Clinical trials: Menopausal Depression
Depressive Disorder, Mood Disorder
Treatment of Mid-Life-Related Mood Disorders
Dehydroepiandrosterone (DHEA) is a hormone produced by the adrenal gland. As humans grow older the levels of DHEA naturally decrease.
- Trial name
- NCT00001487
- Testing
- Dehydroepiandrosterone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Mental Health (NIMH)
Menopause, Depression
Brain Imaging Study in Menopausal Women With and Without Major Depressive Disorder
The purpose this study is to measure cortical gama-aminobutyric acid levels (GABA) levels in menopausal women with major depressive disorder and healthy subjects using nuclear magnetic resonance spectroscopy (MRS).
- Trial name
- NCT00626340
- Testing
- MDD diagnosis and Estrogen treatment, MDD diagnosis and Fluoxetine treatment, MDD diagnosis with both Estrogen and Fluoxetine treatment
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Menopause, Menopause Related Conditions
Solution-focused Counseling for Menopausal Symptoms
This research will be conducted in a prospective pre-test post-test measurement randomized controlled experimental design. The population of the study consists of women who have entered menopause and live in Karabük.
- Conditions
- Menopause, Menopause Related Conditions, Menopausal Depression
- Trial name
- NCT06582433
- Testing
- Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Depressive Disorder, Major, Menopause
Estrogen and Perimenopausal Depression
During perimenopause (the time just prior to menopause), women often notice many biological, psychological, and social changes. In particular, some women experience depressive symptoms during perimenopause that are severe enough…
- Trial name
- NCT00229450
- Testing
- Estrogen
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of California, Los Angeles
Anxiety Disorder, Depressive Disorder
Sub-Trial of the Youth Readiness Intervention (YRI): Treatment of Control Group and Addition of Stress Biomarkers
This research is a continuation of the Youth Readiness Intervention (YRI) randomized clinical trial by adding additional pre and post intervention data collection upon treatment of the control group (N=222) with the intervention…
- Conditions
- Anxiety Disorder, Depressive Disorder, Social Problems, Stress, Psychological
- Trial name
- NCT02128568
- Testing
- Youth Readiness Intervention
- Where
- Sierra Leone
- Sponsor
- Harvard School of Public Health (HSPH)
Depression
Study on Allopregnanolone and Depression in Women Across the Menopause Transition
This study aims to identify how enhanced allopregnanolone activity (via pregnenolone) affects behavior and neurobiology that may underlie perimenopausal depression.
- Trial name
- SADIE-P (NCT06238700)
- Testing
- pregnenolone
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Beth Israel Deaconess Medical Center
Menopause
Clinical Pilates and Aerobic Exercise in Menopause
To the best of our knowledge, there is no study in the literature that examined the effects of clinical Pilates training on vasomotor symptoms, quality of life, depression, and sleep problems versus aerobic exercises in…
- Trial name
- NCT05764031
- Testing
- Clinical pilates exercise, Aerobic exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hasan Kalyoncu University
Major Depressive Disorder, Vasomotor Symptoms
Desvenlafaxine Succinate (Pristiq): Postmarketing Surveillance Study Among Filipino Patients
This is a non-interventional study to review safety data on administration of desvenlafaxine succinate among Filipino patients with MDD and VMS per usual clinical practice within the first three years post commercial distribution.
- Trial name
- NCT01353963
- Testing
- desvenlafaxine succinate
- Where
- 3 sites in Philippines
- Volunteers
- 13 people
- Sponsor
- Pfizer
Major Depressive Disorder
Duloxetine for Major Depression in Peri-/Postmenopausal Women
The main objective of this study is to characterize a range of brain activation symptoms associated with major depression in peri- and post-menopausal women.
- Trial name
- NCT00889369
- Testing
- Duloxetine
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Cancer
Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer
RATIONALE: Telephone counseling by trained counselors may enhance the well-being and quality of life of patients who have undergone stem cell transplantation for cancer.
- Trial name
- NCT00049465
- Testing
- fatigue assessment and management, management of therapy complications, psychosocial assessment and care
- Where
- 9 sites in United States
- Sponsor
- Fred Hutchinson Cancer Center
Insomnia, Menopause Related Conditions
Targeting Insomnia to Prevent Depression in the Menopause Transition
This randomized clinical trial is focused on perimenopausal women who have difficulty sleeping. It will randomize digital cognitive behavioral therapy for insomnia (dCBT-I) or a sleep hygiene intervention (SHI).
