Clinical trials: Mental Illness Persistent, active
COVID-19, Long COVID
Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain.
This study aims to verify the efficacy/effectiveness of treatment with transcranial direct current stimulation (TDCS) in patients with Long Covid who experience headaches, migraines, and chronic pain, such as arthralgia and…
- Conditions
- COVID-19, Long COVID, Long Covid19, SARS CoV 2 Infection
- Trial name
- NCT05780450
- Testing
- Transcranial Direct Current Therapy (tDCS)
- Where
- 2 sites in Spain
- Volunteers
- 87 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
Consciousness Disorders
Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU
Disorders of consciousness (DoC) caused by severe brain injury affect millions of people worldwide each year. A patient's level of consciousness in the intensive care unit (ICU) significantly impacts the recovery from disability…
- Trial name
- COMPASS (NCT06568536)
- Testing
- Repeated behavioral assessments, functional electroencephalography and brain imagery, TMS-EEG
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Dementia
Environmental and Sensory Intervention for Nursing Home Residents With Dementia Who Exhibit Persistent Vocalizations
The purpose of this study is to test a person-centered, nature-based non-pharmacological intervention for nursing home residents living with dementia who exhibit persistent vocalizations.
- Trial name
- EASE (NCT06568107)
- Testing
- Environmental And Sensory Experience (EASE) intervention
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Drexel University
Insomnia
Group-Based Brief Behavioral Therapy for Insomnia for Patients With Chronic Mental Illness
The goal of this clinical trial is to evaluate the effectiveness of a short-term, group-based Brief Behavioral Therapy for Insomnia (BBTI) intervention in chronic psychiatric patients at a hospital day ward.The main questions it…
- Trial name
- NCT07779499
- Testing
- Brief Behavioral Treatment for Insomnia in chronic mental health
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Disorder of Consciousness, Unresponsive Wakefulness Syndrome
Auditory Processing in DOC Patients
This prospective observational study investigates whether electroencephalography (EEG) can improve the differentiation between unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) in patients with severe…
- Conditions
- Disorder of Consciousness, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- AUD-DOC (NCT07455682)
- Testing
- Coma Recovery Scale-Revised (CRS-R), Electroencephalography (EEG)
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Caregiver Stress, Caregiver Stress Syndrome
ACT Group for Family Caregivers of Stroke Survivors
The goal of this study is to evaluate the efficacy of group-based ACT intervention in improving the levels of psychological distress in caregivers of stroke survivors. The main questions it aims to answer are: 1.
- Conditions
- Caregiver Stress, Caregiver Stress Syndrome, Caregiver Burnout, Caregiver Distress
- Trial name
- NCT07528261
- Testing
- Group-based ACT Intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Wright Institute
Disorder of Consciousness
Neurorehabilitation in Patients With Disorders of Consciousness: Multidimensional Ambispective Study on the Impact of Single and Combined Approaches
Disorders of consciousness (DOC), such as the vegetative state/unresponsive wakefulness syndrome (VS/UWS) and the minimally conscious state (MCS), represent severe clinical conditions arising from acquired brain injury (ABI)…
- Trial name
- NCT07385508
- Testing
- Multidisciplinary neurorehabilitation
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Schizophrenia
Promoting Activity and Cognitive Enrichment in Schizophrenia (PACES)
This project will conduct a confirmatory efficacy trial of two novel psychosocial interventions, Cognitive Enhancement Therapy and Enriched Supportive Therapy, for the treatment of persistent negative symptoms in schizophrenia.
- Trial name
- NCT04143126
- Testing
- Cognitive Enhancement Therapy, Enriched Supportive Therapy
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Pittsburgh
Mild Cognitive Impairment, Persistent Atrial Fibrillation
EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive Impairment
The goal of this clinical trial is to evaluate the effect of catheter ablation of persistent atrial fibrillation on cognitive function in patients with mild cognitive impairment.
- Trial name
- NCT05790707
- Testing
- Atrial fibrillation ablation + antiarrhythmic drugs, Antiarrhythmic drug
- Where
- 8 sites in France
- Volunteers
- 120 people
- Sponsor
- Poitiers University Hospital
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Promoting Recovery After Brain Injury Using Focused Ultrasound
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover.
