
- NCT05934149
- Where
- 25 sites in United States, Canada
- Volunteers
- 3,500 people
- Sponsor
- Lupus Research Alliance
Optic Neuritis, Transverse Myelitis
Swiss Pediatric Inflammatory Brain Disease Registry (Swiss-Ped-IBrainD)
The Swiss-Ped-IBrainD is a national patient registry that collects information on diagnosis, symptoms, treatment, and follow-up of pediatric patients with an inflammatory brain disease in Switzerland.
- Conditions
- Optic Neuritis, Transverse Myelitis, Acute Disseminated Encephalomyelitis, Multiple Sclerosis
- Trial name
- NCT05017142
- Where
- 13 sites in Switzerland
- Volunteers
- 500 people
- Sponsor
- University of Bern
Meningitis Streptococcal, Hiv
Treatment With Tamoxifen in Cryptococcal Meningitis
The purpose of this study is to develop initial efficacy, feasibility, and safety data regarding the use of Tamoxifen in combination with amphotericin B and fluconazole in the treatment of cryptococcal meningitis.
- Conditions
- Meningitis Streptococcal, Hiv, Meningitis, Meningoencephalitis
- Trial name
- NCT03112031
- Testing
- Tamoxifen, Amphotericin B, Fluconazole
- Where
- 3 sites in Vietnam
- Volunteers
- 50 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Meningitis, Encephalitis
BIGlobal Intervention Study: Improving Diagnosis and Management of Suspected Brain Infections Globally
Background: Patients with suspected brain infections pose major challenges to low and middle income countries, including their disproportionately high burden, diverse causes with inadequate surveillance, requirement for invasive…
- Conditions
- Meningitis, Encephalitis, Abscess Brain
- Trial name
- NCT04190303
- Testing
- Pragmatic, multi-component package
- Where
- 4 sites in Brazil, India and 1 more
- Volunteers
- 2,233 people
- Sponsor
- University of Liverpool
Meningitis, Meningitis/Encephalitis
Optic Nerve Ultrasound for Assessing Cerebral Inflammation and Intracranial Hypertension in Cerebral Pathologies
Timely detection of signs of raised intracranial pressure or persistent inflammation within the meninges can expedite therapeutic decisions improving the prognosis of patients with brain damage.
- Conditions
- Meningitis, Meningitis/Encephalitis, Stroke, Ultrasound
- Trial name
- EICON (NCT07332234)
- Testing
- Optic Nerve Sheath Diameter
- Where
- 2 sites in Romania
- Volunteers
- 200 people
- Sponsor
- Spitalul Clinic de Boli Infecțioase și tropicale "Dr. Victor Babeș"
Infections Nervous System
Molecular Panel Evaluation for Diagnosis of Infections of the Central Nervosous System
Infections involving the central nervous system (CNS), such as meningitis/encephalitis (ME), are serious clinical conditions associated with high morbidity and mortality rates, as well as significant long-term consequences.
- Trial name
- NCT06720519
- Testing
- QIAstat-Dx®Meningitis/Encephalite Panel
- Where
- Italy
- Volunteers
- 170 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Encephalitis, Meningitis
Precision Diagnosis of Acute Infectious Diseases; Neuroinflammatory Cohort
This study aims to use a clinically validated metagenomic next-generation sequencing (mNGS) assay to provide a demonstration of precision medicine for diagnosis of acute infectious disease in hospitalized patients.
- Trial name
- PDAID (NCT02910037)
- Testing
- mNGS for pathogen detection
- Where
- 7 sites in United States
- Volunteers
- 214 people
- Sponsor
- University of California, San Francisco
Stroke, Headache
A Diagnostic Test on DeepDoc-an AI-based Decision Support System
DeepDoc is an AI-based decision support system for the early etiology diagnosis of neurological diseases using clinical data points from patients admitted to hospital within 24 hours.This study aims to evaluate whether the…
- Conditions
- Stroke, Headache, Vertigo, Meningitis/Encephalitis
- Trial name
- NCT04055766
- Testing
- DeepDoc AI-based Decision Support System
- Volunteers
- 4,000 people
- Sponsor
- Xijing Hospital
Encephalitis, Meningitis
Optimal Encephalitis/Meningitis Roadmap Via Precise Diagnosis and Treatment
Encephalitis and meningitis are serious central nervous system diseases. There is currently a lack of comprehensive and accurate diagnosis and treatment pathways.
- Conditions
- Encephalitis, Meningitis, Meningoencephalitis, Next-Generation Sequencing
- Trial name
- NCT04946682
- Testing
- Types of etiological diagnostic methods
- Where
- 7 sites in China
- Volunteers
- 484 people
- Sponsor
- Wen-hong Zhang