Clinical trials: Menopause
Menopause Surgical
Hormonal Regulation of Cardiometabolic Health Study
The goal of this observational study is to understand how the loss of ovarian function after oophorectomy affects the health and well being of women aged 35-50. The study focuses on four areas: 1.
- Trial name
- HoCa (NCT07406412)
- Testing
- Surgical removal of ovaries, Hormone Replacement Therapy (HRT)
- Where
- 7 sites in Finland
- Volunteers
- 120 people
- Sponsor
- University of Jyvaskyla
Osteoporosis, Post-Menopausal
Bone Marker Changes With Teriparatide/Postmenopausal Osteoporosis
To test the hypothesis that Teriparatide injections given 20 micrograms/daily subcutaneously, for one month, are able to produce reliable changes in the bone marker in a severe osteoporotic population
- Trial name
- NCT00532545
- Testing
- Teriparatide
- Where
- 7 sites in Puerto Rico
- Volunteers
- 45 people
- Sponsor
- Eli Lilly and Company
Dehydration, Menstruation
Hydration & Female Life Stages
Female life stages including premenopausal, perimenopausal, postmenopausal, are characterized by changing concentrations and patterns of hormones.
- Conditions
- Dehydration, Menstruation, Pre-menopause, Peri-menopausal Women
- Trial name
- NCT07653620
- Testing
- electrolyte beverage
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Sarcopenia, Physical Inactivity
Women in Action: A Multicomponent Intervention for Older Women
"Women in Action" is a quasi-experimental, mixed-methods study evaluating a 16-week multicomponent intervention (supervised strength/aerobic/balance training plus psychoeducational and nutrition-focused behavioral workshops) for…
- Conditions
- Sarcopenia, Physical Inactivity, Menopause, Healthy Aging
- Trial name
- WIA (NCT07860424)
- Testing
- Multicomponent exercise, nutrition, and psychoeducational program
- Where
- 2 sites in Spain
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Universidad de Oviedo
Postmenopausal Symptoms, Menopause
Dose-Finding Safety and Efficacy Trial of Org 50081 (Esmirtazapine) in the Treatment of Vasomotor Symptoms (177001/P06472/MK-8265-013)
To investigate efficacy and safety of 4 doses of esmirtazapine, compared to placebo, in the treatment of moderate to severe hot flushes (vasomotor symptoms) associated with the menopause.
- Conditions
- Postmenopausal Symptoms, Menopause, Vasomotor Symptoms
- Trial name
- NCT00535288
- Testing
- Esmirtazapine
- Volunteers
- 946 people
- Sponsor
- Merck Sharp & Dohme LLC
Postmenopausal Women With Moderate Vasomotor Symptoms
Clinical Trial to Evaluate the Efficacy of FITOGYN Versus Placebo on the Vasomotor Symptomatology Associated With Menopause
The purpose of this study is to evaluate the efficacy of FITOGYN vs. placebo on the vasomotor symptomatology associated with menopause, to evaluate the symptoms of anxiety, the metabolic parameters in menopause and to evaluate…
- Trial name
- TRYSEM (NCT01116310)
- Testing
- Soy isoflavones (Glycine max L) and red clover extract (Trifolium pretense L)
- Where
- 20 sites in Spain
- Volunteers
- 166 people
- Sponsor
- Laboratorios Casen-Fleet S.L.U.
Glucose Monitoring, Continuous, Whole Body Protein Metabolism
Effects of Amylopectin Chromium Blend on Whole-Body Protein Kinetics and Glucose in Peri/Post-Menopausal Women
The goal of this study is to better understand how an amylopectin chromium blend may influence whole body protein balance in women during midlife, when hormonal changes can adversely affect protein metabolism and muscle…
- Conditions
- Glucose Monitoring, Continuous, Whole Body Protein Metabolism, Peri-menopausal Women, Post-menopause
- Trial name
- NCT07402382
- Testing
- Amylopectin-chromium blend, Concentrated Amylopectin-chromium blend
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nutrition 21, Inc.
Women, Aging
Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women
To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.
- Conditions
- Women, Aging, Menopause
- Trial name
- NCT07674680
- Testing
- Gemtesa
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Hot Flushes, Menopause, Postmenopause
Comparison of Estrogen and Methyltestosterone Combination Treatments for Postmenopausal Hot Flushes
This is a research study to evaluate the effectiveness, safety and side effects of several dose levels of esterified estrogens (EE) and methyltestosterone (MT) given individually and in combination compared to a placebo (a tablet…
- Trial name
- NCT00160342
- Testing
- Esterified Estrogens (EE) and Methyltestosterone (MT)
- Where
- 125 sites in United States, Canada and 1 more
- Volunteers
- 1,251 people
- Sponsor
- Solvay Pharmaceuticals
Menopause, Menopausal Syndrome
Predictors of Religious Orientation Attitudes in Menopausal Women
This descriptive, cross-sectional study examines whether the severity of menopausal symptoms and attitudes toward sexual myths predict intrinsic religious orientation in menopausal women.
