Clinical trials: Mental Illness
Posttraumatic Stress Disorders
PTSD Symptom Reduction by Propranolol Given After Trauma Memory Activation
This study is a randomized, double-blind, placebo-controlled clinical trial of propranolol combined with trauma memory reactivation, to determination if this approach is effective in treating PTSD symptoms.
- Trial name
- NCT00645450
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Office of Research and Development
Anorexia Nervosa
Drug Transport in Patients With Anorexia Nervosa
The aim of this study is to investigate whether patients with anorexia nervosa have elevated plasma cholesterol levels and, if elevated plasma cholesterol levels influence drug transport by the ABC-transporter P-gp…
- Trial name
- NCT00176150
- Where
- Germany
- Sponsor
- Heidelberg University
Brain Diseases, Epilepsy
Amygdala Memory Enhancement
The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories.
- Conditions
- Brain Diseases, Epilepsy, Memory Disorders, Traumatic Brain Injury
- Trial name
- NCT05065450
- Testing
- Intracranial Stimulation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Washington University School of Medicine
Borderline Personality Disorder
Creativity Group for Borderline Personality Disorder
The investigators hypothesize that a creativity skills group for Borderline Personality Disorder can reduce symptoms of BPD, depression, and anxiety.
- Trial name
- NCT01343550
- Testing
- creativity group
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- State University of New York - Upstate Medical University
Schizophrenia, Schizoaffective
Treatment of Refractory Schizophrenia With Riluzole
The proposed study would evaluate the benefits of riluzole add-on treatment to patients with schizophrenia who are already receiving medications, but still experience symptoms.
- Trial name
- NCT00375050
- Testing
- Riluzole
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Yale University
Silent Cerebral Infarct, Biomarkers / Blood
Biomarkers as Prognostic Factors of Silent, Cerebral Infarctions in Patients Undergoing High-thromboembolic-risk Transcatheter Interventions
Background: The transcatheter interventions with high thromboembolic risk, as transcatheter carotid angioplasty or transcatheter ablation of cardiac arrhythmias are associated with asymptomatic strokes- silent strokes.
- Conditions
- Silent Cerebral Infarct, Biomarkers / Blood, Cardiac Ablation, Cognitive Impairment
- Trial name
- PRINCESS (NCT07844850)
- Testing
- High-thromboembolic-risk transcatheter interventions
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Sleep Deprivation, Obesity
Effects of Sleep Restriction on BAT Activation in Humans
The goal of this proposed research is to test the hypothesis that long-term mild sleep restriction (SR), as occurs frequently in adults and adolescents, leads to a positive energy balance and weight gain. Aim 1.
- Trial name
- BAT (NCT02770118)
- Testing
- Partial Sleep Restriction, Total Sleep Deprivation, Habitual Sleep
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Columbia University
Bipolar Disorder
Effects of an Integrative Psychological Program in Bipolar Disorder
Bipolar disorder is related to a high level of personal, familial, social and economic burden. There is a need for feasible adjunctive psychological interventions to use in clinical practice as a complement of pharmacotherapy to…
- Trial name
- NCT04031560
- Testing
- Integrative treatment
- Where
- Spain
- Volunteers
- 124 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Autism Spectrum Disorder, ADHD
Therapeutic Use of rTMS in Pediatric ASD and ADHD Cohorts
In this interventional, pilot clinical trial investigators will stimulate the dorsolateral prefrontal cortex (DLPFC) in patients with Autism and ADHD.
- Conditions
- Autism Spectrum Disorder, ADHD, Neurodevelopmental Disorders
- Trial name
- NCT06069323
- Testing
- repetitive Transcranial Magnetic Stimulation
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ospedali Riuniti di Foggia
Schizophrenia
Using D-cycloserine to Enhance the Benefits of Cognitive Behavioral Therapy for Schizophrenia
This study will examine whether pretreatment with D-cycloserine before cognitive behavioral therapy can reduce impairments still present in people with stable cases of schizophrenia as well as determine which traits make…
- Trial name
- NCT00742079
- Testing
- D-cycloserine, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Sleep Initiation and Maintenance Disorders, Pain
Pilot Study of Cyclobenzaprine for Treatment of Sleep Disturbance in Aromatase Inhibitor-treated Breast Cancer Patients
Many women with breast cancer who are treated with aromatase inhibitor medications develop difficulty sleeping and fatigue during treatment.
