Clinical trials: Menopausal
Atrophy, Vaginal Diseases
A Clinical Study to Evaluate Ospemifene in the Treatment of Vulvar and Vaginal Atrophy in Postmenopausal Women
The purpose of this study is to determine whether ospemifene is more effective than placebo in the treatment of vulvar and vaginal atrophy (VVA) in postmenopausal women.
- Trial name
- NCT00276094
- Testing
- Ospemifene 30 mg, Ospemifene 60 mg, Nonhormonal vaginal lubricant
- Volunteers
- 826 people
- Sponsor
- Shionogi
Early Menopause
Singapore Population Research on Integrated exposoMe & Early Menopause
Brief Summary The goal of this observational study is to learn how environmental factors, lifestyle choices, and social conditions affect the timing of menopause in Asian women aged 40-50 years living in Singapore.
- Trial name
- SG-PRIME (NCT07100639)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
to Assess Changes in Body Composition After Dietary Supplementation With Sinetrol
A Randomized, Double-blind, Placebo-controlled, Parallel Study to Assess the Effect of Sinetrol on Body Composition &Metabolic Health in Peri-menopausal/Early Menopausal Women
The menopausal transition is associated with significant hormonal and metabolic changes, primarily driven by a decline in estrogen levels.
- Trial name
- MENOFIT (NCT07782853)
- Testing
- dietary supplementation
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- DR Healthcare - biotexia
Hysteroscopy
Oral Tramadol Versus Oral Dexketoprofen for Reducing Pain During Office Hysteroscopy
Two hundreds and twenty five postmenopausal women undergoing outpatient hysteroscopy and endometrial biopsy will be randomly divided into three equal groups.
- Trial name
- NCT03585036
- Testing
- dexketoprofen, Tramadol
- Volunteers
- 210 people
- Sponsor
- Cairo University
Menopause, Hot Flashes
Validation of an Objective Instrument to Measure Hot Flashes During Menopause
The overarching aim of this study is to assess the validity of the iButton®, a dual temperature and humidity sensing device (DS1923; Maxim IntegratedTM), as an objective method to assess hot flash incidence and dynamics in both a…
- Trial name
- FLAME (NCT03642119)
- Testing
- iButton®
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Effects of Chemotherapy
Assessing Fertility Potential in Female Cancer Survivors
Hypothesis: Girls and women exposed to chemotherapy and/or radiation therapy experience endocrine changes more similar to women in their late reproductive years than to same-age peers.
- Trial name
- NCT01143844
- Where
- 2 sites in United States
- Volunteers
- 391 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Menopause, Menopausal Syndrome
Predictors of Religious Orientation Attitudes in Menopausal Women
This descriptive, cross-sectional study examines whether the severity of menopausal symptoms and attitudes toward sexual myths predict intrinsic religious orientation in menopausal women.
- Conditions
- Menopause, Menopausal Syndrome, Sexual Dysfunction
- Trial name
- MENO-RO (NCT07797296)
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- KTO Karatay University
Exercise Training, Post-menopausal Women
Stem Cell Recruitment in Exercised Skeletal Muscles of Older Women by Phytosteroid Rg1
The goal of this interventional study is to observe the effects of bone marrow stem cell behavior in skeletal muscle of women between 60 to 75 years old after a single moderate resistance exercise session.
- Conditions
- Exercise Training, Post-menopausal Women, Bone Marrow Stem Cells, Skeletal Muscle Recovery
- Trial name
- NCT07093190
- Testing
- exercise following Rg1 consumption
- Where
- Taiwan
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Taipei
Vulvo Vaginal Atrophy, Genitourinary Syndrome of Menopause (GSM)
Treatment of Vulvo-vaginal Atrophy (VVA) Using Vaginal Dilator in Addition to Usual Treatment
This is a randomized, controlled trial aiming to evaluate the effectiveness of adding vaginal dilators to the treatment of vulvovaginal atrophy.
- Conditions
- Vulvo Vaginal Atrophy, Genitourinary Syndrome of Menopause (GSM), Vaginal Atrophy in Breast Cancer Patients, Vaginal Atrophy Patients With GSM
- Trial name
- NCT06828640
- Testing
- vaginal dilators
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Overactive Bladder, Caffeine
"The Effects of Caffeine on Overactive Bladder Symptoms and Mental Health in Postmenopausal Women"
The purpose of this study is to observe effects of caffeine on overactive bladder symptoms and wellbeing. This study looks at whether caffeine has bad effects on urinary symptoms or if lower doses of caffeine decrease the…
- Conditions
- Overactive Bladder, Caffeine, Menopause
- Trial name
- NCT02180048
- Testing
- 400 mg of caffeine/day (Two 200mg pills/day)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Hypoactive Sexual Desire Disorder
A Study Evaluating the Effects of Topical Clitoral Estradiol Cream in Post Menopausal Women
The purpose of this research study is to learn about sexual function in postmenopausal women and to determine whether the use of topical clitoral application of estradiol improves women's libido, arousal, and orgasmic ability.