- Trial name
- ReBOUND (NCT07277309)
- Testing
- Low-intensity focused ultrasound
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Massachusetts General Hospital
Mental Illness Persistent
"CoMBI-SMI Multicenter Study: A Person-Centered Cognitive-Behavioral Intervention for Severe Mental Illness"
This observational multicenter study aims to evaluate whether the Cognitive Model for Behavioral Interventions - Severe Mental Illness (CoMBI-SMI) can reduce challenging behaviors and psychological symptoms in adults (aged 18 and…
- Trial name
- CoMBI-SMI (NCT07006623)
- Testing
- CoMBI-SMI
- Where
- Netherlands
- Volunteers
- 99 people
- Sponsor
- Vrije Universiteit Brussel
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Post-Concussion Syndrome, Concussion, Brain
Personalized Brain Stimulation to Treat Chronic Concussive Symptoms
The goal of this study is to investigate a new treatment for chronic symptoms after concussion or mild traumatic brain injury in people aged 18-65 years old.
- Conditions
- Post-Concussion Syndrome, Concussion, Brain, Mild Traumatic Brain Injury, Head Injury
- Trial name
- NCT06073886
- Testing
- Active cTBS, Imaginal exposure
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of California, Los Angeles
Traumatic Brain Injury, Post-Concussive Symptoms
Long-Term Outcomes Following HBOT
This study is designed to better understand the long-term effects of hyperbaric oxygen therapy (HBOT). Our goal is to determine whether improvements after treatment are maintained over time and whether additional benefits appear…
- Conditions
- Traumatic Brain Injury, Post-Concussive Symptoms, Post-Traumatic Stress Disorder
- Trial name
- NCT07732374
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Summit Hyperbarics and Wellness
Post Operative Pain, Opioid Use, Unspecified
Sensory Outcomes in Active Substance Users
The incidence and severity of postoperative pain after spine surgery are notably high, often requiring intensive management and potentially affecting the patient's recovery, satisfaction, and long-term outcomes.
- Trial name
- NCT06639438
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Medical Center
Persistent Depressive Disorder, Treatment-resistant Depression
A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients
The purpose of this study is to compare the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) conducted over 16 weeks (acute and continuation treatment) with Behavioral Activation (BA; same dose and duration) in…
- Trial name
- ChangePDD (NCT04996433)
- Testing
- inpatient CBASP individual therapy, inpatient CBASP group therapy, inpatient CBASP nurse contact
- Where
- 8 sites in Germany
- Volunteers
- 396 people
- Sponsor
- University of Greifswald
Auditory Verbal Hallucinations, Schizophrenia
Theta-Burst Transcranial Magnetic Stimulation for Treatment-Resistant Auditory Hallucinations
The goal of this clinical trial is to learn whether theta-burst transcranial magnetic stimulation (TBS), a non-invasive brain stimulation technique, can help reduce persistent auditory verbal hallucinations (hearing voices) in…
- Conditions
- Auditory Verbal Hallucinations, Schizophrenia, Schizoaffective Disorder, Psychotic Disorders
- Trial name
- NCT07902518
- Testing
- Theta-Burst Transcranial Magnetic Stimulation (TBS)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Delirium, Postoperative Cognitive Dysfunction
Dexmedetomidine to Reduce the Incidence of POCD After Open Cardiac Surgery
Anesthesia is a drug induced, reversible, comatose state that facilitates surgery and it is widely assumed that cognition returns to baseline after anesthetics have been eliminated.
- Conditions
- Delirium, Postoperative Cognitive Dysfunction, Dexmedetomidine, Cognitive Impairment
- Trial name
- NCT03480061
- Testing
- Dexmedetomidine Hydrochloride Group
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Sunnybrook Health Sciences Centre
Disorder of Consciousness
Apomorphine in Severe Brain-injured Patients
Background: Patients who survive severe brain injury may develop chronic disorders of consciousness (DoC). Treating these patients to improve recovery is extremely challenging because of scarce and inefficient therapeutical…
- Trial name
- APODoC (NCT05213169)
- Testing
- Apomorphine Hydrochloride 5mg/ml, Sodium chloride 9mg/ml
- Where
- 4 sites in Belgium, Spain
- Volunteers
- 48 people
- Sponsor
- University of Liege
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Ultrasound Stimulation for Patients in a Disorder of Consciousness
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover.
- Trial name
- tFUS (NCT06939348)
- Testing
- The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles