Clinical trials: Mental Illness
Schizophrenia, Schizoaffective Disorder
RCT of Methotrexate Added to Treatment As Usual in Schizophrenia
The aim of the this study is to evaluate the effectiveness of methotrexate added to treatment as usual on positive and negative symptoms, cognitive and social functioning and quality of life of patients suffering from…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- RECOVERY (NCT02074319)
- Testing
- Methotrexate
- Where
- 4 sites in Pakistan
- Volunteers
- 92 people
- Sponsor
- Pakistan Institute of Living and Learning
Major Depression, Dysthymia
Are Two Antidepressants a Good Initial Treatment for Depression?
Relatively drug naive patients will receive two antidepressant medications as initial treatment.
- Conditions
- Major Depression, Dysthymia, Depression NOS
- Trial name
- NCT00296712
- Testing
- escitalopram + bupropion
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- New York State Psychiatric Institute
Amphetamine Addiction
The Application of Cognitive Rehabilitation Therapy for Amphetamine-type Stimulants Addiction
The computerized cognitive rehabilitation therapy will be used to treat amphetamine-type stimulant (ATS) addiction.
- Trial name
- NCT03318081
- Testing
- cognitive function rehabilitation and bias modification
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Aging, Cognitive Impairment
Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities
The aim of this study is to design a sleep and mindfulness intervention to improve sleep, quality of life, and cognitive function among older adults.
- Conditions
- Aging, Cognitive Impairment, Sleep
- Trial name
- NCT06989619
- Testing
- Sleep health and mindfulness intervention
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Intellectual Disability, Variable
A Pilot Project to Facilitate Dental Care and Reduce Barriers For Youth With Disabilities
This randomized clinical trial is an innovative pilot project to determine the acceptance and impact of telehealth visits on youth with intellectual and developmental disabilities (IDD), their caregivers, and dentists.
- Trial name
- NCT06710483
- Testing
- Pre-Dental Telehealth (PDT)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston University
Prematurity, Neurodevelopmental Disorder
Effect of Early L-Carnitine Supplementation on Neurodevelopmental Outcomes in Very Preterm Infants
Preterm infants are vulnerable to brain injury, nutritional deficiencies and poor early growth which places them at increased risk for developmental problems later in life.
- Conditions
- Prematurity, Neurodevelopmental Disorder, Carnitine Deficiency
- Trial name
- NCT01783041
- Testing
- L-carnitine, 5% Dextrose
- Where
- 2 sites in United States
- Volunteers
- 144 people
- Sponsor
- Montefiore Medical Center
COPD, Cognitive Impairment
Working Memory Training in COPD Patients: the Cogtrain-Trial
General cognitive impairment is highly prevalent in chronic obstructive pulmonary disease (COPD) patients. Domain-specific cognitive impairments include deficits in domains such as cognitive flexibility, verbal memory, working…
- Trial name
- NCT03073954
- Testing
- Working memory training, Standardised healthy lifestyle coaching
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Maastricht University Medical Center
Sleep Apnea Syndromes, Cardiovascular Diseases
The Link Between Clinical and Physiological Sleep Data and Health-related Outcomes
Emerging evidence suggests that sleep-related disturbances such as sleep-disordered breathing (e.g. sleep apnea), sleep fragmentation, abnormal sleep architecture, and periodic limb movements (PLMs) are closely linked with…
- Conditions
- Sleep Apnea Syndromes, Cardiovascular Diseases, Sleep Initiation and Maintenance Disorders, Nocturnal Myoclonus Syndrome
- Trial name
- NCT03383354
- Testing
- Sleep-related disturbances (exposure)
- Where
- Canada
- Volunteers
- 5,000 people
- Sponsor
- Sunnybrook Health Sciences Centre
Bipolar Disorder
Evaluating the Effectiveness of Imagery Focussed Therapy
This study explores the effectiveness of a brief Imagery-focussed Cognitive Therapy (imCT) compared to psychoeducation, regarded as treatment as usual for this patient population, in patients suffering from BD receiving mood…
- Trial name
- NCT03750305
- Testing
- imagery-focused Cognitive Therapy, TAU
- Where
- Netherlands
- Volunteers
- 62 people
- Sponsor
- Maastricht University
Schizophrenia
F17464 in Acute Schizophrenia Trial
The purpose of this study is to evaluate the potential efficacy of oral F17464 in comparison to placebo over 6 weeks in patients with acute exacerbation of schizophrenia.
- Trial name
- FAST (NCT02151656)
- Testing
- F17464
- Where
- 27 sites in France, Hungary and 3 more
- Volunteers
- 158 people
- Sponsor
- Pierre Fabre Medicament
Sleep Quality, Implementation
Cascading A Healthy Sleep Intervention In Vocational Education
Sleep is crucial for the mental, cognitive and physical health of adolescents. However, teenagers in 2024 sleep less and less and their sleep is of poorer quality.
