Clinical trials: Mental Illness
Alzheimer's Disease
Evaluation of the Efficacy and Safety of Azeliragon (TTP488) in Patients With Mild Alzheimer's Disease
This is a study to evaluate the efficacy and safety of azeliragon in patients with mild Alzheimer's disease. Patients will receive either azeliragon or placebo with a patient's participation lasting approximately 18 months.
- Trial name
- STEADFAST (NCT02080364)
- Testing
- Azeliragon
- Where
- 115 sites in United States, Australia and 5 more
- Volunteers
- 880 people
- Sponsor
- vTv Therapeutics
Panic; Agoraphobia
Virtual Reality for Panic Disorder With Agoraphobia
Panic disorder with agoraphobia (PDA) is associated with considerable personal distress, functional disability and societal costs.
- Trial name
- NCT03101332
- Testing
- Virtual Reality cognitive behavior therapy
- Where
- 2 sites in Sweden
- Volunteers
- 12 people
- Sponsor
- Karolinska Institutet
Substance Dependence
Study To Investigate If Repeat Doses Of GSK598809 Are Safe And Well Tolerated And To Evaluate Blood Levels Of GSK598809
GSK598809 is being developed as an innovative treatment for substance dependence and potentially other compulsive behavioral disorders.
- Trial name
- NCT00437632
- Testing
- GSK598809, Caffeine
- Where
- United Kingdom
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Postoperative Delirium
Automated Pupillometry in Patients Underwent Cardiac Surgery to Predict Postoperative Delirium
The rate of postoperative delirium in patients who underwent cardiac surgery is very high. Different predictors and/or scores were studied for the prediction of Post Operative Delirium (POD)after heart surgery, but none of them…
- Trial name
- NCT06255132
- Testing
- Automated pupillometer NPi-200
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Posttraumatic Stress Disorder
Randomized Placebo-controlled Study of MDMA-assisted Therapy in People With PTSD - Israel
The goal of this clinical trial is to learn if MDMA-assisted therapy can treat PTSD in participants with PTSD. Researchers will compare two sessions of MDMA-assisted therapy with two sessions of low dose (active placebo)…
- Trial name
- NCT00402298
- Testing
- Full Dose Midomafetamine HCl, Low Dose Midomafetamine HCl
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Resilient Pharmaceuticals
Gonad Regulating Hormone Adverse Reaction, Analgesic Adverse Reaction
Neurobehavioral Development in Toddlers and Preschoolers in Relation to Prenatal Exposure of Mild Analgesics (NeuroToP - a COPANA Follow up)
Fundamental aspects of both neurological and reproductive function are established in fetal life, and there is a present increased awareness of the potential effects of fetal exposures on neurodevelopmental and reproductive…
- Conditions
- Gonad Regulating Hormone Adverse Reaction, Analgesic Adverse Reaction, Developmental Disability, Adhd
- Trial name
- NeuroToP (NCT07316387)
- Where
- Denmark
- Volunteers
- 685 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Erectile Dysfunction
Clinical Investigation Using MED3000 Gel or Tadalafil Tablets in the Treatment of Erectile Dysfunction
An open-label investigation using MED3000 gel or tadalafil (5 mg) tablets in the treatment of erectile dysfunction in patients from 22 to 70 years of age. Each patients will be expected to participate for up to 30 weeks.
- Trial name
- NCT04984993
- Testing
- MED3000 (Male), Tadalafil 5mg (Male), MED3000 (Female)
- Where
- 18 sites in United States, Bulgaria and 2 more
- Volunteers
- 116 people
- Sponsor
- Futura Medical Developments Ltd.
Veterans Family, Military Family
Family Psychoeducation for Military Veterans: A Pilot Study
Operational Stress Injuries (OSIs), including post traumatic stress disorder (PTSD), are prevalent among veterans deployed in recent combat missions, the effects of which are experienced within their families.
- Conditions
- Veterans Family, Military Family, Trauma, Psychological
- Trial name
- NCT04180293
- Testing
- Pilot psychoeducation program, Program evaluation
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Autistic Disorder
Treatment of Autism in Children and Adolescents
This study is designed to determine the effectiveness of risperidone, a drug treatment for the interfering symptoms of Autistic Disorder in children and adolescents between the ages of 5 and 17.
