Clinical trials: Menopause Syndrome
Genitourinary Syndrome of Menopause
Silicone Gel vs. Estrogen Vaginal Cream for the Management of Genitourinary Syndrome of Menopause
The goal of this randomized controlled trial is to test the efficacy of StrataMGT in the management of Genitourinary Syndrome of Menopause (GSM) compared to estrogen therapy.
- Trial name
- VITAL-E (NCT05672901)
- Testing
- StrataMGT, Estrace 0.01% Vaginal Cream
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Stratpharma AG
Turner Syndrome, Ovarian Failure, Premature
Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure
Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition.
- Conditions
- Turner Syndrome, Ovarian Failure, Premature, Sex Chromosome Aberrations, Menopause
- Trial name
- NCT00471731
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Vaginal Atrophy, Genitourinary Disease
Effect of Hybrid Laser 10600+1540 nm on GSM
The primary objective of the study is to clinically confirm, by comparison with a control group, the performance of the 10600 +1540 nm laser in the improvement of atrophic vaginal epithelium at 3 months after the last laser…
- Trial name
- NCT03956563
- Testing
- Youlaser MT Group 2, Youlaser MT Group 1
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Quanta System, S.p.A.
Vulvar Atrophy, Vulvovaginal Signs and Symptoms
Changes in the Impact of Genitourinary Syndrome of Menopause With a Novel Nonhormonal Vulvovaginal Gel Assessed by PROMs.
The goal of this clinical trial is to improve the management of Genitourinary syndrome of menopause (GSM) to preliminary assess safety and effectivity of a novel hormone-free mucosa composition (XCMIM20m) applied topically to the…
- Conditions
- Vulvar Atrophy, Vulvovaginal Signs and Symptoms, Genitourinary Syndrome of Menopause, Quality of Life
- Trial name
- STOPGSMP (NCT06962345)
- Testing
- Hormone-free vulvovaginal gel with the tested composition XCMIM20m
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Mucosa Innovations, S.L.
Bone Diseases, Metabolic Syndrome X
Effect of Exercise and Phytoestrogen on Bone, Metabolic Syndrome Criteria and Complaints of the Early Menopause
The aim of the study is to compare the effect of a progressive, periodized exercise training designed to impact bone, CHD-risk-factors and menopausal complaints versus the combined effect of exercise and "phytoestrogen"…
- Conditions
- Bone Diseases, Metabolic Syndrome X, Coronary Disease
- Trial name
- NCT00663104
- Testing
- exercise, exercise + cimicifuga racemosa
- Where
- Germany
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Genitourinary Syndrome of Menopause
Er:YAG Laser Combined With Vaginal Estriol for Genitourinary Syndrome of Menopause
Chronic hypoestrogenism in postmenopausal women significantly impacts the urogenital epithelium, leading to Genitourinary Syndrome of Menopause (GSM) and increasing susceptibility to gynecological infections due to vaginal pH…
- Trial name
- NCT06873971
- Testing
- Topical estrogen therapy based on estriol (E3), Active Er:YAG Laser
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Menstrual Cycle, Ovulation
Apple Women's Health Study
This is an observational longitudinal study to advance the understanding of menstrual cycle and gynecologic health conditions including PCOS, infertility and breast cancer.The study will be hosted within the Research…
- Conditions
- Menstrual Cycle, Ovulation, Menstruation, Polycystic Ovary Syndrome
- Trial name
- NCT04196595
- Where
- United States
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- Apple Inc.
Menopausal Syndrome
A Muticenter Clinical Study of Chinese Herbal Compound TJAOA102 in Alleviating Menopausal Syndrome
Currently, TCM recipes are widely used in treating menopausal syndrome(MS) with obvious efficiency and slight side effects. We have developed the Chinese herbal compound TJAOA102 and has validated its effects in animals.
- Trial name
- NCT05522621
- Testing
- TJAOA102
- Volunteers
- 100 people
- Sponsor
- Tongji Hospital
HIV Infections
Evaluating the Pharmacokinetics of 400 mg Oral Dose of Raltegravir in HIV-Infected Pre-Menopausal Women
The purpose of this study is to characterize the pharmacokinetics of raltegravir in cervicovaginal fluids as compared to blood plasma of HIV-infected pre-menopausal women.
