Clinical trials: Mental
Obsessive Compulsive Disorder (OCD)
Long-term Follow-up in Patients With Deep Brain Stimulation (DBS) for Obsessive Compulsive Disorder (OCD).
For this human research, 17 treatment-refractory OCD patients who already received DBS implants for treatment refractory OCD between June 1998 and October 2007 will be included.
- Trial name
- NCT01879254
- Testing
- Deep Brain Stimulation
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cognitive Impairments, Aging
Molecular Hydrogen for Cognitive Function and Performance in Elderly
A variety of non-pharmacological interventions have been used in the management of Alzheimer's disease (AD) and similar cognitive disorders in elderly, yet no therapeutic modality has demonstrated conclusive positive results in…
- Trial name
- NCT02830854
- Testing
- Molecular Hydrogen
- Where
- Serbia
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Novi Sad, Faculty of Sport and Physical Education
Depression, Cognitive Decline
Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)
Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD).
- Trial name
- ADEPT-ICU (NCT06627894)
- Testing
- Therapist-Assisted Internet Cognitive-Behavioral Therapy for Depression, Active Control
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Schizophrenia, Quality of Life
Milestones of Adjustment Post-Psychosis
This nested design clinical outcome study of psychiatric case manager education on disease state, psychopharmacology of schizophrenia, relapse, motivational interviewing, and the process of psychological adjustment post-psychosis…
- Conditions
- Schizophrenia, Quality of Life, Adjustment, Psychological, Medication Adherence
- Trial name
- MAPP (NCT01192594)
- Testing
- Training in all modules including MAPP Recovery Model, Training in all modules except MAPP Recovery Model
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Yale University
Anxiety, Child, Only
The Effect of "Quantum Touch" Application on Transfer Anxiety in Pediatric Patients and Their Parents Planned to Be Hospitalized in the Emergency Department
Anxiety, which is a subjective experience in which many emotions such as worry, uncertainty, restlessness, and sadness are experienced together, is defined as "a state of tension that arises as a result of the internal conflict…
- Conditions
- Anxiety, Child, Only, Emergencies
- Trial name
- NCT05380466
- Testing
- Quantum Touch
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Medeniyet University
Refugee, Mental Health
Impact of the War in Ukraine on the Mental Health of Refugees Residing in Spain
Background: Following the outbreak of war in Ukraine on 24 February 2022, thousands of Ukrainians are crossing the borders every day in search of a place that offers them stability and security.
- Conditions
- Refugee, Mental Health, War Injury
- Trial name
- NCT07427056
- Where
- Spain
- Volunteers
- 123 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Major Depressive Disorder, Anxiety Disorders
Brain Hippocampal Volume Relationship With Anxious Symptoms in Major Depressive Patients
The objective of this transversal study is to determine if there is a difference in the volume of the hippocampus with the degree of anxiety.
- Trial name
- NCT04430556
- Testing
- Sertraline
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Schizophrenia, Clinical High Risk for Psychosis (CHR)
Mobile Thinking Intervention: A Inital Test
This study will test the inital efficacy of a brief mobile intervention targeting biased thinking.
- Trial name
- NCT06909422
- Testing
- Mobile Intervention for Biased Thinking
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Critical Illness
Consequences of Hypoglycemia on Intensive Care Unit (ICU) Patients
Hypoglycemia occurs frequently during intensive blood glucose control in critically ill patients. The incidence of hypoglycaemia is associated with impaired outcome.
- Trial name
- NCT00662922
- Where
- Germany
- Volunteers
- 74 people
- Sponsor
- University Hospital Muenster
Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease
Addressing Dementia Via Agitation-Centered Evaluation
This is a multi-center, randomized, double-blind, placebo-controlled study, to assess the efficacy and safety of AXS-05 in the treatment of agitation in patients with Alzheimer's disease.
- Conditions
- Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease, Agitation,Psychomotor
- Trial name
- ADVANCE (NCT03226522)
- Testing
- AXS-05, Bupropion
- Where
- 78 sites in United States, Australia
- Volunteers
- 366 people
- Sponsor
- Axsome Therapeutics, Inc.
