Clinical trials: Mental Impairment
Alzheimer Disease, Dementia Alzheimers
Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside
This project's main goal is to use state-of-the-art passive sensing techniques to identify digital biomarkers that relate to bioenergetic changes in the brain due to nicotinamide riboside supplementation in those with mild…
- Conditions
- Alzheimer Disease, Dementia Alzheimers, Dementia, Cognitive Impairment
- Trial name
- Emerald-NRAD (NCT05245903)
- Testing
- Emerald Device Monitoring
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mclean Hospital
Mild Cognitive Impairment (MCI), Dementia Alzheimer Type
Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort
The goal of this observational study is to learn how daily emotional stress affects cognitive function and inflammation in community-dwelling older adults aged 60 and older in Seoul, Republic of Korea.
- Conditions
- Mild Cognitive Impairment (MCI), Dementia Alzheimer Type, Chronic Pain, Depression - Major Depressive Disorder
- Trial name
- KoCoA cohort (NCT07485387)
- Where
- South Korea
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Korea University
Parkinson Disease, Mild Cognitive Impairment
Parkinson's Disease With Mild Cognitive Impairment Treated With Nicotinic Agonist Drug
To test for the first time the potential of a nicotinic agonist on cognitive symptoms in people with mild cognitive impairment (MCI) in Parkinson's disease (PD), referred to as PD-MCI.
- Trial name
- PD-MIND (NCT04810104)
- Testing
- AZD0328
- Sponsor
- King's College London
Dementia, Motor Impairments
PERDOVE ANZIANI: a Prospective Cohort Study on Older Patients
This prospective observational cohort study aims at studying functional and clinical outcomes of patients (N = 329) admitted to 4 geriatric hospital facilities of the St John of God Order in Northern Italy during an index period…
- Conditions
- Dementia, Motor Impairments, Stroke, Thighbone Fractures
- Trial name
- NCT01699984
- Where
- 4 sites in Italy
- Volunteers
- 329 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Executive Dysfunction, Mild Cognitive Impairment (MCI)
Feasibility Study of Mixed Reality Exergame on Performance and Cortical Outcomes
The executive dysfunctions are a problem in individuals with MCI which predict conversion to dementia and is positively related to physical activity level.
- Trial name
- NCT06843733
- Testing
- Mixed reality exergame, Education
- Where
- Thailand
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Alcohol Drinking, Alcohol Intoxication
Smartphone-paired Breathalyzers and Loss- and Gain-framed Texts for Reducing Drinking and Driving
This project aims to demonstrate the feasibility of a scalable behavioral intervention using smartphone-paired breathalyzers and text message aimed at reducing drinking and driving among individuals who report heavy drinking.
- Conditions
- Alcohol Drinking, Alcohol Intoxication, Alcohol Impairment, Drive
- Trial name
- BESAFE (NCT03335735)
- Testing
- Loss-framed text message, Gain-Framed text message
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Mild Cognitive Impairment, So Stated, Cocaine Use Disorder
Occupational Therapy-Based Cognitive Rehabilitation of Cocaine Abusers: A Pilot Study
This study integrates a model of occupational-therapy based cognitive rehabilitation as part of a comprehensive treatment plan for cocaine abusers.
- Trial name
- NCT01684293
- Testing
- Occupational therapy-based cognitive rehabilitation, Psychoeducation/games
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Alzheimer Disease, Cognitive Impairment
CBB Satisfaction Survey
The Cogstate Brief Battery (CBB) is a computerized measure for cognitive screening that consists of four cognitive tasks to assess psychomotor function, attention, learning, and working memory, and provides an easy-to-interpret…
- Trial name
- NCT06496347
- Where
- Taiwan
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Cheng Sheng Chen
Cognitive Impairment, Poor Nutrition
The PROtein Enriched MEDiterranean Diet and EXercise Trial for Older Adults At Risk of Undernutrition
PROMED-EX is a single-blind, parallel group randomised controlled trial to determine the effect of a PROtein enriched MEDiterranean diet (PROMED) in comparison to a PROtein enriched MEDiterranean diet and EXercise (PROMED-EX)…
- Conditions
- Cognitive Impairment, Poor Nutrition, Cognitive Decline
- Trial name
- PROMED-EX (NCT05166564)
- Testing
- A Protein Enriched Mediterranean Diet (PROMED) Intervention, A Protein Enriched Mediterranean Diet & Exercise (PROMED-EX) Intervention
- Where
- United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Cognitive Impairment
Family-Centered Songwriting in Pediatric Palliative Care
This study evaluates the feasibility and efficacy of a family-centered songwriting intervention for cognitively-impaired children referred to a palliative care service.
