Clinical trials: Menopause, completed
Breast Cancer, Hot Flashes
Effect of Non-estrogenic Pollen Extract PCC-100 on Hot Flushes
Many postmenopausal women have vasomotor symptoms during adjuvant hormonal treatment for breast cancer. PCC-100 is a pollen extract used for alleviation of postmenopausal symptoms.
- Conditions
- Breast Cancer, Hot Flashes, Postmenopausal Symptoms
- Trial name
- NCT03684096
- Testing
- non-estrogenic pollen extract PCC-100
- Where
- Belgium
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Breast Cancer Female
Letrozole in Post-Menopausal Patients With Operable Hormone-Sensitive Breast Cancer
A short pre-surgical non-therapeutic trial involving postmenopausal women with newly diagnosed eR+, HeR2-negative operable breast cancers.
- Trial name
- NCT03747042
- Testing
- Letrozole
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Texas Southwestern Medical Center
Menopause
Hormonal Replacement Therapy and Small Artery Function
Endothelial dysfunction in resistance arteries in women after the menopause is important for the development of high blood pressure and cardiovascular disease
- Trial name
- HRT (NCT00564031)
- Testing
- Femanest, gestapuran, Femanest plus Gestapuran
- Where
- Sweden
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Menopause
Menopause Sample Collection
This study will provide daily urine samples from women during early and late stage peri-menopause as well as post-menopause over the course of three calendar months in order to maintain the SPD sample bank.
- Trial name
- NCT04853472
- Where
- United Kingdom
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- SPD Development Company Limited
Age-associated Memory Impairment, Alteration of Cognitive Function
Hormones and Cognition in the Menopausal Transition
The purpose of this study is to determine if the menopausal transition is associated with subjective and objective cognitive declines that ameliorate in menopause.
- Trial name
- NCT01429103
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Postmenopausal Women
The Effect of Mindfulness Stress Reduction Program on Menopausal Complaints and Quality of Life
The study was conducted to determine the effect of the mindfulness stress reduction program (MBSR) applied to postmenopausal women on menopausal complaints and quality of life.
- Trial name
- NCT04762095
- Testing
- mindfulness stress reduction program
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- NURDİLAN SENER
Menopause, Menopause Related Conditions
A Home-based Breathing Training on Menopausal Symptoms
This is a prospective, triple-blinded and randomized controlled trial examining the effects of a home-based breathing training assisted with biofeedback on menopausal symptoms and autonomic functions among community menopausal…
- Trial name
- NCT03082040
- Testing
- home-based breathing training
- Where
- Taiwan
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Ministry of Science and Technology, Taiwan
Chronic Kidney Disease, Secondary Hyperparathyroidism
Quality of Life in Greek Hemodialysis Patients Receiving Zemplar Intravenous
The purpose of this study is to assess health-related Quality of Life (QoL) changes in participants with chronic kidney disease (CKD) and secondary hyperparathyroidism (sHPT) undergoing hemodialysis and receiving paricalcitol…
- Trial name
- QUALITIZE (NCT01368042)
- Where
- 11 sites in Greece
- Volunteers
- 265 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Bone Loss, Age-related
Microbiota and Bone Fragility:Study of the Relation Between Gut Microbiota and Bone Microarchitecture
Gut microbiota regulate metabolism of their human host. Some diseases are associated with variations in gut microbiota diversity and higher fracture risk.
- Trial name
- MICROBONE (NCT04265742)
- Testing
- bone densitometry, High resolution peripheral QCT, Collection of biological samples
- Where
- France
- Volunteers
- 440 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Postmenopausal Osteoporosis
A Multicenter, Randomized Placebo Controlled Pilot MicroCT Study to Estimate the Effect of Treatment With Denosumab (AMG 162) and Alendronate Sodium in Postmenopausal Women With Low Bone Mineral Density
This study is structured to estimate the effect of denosumab, compared to placebo and alendronate, on several bone parameters.
- Trial name
- NCT00293813
- Testing
- Alendronate, Denosumab
- Volunteers
- 247 people
- Sponsor
- Amgen
Breast Cancer, Menopause
Study to Assess Efficacy of Risedronate in Preventing Bone Loss in Postmenopausal Women Treated for Breast Cancer
Aromatase inhibitor therapy is in France the adjuvant reference treatment for postmenopausal women with early-stage breast cancer. This treatment induces bone loss and a higher risk of fractures.