- Conditions
- Menopause, Menopausal Syndrome, Sexual Dysfunction
- Trial name
- MENO-RO (NCT07797296)
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- KTO Karatay University
Osteoporosis, HIV
Bone Health in Aging HIV Infected Women
Design: Open-label randomised multicenter international strategic trial of older women on combination antiretroviral therapy (cART) containing tenofovir-emtricitabine (TDF/FTC) with HIV RNA suppression for > 6 months to : 1.
- Conditions
- Osteoporosis, HIV, Menopause
- Trial name
- BEING (NCT02815566)
- Testing
- tenofovir-alafenamide-emtricitabine, tenofovir-emtricitabine
- Where
- 7 sites in Canada, Italy
- Volunteers
- 34 people
- Sponsor
- University Health Network, Toronto
Postmenopausal Atrophic Vaginitis, Postmenopausal Symptoms
LASER and Radiofrequency and Genitourinary Syndrome of Menopause
This is a randomized controlled trial to evaluate the use of LASER, Micro Ablative radiofrequency and topic strogen to treat symptoms of vulvovaginal atrophy of post menopause.
- Conditions
- Postmenopausal Atrophic Vaginitis, Postmenopausal Symptoms, Genitourinary Symptoms
- Trial name
- EPMLARF-arm1 (NCT04045379)
- Testing
- LASER, Microablative Radiofrequency, Estriol
- Where
- Brazil
- Volunteers
- 195 people
- Sponsor
- Federal University of São Paulo
Endometriosis
A Study to Investigate the Safety, Tolerability, Food Effect, Pharmacokinetics and Pharmacodynamics of FOR-6219
This is a randomised, double-blind, placebo-controlled, Phase I/Ib study which will assess the safety, tolerability, food effect, pharmacokinetics and pharmacodynamics of FOR-6219, a hydroxysteroid (17B) dehydrogenase (HSD17B1)…
- Trial name
- NCT03709420
- Testing
- FOR-6219
- Where
- United Kingdom
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Forendo Pharma Ltd
Menopause, Opinions
Opinion of Brazilian Gynecologists on Hormone Therapy for Menopause and Prescriptive Habits
To evaluate Brazilian gynecologists, through structured online questionnaires, with questions directed to their opinions and prescriptive habits about menopause hormone therapy.
- Conditions
- Menopause, Opinions, Hormone Replacement Therapy
- Trial name
- NCT05072756
- Testing
- Applying a questionnaire
- Where
- Brazil
- Volunteers
- 1,339 people, healthy volunteers welcome
- Sponsor
- Faculdade de Medicina do ABC
Menopause
Hormonal Replacement Therapy and Small Artery Function
Endothelial dysfunction in resistance arteries in women after the menopause is important for the development of high blood pressure and cardiovascular disease
- Trial name
- HRT (NCT00564031)
- Testing
- Femanest, gestapuran, Femanest plus Gestapuran
- Where
- Sweden
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Postmenopause, Hot Flashes
Comparison of Fluoxetine Versus Citalopram Therapy to Control Postmenopausal Vasomotor Syndrome
This study determined the efficacy of non-hormonal therapy with citalopram compared to fluoxetine, for the treatment of menopausal symptoms in Mexican women with vasomotor syndrome (VMS) and urogenital syndrome.
- Trial name
- NCT05346445
- Testing
- Fluoxetine 20 MG, Citalopram 20mg
- Where
- Mexico
- Volunteers
- 91 people
- Sponsor
- Hospital Regional 1o de Octubre
Breast Cancer, Endometrial Cancer
Genistein in Preventing Breast or Endometrial Cancer in Healthy Postmenopausal Women
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of genistein may be effective in preventing breast or endometrial cancer.
- Trial name
- NCT00099008
- Testing
- Genistein
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cardiovascular Disease, Skin Health
Effects of Anthocyanin on Skin Health and Markers of Cardiovascular Disease Risk
The purpose of this study is to determine whether short-term exposure to a compound found in some fruits and vegetables (anthocyanin), is effective in improving skin health and reducing the levels of various markers of…
- Conditions
- Cardiovascular Disease, Skin Health, Postmenopause
- Trial name
- NCT00574574
- Testing
- anthocyanin
- Where
- United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Bone Diseases, Metabolic Syndrome X
Effect of Exercise and Phytoestrogen on Bone, Metabolic Syndrome Criteria and Complaints of the Early Menopause
The aim of the study is to compare the effect of a progressive, periodized exercise training designed to impact bone, CHD-risk-factors and menopausal complaints versus the combined effect of exercise and "phytoestrogen"…
- Conditions
- Bone Diseases, Metabolic Syndrome X, Coronary Disease
- Trial name
- NCT00663104
- Testing
- exercise, exercise + cimicifuga racemosa
- Where
- Germany
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Menopause, Healthy
Bleeding Profile With Continuous Hormone Replacement Therapy of Activelle® in Postmenopausal Women
This study is conducted in Europe. The aim of this study is to investigate the bleeding profile after switch from Trisekvens® to Activelle® (1.0 mg estradiol / 0.5 mg norethisterone acetate (NETA)).
- Trial name
- NCT01705249
- Testing
- 1.0 mg estradiol / 0.5 mg norethisterone acetate (NETA)
- Where
- 19 sites in Norway, Sweden
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
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