Schizophrenia
Effectiveness of Aripiprazole Long-acting Injection in Recent Onset and Chronic Schizophrenia Patients
The aim of the study is to investigate the effectiveness of Aripiprazole long-acting injection in recent onset and chronic schizophrenia patients
- Trial name
- NCT03839251
- Testing
- abilify maintena
- Where
- 5 sites in South Korea
- Volunteers
- 82 people
- Sponsor
- Chonbuk National University Hospital
Postoperative, Delirium
Dexmedetomidine for the Treatment of Delirium After Heart Surgery
Primary hypothesis: Dexmedetomidine is equal or superior to haloperidol and placebo in the treatment of psychomotor confusion in patients who are recovering from heart surgery.
- Conditions
- Postoperative, Delirium, Psychomotor, Confusion
- Trial name
- DexinDelir (NCT01140529)
- Testing
- Dexmedetomidine, Haloperidol, Saline
- Where
- Sweden
- Volunteers
- 3 people
- Sponsor
- Thorax-Kärlkliniken
Diabetes Mellitus, Type 1
Testing an Integrated Care Model Trial
This study aims to test the use of an adapted collaborative care model for improving the health outcomes of adults diagnosed with type 1 diabetes (T1D). The duration of the study is 18 months with 4 study survey points.
- Trial name
- NCT06448429
- Testing
- Usual care, Collaborative care model (CoCM)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emory University
Abnormality of the Neck, Fetus; Abnormal, Affecting Management of Pregnancy
Antenatal Detection by Array CGH Genomic Rearrangements Unbalanced Front Uninsulated Thick Neck or a Combination of Two Signs of Ultrasound Calling Normal Karyotype
This is the first study with a real diagnostic and prognostic focus in prenatal. In addition to this innovative aspect, the identification of cryptic imbalances in fetuses with malformative syndrome would be an invaluable…
- Trial name
- CGH Array (NCT03239002)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Lille
Radiation Therapy
EVALUATION OF THE BENEFITS OF SOPHROLOGY FOR PATIENTS UNDERGOING RADIOTHERAPY
Anxiety is a common symptom among patients undergoing radiation therapy, stemming from their cancer diagnosis, anticipation of side effects, and the specific challenges associated with the treatment sessions.
- Trial name
- SORA-RT (NCT07652060)
- Testing
- Sophrology
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Clinique Pasteur Lanroze
Obsessive Compulsive Disorder
Efficacy of Adding Topiramate to Current Treatment in Refractory Obsessive Compulsive Disorder (OCD)
SRI's are considered first-line treatments for OCD, however many patients continue to have significant symptoms despite an adequate trial of an SRI.
- Trial name
- NCT00182520
- Testing
- Topiramate
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- McMaster University
Alzheimer's Disease
AC-1204 Long-term Efficacy Response Trial (ALERT Protocol)
The study will evaluate the safety \& efficacy of AC-1204, a ketogenic compound, administered orally on a daily basis for 6 months.
- Trial name
- ALERT (NCT01211782)
- Testing
- caprylic triglyceride, long-chain triglyceride
- Where
- United States
- Sponsor
- Cerecin
Depression, Anxiety
Evaluation of Text Message Engagement Support of Mindfulness Smartphone Applications
The aim of this study is to assess the usability of two mindfulness smartphone applications (apps) and to evaluate whether text message support can promote engagement with those apps through a 4-week trial comparing support vs.
- Trial name
- NCT03633682
- Testing
- Headspace - Meditation and Mindfulness App, Stop, Breathe, & Think - Meditation and Mindfulness App
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Treatment Resistant Depression
Neurobiological Analyses Within the FORESEE III Study
In this observational, non-invasive clinical study different neurobiological analyses will be performed in a group of patients with severe treatment resistant major depression participating in an efficacy study of deep brain…
- Trial name
- NCT04021823
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Freiburg
Substance-related Disorders
Project CHOICE: Efficacy Testing of CHOICE and CHOICE+Normative Feedback Interventions
This study will use a pilot test format to examine the efficacy of a brief Motivational Interviewing (MI) intervention developed by the investigator Dr.
- Trial name
- CHOICE (NCT02083523)
- Testing
- Motivational Interview with Normative Feedback, Motivational Interview
- Volunteers
- 48 people
- Sponsor
- University of Illinois at Urbana-Champaign
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