Clinical trials: Mental Impairment
Cognitive Impairment Associated With Schizophrenia (CIAS), Cognitive Impairment
A Study to Evaluate RL-007 in the Treatment of Cognitive Impairment Associated With Schizophrenia (CIAS)
The goal of this clinical trial is to evaluate if the investigational drug, RL-007, can improve the cognitive performance of subjects with schizophrenia. The main questions the study aims to answer are: 1.
- Conditions
- Cognitive Impairment Associated With Schizophrenia (CIAS), Cognitive Impairment, Schizophrenia
- Trial name
- NCT05686239
- Testing
- RL-007 (Inidascamine)
- Where
- 36 sites in United States, Bulgaria and 2 more
- Volunteers
- 242 people
- Sponsor
- Recognify Life Sciences
Mild Cognitive Impairment
NAD Therapy for Improving Memory and Brain Blood Flow in Older Adults With Mild Cognitive Impairment
This study will provide insight into whether a nutritional supplement, nicotinamide riboside (NR), improves memory and brain blood flow in older adults with low memory abilities.
- Trial name
- NCT03482167
- Testing
- Niagen®
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Delaware
Mental Health, Depression
rTMS for Emotional Difficulties in Verterans
Mental illness rarely occurs as a single, easily categorized condition. Instead, multiple disorders often co-occur. This complicates the treatment plan for many Veterans, especially those suffering the most severe dysfunction.
- Conditions
- Mental Health, Depression, rTMS, Anxiety
- Trial name
- rTMS (NCT03749967)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Schizophrenic Disorder, Cognitive Impairment
Sodium Butyrate For Improving Cognitive Function In Schizophrenia
The purpose of this grant is to evaluate the efficacy of sodium butyrate as a novel treatment for cognitive deficits in schizophrenia (SZ).
- Trial name
- NCT03010865
- Testing
- Sodium Butyrate
- Where
- China
- Sponsor
- Shanghai Mental Health Center
Dementia
Family Involvement Hospital Ethnography
The goal of this observational study is to learn about the role of family members in caring for hospitalized older adults with cognitive impairment. The main questions it aims to answer are: 1.
- Trial name
- NCT06374992
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Duke University
Old Age; Dementia
Tango for Older People With Dementia
Cognitive impairment (CI) is the leading cause of loss of autonomy and has a huge impact on physical performance and quality of life (QOL) in older people.
- Trial name
- NCT05744011
- Testing
- Tango intervention, Adapted Physical Activity
- Where
- 2 sites in France
- Volunteers
- 124 people
- Sponsor
- University of Burgundy
Mild Cognitive Impairment (MCI)
Assessing Treatment With High-phenolic EVOO Supplements for Neurovascular Activity
The goal of this clinical trial is to determine whether the extra-virgin olive oil (EVOO) phenolic dietary supplement can improve memory function and modulate biomarkers among individuals with mild cognitive impairment (MCI).
- Trial name
- ATHENA (NCT07741773)
- Testing
- EVOO-phenolics dietary supplement
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Augusta University
Mild Cognitive Impairment
Making Memory Better for Seniors With Mild Cognitive Impairment
The purpose of this study is to investigate the feasibility and effectiveness of a cognitive training group in individuals with Mild Cognitive Impairment, using a new paradigm that will optimize ecological validity by (1)…
- Trial name
- NCT01532739
- Testing
- Cognitive training
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Nova Scotia Health Authority
Brain Concussion, Brain Trauma
tDCS and Cognitive Training in Active Duty Service Members With Mild TBI: A Pilot Study
The proposed study will evaluate a new approach to cognitive rehabilitation of mild traumatic brain injury (mTBI) using a brain stimulation technique called transcranial direct current stimulation (tDCS).
- Conditions
- Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries
- Trial name
- NCT04925453
- Testing
- active tDCS and cognitive training intervention
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- United States Naval Medical Center, San Diego
Developmental Language Disorder and Language Impairment, Anxiety Disorders and Symptoms
Reducing Anxiety Problems Among Children Indicated to Have Developmental Language Disorder
This study aims to pilot a world-first intervention, a mental health intervention augmented for children indicated with developmental language disorder (DLD).
