Clinical trials: Menopause Syndrome
Vulvovaginal Atrophy
Photobiomodulation Effect on Vulvovaginal Atrophy in Postmenopausal Women.
Menopause is a physiological event and is defined as the loss of ovarian follicular activity, with consequent permanent cessation of menstrual cycles.
- Trial name
- NCT04487392
- Testing
- Estrogen vaginal cream group (group A), Photobiomodutation group (group B)
- Sponsor
- University of Nove de Julho
Menopausal Syndrome
Early Menopause Hormone Treatment and Cognition
The objective of this study is to evaluate the neurobiological effects of hormone therapy (HT) in healthy early postmenopausal women.
- Trial name
- R21 (NCT01046643)
- Testing
- Estradiol (E2), Progesterone (P10) x90, Progesterone (P10) x10
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Kallmann Syndrome, Hypogonadotropic Hypogonadism
Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hypogonadism
Observe the therapeutic efficacy of human menopausal gonadotropin combining with human chorionic gonadotropin in adolescent boys with congenital hypogonadotropic hypogonadism.
- Trial name
- NCT02880280
- Testing
- Human Menopausal Gonadotropin, Human Chorionic Gonadotropin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Children's Hospital
Genitourinary Syndrome of Menopause, Sexual Function Disturbances
The Ultrasonographic Assessment of Efficacy of Injectable Hyaluronic Acid for Genitourinary Syndrome of Menopause
Genitourinary syndrome of menopause (GSM) is a definition including vaginal dryness, burning, vaginal pruritus, dyspareunia and urinary symptoms which can have a negative effect on women's sexuality and quality of life.
- Trial name
- NCT05561972
- Testing
- injectable multifractional intercalated hyaluronic acid [Armonia®, Regenyal, Italy]
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Maltepe University
Breast Cancer Female, Cardiometabolic Syndrome
Metabolic Flexibility and Autonomic Control After Muscle Power vs Metabolic Power Training in Postmenopausal Oncological Women: the POWER Health Study
POWER Health is a randomized clinical trial with a two-arm parallel design whose objectives are 1) to study metabolic flexibility and autonomic function (both capacities that describe cardiovascular health) in a sample of…
- Conditions
- Breast Cancer Female, Cardiometabolic Syndrome, Metabolism Disorder, Lipid, Autonomic Dysfunction
- Trial name
- POWER Health (NCT06336070)
- Testing
- HIIT program (8 weeks), MPI program (8 weeks)
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- University of Valencia
Breast Cancer, Genitourinary Syndrome of Menopause
A Novel Therapy for Breast Cancer Survivors With Genitourinary Syndrome of Menopause
The purpose of this study is to determine whether platelet rich plasma (PRP) injections to the vulva and vagina will improve symptoms of genitourinary syndrome of menopause (GSM) in breast cancer patients.
- Trial name
- NCT05812924
- Testing
- Platelet-rich plasma (PRP)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Miami
Genitourinary Syndrome of Menopause, Female
The Effect of Counseling Based on the Roy Adaptation Model on Sexual Life and Quality of Life in Menopause
In this study, it was aimed to determine the effect of the support and counseling program based on the Roy Adaptation Model given to postmenopausal women with Genitourinary Syndrome on their sexual life and quality of life.
- Conditions
- Genitourinary Syndrome of Menopause, Female, Postmenopause
- Trial name
- NCT06605742
- Testing
- Consultancy
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Climacteric Syndrome
Efficacy and Safety of Passiflora Incarnata and Isoflavona Combination in the Treatment of Climacteric Symptoms
The purpose of this study is to evaluate the effects of Passiflora incarnata and Isoflavone combination in relieving the symptoms associated with Climacteric Syndrome.
- Trial name
- Monalisa (NCT01695616)
- Testing
- Active drug
- Where
- Brazil
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Menopause Syndrome, Menopause Surgical
Paroxetine Versus Placebo for Vasomotor Symptom Management in Surgical Menopause
evaluate the efficacy of paroxetine in the management of vasomotor symptoms in patients with surgical menopause, in order to seek an alternative therapy to hormone therapy, which is associated with proinflammatory and…
- Conditions
- Menopause Syndrome, Menopause Surgical, Hot Flashes
- Trial name
- MENOXTINA (NCT06763484)
- Testing
- Paroxetine
- Where
- Honduras
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Honduras
Genitourinary Syndrome of Menopause (GSM)
Effects of Fractional CO2 Vaginal Laser in Postmenopausal Women With Genitourinary Syndrome of Menopause
This study evaluated the effects of fractional carbon dioxide (CO2) vaginal laser treatment in postmenopausal women with genitourinary syndrome of menopause.
- Trial name
- NCT07858994
- Testing
- Fractional CO2 Vaginal Laser
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Karina Amar Svec
Dyspareunia
Treating Postmenopausal Dyspareunia Where it Hurts
The purpose of this study is to compare the effectiveness of two low doses of estrogen cream applied to a new location for the treatment of moderate or severe pain during sexual intercourse in postmenopausal women.
