Clinical trials: Menopausal Vasomotor Symptoms
Hot Flashes, Hot Flushes
Stellate Ganglion Blockade in Post-Menopausal Women
Hot flashes and night sweats (vasomotor symptoms, VMS) affect 80% of women during the menopausal transition (MT). VMS are associated with decreased quality of life, increased depressive and anxiety symptoms, memory complaints…
- Conditions
- Hot Flashes, Hot Flushes, Vasomotor Symptoms
- Trial name
- R01 (NCT02907983)
- Testing
- Stellate Ganglion Block Injection with Bupivicaine, Saline injection
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Vasomotor Symptoms; Hot Flashes
Study of Erenumab (AMG 334) in Women With Hot Flashes
The primary objective of this study was to evaluate the frequency of moderate to severe daily hot flashes 4 weeks after a single dose of erenumab (AMG 334) in women with hot flashes associated with menopause.
- Trial name
- NCT01890109
- Testing
- Erenumab
- Where
- 7 sites in United States
- Volunteers
- 103 people
- Sponsor
- Amgen
Post Menopausal
Effects of Progressive Resistance Training Vasomotor Symptoms in Post Menopausal Women
The study will be a randomized clinical trial and will be conducted in Civil Hospital and Kalsoom Hospital Samundry. This study will be completed in time duration of 10 months after the approval of synopsis.
- Trial name
- NCT06166264
- Testing
- Progressive resistance training, Control group
- Where
- Pakistan
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Hot Flushes
E4Relief (Response to Estetrol in Life Improvement for MEnopausal-associated Hot Flushes)
This dose-finding study is being conducted to select the daily oral dose of estetrol (E4) for the treatment of vasomotor symptoms (VMS) in post-menopausal women.
- Trial name
- NCT02834312
- Testing
- Estetrol
- Where
- Belgium
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Donesta Bioscience
Post-menopausal Vasomotor Symptoms
Dose-ranging, PK, Safety, Efficacy Study of Osanetant in Patients With Moderate/Severe VMS Associated With Menopause
In this clinical research study, subjects will be given the study drug, ACER-801 (osanetant) or placebo (looks like the study drug but contains no active ingredients).
- Trial name
- NCT05325775
- Testing
- ACER-801 50 mg BID, ACER-801 100 mg BID, ACER-801 200 mg BID
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Acer Therapeutics Inc.
Hot Flashes
Breeze3:Study of Gabapentin Extended Release in the Treatment of Vasomotor Symptoms(Hot Flashes)in Postmenopausal Women
Depomed's Gabapentin Extended Release is an investigational, extended release formulation of Gabapentin that is being studied for the treatment of Hot Flashes/Hot Flushes in postmenopausal women
- Trial name
- Breeze3 (NCT01080300)
- Testing
- Gabapentin Extended Release
- Where
- 66 sites in United States
- Volunteers
- 600 people
- Sponsor
- Depomed
Menopause
Effect of Nuvigil on Fatigue
The purpose of this study is to determine if armodafinil improves quality of life and is an effective treatment of fatigue in symptomatic perimenopausal and postmenopausal women.
- Trial name
- NCT01460628
- Testing
- Armodafinil
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hot Flashes
A Study in Germany to Learn About the Value of Fezolinetant in Treating Hot Flashes and Night Sweats in Women During Menopause
This study is for women in Germany who are going through menopause. They have symptoms including hot flashes and night sweats (also called vasomotor symptoms).
- Trial name
- GRACE (NCT07455812)
- Testing
- Fezolinetant
- Where
- Germany
- Volunteers
- 105 people
- Sponsor
- Astellas Pharma Europe Ltd.
Healthy
A Randomized, Double Blind, Placebo Controlled, Clinical Study to Examine the Benefits of an Oral Product in Panelists With Menopausal Symptoms Including Vasomotor Symptoms (VMS).
Randomized, Double-Blind, Placebo-Controlled, Single-Center Clinical Study with a Run-in Baseline, Daily Diary Log, and Validated Questionnaires (Greene GCS) with Oral Dietary Supplement
- Trial name
- NCT07033013
- Testing
- Dietary Supplement with actives
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Olly, PBC
Menopause
Pilot Study - Impact of Traditional Acupuncture on Menopause
This pilot project is a randomized research study to examine the effects of acupuncture on menopausal symptoms. The investigators will recruit up to 45 Cedars employees (excluding Dr Bairey Merz's employees) with menopausal…
- Trial name
- NCT00950482
- Testing
- TA, AA, WC
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Women in the Menopausal Period
ROSA-B: ALAN Exposure and Brain Health in Midlife Women With VMS
This randomized, parallel-group study will examine how artificial light exposure during nighttime awakenings affects sleep and brain health in midlife women experiencing vasomotor symptoms, such as hot flashes and night sweats.