- Trial name
- NCT04198038
- Testing
- Songwriting with licensed music therapist
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt University
MCI, Mild Cognitive Impairment (MCI)
Prevalence of Mild Cognitive Impairment and Dementia in Patients Admitted to Non-neurological Rehabilitation Wards
Cognitive impairment is common among older adults hospitalized for non-neurological conditions but often goes unrecognized, particularly in rehabilitation settings where clinical attention is mainly focused on physical recovery.
- Conditions
- MCI, Mild Cognitive Impairment (MCI), Mild Cognitive Impairment, Cognitive Deficit
- Trial name
- COGinREHAB (NCT07731334)
- Testing
- Cognitive and clinical screening, Extended neuropsychological assessment, Blood biomarker sampling and APOE genotyping
- Where
- 3 sites in Italy
- Volunteers
- 384 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Mild Cognitive Impairment, Dementia
COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE
This retrospective study is a more extensive, confirmatory analysis of the cognitive and functional outcomes initially seen in 2 groups of MCI/dementia patients in Springfield, MA and compares specialized dementia care and a…
- Conditions
- Mild Cognitive Impairment, Dementia, Hypoxia, Hyperhomocysteinemia
- Trial name
- NCT02860338
- Volunteers
- 900 people
- Sponsor
- Clionsky Neuro Systems Inc.
Cognitive Dysfunction
Integrative Therapy for Holistic, Natural Cognition and Lifestyle Rehabilitation
An observational study to determine outcomes of older adults who are under naturopathic medical care for cognitive complaints at a specific clinic in Southern California.
- Trial name
- ITHNCLR (NCT04284449)
- Testing
- Whole-practice cognitive optimization
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
Malnutrition, Falling
Identification of Risk Patients in Emergency Medical Services
Background: Inadequate nutrition has been associated with growing risk of falling and impaired ability in elderly patients. Falling is a significant threat to the health of the elderly.
- Conditions
- Malnutrition, Falling, Cognitive Impairment
- Trial name
- NCT03759314
- Testing
- Observation
- Where
- Finland
- Volunteers
- 500 people
- Sponsor
- Helsinki University Central Hospital
Frailty, Age-Related Macular Degeneration
Visual Frailty in Ageing
The goal of this observational study is to define visual frailty and refine monitoring for an ageing population. It involves piloting a visual frailty assessment tool in a cohort of patients aged 60 and above with a known…
- Conditions
- Frailty, Age-Related Macular Degeneration, Functional Status, Mental Health
- Trial name
- VFiA (NCT06604104)
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Aging, Mild Cognitive Impairment
My Healthy Brain: Preserving and Promoting Brain Health Through Evidence-based Practices
The objective of this trial is to demonstrate early proof-of-concept for My Healthy Brain, an 8-week group program that directly targets multiple lifestyle factors associated with brain health and prevention of cognitive decline.
- Conditions
- Aging, Mild Cognitive Impairment, Dementia, Old Age; Dementia
- Trial name
- NCT04537728
- Testing
- My Healthy Brain Version 2
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Cognitive Impairment, Mild, Dementia
Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo.
- Conditions
- Cognitive Impairment, Mild, Dementia, Cardiovascular Diseases
- Trial name
- PREVENTABLE (NCT04262206)
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- 106 sites in United States, Puerto Rico
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Mild Cognitive Impairment, Alzheimer Dementia
Brain Fitness APP for Cognitive Enhancement
Memory and cognitive declines are associated with normal brain aging but are also precursors to dementia, in particular the so called the pandemic of the century, Alzheimer's disease.
- Trial name
- NCT03587012
- Testing
- Brain fitness app, Brain fitness app with tACS
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Depression, Mild Cognitive Impairment
Combination Treatment Study for Memory Impairment and Depression
Patients presenting with depression (DEP) and cognitive impairment (CI), represent a unique, understudied population that is difficult to diagnose, treat and estimate prognosis.
- Trial name
- DEP-CI (NCT01658228)
- Testing
- Donepezil, Citalopram, Venlafaxine
- Where
- 2 sites in United States
- Volunteers
- 86 people
- Sponsor
- New York State Psychiatric Institute
Dementia, Cognition Disorders
Cerebral Amyloid Imaging Using Florbetapir (AV-45)
This study is aimed at examining the interest of amyloid radiotracer Florbetapir (18F-AV-45) for the etiological diagnosis of poststroke cognitive impairment and dementia
- Trial name
- IDEA3 (NCT02813434)
- Testing
- florbetapir
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
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