- Trial name
- NCT03240081
- Testing
- 50mcg estradiol cream, 100mcg estradiol cream
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Rotator Cuff Tears, Rotator Cuff Injuries
Estradiol Supplementation and Rotator Cuff Repair
Rotator cuff tears in the shoulder are common causes of pain and disability, often fail to heal with surgery, and tears, worse outcomes after surgery, and failure of healing are associated with estradiol deficiency.
- Conditions
- Rotator Cuff Tears, Rotator Cuff Injuries, Rotator Cuff Syndrome, Menopause Related Conditions
- Trial name
- ESTRCR (NCT06318403)
- Testing
- Transdermal estrogen, Rotator Cuff Repair Surgery
- Volunteers
- 58 people
- Sponsor
- University of Utah
Genitourinary Syndrome of Menopause
RCT of Laser Therapy for GSM
The aim of the current study is to assess whether the CO2-laser results in superior alleviation of GSM symptoms compare to Er:YAG-laser.
- Trial name
- NCT03288883
- Testing
- Photothermal Non-ablative Erbium:YAG-laser, Fractional Microablative CO2-laser
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Menopausal Syndrome
Efficacy and Safety of Traditional Chinese Medicine Intervention for Women With Menopausal Syndrome
The purpose of this multiple-centered, randomized, controlled study is to investigate the efficacy and safety of a combination using herbs prescription and traditional Chinese medicine (TCM) emotion treatment in women with…
- Trial name
- NCT00933725
- Testing
- TCM intervention, Western intervention
- Where
- 8 sites in China
- Volunteers
- 194 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Fragile X Syndrome, FMR1 Premutation
The Natural History of Reproductive and Overall Health in Girls and Women With a Pre-Mutation in the FMR1 Gene; Creation of a Patient Registry
Background: In human DNA, the Fragile X (FMR1) gene helps to regulate the nervous and reproductive systems. If the gene is abnormal, it can cause different kinds of problems, such as abnormal menstrual periods, decreased…
- Conditions
- Fragile X Syndrome, FMR1 Premutation, Primary Ovairan Insufficiency, Premature Ovarian Failure
- Trial name
- NCT01187524
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Genitourinary Syndrome of Menopause (GSM), Breast Cancer
Efficacy of Non-ablative Radiofrequency Combined With Pelvic Floor Muscle Training for Genitourinary Syndrome of Menopause in Breast Cancer Survivors (RF-SGM)
The goal of this clinical trial is to find out whether non-ablative radiofrequency (RF) applied together with pelvic-floor muscle exercises can ease vaginal dryness and other symptoms of genitourinary syndrome of menopause (GSM)…
- Trial name
- NCT07034976
- Testing
- Active Radiofrequency (Capenergy C500 UpGradeC200)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Menopausal Syndrome, Cognitive Decline
Algal Lutein Against Decline of Intellectual Nimbleness
Lutein is a xanthophyll pigment found in photosynthesizing organisms. Its beneficial effects on health, including brain function and visual performance, have been recognized for many years.
- Conditions
- Menopausal Syndrome, Cognitive Decline, Obesity & Overweight, Menopause
- Trial name
- ALADIN (NCT07600567)
- Testing
- Lutein
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Menopausal Syndrome, Atherosclerosis
Study of Anti-atherosclerotic and Estrogen-like Activity of Karinat in Perimenopausal Women
The purpose of this study is to investigate the anti-atherosclerotic and anti-climacteric action of natural drug Karinat based on phytoestrogen-rich botanicals in perimenopausal women.
- Trial name
- PEARS (NCT01741974)
- Testing
- Karinat
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Institute for Atherosclerosis Research, Russia
Genitourinary Syndrome of Menopause
Concomitant Treatment with Topical Hyaluronic Acid and High Concentration Oxygen Therapy (Vaginal Natural Oxygenation Device - VNOD) in the Improvement of Symptoms Related to Genitourinary Syndrome of Menopause in Women with Natural and Oncological Postmenopause: Open-Label, Single-Center, Randomize
The Caress study is a single-center, open-label, randomized controlled trial (RCT) evaluating the efficacy of a combined treatment using topical hyaluronic acid and high-concentration oxygen therapy (Vaginal Natural Oxygenation…
- Trial name
- Caress (NCT06879938)
- Testing
- High-concentration vaginal oxygen therapy (Caress Flow) with topical hyaluronic acid, hyaluronic acid-based gel (Hydeal-D®)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Menopausal Syndrome, Hot Flashes
Sulpiride Versus Placebo for Reducting Hot Flushes During Climacteric
Introduction: Estrogen hormonal therapy associated or not with progestagen is the standard therapy for the treatment of hot flushes.
- Trial name
- NCT02749747
- Testing
- Sulpiride use
- Where
- Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre