Clinical trials: Mental Illness
Cognitively Normal, Mild Cognitive Impairment
Longitudinal Changes of [18F]PI-2620 Positron Emission Tomography in Subjects With Cognitively Normal, Mild Cognitive Impairment and Alzheimer's Disease
The overall goal of this imaging trial is to evaluate crosssectional difference and longitudinal changes of [18F]PI-2620, a tau targeted positron emission computed tomography radioligand, in cognitively normal individuals, and…
- Conditions
- Cognitively Normal, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT03903211
- Testing
- [18F]PI-2620
- Where
- South Korea
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Jae Seung Kim
Post Traumatic Stress Disorder
Effects of Stellate Ganglion Block in Post-traumatic Stress Disorder
This study will enroll patients meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for post-traumatic stress disorder (PTSD).
- Trial name
- NCT05391971
- Testing
- Bupivacaine, Saline
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- NYU Langone Health
Schizophrenia
A Phase I- Sequential Cohort Dosing to Determine Maximum Tolerated Dose in Healthy Male Volunteers.
This is a prospective, 8-day, randomized, double-blind, placebo-controlled, sequential-cohort study designed to evaluate the safety, tolerability, and MTD of single escalating oral doses of NW-3509A in healthy male volunteers.
- Trial name
- NCT01955564
- Testing
- NW-3509a
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Newron Pharmaceuticals SPA
Tobacco Use Disorder
Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers
This study will examine extended exposure to cigarettes varying in nicotine content among adults with opioid use disorder. Those with opioid use disorder are at increased risk for smoking, nicotine dependence, and using high…
- Trial name
- P2S2 (NCT02250664)
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Delirium, Confusion
Improving Safety of Diagnosis and Therapy in the Inpatient Setting
To improve the safety of diagnosis and therapy for a set of conditions and undifferentiated symptoms for hospitalized patients, the investigators will employ a set of methods and tools from the disciplines of systems engineering…
- Conditions
- Delirium, Confusion, Mental Status Change, Back Pain
- Trial name
- PSLL2-0 (NCT04393909)
- Testing
- Diagnostic Uncertainty Educational Curriculum, Diagnostic Timeout, Patient Diagnostic (Dx) Questionnaire
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Brigham and Women's Hospital
INSOMNIA
A Non-inferiority Study With Two Treatment Arms Eszopiclone 3 mg Versus Zopiclone 7.5 mg - for the Treatment of Insomnia
The primary objective of the study is to determine whether eszopiclone (Eurofarma) is non-inferior to the reference drug zopiclone (Imovane®, Sanofi-Aventis) in the treatment of insomnia.
- Trial name
- Eszo (NCT01100164)
- Testing
- Eszopiclone, Zopiclone
- Where
- Brazil
- Volunteers
- 263 people
- Sponsor
- Eurofarma Laboratorios S.A.
Schizophrenia
Olanzapine Versus Placebo in the Treatment of Adolescents With Schizophrenia
This study is to determine the efficacy (how well the drug works), safety, and any side effects of olanzapine compared to placebo in the treatment of schizophrenia in adolescents.
- Trial name
- NCT00051298
- Testing
- Olanzapine
- Where
- 25 sites in United States, Russia
- Volunteers
- 107 people
- Sponsor
- Eli Lilly and Company
Alzheimer Disease
Renji Alzheimer's Disease Neuroimaging Cohort Study
This study focuses on the population of Alzheimer disease (AD). Based on Aβ(A)-Tau(T)-Vascular(V)-Neurodegeneration(N) (ATV(N))-AD evaluation system of NIA-AA Association, it can accurately diagnose and predict early AD.
- Trial name
- NCT05433363
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Developmental Disability
Developing and Examine the Efficacy of the Family-Centered Multi-Sensory Environment Intervention on Parent's Empowerment and Children's Engagement (MSE-PEACE) in Children With Developmental Disabilities and Their Parents: A Mixed Methods Study
The goal of this clinical trial is to learn whether a family-centered multi-sensory environment (MSE-PEACE) can help children with developmental disabilities and support their parents.
- Trial name
- MSE-PEACE (NCT07118293)
- Testing
- MSE-PEACE
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Cheng Kung University
Post-cardiac Surgery
Clinical Pilates (CP) Exercises and Kinesiophobia in CABG
To determine Effect of Clinical Pilates (CP) exercises on kinesiophobia and post-operative cardiopulmonary parameters in CABG patients.
