Clinical trials: Mental Impairment
Depression
Effectiveness of Methylphenidate in Improving Cognition and Function in Older Adults With Depression
This study will evaluate the safety and effectiveness of methylphenidate in improving cognition and function in older adults with depression.
- Trial name
- NCT00602290
- Testing
- Citalopram, Methylphenidate (MPH)
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- University of California, Los Angeles
Brain Fog
Efficacy of Acupuncture in Patients Post-Covid Brain Fog
After being infected with Covid-19, many people developed to Brain fog. The treatment strategy now is based on the presumed pathological phenomenon and the physician's clinical experience.
- Trial name
- NCT06144320
- Testing
- Acupuncture
- Volunteers
- 40 people
- Sponsor
- China Medical University Hospital
Amnestic Mild Cognitive Impairment - aMCI, Insomnia
Targeting Sleep and Slow-Wave Activity to Enhance Cognition in MCI
Study Description As most clinical trials in Alzheimer's disease (AD) have been unsuccessful to date, it has become increasingly crucial to focus on treating earlier stages of the disease.
- Trial name
- TASSLE (NCT07911826)
- Testing
- active intervention, Control Intervention
- Volunteers
- 50 people
- Sponsor
- New York State Psychiatric Institute
Chronic Rhinosinusitis, Sleep Disorders
Sleep Disturbance and Daytime Fatigue as Predictors of Cognitive Decline and Functional Decline in Chronic Rhinosinusitis
FOCUS-CRS is a cross-sectional observational study examining the relationship between sleep disturbance, daytime fatigue, and cognitive and functional health in patients with chronic rhinosinusitis (CRS).
- Conditions
- Chronic Rhinosinusitis, Sleep Disorders, Fatigue, Cognitive Dysfunction
- Trial name
- SNOOZE-CRS (NCT07242040)
- Testing
- Self-Reported Questionnaires for Sleep, Fatigue, and Quality of Life
- Where
- Egypt
- Volunteers
- 134 people
- Sponsor
- Sinai University
Cerebral Small Vessel Diseases
Clinical Observation for the Therapeutic Effect of mNGF on Cognitive Decline in Cerebral Small Vessel Disease
This study was a multicenter, prospective, randomized controlled trial. In this study, 510 patients with cognitive impairment of cerebral small vessel disease who met the inclusion criteria are randomly included in multiple…
- Trial name
- NCT04041349
- Testing
- mouse nerve growth factor
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhujiang Hospital
Mild Cognitive Impairment, Dementia, Mild
Driving Evaluation and Fitness for Persons With Cognitive Impairments
Driving is an important activity for older adults because it frequently relates to personal independence and wellbeing. This study compared the driving behaviors of older drivers with normal cognition and with MCI in unfamiliar…
- Conditions
- Mild Cognitive Impairment, Dementia, Mild, Driving Impaired, Drive
- Trial name
- NCT04648735
- Testing
- driving evaluation and practice
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National Cheng Kung University
Delirium, Cognitive Impairment
Validation of the PreSchool Confusion Assessment Method for the Intensive Care Unit (psCAM-ICU)
The investigators hypothesize that critical care trained registered nurses and physicians can perform measurements of cognitive impairment in critically ill pediatric patients in a reliable and valid manner.
- Trial name
- NCT02481115
- Volunteers
- 300 people
- Sponsor
- Vanderbilt University
Alzheimer Disease and Related Dementias, Cognition
Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome
The objective of this study is to determine the effects of a 6-month, home-based personalized transcranial direct current stimulation (tDCS) intervention targeting the left dorsolateral prefrontal cortex on cognitive function…
- Conditions
- Alzheimer Disease and Related Dementias, Cognition, Mobility Disability
- Trial name
- TDCS4MCR (NCT06821568)
- Testing
- Personalized Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States, Israel
- Volunteers
- 128 people
- Sponsor
- Hebrew SeniorLife
Cognitive Impairment, Schizophrenia
Effects of Eltoprazine on Cognitive Impairment Associated With Schizophrenia (CIAS) in Adults
The purpose of this study is to determine if eltoprazine (as an adjunct to anti-psychotic medication) improves one or more aspects of cognitive impairment in adult schizophrenic patients.
- Trial name
- NCT01266174
- Testing
- Eltoprazine
- Where
- 6 sites in United States
- Volunteers
- 31 people
- Sponsor
- Amarantus BioScience Holdings, Inc.
Alzheimer Dementia
A Pilot of Methylphenidate in Mild Cognitive Impairment and Dementia Participants.
Investigators are doing this research study to find out if methylphenidate (MPH) can help people with Mild Cognitive Impairment (MCI) or mild dementia likely due to Alzheimer's Disease (AD) and related disorders (ADRD).
