Clinical trials: Menopause, Premature
Autoimmune Prematur Ovarian Insuffience
Immunomodulatory Therapy to Restore Ovarian Function and Improve Fertility in Women With Autoimmune Premature Ovarian Insufficiency
Several autoimmune diseases such as Addison's disease are associated with failing ovarian function, known as premature ovarian insufficiency (POI), which can lead to early menopause and reduced fertility.The underlying cause of…
- Trial name
- REFINE (NCT07509840)
- Testing
- Rituximab (Arm A), Rituximab (Arm B)
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Angelica Lindén Hirschberg
Fertility Disorders, Turner Syndrome
The Danish TURNER Cryopreservation Study
The goal of this clinical trial is to investigate if cryopreservation of ovarian tissue in girls with Turner syndrome can improve their fertility and lead to increased number of liveborn babies of Turner syndrome mothers.
- Conditions
- Fertility Disorders, Turner Syndrome, Premature Ovarian Failure
- Trial name
- DANTE (NCT05740579)
- Testing
- laparoscopic cryopreservation of one ovary
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Primary Ovarian Insufficiency, Premature Ovarian Failure
A Therapeutic Trial of Human Amniotic Epithelial Cells Transplantation for Primary Ovarian Failure
This project will clarify the safety and effectiveness of human amniotic epithelial cells transplantation for the treatment of primary ovarian failure (POF) patients and provide a new therapeutic method for patients with…
- Conditions
- Primary Ovarian Insufficiency, Premature Ovarian Failure, Infertility
- Trial name
- POF (NCT02912104)
- Testing
- human amniotic epithelial cells (hAECs) transplantation
- Where
- China
- Volunteers
- 36 people
- Sponsor
- International Peace Maternity and Child Health Hospital
Perimenopausal Disorder, Menopause
Inovium Ovarian Rejuvenation Trials
The Inovium Ovarian Rejuvenation Treatment is a PRP-based autologous treatment used in combination with a stimulated IVF sequence and Pre-Implantation Genetic Screening to treat infertility in women experiencing menopause…
- Conditions
- Perimenopausal Disorder, Menopause, Menopause, Premature, Menopause Related Conditions
- Trial name
- NCT03178695
- Testing
- Autologous PRP injection into human ovarian tissue
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ascendance Biomedical
Primary Ovarian Insufficiency
Human Umbilical Cord Mesenchymal Stem Cells (HUC-MSCs) Transplantation in Women With Primary Ovarian Insufficiency (POI)
There is a high incidence of women suffering from Primary Ovarian Insufficiency (POI). One of the most common treatments for POI is hormone replacement therapy (HRT), but HRT doesn't work well, and it has been shown to increase…
- Trial name
- NCT03033277
- Testing
- HUC-MSCs transplantation
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Chinese Academy of Sciences
Gonadal Dysfunction, Gonadal Failure
Fertility Enhancement Through Regenerative Treatment in Ovaries and Testes
This study investigates the safety and efficacy of stem cell or stem cell-derived exosome therapy for gonadal failure, including testicular failure, hypogonadism, ovarian insufficiency, and premature ovarian failure (POF).
- Conditions
- Gonadal Dysfunction, Gonadal Failure, Azoospermia, Testosterone Deficiency
- Trial name
- FERTILE (NCT06841328)
- Testing
- Stem cells
- Where
- United Arab Emirates
- Volunteers
- 60 people
- Sponsor
- Jumeirah American Clinic
Activation of Primordial Follicles
In Vitro Follicle Activation in Patient With Premature Ovarian Failure Under 36 Years Old
This is a clinical trial that the investigators aim to validate In-vitro Activation (IVA) treatment protocol, which was previously defined by Kazuhiro Kawamura (MD) and Aaron Hsueh (PhD), in Turkish patient with Premature Ovarian…
- Trial name
- NCT04131244
- Testing
- In vitro activation of primordial follicles by PTEN inhibitor and AKT stimulator
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Hacettepe University
Turner Syndrome, Hypogonadism
Estrogen Treatment (Oral vs. Patches) in Turner Syndrome
The study attempts to evaluate if the way of administering estrogen, the principal female hormone, via patches or orally, affects the way estrogen works in girls with Turner Syndrome.
- Conditions
- Turner Syndrome, Hypogonadism, Premature Ovarian Failure
- Trial name
- NCT00140998
- Testing
- 17 beta estradiol
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Nemours Children's Clinic
Planned RRSO
E2 and LDX for the Treatment of Cognitive Complaints After Oophorectomy
This project seeks to address cognitive disturbance, which is a frequent adverse sequelae of riskreducing bilateral salpingo-oophorectomy (RRSO) with or without post-procedure chemotherapy and adjunctive treatments.
- Trial name
- E2LDX (NCT01986764)
- Testing
- Lisdexamfetamine, Estradiol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Bone Loss, Bone Loss, Age-related
Strength Training for Osteoporosis Prevention During Early Menopause
The goal of this clinical pilot trial is to learn about the feasibility of a high-intensity resistance training intervention in peri- and early menopausal females.