- Trial name
- NCT06426914
- Testing
- Clinical Pilates, Cardiac Rehabilitation
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Post Traumatic Stress Disorder, Postoperative Complications
PTSD of Surgeons or Anesthesiologists on Prognosis of Surgical Patients
The objective of this prospective cohort study is to explore the association between the development of post-traumatic stress disorder (PTSD) in surgeons and anesthesiologists and postoperative prognosis in surgical patients they…
- Conditions
- Post Traumatic Stress Disorder, Postoperative Complications, COVID-19
- Trial name
- NCT05732116
- Testing
- PTSD
- Where
- 2 sites in China
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Alzheimer's Disease
Preliminary Efficacy and Safety Study of ST101 Plus Aricept in Alzheimer's Disease
This study will investigate the ability of ST101 to improve memory in people with Alzheimer's disease who currently receive 10 mg Aricept® (donepezil) per day. This study also will examine the safety and tolerability of the drug.
- Trial name
- NCT00842816
- Testing
- ST101
- Where
- 30 sites in United States, Canada
- Volunteers
- 210 people
- Sponsor
- Sonexa Therapeutics, Inc.
Alzheimer Disease
Mitochondrial Function and Metabolomic Profile in Alzheimer's Disease and Related Dementias
This project aims to study on one hand the early mitochondrial alterations, common or specific, occurring in peripheral cells of patients with Alzheimer's disease or related dementia and, on the other hand, identify the…
- Trial name
- AMPAlz (NCT06880406)
- Testing
- MMSE and blood draw
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Conversion Disorder
TMS and Attentional Bias in Functional Motor Disorder
Functional motor disorders, also called motor conversion disorder, are common reasons for attendance at neurology outpatient clinics.
- Trial name
- NCT02102906
- Testing
- Transcranial magnetic stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Edinburgh
Hereditary Ataxia
Clinical and Molecular Correlations in Spinocerebellar Ataxia Type 10 (SCA10)
OBJECTIVES: I. Clinically evaluate members from families with a dominantly inherited ataxia and collect blood, skin and muscle samples for detailed molecular studies. II.
- Trial name
- NCT00004306
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Office of Rare Diseases (ORD)
Anxiety, Depression
Mobile Mental Health Stigma Reduction Intervention Among Black Adults
Major depressive and anxiety disorders are highly prevalent in the general population and are a leading cause of disability. Black adults have a high burden of depression and anxiety.
- Conditions
- Anxiety, Depression, Health Knowledge, Attitudes, Practice, Stigmatization
- Trial name
- NCT06316804
- Testing
- Video Intervention 1, Video Intervention 2, Video Intervention 3
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Alcoholism
Combining Medications for the Treatment of Alcohol Dependence: An Inpatient Preliminary Study
We propose to conduct an inpatient pilot study to test the safety and potential efficacy of topiramate and naltrexone in combination for the treatment of alcoholism.
- Trial name
- NCT00769158
- Testing
- Topiramate and Naltrexone
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Bankole Johnson
Acceptance and Commitment Therapy, Caregiver Burden
Acceptance and Commitment Therapy (ACT) Tele-Counselling
A randomized 2-group controlled trial will be conducted to explore the potential effect and potential feasibility of a new Acceptance and Commitment Therapy (ACT) tele-counselling program to improve mental health services for…
- Conditions
- Acceptance and Commitment Therapy, Caregiver Burden, Digital Health, Technology
- Trial name
- NCT05385458
- Testing
- ACT Intervention, Usual Care
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of New Brunswick
Cognitive Disorders, HIV Infections
Parallel Group, Placebo-Controlled, Tolerability, Safety, and Efficacy Study of OPC-14117 in HIV Dementia
To assess the tolerability and safety of OPC-14117. To evaluate effects of OPC-14117 on cognitive function, quality of life, and activities of daily living.
- Trial name
- NCT00002148
- Testing
- OPC 14117
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Rochester
Smoking Cessation, Cardiovascular Disease
What Are the Effects of Varenicline Compared With Nicotine Replacement Therapy on Long Term Smoking Cessation and Clinically Important Outcomes?
Introduction: Smoking is a major avoidable cause of ill-health and premature death. Treatments that help patients successfully quit smoking have an important effect on health and life expectancy.
- Conditions
- Smoking Cessation, Cardiovascular Disease, Respiratory Disease, Myocardial Infarction
- Trial name
- NCT02681848
- Testing
- Varenicline, Nicotine replacement therapy
- Volunteers
- 180,000 people
- Sponsor
- University of Bristol
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