Clinical trials: Menopausal
Breast Cancer
HOBOE: A Phase 3 Study of Adjuvant Triptorelin and Tamoxifen, Letrozole, or Letrozole and Zoledronic Acid in Premenopausal Patients With Breast Cancer.
The HOBOE study was amended in November 2009, and, after reaching enrollment of the first 500 patients, the study began recruiting premenopausal patients only.
- Trial name
- HOBOE (NCT00412022)
- Testing
- tamoxifen, triptorelin, letrozole
- Where
- 20 sites in Italy
- Volunteers
- 1,294 people
- Sponsor
- National Cancer Institute, Naples
Comparing Bioavailability When Makena® is Administered in Healthy Post-menopausal Women
Comparing Bioavailability When Preservative-free Makena® (Hydroxyprogesterone Caproate Injection, 250 mg/mL) is Administered as an Intramuscular Manual Injection or as a Subcutaneous Injection Using an Auto-injector in Healthy Post-menopausal Women
To demonstrate that a single dose of Makena® delivered SQ via auto-injector has comparable bioavailability to a single IM injection of Makena®.
- Trial name
- NCT02940522
- Testing
- Makena® (Hydroxyprogesterone Caproate Injection, 250 mg/mL)
- Where
- 5 sites in United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- AMAG Pharmaceuticals, Inc.
Menopause, Obesity
Effects of SlimTrack® Platform on Diet Adherence, Anthropometry and Arterial Stiffness in Postmenopausal Women
Introduction:The weight gain expected in the postmenopausal period has deleterious effects on the physical and mental health of the female population.
- Conditions
- Menopause, Obesity, Overweight
- Trial name
- SlimTrack (NCT06497946)
- Testing
- SlimTrack Plataform, Diet prescription
- Where
- Brazil
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Hot Flashes
A Study to Find the Best Dose of Fezolinetant to Treat Hot Flashes in Women Going Through Menopause
This study is for menopausal women who have hot flashes. Menopause, a normal part of life, is the time after a woman's last period. Hot flashes often occur during menopause. They can disrupt a woman's daily life.
- Trial name
- Starlight (NCT05034042)
- Testing
- Fezolinetant
- Where
- 40 sites in Japan
- Volunteers
- 147 people
- Sponsor
- Astellas Pharma Inc
Metabolic Syndrome in Postmenopausal Females
Effects of Gum Arabic on Metabolic Syndrome Parameters in Postmenopausal Women
Gum Arabic ingestion has been proved to decrease some of the inflammatory markers in some metabolic diseases that have an inflammatory background. Nevertheless, the mechanism/s by which it does so is uncertain.
- Trial name
- NCT04978103
- Testing
- Gum Arabic
- Where
- Sudan
- Volunteers
- 100 people
- Sponsor
- University of Khartoum
Major Depressive Disorder, Insomnia
Quetiapine Extended Release (XR) for the Treatment of Menopausal Depression
The study was designed to examine the efficacy and tolerability of quetiapine XR for the treatment of women who suffer from depression in the context of the menopausal transition and postmenopausal years.
- Conditions
- Major Depressive Disorder, Insomnia, Hot Flashes
- Trial name
- NCT00723970
- Testing
- Quetiapine Extended Release
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Perimenopausal Women, Postmenopausal
Online Physical Activity Intervention for Peri- and Post-menopausal Working Women
It is the purpose of this clinical trial to examine the feasibility and acceptability of a brief online physical activity group (incorporating motivational interviewing) for UK women who are currently experiencing peri- or…
- Trial name
- NCT06821841
- Testing
- Online Physical Activity Group, Information Leaflet
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Canterbury Christ Church University
Menopause, Cardiac Function Impaired
Effects of Exercise Training on Cardiovascular Health in Middle-aged Women
The hypothesis of the present study is that physical training can oppose detrimental changes in cardiovascular and metabolic health associated with estrogen loss after menopause.
- Conditions
- Menopause, Cardiac Function Impaired, Cardiovascular Diseases, Blood Platelet Disorders
- Trial name
- NCT02135575
- Testing
- Spinning
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Hypertensiona, Menopause
EFFECTS of BEETROOT JUICE INTAKE and PHYSICAL EXERCISE in POSTMENOPAUSAL HYPERTENSIVE WOMEN
The goal of this clinical trial is to verify the hemodynamic and biomarker responses of aerobic physical exercise and beetroot juice intake in postmenopausal women with hypertension.
- Trial name
- EBJPEPHW (NCT06585904)
- Testing
- 1 dose of Beetroot juice intake, Exercise
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- Federal University of Uberlandia
Perimenopause, Menopausal Symptoms
A Study to Evaluate the Efficacy of a Postbiotic Supplement on Menopausal Symptoms in Premenopausal Women
The goal of this consumer health study is to evaluate the effect of resW™ Perimenopause Postbiotic on menopausal symptom severity, menopause-related quality of life, and selected microbiome-related outcomes in generally healthy…
- Conditions
- Perimenopause, Menopausal Symptoms, Menopause-Related Quality of Life, Microbiome
- Trial name
- RESW101 (NCT07570043)
- Testing
- Supplement
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Able Biolabs, LLC
Vulvovaginal Atrophy
Efficacy and Safety of HYDEAL-D Vaginal Pessaries Application on the Treatment of Vaginal Atrophy in Post-menopause Women
This study evaluates the efficacy and safety of hyaluronic acid derivative based vaginal pessaries for the treatment of symptoms of vulvo-vaginal atrophy in post-menopausal women.