- Trial name
- NCT00961272
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Kristine Patterson, MD
Endocrine System Diseases, Gonadal Disorders
Comparison of Micro-dose Human Chorionic Gonadotropin (hCG) With Human Menopausal Gonadotropin (HMG) in Polycystic Ovary Syndrome
The purpose of this study is to compare the effectiveness of low dose human chorionic gonadotropin (HCG) in combination with clomiphen citrate to induce ovulation and its endocrine response in patients who had previously failed…
- Trial name
- NCT00947713
- Testing
- low dose human chorionic gonadotropin, Clomiphen citrate plus HMG
- Where
- Iran
- Volunteers
- 10 people
- Sponsor
- Royan Institute
Genitourinary Syndrome of Menopause
Comparison of Vaginal Hyaluronic Acid Treatment Over Autologous Platelet Rich Plasma Treatment for Genitourinary Syndrome of Menopause
Genitourinary syndrome of menopause (GSM) is a collection of symptoms and signs caused by hypoestrogenic changes to the labia majora/minora, clitoris, vestibule/introitus, vagina, urethra, and bladder that occur in menopausal…
- Trial name
- NCT05571527
- Testing
- Platelet Rich Plasma treatment, Vaginal Hyaluronic Acid supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Obesity, Menopause
A Cohort Research of Genetic Susceptibility for Common Obesity in Women
Not many studies examined genetic determinants of obesity in women. As pre-menopausal and post-menopausal women appear to have different propensities for fat deposition, genetic loci linked with obesity-related phenotypes might…
- Trial name
- CROWN (NCT01488903)
- Where
- Taiwan
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Menopause
QXZS in Menopausal Syndrome Based on 16S rRNA Sequencing Technology
The goal of this clinical trial is to explore the differences of intestinal flora and saliva flora between menopausal women, and the changes after medication, to find the association between the two and menopausal syndrome.
- Trial name
- NCT06143696
- Testing
- Qingxin Zishen decoction, Femoston
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yun Chen
Depressive Syndrome
Osteoporosis Treatment in Post-menopausal Women
The study will be conducted to assess the depressive symptoms and related markers in the postmenopausal female after anti-osteoporosis treatment.
- Trial name
- NCT03006003
- Testing
- Raloxifene, Alendronate
- Where
- 2 sites in Taiwan
- Volunteers
- 500 people
- Sponsor
- Taichung Veterans General Hospital
Postmenopausal Syndrome
Evaluating the Roles of Estrogen and Progesterone in Heart Metabolism
Estrogen and progesterone are two main female sex hormones. When a woman goes through menopause, the body's production of estrogen and progesterone significantly decreases.
- Trial name
- Estrogen (NCT00565916)
- Testing
- Estrogen, Progesterone
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Women With Breast Cancer
Effect of Intravaginal Prasterone on Symptoms of Genitourinary Syndrome of Menopause (GSM) in Women in Menopause With Previous Breast Cancer
The goal of this interventional study is to evaluate the effect of Intravaginal Prasterone for the treatment of moderate to severe symptoms of genitourinary syndrome (GSM) due to natural, surgical or treatment-induced menopause…
- Trial name
- PROPOSE (NCT06611514)
- Testing
- Prasterone (DHEA)
- Where
- Italy
- Volunteers
- 95 people
- Sponsor
- European Institute of Oncology
Nutrition, Metabolic Syndrome
Impact of Genetic Polymorphisms And DASH Diet On Weight Loss Progression In Climacteric Women With Metabolic Syndrome
Metabolic syndrome is a multifactorial inflammatory condition that is very prevalent in overweight women with type 2 diabetes. However, there seems to be great benefit in changing lifestyle and dietary patterns in the treatment…
- Conditions
- Nutrition, Metabolic Syndrome, Obesity, Weight Loss
- Trial name
- NCT06978504
- Testing
- DASH diet
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nutrindo Ideais Research Center
Menopause, Menopause Hot Flashes
Effects of a Dietary Intervention Based on the Dietary Guidelines for the Brazilian Population on the Reduction of Menopausal Symptoms in Overweight and Obese Women
The menopausal transition is associated with significant hormonal changes that negatively impact many women's quality of life. Vasomotor symptoms, sleep disturbances, mood changes, and genitourinary symptoms are frequently…
- Conditions
- Menopause, Menopause Hot Flashes, Overweight , Obesity, Perimenopause, Climacteric Syndrome
- Trial name
- NCT07822230
- Testing
- Nutritional guidelines on healthy eating based on the Dietary Guidelines for the Brazilian Population in printed material and 5 in-person and virtual meetings, Nutritional guidelines on healthy eating based on the Dietary Guidelines for the Brazilian Population only in printed material
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Coronary Artery Disease (CAD), Menopause
Serum Endogenous Estrogens, Estrogen Receptors, and Sirtuin-1 and -3 After Resveratrol Supplementation
Atherosclerotic coronary artery disease (CAD) is a leading cause of mortality among postmenopausal women. Resveratrol, a phenolic compound with antioxidant properties, may influence lipid metabolism, endothelial function, and…
- Conditions
- Coronary Artery Disease (CAD), Menopause, Hormones
- Trial name
- RESEARCH (NCT07865377)
- Testing
- Trans-resveratrol, 1000 mg daily for 90 days
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- InCor Heart Institute
Genitourinary Syndrome of Menopause, Vulvovaginal Atrophy
Multi-polar RF and PEMF for Treatment of Vulvovaginal Atrophy
The study evaluates the use of multi-polar radiofrequency (RF) and pulsed electro-magnetic fields (PEMF) energies for the treatment of symptoms related to genitourinary syndrome of menopause (GSM)/vulvovaginal atrophy (VVA).
- Conditions
- Genitourinary Syndrome of Menopause, Vulvovaginal Atrophy, Menopause
- Trial name
- NCT04607798
- Testing
- Radiofrequency and pulsed electro-magnetic fields treatment
- Where
- Ukraine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Venus Concept