Clinical trials: Mental Impairment
Cognitive Symptoms
Chemotherapy-Induced Cognitive Impairment
The investigators overall research hypothesis is that systemic chemotherapy induces structural changes in the white matter of the brain as demonstrated with Diffusion Tensor Imaging (DTI) and functional changes in well-defined…
- Trial name
- CICI (NCT01578083)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Jay F. Piccirillo, MD
Mild Cognitive Impairment
Driving Ability Among People With Mild Cognitive Impairment
The Purpose of this study is to assess the effect of MCI on driving ability by using on road driving test. The relationship between their driving outcome and their cognitive decline will be examined.
- Trial name
- MCI (NCT01608256)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel Aviv University
Depression in Old Age, Psychotherapy
Engage for Late-Life Depression and Comorbid Executive Dysfunction
Although there are an increasing number of mental health treatment adaptations for older adults, there are still a number of factors to consider when making these adaptations.
- Conditions
- Depression in Old Age, Psychotherapy, Mild Cognitive Impairment, Executive Dysfunction
- Trial name
- NCT05356611
- Testing
- Engage
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Nevada, Las Vegas
Cancer, Cognitive Impairment
Cancer and Mild Cognitive Impairment a Patient-Caregiver Behavioral Intervention
The purpose of this study is to see whether programs that include both a patient and their spouse or a patient and family caregiver (known as a dyad) are helpful for families in which one member of the dyad has cancer and mild…
- Trial name
- NCT04826315
- Testing
- COPE +
- Where
- United States
- Sponsor
- Duke University
Mild Cognitive Impairment, Mild Cognitive Impairment (MCI)
Community-based Multi-domain Intervention to Detect and Delay Cognitive Decline in Community-dwelling Older Adults: A Pilot Study
The incidence of cognitive impairment and its burden are increasing with a rapidly ageing population. In Singapore, the prevalence of dementia among older adults aged 60 and above is approximately 10%, which will translate to…
- Trial name
- NCT07099040
- Testing
- Social support, Health coaching, Physical Activity
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Stroke, Cognitive Impairment
Gaming Apps Post-Stroke
The investigators aim to explore the effect of puzzle mobile or tablet-based games on problem-solving impairment resulting from a first-time stroke.
- Conditions
- Stroke, Cognitive Impairment, Executive Dysfunction, Cognitive Change
- Trial name
- GAPS (NCT04637100)
- Testing
- Mobile or tablet-based gaming applications, Stroke-related educational videos
- Where
- United States
- Sponsor
- Loma Linda University
Healthy, Cognitive Impairment
Post Hoc Analysis and Clinical Data Collection for Subjects Tested With Brain Network Activation (BNA™) Technology
The study is designed to collect data that will aid in future scientific and engineering exploration of correlations between clinical assessments and BNA scores.
- Conditions
- Healthy, Cognitive Impairment, Neurological Disorder
- Trial name
- NCT03699514
- Testing
- Brain Network Activation (BNA™) technology
- Where
- 4 sites in United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
Mild Cognitive Impairment (MCI)
Evaluation of the Impact of Medium-chain Fatty Acids in the Evolution of Newly Diagnosed Mild Cognitive Impairment
Mild cognitive impairment (MCI) is considered the intermediate stage between the changes observed in physiological aging and dementia.
- Trial name
- MCI-MCT (NCT06951932)
- Testing
- Mediterranean-type diet with MCT supplementation, Mediterranean-type food regimen using extra virgin olive oil
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Functional Status, Cognitive Impairment
Effects of a Daily Cognition Training in Older Adults Without Cognitive Impairment
To evaluate the effectiveness of a daily cognition training programme versus a traditional cognitive stimulation programme in cognitively unimpaired older adults on cognitive function, emotional state, frailty and functionality.
- Conditions
- Functional Status, Cognitive Impairment, Occupational Therapy
- Trial name
- NCT05688163
- Testing
- programme based on everyday cognition, traditional cognitive stimulation
- Where
- Spain
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Multiple Sclerosis (MS) - Relapsing-remitting, Anxiety
Psychological Interventions for Multiple Sclerosis: Effects on Anxiety, Depression, and Cognition.
This study evaluated the efficacy of two structured psychological interventions in individuals with relapsing-remitting multiple sclerosis (RRMS).