- Trial name
- NCT03557398
- Testing
- Hydeal-D vaginal pessaries
- Where
- 2 sites in Slovakia
- Volunteers
- 40 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Vulvovaginal Atrophy
Investigation of Non-inferiority of Treatment of Vulvovaginal Dryness With WO2085 Moisturising Cream in Comparison to a Cream With 0.1% Estriol
The aim of the study is to gain further experience with regard to the performance of the medical device WO2085 Moisturising Cream in comparison to a cream with 0.1% estriol.
- Trial name
- NCT03044652
- Testing
- WO2085 Moisturising Cream, Estriol Cream 0.1%
- Where
- 5 sites in Germany, Switzerland
- Volunteers
- 172 people
- Sponsor
- Dr. August Wolff GmbH & Co. KG Arzneimittel
Menopause, Cardiovascular Risk Factor
Effect of 4 Weeks of Citrulline and Glutathione Supplementation on Arterial Function
Examining the effects of 4 weeks of Citrulline alone or in combination with glutathione on the arterial function of postmenopausal women.
- Trial name
- NCT04672447
- Testing
- L-Citrulline, Glutathione
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Sexuality, Menopause
The Effect of Sexual Health Education Given to Women in the Postmenopausal Period on Sexual Life
With this study, it is aimed to evaluate the effect of sexual health education given to women in the postmenopausal period on sexual myths, sexual distress and sexual quality of life.
- Conditions
- Sexuality, Menopause, Sexual Behavior
- Trial name
- NCT05560178
- Testing
- SEXUAL HEALTH EDUCATION
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Breast Cancer, Healthy Volunteers
Study to Determine Absorption, Metabolism, and Excretion of [14C]-SAR439859, and to Assess Absolute Oral Bioavailability of Amcenestrant (SAR439859), in Healthy Post-menopausal Women
Primary Objectives: To assess the excretion balance after oral and IV administration of [14C]-SAR439859 To assess PK of total radioactivity, [14C] -SAR439859 and its metabolite (M7) after IV administration of [14C]-SAR439859 and…
- Trial name
- NCT04940026
- Testing
- amcenestrant, [14C]-SAR439859 microtracer, [14C]-SAR439859
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Sanofi
Menopause, Burnout Syndrome
Menopausal Symptoms and Burnout: Comparison of Occupational Health Issue Among Health Professionals in UMC Hospitals
This study aims at evaluating the burnout in women healthcare providers (physicians and nurses) Kazakhstan settings, and to investigate the potential parameters that play a role in increasing the risk of burnout.
- Trial name
- NCT04728126
- Testing
- Survey
- Volunteers
- 320 people
- Sponsor
- Nazarbayev University Medical Center
Joint Discomfort, Joint Pain, Stiffness, Function
JDS-HF3.0 Supplementation on Menopause Related Quality of Life Outcomes in Postmenopausal Women
The goal of this interventional study is to evaluate whether the study product can help improve quality of life and reduce common menopause symptoms-such as joint discomfort, hot flashes and night sweats-in women aged 50-70.
- Conditions
- Joint Discomfort, Joint Pain, Stiffness, Function, Joint Pain, Hot Flashes
- Trial name
- NCT07238478
- Testing
- JDS-HF3.0
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Bonafide Health
Menopausal and Other Perimenopausal Disorders
Pilot Study to Investigate the Impact of an App on the Quality of Life and Symptoms of Individuals Affected by Menopause
The study explores the impact of a digital app for the self-management of (peri-)menopausal disorders. A total of 224 participants were randomized into an intervention and a control group.
- Trial name
- NCT06987617
- Testing
- Menopause App
- Where
- Germany
- Volunteers
- 224 people
- Sponsor
- Endo Health GmbH
Coronary Artery Disease
Comparison of Predictive Factors Related to Coronary Artery Disease
In Taiwan, heart disease and cerebrovascular disease ranked the second and third of ten leading causes of death in female in 2007; half of these deaths is due to coronary artery disease (CAD).
- Trial name
- NCT01136343
- Testing
- lifestyle modified project
- Where
- Taiwan
- Volunteers
- 130 people
- Sponsor
- Taipei Medical University WanFang Hospital
Menopause, Opportunistic Salpingectomy
Menopausal Impact of Opportunistic Salpingectomy for Ovarian Cancer Prevention
The goal of this clinical trial is to find out whether removing the fallopian tubes at the time of hysterectomy leads to an earlier menopause.
- Trial name
- MISSION-O (NCT07423143)
- Testing
- Opportunistic salpingectomy
- Where
- Sweden
- Volunteers
- 2,100 people
- Sponsor
- Umeå University
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