- Trial name
- NCT07443644
- Testing
- digital cognitive behavioral therapy for insomnia, Digital sleep hygiene education
- Volunteers
- 230 people
- Sponsor
- SRI International
Perimenopause, Perimenopause-Related Depression
Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY)
This observational study examines the safety and effects of injecting Muse cells (a type of naturally occurring stem like cells found in adult tissues such as fat or bone marrow) directly into the ovaries of women aged 28 to 70…
- Conditions
- Perimenopause, Perimenopause-Related Depression, Premature Ovarian Insufficiency, Premature Ovarian Failure (POF)
- Trial name
- MUSE-OVARY (NCT07511660)
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- Healing Hope International
Depression, Insomnia
Cognitive Behavioral Therapy for Insomnia and Depression Among Menopausal Women
Considering physical and psychological problems that threaten women during the menopausal period, it seems that therapies that can help women cope with these problems, especially psychological ones, will be useful.
- Conditions
- Depression, Insomnia, Cognitive Behavioral Therapy, Menopausal Depression
- Trial name
- NCT05920460
- Testing
- Cognitive Behavioral Therapy Program
- Where
- 2 sites in Egypt
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Menopause, Depression
Impact of Hot Flashes on Sleep and Mood Disturbance
We plan to enroll premenopausal women in a trial investigating the impact of hot flashes developed in response to an injection of a gonadotropin-releasing hormone agonist (GnRHa), leuprolide (brand name: Lupron), on sleep…
- Conditions
- Menopause, Depression, Hot Flashes
- Trial name
- NCT01116401
- Testing
- leuprolide
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Menopausal Depression
Cognitive Behavioural Therapy for Menopausal Symptoms
This study examined the effectiveness of a new cognitive-behavioural therapy for menopausal symptoms (CBT-Meno). Half of participants were randomly assigned to the 12-week CBT-Meno program and half to a 12-week waitlist.
- Trial name
- CBTMENO (NCT02480192)
- Testing
- CBT for Menopausal Symptoms (CBT-Meno)
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Postpartum Depression, Depression
Screening Evaluation for Women With Postpartum Depression
This study evaluates the relationship between mood changes and hormones in women with postpartum depression (PPD). This is an observational study; volunteers who participate will not receive any new or experimental therapies.
- Trial name
- NCT00056901
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder, Menopausal Staging and Vasomotor Symptoms (for Females)
Desvenlafaxine Succinate (DVS) for Major Depressive Disorder (MDD) in Midlife Men and Women
The main objective of this study is to characterize a range of brain activation symptoms associated with depression and response to treatment in midlife men and women with MDD, using MRI and functional MRI.
- Trial name
- DVS (NCT00888862)
- Testing
- Desvenlafaxine Succinate
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Bipolar Disorder, Major Depressive Disorder
Cognitive Behavioral Group Therapy for the Management of Menopause Symptoms in Mood Disorders
The general objective of this study is to advance insight into non-pharmacological treatments for maturing women that impact psychological health and wellbeing of women adapting to menopause, a natural but often challenging…
- Conditions
- Bipolar Disorder, Major Depressive Disorder, Menopause
- Trial name
- Conklin MWW (NCT02860910)
- Testing
- Cognitive Behavioral Group Therapy
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Danette Conklin, PhD
Metabolic Syndrome
Effects of a Zumba Dance Program for Postmenopausal Women With Metabolic Syndrome
The aim of this study is to examine the effects of a 12-week Zumba dance intervention on fitness, anthropometric and psychometric parameters and eating behavior.
- Trial name
- ZumBeat (NCT02384694)
- Testing
- Zumba dance
- Where
- Switzerland
- Volunteers
- 17 people
- Sponsor
- University of Basel
Menopause, Sleep Disturbance
Radicle Revive 24: A Study of Health and Wellness Products on Menopausal Health and Related Health Outcomes
A randomized, double-blind, placebo-controlled, direct-to-consumer trial assessing the impact of health and wellness products on hormonal health and associated health outcomes in women with menopausal health issues
- Conditions
- Menopause, Sleep Disturbance, Anxiety, Depression
- Trial name
- NCT06749288
- Testing
- Radicle Revive Active Study Product 4.1 Usage
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Radicle Science