- Conditions
- Multiple Sclerosis (MS) - Relapsing-remitting, Anxiety, Depression, Cognitive Impairment
- Trial name
- MS-PSY (NCT07273604)
- Testing
- Cognitive Behavioral Therapy (CBT), Psychophysiological Regulation Therapy (PRT)
- Where
- Spain
- Volunteers
- 148 people
- Sponsor
- Moisés Bermúdez Hernández
Cognitive Decline
Metabolic Syndrome, Inflammation, and Risk of Cognitive Decline
The purpose of this study is to determine if the metabolic syndrome is a risk factor for cognitive decline and if this association is modified by inflammation.
- Trial name
- NCT00099567
- Where
- 2 sites in United States
- Volunteers
- 2,632 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Alzheimers Disease, Mild Cognitive Impairment
Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease
In people with Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), reduced capacity for locomotor adaptation is a fundamental but poorly understood mechanism that can be a sensitive biomarker of cognitive-motor…
- Trial name
- NCT06484244
- Testing
- 5 Sessions of Split-belt Treadmill-based Locomotor Adaptation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Cognitive Impairment, Stroke
Addressing Problems in Managing Daily Tasks Due to Poststroke Cognitive Impairments
The purpose of this study is to investigate feasibility aspects of an intervention targeting problems in managing daily tasks due to mild-to-moderate poststroke cognitive impairments.
- Trial name
- NIOTI-stroke (NCT05829421)
- Testing
- Impairment-specific occupational therapy (OT) intervention
- Where
- 4 sites in Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Emma Ghaziani
Mild Cognitive Impairment, Mild Dementia
Validation of the German Version of the Amsterdam Instrumental Activities of Daily Living Questionnaire®
Pretest and validation of the German version of the Amsterdam instrumental activities of daily living questionaire short in elderly people with normal cognition, mild cognitive impairment (MCI) or mild dementia in the German…
- Trial name
- NCT04012398
- Testing
- Amsterdam IADL Questionnaire short, German version
- Where
- Switzerland
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Zurich University of Applied Sciences
Schizophrenia
Memantine add-on for Cognitive and Negative Symptoms of Schizophrenia
The specific aim of this project is to test if memantine add-on therapy will be helpful for patients with first episode schizophrenia who present with or without cognitive impairments and negative symptoms, to examine the…
- Trial name
- NCT02001103
- Testing
- Memantine
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Age-Related Memory Disorders
Nicotine Treatment of Mild Cognitive Impairment (MCI)
The purpose of this 12-month study is to determine whether nicotine, administered in the form of nicotine patches, can improve symptoms of memory loss in some people experiencing mild memory problems (referred to in this study as…
- Trial name
- NCT00091468
- Testing
- Transdermal nicotine patch
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institute on Aging (NIA)
Mental Health Impairment, Obesity, Adolescent
Mental Health in Children and Youth Within Pediatric Care
Over the last decades, there has been an increase in the number of children and youth with mental illness, such as anxiety and depression.
- Conditions
- Mental Health Impairment, Obesity, Adolescent, IBD
- Trial name
- PHU (NCT04094324)
- Testing
- Questionnaires
- Where
- 2 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Region Skane
Impaired Health, Disease
The Lolland-Falster Health Study
The study is a epidemiological, cross-sectional study in a mainly rural area of Denmark in Denmark. Life expectancy is shorter, morbidity is higher, and social problems more prevalent than in the urban areas of the country.
- Conditions
- Impaired Health, Disease, Wellbeing, Mental Disorders
- Trial name
- LOFUS (NCT02482896)
- Where
- Denmark
- Volunteers
- 25,000 people
- Sponsor
- Region Sjælland
Intellectual Disability, Neurodevelopmental Disorders
Physical Activity and Community EmPOWERment Project
Purpose: Conduct a wait-list randomized controlled trial (RCT) of an inclusive physical activity program called PACE for adults with intellectual disability (ID) who are not yet showing signs of Alzheimer's Disease…
- Conditions
- Intellectual Disability, Neurodevelopmental Disorders, Autism Spectrum Disorder, Down Syndrome
- Trial name
- PACE (NCT06740162)
- Testing
- PACE Program
- Where
- 2 sites in United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Age-related Macular Degeneration, Dementia
Words on the Brain: Can Reading Rehabilitation for Age-Related Vision Impairment Improve Cognitive Functioning?
Age-related vision impairment and dementia both become more prevalent with increasing age. Research into the mechanisms of these conditions has proposed that some of their causes (e.g., macular degeneration/glaucoma and…
- Conditions
- Age-related Macular Degeneration, Dementia, Low Vision, Low Vision Aids
- Trial name
- WOTB (NCT04276610)
- Testing
- Low Vision Reading Rehabilitation
- Where
- 2 sites in Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
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