- Trial name
- NCT00005014
- Testing
- Risperidone
- Where
- 5 sites in United States
- Volunteers
- 101 people
- Sponsor
- National Institute of Mental Health (NIMH)
Posttraumatic Stress Disorder
Predicting Responses to PTSD Treatment With Iris and Cardiovascular Tests
Post-traumatic stress disorder (PTSD) affects many individuals who experience a traumatic event. There are a variety of treatment options for PTSD, including psychotherapy (talk therapy) options, as well as medications, such as…
- Trial name
- PREDICT (NCT03539614)
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- VA Office of Research and Development
Mental Health Disorder, Obesity
Improving Mental Health in Youth and Lowering Risk for Obesity Through a Digital Preventative Product
The goal of this study is to test the feasibility and utilization of a redesigned mobile app and health coaching platform (Vira) in youth (aged 18-25 years) with elevated depressive symptoms who are overweight/obese and/or…
- Conditions
- Mental Health Disorder, Obesity, Overweight
- Trial name
- NCT05638516
- Testing
- Vira mobile app intervention, Vira mobile app intervention + coaching
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Ksana Health
Cancer, Cognitive Impairment
Cancer and Mild Cognitive Impairment Dyadic Intervention
The purpose of this study is to see whether programs that include both a patient and their spouse or a patient and family caregiver (known as a dyad) are helpful for families in which one member of the dyad has cancer and mild…
- Trial name
- NCT05144516
- Testing
- Behavioral: COPE +
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Duke University
Alzheimer's Disease
A Study to Test the Efficacy, Safety, and Tolerability of Bepranemab (UCB0107) in Patients With Mild Cognitive Impairment or Mild Alzheimer's Disease (AD)
The purpose of the study is to investigate the effect of bepranemab versus (vs) placebo on the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) up to Week 80 in study participants with prodromal or mild Alzheimer's Disease…
- Trial name
- NCT04867616
- Testing
- Bepranemab
- Where
- 103 sites in United States, Belgium and 8 more
- Volunteers
- 466 people
- Sponsor
- UCB Biopharma SRL
Alzheimer's Disease
A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease
This is a multicentre, randomized, double-blind, placebo-controlled, parallel group Phase II study to evaluate the efficacy and safety of VHB937 in participants with early AD followed by an Extension.
- Trial name
- NCT07094516
- Testing
- VHB937
- Where
- 73 sites in United States, Australia and 13 more
- Volunteers
- 97 people
- Sponsor
- Novartis Pharmaceuticals
Intellectual Disability
Physical Activity, mHealth and Intellectual Disability - a Pilot Study
The main objective of this pilot study is to assess distant procedures, study experiences and feasibility of a planned randomized controlled trial investigating the use of a mHealth support tool on physical activity for…
- Trial name
- NCT04929106
- Testing
- mHealth support tool
- Where
- Norway
- Volunteers
- 9 people
- Sponsor
- University Hospital of North Norway
Attention Deficit/Hyperactivity Disorder
An SMS Intervention to Improve Adherence to Stimulant Medications in Adults With ADHD
This study will assess the efficacy of the text messaging (SMS-based) disease management intervention to improve adherence to stimulants in adults with Attention Deficit/Hyperactivity Disorder (ADHD).
- Trial name
- NCT04189536
- Testing
- SMS Intervention
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Massachusetts General Hospital
Dyslexia
Dopaminergic Enhancement of Learning and Memory in Healthy Adults and Patients With Dyslexia
This study aims to determine whether levodopa, in combination with a high frequency training of (grammatical) rules, is effective in boosting learning success in healthy subjects and whether this kind of training in combination…
- Trial name
- NCT00111371
- Testing
- Levodopa
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Major Depressive Disorder
Biomarkers of Social Sensitivity in Major Depression
Major depression disorder (MDD) is a frequent and disabling mental disorder with great risk of recurrence and chronicity. Interpersonal factors are among the strongest predictors of the course and duration of an episode of…
- Trial name
- SENSO (NCT02214511)
- Testing
- emotional facial stimuli, Cyberball game
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Grief
A Grief Support App for Adults Experiencing Bereavement
Losing a loved one is a difficult experience. Some people may require psychological support, but even for those who do not, grief can often feel overwhelming.
- Trial name
- NCT07862244
- Testing
- Self-guided grief app (Daybreak), Waiting list
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
Cardiac Arrest, Neurologic Dysfunction
Identification of Neuroprognostic Factors for Out-of-hospital Cardiopulmonary Arrest (MIRA29)
From the informatized prehospital care registry, data will be collected anonymously for all patients' requiring cardiopulmonary resuscitation for an out-of-hospital cardiac arrest within the Norther Finistere sanitary region.
- Conditions
- Cardiac Arrest, Neurologic Dysfunction, Cognitive Impairment
- Trial name
- MIRA29 (NCT06569134)
- Where
- 2 sites in France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Brest
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