- Trial name
- NCT01921296
- Testing
- Cyclobenzaprine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Lynn Henry
Social Stigma, Virtual Reality
Effects of Virtual Reality Software on Levels of Stigma Towards People With Mental Illness.
The purpose of the research is to contribute to the reduction of stigma among university students among people with serious psychiatric illnesses and to improve future educational processes focused on the social inclusion of…
- Trial name
- NCT05393596
- Testing
- Virtual Reality Software Intervention
- Where
- Chile
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Universidad del Desarrollo
Major Depressive Disorder
Brain Regulation of Emotions in People With Depression and Anhedonia
This study will use magnetic resonance imaging (MRI) to examine how the brain regulates emotions in healthy people and in patients who have major depression and anhedonia (loss of feeling of pleasure in things that normally give…
- Trial name
- NCT00059579
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Disorder, Schizophrenia
eVAluatIon of OLanzapine TreatmEnT
This clinical observational study aims to investigate the efficacy of olanzapine (Villamos ®) in accordance with the instructions attached thereto in standard clinical practice, followed by the physician to the patient.
- Trial name
- VIOLET (NCT02006862)
- Where
- Greece
- Volunteers
- 468 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Insomnia
Perspectives of Parents About Their Infants' Sleep
Behavioral insomnia of childhood (BIC) is a common problem in early infancy. The whole family is affected by the problem, but research usually relies only on maternal perception and report.
- Trial name
- NCT05092308
- Volunteers
- 60 people
- Sponsor
- Marmara University
Dissociation
Mechanistic Interventions and Neuroscience of Dissociation
The purpose of this study is to test the neurophysiological mechanisms of an intervention to reduce symptoms of dissociation in traumatized people.
- Trial name
- MIND (NCT04670640)
- Testing
- Vibration, Breath Focus, No Distractions
- Where
- 2 sites in United States
- Volunteers
- 350 people
- Sponsor
- Emory University
Generalized Anxiety Disorder
POC Study in Partially Responsive Generalized Anxiety Disorder
This study aims to evaluate whether PF-06372865 is safe and effective in the treatment of sub-optimally controlled symptoms of generalized anxiety disorder during two 4-week treatment periods using a Sequential Parallel…
- Trial name
- NCT02310568
- Testing
- PF-06372865.
- Where
- 47 sites in United States
- Volunteers
- 90 people
- Sponsor
- Pfizer
Fragile X Syndrome, Fragile X Mental Retardation Syndrome
A Trial of Metformin in Individuals With Fragile X Syndrome (Met)
This study is a controlled trial of metformin in individuals with fragile X syndrome between the ages of 6 and 35 years. Participants will be randomized in a double-blind design to either drug or placebo and will attend three…
- Conditions
- Fragile X Syndrome, Fragile X Mental Retardation Syndrome, Mental Retardation, X-Linked, Genetic Diseases, X-Linked
- Trial name
- NCT03862950
- Testing
- Metformin
- Where
- 2 sites in Canada
- Volunteers
- 125 people
- Sponsor
- University of Alberta
Magnetic Resonance Imaging, Alzheimer's Disease
fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease
The purpose of this study is to investigate the organization of memory and develop future methods for early detection of AD. Using functional magnetic resonance imaging (fMRI), we examine the responsiveness of the brain to memory…
- Conditions
- Magnetic Resonance Imaging, Alzheimer's Disease, Dementia, Adult Children
- Trial name
- ALZ (NCT00478491)
- Where
- United States
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Psychosis
To Demonstrate the Relative Bioequivalency of Generic Haloperidol Tablets Versus Haldol in Normal Volunteers
To demonstrate the relative bioequivalency of generic Haloperidol tablets versus Haldol in normal volunteers.
- Trial name
- NCT00946491
- Testing
- Haloperidol 10 mg Tablets (Cord Laboratories), Haldol 10 mg Tablets (McNeil Pharmaceuticals)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sandoz
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