- Conditions
- Bone Loss, Bone Loss, Age-related, Osteoporosis, Musculoskeletal Diseases
- Trial name
- STOP-EM (NCT05961371)
- Testing
- Resistance Training
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Infertility, Female, Premature Ovarian Failure
Second Step Protocol in Poor Ovarian Responder (POR)
Reduced ovarian reserve and the consequent poor ovarian response are very recurent in infertile patients, indeed a percentage of 10%-24% of couples addressed to infertility program may be classified as Poor Ovarian Responder…
- Conditions
- Infertility, Female, Premature Ovarian Failure, Fertility Disorders
- Trial name
- POR (NCT03480412)
- Testing
- Follicular Phase, Luteal Phase
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Anti-Müllerian Hormone, Polycystic Ovarian Syndrome
Clinical Application of Serum Anti-Müllerian Hormone (AMH) Measurements
This study aims to assess the association of Anti-Müllerian hormone (AMH) with polycystic ovarian syndrome, premature ovarian insufficiency and fertility. The main objectives include the following: 1.
- Conditions
- Anti-Müllerian Hormone, Polycystic Ovarian Syndrome, Premature Ovarian Insufficiency, Fertility Issues
- Trial name
- NCT05858307
- Where
- Hong Kong
- Volunteers
- 300 people
- Sponsor
- Chinese University of Hong Kong
Premature Ovarian Insufficiency
A Multicenter Observational Study on the Development and Health Effects of Premature Ovarian Insufficiency
Premature ovarian insufficiency (POI) refers to the occurrence of ovarian hypofunction in women before the age of 40, which seriously affects women's overall health and quality of life.
- Trial name
- POI (NCT06067529)
- Where
- 2 sites in China
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Cognitive Impairments, RRSO
LDX for the Treatment of Cognitive Functioning Issues in Women Post-Oophorectomy
This is a double-blind, placebo-controlled, study testing whether LDX improves cognitive function and EF in 20 postmenopausal women who report onset of cognitive difficulties after oophorectomy (with or without subsequent…
- Trial name
- LDX (NCT01986777)
- Testing
- lisdexamfetamine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Primary Ovarian Insufficiency, Infertility
In Vitro Follicle Activation
The purpose of this study is to evaluate the effectiveness of an experimental treatment, known as in vitro activation (IVA) of dormant ovarian follicles, for infertility in women diagnosed with primary ovarian insufficiency (POI).
- Trial name
- IVA (NCT02496598)
- Testing
- In Vitro Follicle Activation (IVA), Follicle Activation
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- National Foundation for Fertility Research
Primary Ovarian Insufficiency, Low Ovarian Reserve
Rejuvenation of Premature Ovarian Failure With Stem Cells
The ROSE-1 study is designed to determine the efficacy of bone marrow derived stem cell therapy on ovarian function recovery in subjects with idiopathic and other types of premature or primary ovarian failure (POF or POI) and low…
- Conditions
- Primary Ovarian Insufficiency, Low Ovarian Reserve, Premature Ovarian Failure
- Trial name
- ROSE-1 (NCT02696889)
- Testing
- ROSE-1 Protocol
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Illinois at Chicago
Premature Ovarian Failure
Autologous ADMSC Transplantation in Patients With POI
The primary ovarian insufficiency (premature ovarian failure, premature ovarian insufficiency, premature menopause) is a hypergonadotropic hypogonadism, that failure of the ovarian function in woman younger than 40 years.
- Trial name
- ADMSC (NCT06132542)
- Testing
- stem cell therapy
- Where
- Mongolia
- Volunteers
- 10 people
- Sponsor
- Mongolian National University of Medical Sciences
Menopause, Testosterone Deficiency
Estradiol and Testosterone Subdermal Implants for Menopause Treatment (ESTIME)
Estrogen and androgen deficiencies negatively impact the quality of life of women at different stages of life, especially after menopause. New modalities and new therapeutic alternatives have been researched.
- Conditions
- Menopause, Testosterone Deficiency, Estrogen Deficiency
- Trial name
- ESTIME (NCT06343870)
- Testing
- testosterone pellet (100 mg)
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- University of Sao Paulo General Hospital
Premature Ovarian Insufficiency
Effect and Mechanism of Jiajian Guishen Optimized Formula on Premature Ovarian Insufficiency: Insights Into m6A Modification and Oxidative Stress
The goal of this clinical study is to evaluate the effectiveness of JiaJian GuiShen Optimized Formula (JJGS) and explore its mechanisms involving m6A modification and oxidative stress in women with premature ovarian insufficiency…
- Trial name
- JJGS ; POI (NCT07843030)
- Testing
- JJGS
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Shi Yun
Premature Ovarian Insufficiency
Phase 1 Clinical Trial of CordSTEM-ST
This clinical study will evaluate the safety and tolerability of CordSTEM-ST after administering a single dose in patients with premature ovarian insufficiency (POI), as well as identify the maximum tolerated dose (MTD) and…
- Trial name
- CBT210-POI_P1 (NCT06578039)
- Testing
- umbilical cord-derived mesenchymal stem cell
- Where
- South Korea
- Volunteers
- 6 people
- Sponsor
- CHABiotech CO., Ltd