Clinical trials: Menopausal
Vaginal Atrophy, Atrophic Vaginitis
ASSIST-VLA: Assessment of Symptom-Specific Improvement in Diagnosed Vaginal Atrophy Following Laser Therapy
Vaginal atrophy patients receiving vaginal laser therapy will be treated with daily 7-0940® following a laser session to evaluate the safety and efficacy of the product as an adjunct treatment.
- Conditions
- Vaginal Atrophy, Atrophic Vaginitis, Genitourinary Syndrome of Menopause (GSM)
- Trial name
- ASSIST-VLA (NCT07346287)
- Testing
- 7-940
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Stratpharma AG
Osteoporosis, Osteopenia
Isoflavones for Promoting Calcium Absorption and Preventing Bone Loss in Post Menopausal Women
Estrogen is a hormone that helps prevent calcium loss and bone breakdown. During menopause, estrogen levels decrease. Insufficient amounts of estrogen may lead to bone loss and possibly osteoporosis.
- Trial name
- NCT00244907
- Testing
- Genistein vs Risedronate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Purdue University
Menopause, Hypoestrogenism
Analysis of the Hormonal Implant and Transdermal Estradiol Gel in Climacteric Women
An open-label, prospective clinical study will be conducted to monitor serum concentration and pharmacokinetic profiles following the subcutaneous implantation of six silicone hormone implants (delivering a total dose of 300 mg…
- Conditions
- Menopause, Hypoestrogenism, Hormonal Therapy
- Trial name
- ARESI (NCT07754630)
- Testing
- implantable estradiol, OESTROGEL - transdermal gel, PENTRAVAN - transdermal gel
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Nutrindo Ideais Research Center
Late-perimenopause, Menopause
Time-Restricted Eating in Combination With a Low Glycaemic Index Diet on Cognitive Function, Biological Ageing and Metabolic Health in Perimenopause and Menopause.
The goal of this randomised controlled trial is to investigate whether Time-Restricted Eating (TRE) combined with a Low Glycaemic Index Mediterranean Diet can improve cognitive function, metabolic health, and biological ageing in…
- Conditions
- Late-perimenopause, Menopause, Perimenopause
- Trial name
- NutriAge (NCT07378787)
- Testing
- Time-Restricted Low-Glycaemic Index Diet
- Where
- 2 sites in Croatia, Cyprus
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nicosia
Anxiety, Climactericum
Effects of Mandala Coloring on Anxiety and Quality of Life of Women in the Climacteric Period
This research was planned as a randomized controlled experimental study in order to reduce the anxiety felt and improve the quality of life by women in the climacteric period.
- Trial name
- NCT05575349
- Testing
- Mandala coloring
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kırklareli University
Cognitive Impairment, Estrogen Deficiency
Effects of Ovarian Hormone Suppression on Vascular and Cognitive Function
Complaints about memory and thinking are common in women as they go through menopause. The female hormone estrogen is important for both the health of both the brain and the blood vessels.
- Conditions
- Cognitive Impairment, Estrogen Deficiency, Menopause, Endothelial Dysfunction
- Trial name
- NCT03112226
- Testing
- GnRHant + E2
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Menopause, Anxiety Disorders
Treating Climacteric Symptoms With a Complex Homeopathic Remedy
The purpose of this study is to determine whether ovaria comp. is effective in relieving climacteric symptoms.
- Conditions
- Menopause, Anxiety Disorders, Depression
- Trial name
- NCT00152776
- Testing
- ovaria comp 10 globuli 3 times per day 24 weeks
- Where
- Germany
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Perimenopause, Menopause
Evaluation of the Effects of Lifestyle Medicine and Mindfulness-based Group Medical Visits on Stress, Microbiome, and Quality of Life in Women Experiencing Perimenopause and Menopause
While perimenopause and menopause are natural biological transitions, women may experience a wide range of physical, emotional, and cognitive symptoms.
- Trial name
- NCT07619352
- Testing
- Navigating Menopause with a Mindfulness-Based Group Medical Visit
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Stress Urinary Incontinence, Postmenopausal Disorder
ToT and Estrogen in Postmenopausal Females
To compare the subjective and objective outcomes of TVT-O procedure alone versus the same procedure followed by the use of premarin vaginal cream for 3 months in postmenopausal female with genuine stress incontinence.
