Clinical trials: Mental Health (Depression)
Depression, Depression in Old Age
Trial to Test Effectiveness of Depression Intervention for Mistreated Older Adults
The investigators developed EM/PROTECT, a behavioral intervention for depressed EM (elderly mistreatment) victims, to work in synergy with EM mistreatment resolution services that provide safety planning, support services, and…
- Conditions
- Depression, Depression in Old Age, Elder Abuse, Anxiety
- Trial name
- NCT04258579
- Testing
- PROTECT with Technology Augmentation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Weill Medical College of Cornell University
Depression, Suicidality
Development and Preliminary Trial of a Brief, Portable Health Intervention for Rural Sexual Minority Emerging Adults
The purpose of this study is to test the feasibility of writing interventions specifically designed for lesbian, gay, and bisexual (LGB) emerging adults (ages 18-29) that are aimed at improving the outcomes: depression…
- Conditions
- Depression, Suicidality, Substance Abuse, HIV
- Trial name
- Project LEAP (NCT03751020)
- Testing
- Expressive Writing (EW) Intervention, Self-Affirmation (SA) Intervention, Control
- Where
- 3 sites in United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Yale University
Nonsuicidal Self Injury, Suicidal Ideation
Digital Mental Health Intervention for Nonsuicidal Self-Injury in Young Adults
This is a feasibility trial of a digital mental health intervention aimed at young adults (ages 18-25) with nonsuicidal self-injury and who are not currently engaged in mental health treatment.
- Conditions
- Nonsuicidal Self Injury, Suicidal Ideation, Depression, Anxiety
- Trial name
- NCT05325944
- Testing
- Self-guided digital intervention for NSSI, Digital intervention for NSSI with coaching, Active control
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Northwestern University
Maternal Behavior, Postpartum Depression
Improving Health Outcomes and Equity by Targeting Postpartum Mothers at Highest Risk
The goal of this educational clinical trial is to identify high-need women most at risk for poor outcomes following delivery, the problems they experience, and to create a system to improve quality of postpartum care for these…
- Trial name
- HOME (NCT06276647)
- Testing
- HOME
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of Pennsylvania
Substance-Related Disorders, Mental Disorder
Community Health Worker Training to Reduce Depression and Substance Use Stigma in TB/HIV Care in South Africa
Poor engagement in care contributes to HIV- and TB-related morbidity and mortality in South Africa (SA). Community health workers (CHWs) are frontline lay health workers who work to re-engage patients who are lost to follow-up…
- Conditions
- Substance-Related Disorders, Mental Disorder, Social Stigma, Depression
- Trial name
- Siyakhana (NCT05282173)
- Testing
- Siyakhana CHW Training
- Where
- South Africa
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Mental Health Issue, Breast Cancer
Evaluating Digital Micro-Interventions to Reduce Distress and Increase Wellbeing in Breast Cancer Survivors
Digital mental and behavioral health interventions have potential to significantly improve accessibility for the large number of breast cancer survivors who need treatments.
- Trial name
- NCT07160439
- Testing
- Digital Micro-Interventions
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Virginia
Childhood Traumatic Grief, Post Traumatic Stress
Randomized Controlled Trial of Trauma-focused CBT in Tanzania and Kenya
The primary goal is to study the effectiveness of Trauma-focused Cognitive Behavioral Therapy (TF-CBT) in treating traumatic grief and traumatic stress for orphaned children and young adolescents in two East African sites with…
- Conditions
- Childhood Traumatic Grief, Post Traumatic Stress, Post Traumatic Stress Disorder, Depressive Symptoms
- Trial name
- NCT01822366
- Testing
- Trauma-focused Cognitive Behavioral Therapy
- Where
- 3 sites in United States, Kenya and 1 more
- Volunteers
- 1,280 people
- Sponsor
- Duke University
Major Depression
PRIME Care (PRecision Medicine In MEntal Health Care)
The focus of this application is on the impact of providing depressed Veterans and their providers with the results of pharmacogenetic (PGx) testing for psychotropic medications.
- Trial name
- PRIME Care (NCT03170362)
- Testing
- Pharmacogenetic Test
- Where
- 24 sites in United States
- Volunteers
- 1,944 people
- Sponsor
- VA Office of Research and Development
Bipolar Disorder, Depression
Implementing Health Plan-Level Care Management for Solo & Small Practices
This study will determine if a version of the chronic care model for individuals with mood disorders seen in small or solo practices can improve patient health.
