Clinical trials: Menopause Syndrome
Genitourinary Syndrome of Menopause
Vaginal Changes After CO2 Laser
Genitourinary syndrome of menopause (GSM) occurs due to a decline in estrogen levels as a woman approaches menopause. The syndrome negatively impacts women's quality of life and is characterized by vaginal dryness, burning…
- Trial name
- OCTRCT (NCT06691178)
- Testing
- Optical coherence tomography (OCT)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Menopause
The Effects of a Novel Probiotic Supplement on Menopausal Symptoms and Bone Health
This Phase II study is designed to evaluate the potential effects of a novel probiotic supplement on the severity of global menopause symptoms (e.g., psychological, somatic, urogenital symptoms) and on bone health in…
- Trial name
- MPS (NCT04001088)
- Testing
- Probiotic
- Where
- 5 sites in United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Lallemand Health Solutions
Obesity
Females, Aging, Metabolism, and Exercise
This study is designed to determine whether a reduction in hormones (such as occurs during menopause) causes a decrease in calories burned during physical activity.
- Trial name
- FAME (NCT01712230)
- Testing
- GnRH agonist, Supervised cardiovascular exercise
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Vaginal Atrophy, Urinary Incontinence,Stress
Low-level Laser Therapy for Genitourinary Syndromes and Stress Urinary Incontinence
Genitourinary syndrome of menopause (GSM) and stress urinary incontinence (SUI) are common for women. Low-level laser therapy (LLLT) was applied for wound healing, but there was no study regarding treatment effect of GSM and SUI.
- Trial name
- NCT06136975
- Testing
- Low-level laser therapy
- Where
- Taiwan
- Volunteers
- 41 people
- Sponsor
- National Taiwan University Hospital
Celiac Disease, Diet, Gluten-Free
Improvement Of Physical And Physiological Parameters In Menopausal Or Post-Menopausal Celiac Women
Celiac disease (CD) is an immunological disorder that mainly affects the small intestine, generating an inflammatory process in response to the presence of gluten (a protein).
- Conditions
- Celiac Disease, Diet, Gluten-Free, Exercise, Resistance Training
- Trial name
- NCT05052164
- Testing
- Gluten-free nutrition plan + exercise group, Gluten-free nutrition plan group, Active Comparator: Celiac controls group
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Alicante
Menopause
Effects of a Seven-day BASIS™ Supplementation on Menopausal Syndromes and Measurements of the Urinary Vitamin B3 and Estradiol Levels in Pre-, Peri- and Post-menopause
The purpose of this study is to determine whether a short supplementation (7days) with BASIS™ increases the natural production of estradiol, measured in urinary waste.
- Trial name
- NCT04841499
- Testing
- BASIS™ (Crystalline Nicotinamide Riboside 250mg and Pterostilbene 50mg)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Postmenopause
AFTER: Altering Fat Through Estrogen and Raloxifene
The purpose of this study is to determine whether estrogens specifically promote a reduction in fat from abdominal regions during weight loss and/or prevent the accumulation of abdominal fat during weight gain.
- Trial name
- NCT00149604
- Testing
- conjugated estrogens, Raloxifene, exercise plus mild caloric restriction for weight loss
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Keratoconjunctivitis Sicca
Efficacy and Safety Study of Nutritional Supplements for Treatments of Dry Eye
The purpose of this study is to determine the effectiveness of a nutritional supplement in post-menopausal women age 40 or older with moderate to severe dry eyes.
- Trial name
- NCT00883649
- Testing
- Hydroeye, Inactive Capsule
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- Virginia Eye Consultants
Genitourinary Syndrome of Menopause
Efficacy of the Use of Cellular Matrix/ A-CP-HA Kit
This study is a randomized, controlled, non-inferiority trial, that will be performed on 192 women on Menopause (absence of menstruation for at least 12 months), with diagnostic of genitourinary syndrome of menopause (SGM) and a…
- Trial name
- CellularMatrix (NCT06425978)
- Testing
- Cellular Matrix / A-CP-HA Kit, Local estrogen therapy (Blissel, estriol 50 micrograms/g vaginal gel)
- Where
- Spain
- Volunteers
- 192 people
- Sponsor
- Fundación Santiago Dexeus Font
Menopause
Multicentre Clinical Trial. Project EXIMe
Objective: to evaluate the effectiveness of an individualized intervention in sexual health conducted in the midwife consultation to improve the quality of life in women with Genitourinary Syndrome of Menopause.
- Trial name
- EXIMe (NCT03558451)
- Testing
- Complex intervention in sexual health, Usual care
- Where
- Spain
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Gerencia de Atención Primaria, Madrid
Climacteric Syndrome
The Effects of Luo-Bu-Fu-Ke-Bi-RI Pill
To investigate the effect of LBFKBRP on climacteric syndrome in women and explore its therapeutic mechanism.