- Trial name
- NCT03811847
- Testing
- Methylphenidate Extended Release Oral Capsule
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Alzheimer Disease, Dementia
A Study of XPro1595 in Patients With Early Alzheimer's Disease With Biomarkers of Inflammation
The goal of this Phase 2 Alzheimer's study is to determine whether 1.0 mg/kg XPro1595 confers a benefit on cognition, function, and biomarkers of white matter and to further evaluate safety and tolerability.
- Conditions
- Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases
- Trial name
- MINDFuL (NCT05318976)
- Testing
- XPro1595
- Where
- 41 sites in Australia, Canada and 6 more
- Volunteers
- 207 people
- Sponsor
- Inmune Bio, Inc.
Alzheimer Disease, Cognition Disorders
Investigation Into Delay to Diagnosis of Alzheimer's Disease With Exelon (InDDEx)
This phase IIIb trial is a prospective, randomized, double-blind, placebo-controlled, 36-month study comparing the length of time of progression from mild cognitive impairment (MCI) to a clinical diagnosis of Alzheimer's disease…
- Trial name
- NCT00000174
- Testing
- Rivastigmine
- Where
- 15 sites in United States
- Sponsor
- Novartis
Mild Cognitive Impairment
Study of the Effects of Adapted Tango and Multidimensional Intervention in pREvention of Dementia in agiNG (STRENGTH)
The STRENGTH project is a randomized controlled trial to assess the effects of a 6 months multimodal intervention consisted of adapted Tango dancing together with music therapy, engagement in social activities, cognitive…
- Trial name
- STRENGTH (NCT04146818)
- Testing
- Adapted Tango Dancing, Control
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
COVID-19, Mental Health Impairment
A Study on a Digital Platform for COVID19+ Patients, Designed to Facilitate Communication and Mental-health Care During and After Hospitalization.
This study presents a digital mental-health protocol designed to offer remote, personalized support to former or current COVID-19 patients. A total of 100 subjects will be enrolled.
- Conditions
- COVID-19, Mental Health Impairment, Telemedicine
- Trial name
- DigiCOVID (NCT05231018)
- Testing
- Psychotherapy
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Cerebral Small Vessel Diseases, Cognitive Impairment
Lacunar Intervention Trial 1 (LACI-1)
Phase II pilot randomised, factorial, short term dose escalation, open label, blinded intermediary endpoint trial, in two hospital centres in the UK, of tolerability and safety of cilostazol, isosorbide mononitrate, both or…
- Conditions
- Cerebral Small Vessel Diseases, Cognitive Impairment, Stroke
- Trial name
- Prevent-SVD (NCT02481323)
- Testing
- isosorbide mononitrate, cilostazol
- Where
- 2 sites in United Kingdom
- Volunteers
- 57 people
- Sponsor
- University of Edinburgh
Cognitive Decline
Analysis of Inflammatory Predictors and Gene Expression in Patients With Mild Cognitive Impairment
A randomized, double-blind, placebo-controlled clinical trial will be conducted, using data from participants who met the diagnostic criteria for mild cognitive impairment and who participated in a primary clinical trial that…
- Trial name
- NCT04934423
- Testing
- Direct Current Transcranial Stimulation - tDCS
- Volunteers
- 40 people
- Sponsor
- Federal University of Paraíba
Alzheimer Disease, Cognitive Impairment
Impact of Physical Activity on Successful Aging
Emerging literature suggests that vascular factors might be involved in the pathogenesis of Alzheimer's disease (AD). Other recent studies demonstrate the positive effects of physical activity on cognitive and behavioral…
- Conditions
- Alzheimer Disease, Cognitive Impairment, Physical Activity
- Trial name
- NCT03034746
- Testing
- Physical activity (PA), cognitive treatment (CT)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Schizophrenia
Prucalopride for Cognitive Functioning in Schizophrenia
A core component of schizophrenia is neurocognitive impairment. The cognitive deficits are prominently seen in memory, attention, working memory, problem solving, processing speed and social cognition.
- Trial name
- NCT06474286
- Testing
- Prucalopride 1 MG
- Where
- India
- Volunteers
- 34 people
- Sponsor
- University of Pittsburgh
Generalized Anxiety Disorder
Pharmacokinetic Study of Buagafuran Capsules in Participants With Hepatic Impairment and Normal Hepatic Function
This study adopts a non-randomized, open label, parallel, single-dose design to evaluate the safety and pharmacokinetic characteristics of Buagafuran capsules in participants with hepatic impairment.
- Trial name
- NCT07457190
- Testing
- Buagafuran
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Beijing Union Pharmaceutical Factory Ltd
Cognition
A Study to Compare Two Medications With an Inactive Medication and Look at the Effect on a Person's Mental Ability
The purpose is to compare solifenacin and oxybutynin with an inactive tablet and assess any potential effects on mental ability.
- Trial name
- SENIOR (NCT01126424)
- Testing
- Solifenacin, Oxybutynin
- Where
- 3 sites in United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
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