Clinical trials: Mental Illness Persistent
Anxiety Disorders, Obsessive-Compulsive Disorder
HANDS-ON: a Personalized, Brief and Intensive Exposure-based Intervention for Youth With Persistent Anxiety or OCD
A substantial part of children/adolescents with anxiety or obsessive-compulsive disorder (AD/OCD) do not profit substantially from first-choice treatment (i.e., cognitive behavioral therapy; CBT).
- Conditions
- Anxiety Disorders, Obsessive-Compulsive Disorder, Obsessive-Compulsive Disorder in Children, Obsessive-Compulsive Disorder in Adolescence
- Trial name
- NCT06152913
- Testing
- HANDS-ON treatment
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Accare
Depression, Postpartum
Integrated Psychological Program for Management of Postnatal Depression and Persistent Postpartum Pain After Childbirth
The integrated psychological program (IPP) is based on evidence from the local population showing that the interventional components (mindfulness training, music listening, video counselling) are amenable to implementation in the…
- Trial name
- CODEPAD-II (NCT05285215)
- Testing
- Integrated psychological program (IPP)
- Where
- Singapore
- Volunteers
- 1,716 people
- Sponsor
- KK Women's and Children's Hospital
Vegetative State
The Prognostic Value of Pupil Near Response in UWS Patients
Previous studies suggest that the stimulus of pupil near response (PNR) may be a conscious perception of a blurred image. Moreover, PNR is a reflex that can be objectively observed and with no motor output, suggesting it might be…
- Trial name
- NCT02832492
- Testing
- pupil near response
- Volunteers
- 20 people
- Sponsor
- Wentao Zeng
Vegetative State, Minimally Conscious State
Transcranial Direct Current Stimulation in Patients With Disorders of Consciousness
Previous studies showed that anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal (DLPF) cortex transiently improves performance of memory and attention.
- Conditions
- Vegetative State, Minimally Conscious State, Disorders of Consciousness
- Trial name
- tDCS in DOC (NCT01673126)
- Testing
- Anodal tDCS
- Where
- Belgium
- Volunteers
- 55 people
- Sponsor
- University of Liege
Pain, Postoperative, Cognitive Function Abnormal
Perioperative Cognitive Training in Thoracic Surgery
More than 30% of patients undergoing thoracic surgical procedures develop persistent post-surgical pain (PPSP), which results in impaired functioning, diminished quality of life, and increased risk of chronic opioid use.
- Conditions
- Pain, Postoperative, Cognitive Function Abnormal, Lung Cancer
- Trial name
- COFLEX-T (NCT04563234)
- Testing
- COFLEX neurocognitive training, Crossword puzzles
- Sponsor
- Washington University School of Medicine
Stress Urinary Incontinence
Autologous Muscle Derived Cells Compared to Placebo for Urinary Sphincter Repair in Post-surgical Female Stress Incontinence
This study evaluates the efficacy and safety of Autologous Muscle Derived Cells for Urinary Sphincter Repair (AMDC-USR; generic name: iltamiocel) compared to a placebo in the reduction of stress incontinence episode frequency in…
- Trial name
- CELLEBRATE (NCT03104517)
- Testing
- AMDC-USR (iltamiocel)
- Where
- 21 sites in United States, United Kingdom
- Volunteers
- 96 people
- Sponsor
- Cook MyoSite
Depression, Cost Benefit Analysis
Dysthymia: Associated Costs, Treatment and Change Process
The study evaluates cost and effect of inpatient versus outpatient treatment of dysthymia, as well as investigates the processes through which psychotherapy works in treating dysthymia.
- Conditions
- Depression, Cost Benefit Analysis, Psychotherapeutic Processes
- Trial name
- DFront (NCT04911829)
- Testing
- Psychotherapy
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Modum Bad
Auditory Hallucinations
CHALLENGE. A Randomised Clinical Trial Examining Virtual Reality Therapy
The study is a randomised, assessor-blinded parallel-groups superiority clinical trial, allocating a total of 266 patients to either the experimental intervention or standard intervention.
- Trial name
- NCT04661163
- Testing
- Psychotherapy
- Where
- Denmark
- Volunteers
- 270 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Minimally Conscious State, Vegetative State
Validation of the Chinese Version of the SECONDs
The aim of this study was to translate the SECONDs from English into Chinese and determine the validity of this Chinese version
- Trial name
- NCT04687553
- Testing
- Simplified Evaluation of CONsciousness Disorders (SECONDs)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Hangzhou Normal University
Post Traumatic Stress Disorder (PTSD)
TMS for PTSD in Youth
The purpose of this study is to test whether transcranial magnetic stimulation, or TMS, is an acceptable and helpful treatment for ongoing symptoms of posttraumatic stress syndrome disorder (PTSD) in 12-20 year olds.
- Trial name
- NCT07401225
- Testing
- MagPro R30 with robotic arm
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Disorders of Consciousness
Beneficial Effects of Preference on Behavior in DOC Patients (COGNICOMA)
Preferred music improves cognitive function in patients with disorders of consciousness (DOC). However, it is still unknown whether it is a general effect of music (because of its acoustic features) or an autobiographical effect…
- Trial name
- COGNICOMA (NCT02759068)
- Testing
- sounds and odors
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Tourette's Disorder, Persistent (Chronic) Motor or Vocal Tic Disorder
Internet-delivered Behaviour Therapy for Children and Adolescents With Tourette's Disorder
The purpose of this trial is to evaluate the clinical efficacy, 12-month durability, and cost-effectiveness of BIP TIC - a therapist-guided and parent-guided internet-delivered behavioural intervention for children and…
- Trial name
- NCT03916055
- Testing
- Exposure and response prevention (ERP), Education on tics
- Where
- Sweden
- Volunteers
- 221 people
- Sponsor
- Karolinska Institutet
Arousal Disorders, Sexual
Neuromodulation of the Dorsal Genital Nerve in Persistent Genital Arousal Disorder
The goal of this clinical trial is to learn if neuromodulation of the dorsal genital nerve works to treat symptoms related to Persistent Genital Arousal Disorder in women.
- Trial name
- NemoPGAD (NCT06790563)
- Testing
- Neuromodulation
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Radboud University Medical Center
Anxiety, Anxiety Depression (Mild or Not Persistent)
The Effect of Patient-Family Communication Via Audio Recording
The study was conducted as a randomized controlled blinded study. The sample consisted of 55 patient relatives (27 in the experimental group and 28 in the control group).
- Conditions
- Anxiety, Anxiety Depression (Mild or Not Persistent), Satisfaction With Care
- Trial name
- NCT06627725
- Testing
- Patient-Family Communication
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Yasemin Kalkan Uğurlu
Chronic Pain, Chronic Pain Due to Injury
Virtual Pain Education for Spinal Cord Stimulation Patients
Chronic pain is a leading cause of disability in the United States. When standard treatments fail, many patients develop treatment resistant pain and undergo Spinal Cord Stimulation (SCS) therapy.
- Conditions
- Chronic Pain, Chronic Pain Due to Injury, Failed Back Syndrome, Persistent Spinal Pain Syndrome
- Trial name
- SCS-PNE (NCT07743905)
- Testing
- SCS-PNE intervention
- Volunteers
- 50 people
- Sponsor
- University of Arkansas
Disorders of Consciousness, Severe Brain Injury
Transcranial Temporal Interference Stimulation In Severely Brain Injured Patients With Disorders of Consciousness
The purpose of this academic lead study is to explore the effect of noninvasive neuromodulation of the CM-pf via tTIS for patients with disorders of consciousness.
- Conditions
- Disorders of Consciousness, Severe Brain Injury, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- NCT06851156
- Testing
- tTIS
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Xijing Hospital
Delirium, Locally Advanced Malignant Neoplasm
Haloperidol and Lorazepam in Controlling Symptoms of Persistent Agitated Delirium in Patients With Advanced Cancer Undergoing Palliative Care
This phase II/IIII trial studies how well haloperidol and lorazepam work in controlling symptoms of persistent agitated delirium in patients with cancer that has spread to other places in the body undergoing palliative care.
- Conditions
- Delirium, Locally Advanced Malignant Neoplasm, Metastatic Malignant Neoplasm, Recurrent Malignant Neoplasm
- Trial name
- NCT03743649
- Testing
- Haloperidol, Lorazepam, Quality-of-Life Assessment
- Where
- 3 sites in United States, Brazil
- Volunteers
- 110 people
- Sponsor
- M.D. Anderson Cancer Center
Consciousness Disorders, Brain Injuries
tDCS in Patients With Disorder of Consciousness Due to Severe Acquired Brain Injury
The present observational study is aimed at reporting the short-, mid- and long-term outcomes of patients with Disorder of Consciousness (DOC), in Vegetative State (VS) or Minimally Conscious State (MCS), due to a severe Acquired…
- Conditions
- Consciousness Disorders, Brain Injuries, Vegetative State, Minimally Conscious State
- Trial name
- NCT03367078
- Testing
- Anodal tDCS, Usual care
- Where
- Italy
- Volunteers
- 1 people
- Sponsor
- Montecatone Rehabilitation Institute S.p.A.
Schizophrenia and Related Disorders, Mental Disorders
A Trial of Extended Reality Activities to Enhance Leisure Participation Among Inpatients With Persistent Mental Health Conditions
The goal of this clinical trial is to evaluate the effects of an extended reality (XR)-enhanced occupational therapy leisure intervention on motivation, emotional engagement, and therapeutic participation among inpatients with…
- Conditions
- Schizophrenia and Related Disorders, Mental Disorders, Inpatients
- Trial name
- XR-MHLP (NCT06964477)
- Testing
- XR-Based Leisure Intervention
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Chia-Hui Hung
Schizophrenia
A Study Of PF-03463275 As Add-On Therapy In Outpatients With Persistent Negative Symptoms Of Schizophrenia
This study is examining the efficacy of PF-03463275 compared to placebo in treating negative symptoms of schizophrenia when added to ongoing antipsychotic treatment in stable outpatients with schizophrenia.
- Trial name
- NCT00977522
- Testing
- PF-03463275
- Where
- 37 sites in United States
- Volunteers
- 207 people
- Sponsor
- Pfizer