- Trial name
- NCT07834944
- Testing
- Artificial Light at Night (ALAN) 100 lux, Artificial Light at Night (ALAN) Dim Light
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Vasomotor; Syndrome, Sleep
The Effect of Laughter Yoga on Vasomotor Symptoms and Sleep Quality
The research was planned as a prospective, randomized controlled experimental study to determine the effect of online laughter yoga applied to menopausal women on vasomotor symptoms (VMS) and sleep quality.
- Trial name
- NCT05859594
- Testing
- Laughter yoga
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mersin University
Menopause
Symptom Management Program Based on Story Theory for Postmenopausal Women (SEMSTOP)
Purpose: To investigate the effect of the Symptom Management Program Based on Story Theory on vasomotor symptoms and sleep quality in postmenopausal women.
- Trial name
- SEMSTOP (NCT05697133)
- Testing
- SEMSTOP, control
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Menopause
A Survey Evaluating Prevalence, Severity and Associated Factors in East Asian Women With Moderate-to-severe Menopause-related Vasomotor Symptoms (MR-VMS)
The purpose of this study is to estimate the prevalence of Vasomotor Symptoms (VMS) and prevalence of moderate to severe VMS in peri-menopausal women and post-menopausal women aged 40-65 in East Asia (China, South Korea and…
- Trial name
- NCT04553029
- Testing
- No intervention
- Where
- 3 sites in China, South Korea and 1 more
- Volunteers
- 3,399 people
- Sponsor
- Astellas Pharma Singapore Pte. Ltd.
Depression, Menopause
Duloxetine for Menopausal Depression
The primary objective of the study is to determine if an eight-week intervention with duloxetine significantly reduces depressive symptoms in symptomatic menopausal women.
- Conditions
- Depression, Menopause, Vasomotor Symptoms
- Trial name
- NCT01117857
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Massachusetts General Hospital
Hot Flashes
A Clinical Trial Assessing Safety of MF101 for Hot Flushes
This Phase 1, open label, randomized clinical trial will enroll 40 generally healthy, postmenopausal women aged 40-65 years old. Women will be randomized to one of two oral doses of MF101 for 4 weeks.
- Trial name
- NCT01300078
- Testing
- MF101
- Where
- 4 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bionovo
Hot Flashes
A Study to Confirm if Fezolinetant Helps Reduce Hot Flashes in Japanese Women Going Through Menopause
Hot flashes are the most common reason women going through menopause seek medical attention. Hormone replacement therapy, or HRT, is most often prescribed to treat hot flashes.
- Trial name
- Starlight 2 (NCT06206408)
- Testing
- Fezolinetant
- Where
- 64 sites in Japan
- Volunteers
- 410 people
- Sponsor
- Astellas Pharma Inc
Menopause Syndrome
Effects of Connective Tissue Manipulation on Menopausal Symptoms
Menopause is defined as the permanent cessation of menstruation as a result of the loss of ovarian follicular function. This process involves some bothersome physical and psychological climacteric symptoms.
- Trial name
- NCT05293860
- Testing
- Connective tissue manipulation, Superficial massage with the head of the therapeutic ultrasound device
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Hacettepe University
Postmenopause
Study Evaluating Estradiol/Trimegestone in Vasomotor Symptoms (VMS) in Post-Menopausal Women.
The purpose of this study is to evaluate vasomotor symptoms (VMS) control of the continuous regimen 17 b estradiol/trimegestone combination.
- Trial name
- NCT00195455
- Testing
- Trimegestone, 17b Estradiol
- Where
- 6 sites in Mexico
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Menopause, Vasomotor; Syndrome
Efficacy of Nano-Pso Therapy in Menopause
Vasomotor syndrome is prevalent in 85% of postmenopausal women, hormone therapy in menopause is first-line therapy, but 38% of patients have some contraindication for its use.
- Trial name
- NCT06432816
- Testing
- NANO-PSO
- Where
- Mexico
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Distribuidora Biolife SA de CV