- Trial name
- NCT03295487
- Testing
- TVT-O
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Kasr El Aini Hospital
Acquired Hypogonadotropic Hypogonadism
Rec-LH PD and Safety Profile in Hypogonadotropic Hypogonadism Men
Objectives: The overall clinical question is whether LH supplementation to men in indication for FSH according to the AIFA note 74, or with HH, will improve spermatogenesis and pregnancy rate (spontaneous or after ART) over FSH…
- Trial name
- RHYTHM (NCT04189133)
- Testing
- Lutropin alfa, Human chorionic gonadotropin
- Where
- 5 sites in Italy
- Volunteers
- 32 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Postmenopausal Osteoporosis, Gut Microbiome
Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal Females
The goal of this clinical trial is to evaluate the effects of blackcurrant (BC) supplementation on changes in bone density and gut microbiome composition in postmenopausal females.
- Conditions
- Postmenopausal Osteoporosis, Gut Microbiome, Menopause
- Trial name
- NCT07365514
- Testing
- Blackcurrant (BC) extract
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Menopause
Reducing Menopausal Symptoms for Women During Menopause Using Group Education in a Primary Health Care Setting
The aim of the study is to investigate if group education about the topic menopause to women in PHC can improve women's menopausal symptoms and reduce depression.
- Trial name
- NCT02852811
- Testing
- Group education
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Menopause, Pre-menopause
Following Lipectomy to Understand Adipose Tissue Re-accumulation
The typical female pattern of accumulating fat in the hips and thighs has long been thought to confer less risk for disease than the typical male abdominal fat pattern.
- Trial name
- FLARE (NCT00995631)
- Testing
- Femoral lipectomy
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Menopausal Hot Flashes
Flushing Reduction Associated With Nitrates
A randomized, double-blinded, placebo-controlled trial of uninterrupted transdermal nitrate therapy in 140 peri- or postmenopausal women who have frequent hot flashes.
- Trial name
- FRAN (NCT02714205)
- Testing
- transdermal nitroglycerin
- Where
- 2 sites in United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Alison Huang, MD
Menopause, Stress Urinary Incontinence
Pelvic Floor Muscle Exercises and Core Exercises in Menopausal Women
The prospective and four-arm randomized controlled study was conducted on n = 136 (34 = control, 34 = kegel, 34 = core, 34 = kegel+ core group) menopausal women at Trakya University Health Research and Application Center Urology…
- Conditions
- Menopause, Stress Urinary Incontinence, Kegel Exercises, Core Strength
- Trial name
- NCT06348342
- Testing
- Pelvic Floor Muscle Exercise, Core Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 136 people
- Sponsor
- Trakya University
Obesity
Effect of Shock Wave Therapy on Truncal Obesity and Lipid Profile in Obese Post Menopausal Women
This study aimed to evaluate the effect of six weeks extracorporeal shockwave therapy (SWT) on truncal obesity and serum lipids in obese postmenopausal women
- Trial name
- NCT05982002
- Testing
- shock wave, Moderate intensity aerobic exercise, Energy-restricted diet
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Menopause, Hot Flashes
PhytoSERM for Menopausal Hot Flashes and Sustained Brain Health
This is a proof-of-concept phase 2 clinical trial to investigate the effect of the phytoestrogenic supplement PhytoSERM on vasomotor symptoms and other symptoms associated with the menopausal transition, and on blood-based…
- Trial name
- HF-Relief (NCT06186531)
- Testing
- PhytoSERM
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- NeuTherapeutics
Healthy
Bioequivalence Study of Fulvestrant Injection 50 mg/mL in Healthy Post-menopausal Female Subjects
The purpose of this study is to demonstrate bioequivalence between the test drug product, fulvestrant Injection, 50 mg/mL, and the Reference Listed Drug, Faslodex® Injection, 50 mg/mL.
- Trial name
- NCT02795039
- Testing
- Fulvestrant
- Where
- 3 sites in Canada
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Fresenius Kabi
Menopause, Premature, Menopause Related Conditions
Autologous PRP Infusion May Restore Ovarian Function and May Promote Folliculogenesis in POI Patients
Autologous PRP intra ovarian infusion may restore ovarian function, may promote folliculogenesis and may improve patients' hormonal profile in patients presenting with POI.
- Conditions
- Menopause, Premature, Menopause Related Conditions, Menopausal Syndrome, Premature Ovarian Failure
- Trial name
- PRP (NCT04031456)
- Testing
- Autologous Platelet Rich Plasma
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genesis Athens Clinic
Female Androgenetic Alopecia
The Use of 5mg Finasteride Versus 200mg Spironolactone and Topical 5% Minoxidil in Treating Postmenopausal Female Androgenetic Alopecia
The investigators propose to conduct a head-to-head, randomized clinical trial to compare the effectiveness of Minoxidil with Spironolactone and Finasteride in treating postmenopausal females with Androgenetic Alopecia (AGA).
- Trial name
- NCT02483195
- Testing
- 5% Minoxidil, 200mg Spironolactone, 5mg Finasteride
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
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