- Trial name
- NCT02041962
- Testing
- Chronic Care Model for Mood Disorders, Educational Control
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- University of Michigan
HIV Infections, Behavioral Symptoms
Friendship Bench Adaptation to Improve Mental Health & HIV Care Engagement Outcomes Among PLWH and PWID in Vietnam
This project will adapt and pilot a feasible and effective problem-solving therapy designed for low-resource settings to address common mental disorders like depression and anxiety - the Friendship Bench- in a Vietnamese…
- Conditions
- HIV Infections, Behavioral Symptoms, Depression, Anxiety
- Trial name
- VITAL (NCT04790201)
- Testing
- Friendship Bench Delivered by Professional Counselor, Friendship Bench Delivered by Lay Counselor, Enhanced Usual Care
- Where
- Vietnam
- Volunteers
- 77 people
- Sponsor
- University of North Carolina, Chapel Hill
Depression, Anxiety
A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental Health
Ketamine-Assisted Psychotherapy (KAP) is a relatively new approach for the treatment of mental health issues, which involves the combination of ketamine, a dissociative anaesthetic with psychedelic properties, and psychotherapy…
- Conditions
- Depression, Anxiety, Post Traumatic Stress Disorder
- Trial name
- NCT05604794
- Testing
- Ketamine-Assisted Psychotherapy (KAP)
- Where
- 11 sites in United States, Canada
- Volunteers
- 1,806 people
- Sponsor
- Field Trip Health
Major Depression
Increasing Use of Mental Health Services
The purpose of this study is to test the effectiveness of Open Door (previously known as the Treatment Initiation Program [TIP]), a brief psychosocial intervention to address the psychological barriers to care and improve the use…
- Trial name
- OpenDoor (NCT00605358)
- Testing
- Open Door intervention
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- Weill Medical College of Cornell University
Depression, Osteoarthritis
Enhancing Well-Being Through Exercise During Old Age
Determine the feasibility of adapting Fit \& Strong!, an evidence-based group physical activity and health education program, to include affect and mood-related content and of employing this intervention among older adults with a…
- Trial name
- NCT04536727
- Testing
- Fit & Strong!, Wait list
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Chronic Pain, Depression, Anxiety
Cognitive Behavioral Therapy and Real-Time Pain Management Intervention for Sickle Cell Via Mobile Applications
The investigators are conducting a comparative effectiveness trial among adult patients with sickle cell disease (SCD) who report chronic pain (N = 350), randomized to receive either mobile phone-delivered computerized cognitive…
- Conditions
- Chronic Pain, Depression, Anxiety, Opioid Use
- Trial name
- CaRISMA (NCT04419168)
- Testing
- cCBT, m-Education
- Where
- 7 sites in United States
- Volunteers
- 359 people
- Sponsor
- University of Pittsburgh
Major Depressive Disorder
The Effectiveness of rTMS in Depressed VA Patients
The purpose of this multi-site trial is to determine if repetitive Transcranial Magnetic Stimulation (rTMS) helps people with depression who have not been helped by medications or who have not been helped enough by medications.
- Trial name
- NCT01191333
- Testing
- rTMS
- Where
- 9 sites in United States
- Volunteers
- 164 people
- Sponsor
- VA Office of Research and Development
Anxiety, Depression
Improving Adherence to Homework During Therapy
The purpose of this study is to expand Adhere.ly- a simple, HIPAA-compliant, web-based platform to help therapists engage clients in practicing therapeutic skills between sessions (homework) during mental health treatment by…
- Conditions
- Anxiety, Depression, Depression/Anxiety
- Trial name
- Adherely STTR (NCT05866185)
- Testing
- Therapy, Therapy + Adhere.ly
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- University of South Florida
Mental Health Issue, Anxiety
Clinical Investigation of Wysa
Mental health concerns are a large burden for individuals, healthcare systems, and the economy. Over a million people are referred to UK mental health services each year, but more than half only receive one session of…
- Conditions
- Mental Health Issue, Anxiety, Depressive Symptoms
- Trial name
- NCT05533190
- Testing
- Wysa AI chatbot mental health app
- Where
- 2 sites in United Kingdom
- Volunteers
- 76 people
- Sponsor
- University of Plymouth
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Infant Development
Maternal Adversity, Vulnerability and Neurodevelopment
Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) project is a prospective community-based, pregnancy and birth cohort of Canadian mother-child dyads.
- Conditions
- Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Infant Development, Infant Behavior
- Trial name
- MAVAN (NCT03434457)
- Where
- Canada
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Mental Health Issue, Hiv
Healthy Mothers: an Intervention to Support Perinatal Women Living With HIV in Kenya
The investigators will recruit 40 pregnant women living with HIV divided into 2 groups (n=20 intervention group, n=20 control group).
- Conditions
- Mental Health Issue, Hiv, Breastfeeding, Exclusive
- Trial name
- NCT05219552
- Testing
- personalized lactation support
- Where
- 2 sites in Kenya
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Transgender, Depression
Mental Health Support for Transgender and Gender-expansive Individuals
This study will evaluate an intervention's feasibility, acceptability and efficacy potential in a one-arm trial with Romanian transgender and gender diverse (e.g., gender non-binary) (TGD) individuals who report depression or…
- Conditions
- Transgender, Depression, Anxiety, Suicidality
- Trial name
- NCT06229132
- Testing
- LGBTQ-affirmative CBT for transgender individuals
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Columbia University