- Trial name
- NCT05846698
- Testing
- Luo-Bu-Fu-Ke-Bi-RI Pill, tibolone
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Guoqing Zhou
Menopause, Vasomotor; Syndrome
Efficacy of Nano-Pso Therapy in Menopause
Vasomotor syndrome is prevalent in 85% of postmenopausal women, hormone therapy in menopause is first-line therapy, but 38% of patients have some contraindication for its use.
- Trial name
- NCT06432816
- Testing
- NANO-PSO
- Where
- Mexico
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Distribuidora Biolife SA de CV
Aging, Menopause
Gonadal Hormone, Gonadotropin and Cardiovascular Events
Deficiency in gonadal hormone has been considered to play a role in ageing related increased incidence of cardiovascular events. But the mechanism has not been fully elucidated.
- Trial name
- NCT02810821
- Where
- China
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Shandong Provincial Hospital
Genitourinary Syndrome of Menopause (GSM), Breast Cancer Female
Genitourinary Syndrome of Menopause in Breast Cancer
This randomized, single-blind clinical trial will compare the effectiveness of multimodal pelvic floor physiotherapy (PPT) and fractional CO2 vaginal laser therapy in reducing genitourinary syndrome of menopause (GSM) symptoms…
- Trial name
- PILME (NCT06721936)
- Testing
- Multimodal pelviperineal physioterapy group, Laser CO2 Therapy group
- Where
- Spain
- Volunteers
- 182 people
- Sponsor
- University of Alcala
Perimenopause, Perimenopausal Women
12-week Multi-vitamin/Mineral Supplementation on Peri-menopause Symptoms, Cognition, Sleep, and Psychological Well-being.
Perimenopause is a stage of transition into menopause that is marked by menopausal symptoms while menstruation is still taking place.
- Conditions
- Perimenopause, Perimenopausal Women, Perimenopause, Climacteric Syndrome
- Trial name
- NCT07242430
- Testing
- Multivitamin/mineral supplement
- Where
- United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Diabetes Mellitus, Type 2, Insulin Resistance
Determinants of Type 2 Diabetes Risk in Middle-aged Black South African Men and Women
There is little known about menopause in African women, whose phenotype differs to Caucasian women, and no data is available on middle-aged black South African men.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Menopause, Hiv
- Trial name
- NCT03408678
- Where
- South Africa
- Volunteers
- 1,025 people
- Sponsor
- University of Witwatersrand, South Africa
Genitourinary Syndrome of Menopause
Natural Topical Treatment for Vulvar and Vaginal Atrophy
Genitourinary syndrome of menopause (GSM) is a chronic and progressive syndrome characterized by a collection of genital and urinary signs and symptoms secondary to the state of hypoestrogenism related to menopause.
- Trial name
- NCT05871255
- Testing
- Zantogin® Gel
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Dr. Amjad Khan
Obesity, Abdominal, Hypertension
Nursing Intervention in Two Risk Factors of the Metabolic Syndrome and Quality of Life in the Climacteric Period
The estrogenic deficit characteristic of the climacteric stage is accompanied by a high incidence of health problems, such as the presence of Metabolic Syndrome risk factors that contribute to the increase of cardiovascular…
- Conditions
- Obesity, Abdominal, Hypertension, Quality of Life, Menopause
- Trial name
- NCT05387174
- Testing
- : Nursing intervention in two risk factors of the Metabolic Syndrome, abdominal obesity and arterial hypertension and quality of life in the climacteric period.
- Where
- Ecuador
- Volunteers
- 80 people
- Sponsor
- Universidad de Concepcion
Genitourinary Syndrome of Menopause (GSM)
Via, a Hyaluronic Acid (HLA) Based Vaginal Moisturizer Study
This study aims to evaluate whether the administration of vaginal estrogen along with Via, a hyaluronic acid-based vaginal moisturizer, offers superior relief from symptoms of genitourinary syndrome of menopause (GSM) in the…
- Trial name
- NCT07038070
- Testing
- Vaginal estrogen tablet, Via Solv Wellness (Hyaluronic Acid Therapy)
- Where
- United States
- Sponsor
- NYU Langone Health
Atrophic Vaginitis, Gynecologic Cancer
Genitourinary Syndrome of Menopause in Thai Gynecologic Cancer Survivors
Women often face common cancers like ovarian, uterine, and cervical cancers. Improvements in cancer detection and treatment mean more women survive.
- Conditions
- Atrophic Vaginitis, Gynecologic Cancer, Lower Urinary Tract Symptoms
- Trial name
- NCT06305494
- Where
- Thailand
- Volunteers
- 425 people
- Sponsor
- Khon Kaen University