- Trial name
- NCT02859285
- Testing
- Estradiol vulvar cream
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- ProHealth Care, Inc
Advanced or Metastatic Breast Cancer
Dose Escalation Study of LEE011 in Combination With Buparlisib and Letrozole in HR+, HER2-negative Post-menopausal Women With Advanced Breast Cancer.
This is a multi-center, open-label, non-randomized, phase I study
- Trial name
- LeeBLet (NCT02154776)
- Testing
- LEE011, Buparlisib, Letrozole
- Where
- 6 sites in United States, Spain
- Volunteers
- 13 people
- Sponsor
- Novartis Pharmaceuticals
Infertility
Use of a Calcium Channel Blocker to Prevent Premature Luteinizing Hormone Surges in Infertility Patients
Nimodipine (Nimotop® Bayer Pharmaceuticals Corporation), unlike other calcium channel blockers is fat soluble and therefore is able to cross the blood-brain barrier1.
- Trial name
- nimodipine (NCT01551368)
- Testing
- Nimodipine
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Mount Sinai Hospital, Canada
Infertility, Female
Androgenic Profile Following Controlled Ovarian Stimulation
In this study the investigators will try to discover whether there is a difference for any of the stimulation preparations - recombinant FSH + recombinant LH (pergoveris \& luveris) vs.
- Trial name
- NCT02992808
- Testing
- recombinant gonadotropins, HP-HMG
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Menopause, Periodontal Diseases
Menopause and Oral Health
Menopause is characterized by major physiological and concomitant psychological changes. The study aimed to evaluate the association between oral health parameters, bone mineral density (BMD) and physiological or psychological…
- Trial name
- NCT05513118
- Testing
- Periodontal clinical examination and gingival crevicular fluid, saliva, dental plaque, serum sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Ege University
Fall Injury, Incontinence
The Effect of Yoga on Decreasing Risk of Fall-Related Injury in Peri and Post-Menopausal
The primary objective of this study is to evaluate the effect of yoga on both fall risk factors AND capacity to successfully control landing and descent during a simulated fall among peri-and post- menopausal women.
- Conditions
- Fall Injury, Incontinence, Balance; Distorted
- Trial name
- NCT05106010
- Testing
- Balance Flow Yoga
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Postmenopausal Osteoporosis
A Study of Ibandronate (Bonviva) in Patients With Post-Menopausal Osteoporosis
This study will evaluate participant-reported preference for either ibandronate or a comparator drug in women with postmenopausal osteoporosis.
- Trial name
- NCT02598440
- Testing
- Alendronate, Ibandronate
- Where
- 54 sites in United States
- Volunteers
- 341 people
- Sponsor
- Hoffmann-La Roche
Menopause, Migraine
The Functional Magnetic Resonance Imaging Study on the Processing of Acute Pain and Cognition Among Perimenopause Women
There lacks effective early screen system for the migraine-susceptible women during the peri-menopause period. The processing of acute pain and cognition as well as the underling functional magnetic resonance imaging (fMRI)…
- Trial name
- NCT02820974
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Menopausal Women, Insomnia
Comparing Digital Therapy, Trazodone, and Daridorexant for Menopause-Related Insomnia Symptoms
The goal of this clinical trial is to learn how three current insomnia therapies (trazodone, daridorexant, cognitive behavioral therapy for insomnia) compare with each other in peri- and post-menopausal women.
- Trial name
- CELESTE (NCT07136415)
- Testing
- Cognitive behavioral therapy for insomnia (CBT-i), Trazodone, Daridorexant
- Where
- 5 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Brigham and Women's Hospital
Hot Flashes
A Study to Confirm if Fezolinetant Helps Reduce Hot Flashes in Japanese Women Going Through Menopause
Hot flashes are the most common reason women going through menopause seek medical attention. Hormone replacement therapy, or HRT, is most often prescribed to treat hot flashes.
- Trial name
- Starlight 2 (NCT06206408)
- Testing
- Fezolinetant
- Where
- 64 sites in Japan
- Volunteers
- 410 people
- Sponsor
- Astellas Pharma Inc
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