Clinical trials: Mental Health (Depression)
Depression, Depressive Disorder
Targeting Adolescent Depressive Symptoms Via Brief, Web-Based Interventions
Major depression (MD) in youth is a serious psychiatric illness with extensive morbidity and mortality. The American Academy of Pediatrics recently released practice guidelines promoting primary care (PC)-based youth MD…
- Conditions
- Depression, Depressive Disorder, Behavioral Symptoms, Mood Disorders
- Trial name
- NCT04066985
- Testing
- Growth Mindset Online Single-Session Program, Self-Kindness Online Single-Session Program, Supportive Therapy Online Single-Session Program (Control)
- Where
- United States
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Child Mind Institute
HIV, HIV - Human Immunodeficiency Virus
Intervention to Reduce HIV Related Stigma Among Pregnant and Postpartum Women
Purpose of this Study: The main purpose of this study is to adapt an existing evidence-based intervention, Project Accept Post-Test Support Services (PTSS) Module 3, specifically for pregnant and postpartum women living with HIV…
- Conditions
- HIV, HIV - Human Immunodeficiency Virus, Postpartum, Pregnancy
- Trial name
- WAT (NCT07064928)
- Testing
- Adapted Project Accept's Post-Test Support Services (PTSS) Module 3
- Where
- Ghana
- Volunteers
- 163 people
- Sponsor
- University of California, San Francisco
Anxiety Depression
Mindfulness-Based Art Therapy and Generation Z
A randomized controlled trial will be conducted to determine the unique role of the arts as a proactive mental health strategy for college students in Generation Z.
- Trial name
- NCT04834765
- Testing
- Mindfulness-based art therapy, Art-only, Mindfulness-only
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Florida State University
Migrants, Anxiety
Status and Predictors of Mental Health Symptoms Among Migrants and Refugees During the COVID-19 Pandemic
Migrants and refugees are vulnerable subgroups in general with regards to symptoms of psychopathology. Furthermore, recent calls for paper urge investigation on current mental health status of migrants and refugees during the…
- Conditions
- Migrants, Anxiety, Depression
- Trial name
- NCT04443764
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Mindfulness, Depression
Internet-based Mindfulness-based Training (iMBT) for People With Depression
The research goals of this randomized controlled trial are to determine the feasibility and the mechanism of change of iMBT that has been developed using the Acceptance Checklist for Clinical Effectiveness Pilot Trials.
- Trial name
- NCT05410132
- Testing
- Internet-delivered Mindfulness Based Training (iMBT)
- Where
- Hong Kong
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Depression, Anxiety
Improving Psychological Wellness After Acquired Brain Injury
The purpose of the study is to investigate the potential benefits of a psychological therapy, called cognitive behaviour therapy (CBT), for improving emotional well being after acquired brain injury and to demonstrate its…
- Conditions
- Depression, Anxiety, Brain Injury
- Trial name
- NCT00866632
- Testing
- Cognitive Behavioural Therapy
- Where
- 2 sites in Canada
- Volunteers
- 75 people
- Sponsor
- Toronto Rehabilitation Institute
Parenting Self-efficacy, Postpartum Anxiety
Essential Coaching Postpartum: Evaluating a Parent-focused Postpartum Text Message Program in Nova Scotia
The transition to parenthood is often an exciting yet hard period for parents. In the first year after a new baby, many parents feel less confident, have more anxiety and depression, and feel more isolated and alone.
- Conditions
- Parenting Self-efficacy, Postpartum Anxiety, Postpartum Depression (PPD), Postpartum Stress
- Trial name
- NCT06996067
- Testing
- Essential Coaching Postpartum
- Where
- Canada
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre
Depression, Anxiety Disorders
Engaging Pacific Islanders in Mental Health Treatment
This study will create and pilot test a culturally grounded intervention (Talking Story) to increase mental health treatment seeking among Pacific Islanders with mental disorders (e.g., major depressive disorder, generalized…
- Trial name
- NCT04890977
- Testing
- Talking Story
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, Riverside
Depression
Tele-SSM: A Telephone Technology Innovation in the Intervention on Supported Self-management for Depression in Vietnam
Tele-SSM is a pre-post mixed-method study to investigate the feasibility, acceptability and the preliminary efficacy of the support self-management skills intervention for depression delivered from distance.