- Conditions
- Breast Cancer, Menopause, Osteopenia
- Trial name
- RISAROS (NCT00859703)
- Testing
- Risedronate
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Menopausal Depression
Tibolone and Placebo in Adjunct to Antidepressant Medication for Women With Menopausal Depression
Longitudinal epidemiological studies have shown that many women experience significant physical and psychological changes as they approach menopause and for a long time following.
- Trial name
- NCT01470092
- Testing
- Tibolone
- Where
- Australia
- Volunteers
- 120 people
- Sponsor
- The Alfred
Restless Legs Syndrome
Effect of Progressive Muscle Relaxation Exercises in Menopausal Women Experiencing RLS.
Restless legs syndrome is a symptom that can be seen in all stages of a woman's life, but its frequency and severity increases with menopause.
- Trial name
- NCT06156007
- Testing
- progressive muscle relaxation exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Gazi University
Menopause
The Effects of Fractal Mindfulness Virtual Reality on Menopause Symptoms
The study aimed to establish the effectiveness of an immersive mindfulness virtual reality intervention using fractal software for women experiencing menopausal symptoms.
- Trial name
- NCT07044284
- Testing
- Fractal mindfulness recombination
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- London Metropolitan University
Menopause
A Pharmacokinetic Evaluation of Bioidentical Compounded Estrogen Cream and Natural Progesterone
Bioidentical compounded hormone therapy (BCHT) is considered a 'safer' option to the conventional hormones (HT) by its proponents. However, there is limited research data to support their claims.
- Trial name
- HRT (NCT00864214)
- Testing
- bioidentical hormone (Biest), bioidentical hormone (Vivelle-Dot)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Menopause, Postmenopausal Vaginal Atrophy
Endometrial Safety of a Low Dose of Vagifem® in Postmenopausal Women With Atrophic Vaginitis
This trial is conducted in Europe. The purpose of this study is to evaluate endometrial safety of intravaginal estradiol (Vagifem®) in healthy postmenopausal women having atropic vaginitis.
- Trial name
- NCT00431132
- Testing
- estradiol, 10 mcg
- Where
- 42 sites in Czechia, Denmark and 5 more
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Psychological Distress, Quality of Life and Menopause
The Effect of Continuous Care Model on Psychological Distress and Quality of Life Among Postmenopausal Women With Urinary Incontinence
This research aimed to evaluate the effect of continuous care model on psychological distress and quality of life among postmenopausal women with urinary incontinence.
- Trial name
- NCT07538752
- Testing
- Continuous Care Model sessions
- Where
- Palestinian Territories
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Al-Quds University
Breast Cancer, Healthy Volunteers
Study to Determine Absorption, Metabolism, and Excretion of [14C]-SAR439859, and to Assess Absolute Oral Bioavailability of Amcenestrant (SAR439859), in Healthy Post-menopausal Women
Primary Objectives: To assess the excretion balance after oral and IV administration of [14C]-SAR439859 To assess PK of total radioactivity, [14C] -SAR439859 and its metabolite (M7) after IV administration of [14C]-SAR439859 and…
- Trial name
- NCT04940026
- Testing
- amcenestrant, [14C]-SAR439859 microtracer, [14C]-SAR439859
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Sanofi
Sleep Initiation and Maintenance Disorders, Menopause
Chinese Herbal Sachet Therapy for Sleep Quality in Menopausal Women
Many women sleep poorly during the menopausal transition. Some prefer not to take hormone therapy or sleeping tablets, and ask their nurses about other options.
- Trial name
- NCT07757724
- Testing
- Traditional Chinese medicine aromatic sachet
- Where
- Macau
- Volunteers
- 122 people
- Sponsor
- Macao Polytechnic University
HIV Prevention
Influence of Reproductive Cycle and Menopause on HIV-1 Infection and TFV Gel Activity
Purpose of the study is to assess tenofovir (TFV) PK and PD endpoints, cervicovaginal safety parameters, susceptibility to HIV-1 infection, and objective measures of vaginal applicator use in premenopausal and postmenopausal…
- Trial name
- NCT01810315
- Testing
- TFV 1% gel, Estradiol vaginal cream
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CONRAD