- Trial name
- NCT07030556
- Testing
- Healthy Sleep Intervention, Co-creation process, Training for teachers
- Where
- Belgium
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Ghent
Schizophrenia
An Extension Study of Safety and Tolerability of SEP-363856 in Adult Subjects With Schizophrenia
An extension study of safety and tolerability of SEP-363856 in adult subjects with schizophrenia
- Trial name
- NCT02970929
- Testing
- SEP-363856
- Where
- 30 sites in United States, Hungary and 3 more
- Volunteers
- 157 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Obesity
MOTIVOB-(Acceptance and Commitment Therapy Group Intervention for Obesity)Section
The purpose of the present study is to compare an Acceptance and Commitment Therapy (ACT) group intervention and a Cognitive Behavioral Therapy (CBT) group in a sample of obese individuals with respect to mid-term outcome.
- Trial name
- MOTIVOB-ACT (NCT03066531)
- Testing
- ACT-based intervention, CBT-based intervention
- Volunteers
- 156 people
- Sponsor
- Istituto Auxologico Italiano
Cancer, Chronic Obstructive Pulmonary Disease
Comparative Trial of Home-Based Palliative Care
Background: To effectively alleviate suffering and improve quality of life for patients with serious illness and their caregivers, palliative care (PC) services must be offered across multiple settings.
- Conditions
- Cancer, Chronic Obstructive Pulmonary Disease, Heart Failure, Dementia
- Trial name
- HomePal (NCT03694431)
- Testing
- Tech-supported HBPC, Standard HBPC
- Where
- 2 sites in United States
- Volunteers
- 3,999 people
- Sponsor
- Kaiser Permanente
Attention Deficit Disorder with Hyperactivity, Attention Deficit Hyperactivity Disorder
Effects of Exercise Intensity on ADHD Symptoms
This project investigates the effects of a bicycling exercise at three levels of exercise intensity (low, moderate, and high) on attention deficit/hyperactivity disorder (ADHD) in college students.
- Conditions
- Attention Deficit Disorder with Hyperactivity, Attention Deficit Hyperactivity Disorder, ADHD
- Trial name
- NCT06753253
- Testing
- Cycling Exercise
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Kent State University
Pregnancy, Breastfeeding
The Effect of Early Versus Traditional Follow-Up on Breastfeeding Rates at 6 Months
The study's purpose is to determine if early (2-3 week) versus traditional (6-8 week) postpartum follow up is associated with a higher rate of breastfeeding at 6 months.
- Conditions
- Pregnancy, Breastfeeding, Contraception, Cervical Cancer
- Trial name
- NCT02221895
- Testing
- Postpartum follow up appointment 2-3 weeks after delivery, Postpartum follow up 6-8wk after delivery
- Where
- United States
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- Madigan Army Medical Center
Implementation Science, Delirium
Behavioral Economic & Staffing Strategies in the ICU
The overarching goal of this study is to support the "real world" assessment of strategies used to foster adoption of several highly efficacious evidence-based practices in healthcare systems that provide care to critically ill…
- Conditions
- Implementation Science, Delirium, Critical Illness, Mechanical Ventilation Complication
- Trial name
- BEST-ICU (NCT06184945)
- Testing
- Realtime audit and feedback, RN Implementation Facilitator
- Where
- 3 sites in United States
- Volunteers
- 16,500 people
- Sponsor
- University of Nebraska
Mood Disorders, Depressive Disorders
Clinical Trials of Two Non-drug Treatments for Chronic Depression
This study investigates the potential efficacy of two nonpharmacologic treatments for nonseasonal depression, bright light exposure or high-density negative air ion exposure.
- Conditions
- Mood Disorders, Depressive Disorders, Depression, Chronic Depression
- Trial name
- NCT00006172
- Testing
- Bright light box, High-output negative ion generator, Low-output negative ion generator
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- New York State Psychiatric Institute
Autism, Emotion Regulation Difficulties
Enhancing Emotion Regulation in Children With Autism Through Extended Reality
Pilot study on the development of an Extended Reality (XR) application to support emotion regulation in children with Autism Spectrum Disorder (ASD) (random assignment to an experimental group, N = 10, and a control group, N =…
- Trial name
- ERAC-XR (NCT07838272)
- Testing
- Extended Reality, Emotion regulation coaching
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Johannes Kepler University of Linz
Schizophrenia
Combining Clemastine and Aerobic Exercise to Treat Cognitive Dysfunction in Schizophrenia by Targeting Myelin Plasticity
Schizophrenia (SZ) is a broad clinical entity characterized by different subjective symptoms,behavioural signs, and disease course.
- Trial name
- OligoTreat (NCT06315972)
- Testing
- clemastine (8 mg/day)
- Volunteers
- 90 people
- Sponsor
- LMU Klinikum
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