- Trial name
- NCT06456775
- Testing
- Tele-SSM
- Where
- Vietnam
- Volunteers
- 75 people
- Sponsor
- Institute for Social Development Studies, Vietnam
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Suicide, Mental Health Disorder
Optimizing a Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents
Despite efforts to prevent suicide, US rates are climbing, and suicide is the second leading cause of death amongst youth. Digital tools, especially personal smartphones, are promising avenues to address these issues and can be…
- Conditions
- Suicide, Mental Health Disorder, Anhedonia
- Trial name
- NCT06665620
- Testing
- ViraBrite nudges
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ksana Health
Advanced Prostate Carcinoma, Metastatic Prostate Carcinoma
Bright White Light Therapy in Reducing Cancer-Related Fatigue and Depression in Advanced Prostate Cancer Patients Undergoing Treatment With ADT Combination Therapy
This phase II trial tests how well bright white light (BWL) therapy works in reducing cancer-related fatigue and depression in patients with prostate cancer that may have spread from where it first started to nearby tissue, lymph…
- Conditions
- Advanced Prostate Carcinoma, Metastatic Prostate Carcinoma, Prostate Carcinoma, Stage III Prostate Cancer AJCC v8
- Trial name
- NCT05869682
- Testing
- Bright White Light Therapy, Combination Drug Therapy, Electronic Health Record Review
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- City of Hope Medical Center
Depression, Healthy
Bone Loss in Premenopausal Women With Depression
The purpose of this study is to determine whether women with major depression lose bone mass at a faster rate than women without depression.
- Conditions
- Depression, Healthy, Osteopenia, Osteoporosis
- Trial name
- NCT00006180
- Testing
- Alendronate
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Anxiety
Feasibility Study of a Music and Social Support Intervention for Postnatal Mothers/Infants
This research study aims to assess the feasibility of conducting a full scale trial of Mamas in Harmony, a group music and social support class delivered by a professional musician for mothers and their babies.
- Trial name
- NCT05930990
- Testing
- Mamas in Harmony
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Cervical Cancer, Psychological Distress
Effect of Two Cognitive-Behavioral Interventions on Cervical Cancer Patients
Cancer represents the second cause of death in general population worldwide and according to statistics, it is expected to increase in the next 20 years.
- Conditions
- Cervical Cancer, Psychological Distress, Coping Skills
- Trial name
- NCT04165460
- Testing
- Psychoeducation, Relaxation, Cognitive Restructuring
- Where
- Mexico
- Volunteers
- 92 people
- Sponsor
- National Institute of Cancerología
Menopause
The Effects of a Novel Probiotic Supplement on Menopausal Symptoms and Bone Health
This Phase II study is designed to evaluate the potential effects of a novel probiotic supplement on the severity of global menopause symptoms (e.g., psychological, somatic, urogenital symptoms) and on bone health in…
- Trial name
- MPS (NCT04001088)
- Testing
- Probiotic
- Where
- 5 sites in United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Lallemand Health Solutions
Depression, Mental Health Issue
Digital Therapeutic Workplace Technology as a Employee Management Tool and Employee's Mental Health Care
The purpose of the study is to determine whether a digital healthcare app for employee's mental health can effectively improve the mental health of Hisbeans's employees and the managerial performance of Hisbeans, which is…
- Trial name
- NCT06295185
- Testing
- application MARO
- Where
- South Korea
- Volunteers
- 165 people
- Sponsor
- Ajou University School of Medicine
Smoking Cessation, Cardiovascular Disease
What Are the Effects of Varenicline Compared With Nicotine Replacement Therapy on Long Term Smoking Cessation and Clinically Important Outcomes?
Introduction: Smoking is a major avoidable cause of ill-health and premature death. Treatments that help patients successfully quit smoking have an important effect on health and life expectancy.
- Conditions
- Smoking Cessation, Cardiovascular Disease, Respiratory Disease, Myocardial Infarction
- Trial name
- NCT02681848
- Testing
- Varenicline, Nicotine replacement therapy
- Volunteers
- 180,000 people
- Sponsor
- University of Bristol
Stress Disorders, Post-Traumatic, Depression
Resettled Refugee Families for Healing
The goal of this type I hybrid effectiveness-implementation trial is to test a family strengthening (FS) model delivered through multiple family groups (MFG) combined with a virtual peer mentoring program called TeenAge Health…
- Conditions
- Stress Disorders, Post-Traumatic, Depression, Antisocial Personality Disorder, Anxiety
- Trial name
- RRF4H (NCT06176638)
- Testing
- RRF4H Combination Intervention
- Where
- United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Depression - Major Depressive Disorder, Anxiety
Validation of Accexible Screening and Self-Administered Activities for Emotional Well-Being in a University Hospital (UaDEC)
Major depressive disorder (MDD) and anxiety are increasingly prevalent among university student populations, yet early detection remains reliant on psychometric instruments tied to diagnostic criteria (e.g., PHQ-9, GAD).
- Trial name
- NCT07578155
- Testing
- AcceXible
- Where
- Mexico
- Volunteers
- 902 people, healthy volunteers welcome
- Sponsor
- Accexible
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