- Trial name
- RAP-iDLD (NCT05552365)
- Testing
- Adapted Cognitive Behavioural, Treatment as Usual
- Where
- Singapore
- Volunteers
- 9 people
- Sponsor
- Nanyang Technological University
Concussion, Mild, Vestibular Impairment
Association of History of Concussion With Vestibular Impairment and Cognitive Function in Sports Athletes
This study investigates the potential relationship between prior concussions and their impact on both vestibular function and cognitive abilities in athletes participating in sports.
- Conditions
- Concussion, Mild, Vestibular Impairment, Cognitive Impairment
- Trial name
- NCT06340100
- Testing
- find association between vestibular impairment , cognitive fiunction with concussin
- Where
- Pakistan
- Volunteers
- 115 people
- Sponsor
- Riphah International University
Alzheimer Disease, Subjective Cognitive Impairment
Comfortage - AD Prevention Strategies
Study is Interventional, cross-sectional, clinical trial without drug and without device
- Conditions
- Alzheimer Disease, Subjective Cognitive Impairment, Mild Cognitive Impairment
- Trial name
- Comfortage-P4 (NCT06896201)
- Testing
- Neuropsychological Assessments and Other Questionnaires, Blood Exams, Fluid Biomarkers, Genetics, Connectivity Analysis
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Alzheimer Disease, Chronic Traumatic Encephalopathy
Visualizing Brain Proteinopathies Using [F-18]Flornaptitril-PET in the Prediction of Clinical Progression of Mild Cognitive Impairment With Either Suspected Chronic Traumatic Encephalopathy or Alzheimer's Disease
CMK-0301 is a multi-site, randomized clinical trial to evaluate the safety and efficacy of [F-18]Flornaptitril-PET (F-18 FNT-PET) for the prediction of clinical progression of Mild Cognitive Impairment (MCI) with either Suspected…
- Trial name
- NCT06254469
- Testing
- [F-18]Flornaptitril
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- CereMark Pharma, LLC
HIV
Does Micro-albuminuria is a Predictive Factor for Cognitive Impairment in Persons Living With HIV (PLHIV) Who Achieve cART-sustained Immunovirological Control ?
Chronic kidney disease (CKD), frequent in PLHIV, is a risk factor for cognitive impairment. Micro-albuminuria is an early manifestation of CKD and a marker of vascular risk, notably affecting the small vessels.
- Trial name
- ALCOVE (NCT02852772)
- Testing
- Cognitive function tests
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Alzheimer Disease, Dementia
Innovations in Dementia Empowerment and Action
The lack of efficacious research-based interventions for such vulnerable older adults with Alzheimer's disease and related dementias (AD/RD) and their caregivers (CGs) is a significant public health problem.
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment, Parkinson Disease Dementia
- Trial name
- IDEA (NCT03550131)
- Testing
- Innovations in Dementia Empowerment and Action (IDEA), Reducing Disabilities in Alzheimer's Disease (RDAD)
- Where
- United States
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- University of Washington
Multiple Sclerosis
Sociocognitive Intervention and Rehabilitation Program in Multiple Sclerosis
Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system, involving inflammation, demyelination, and neurodegeneration. It is the most common non-traumatic disabling disease affecting young adults.
- Trial name
- REACT-MS (NCT07734675)
- Testing
- Sociocognitive rehabilitation via COGWEB platform combined with an emotional processing intervention.
- Where
- 2 sites in Portugal
- Volunteers
- 130 people
- Sponsor
- Sonia Batista
Transient Ischemic Attack, Vascular Cognitive Impairment
Reshaping the Path of Vascular Cognitive Impairment (VCI)
The investigators will conduct a proof-of-concept randomized controlled trial study to provide preliminary evidence of efficacy of a resistance exercise training program for maintaining white matter health and improving cognitive…
- Conditions
- Transient Ischemic Attack, Vascular Cognitive Impairment, Subcortical Vascular Dementia
- Trial name
- NCT02669394
- Testing
- Resistance exercise training, Control: stretching and relaxation program
- Where
- Canada
- Volunteers
- 91 people
- Sponsor
- University of British Columbia
Alzheimer's Disease
Evaluation of Safety & Tolerability of Multiple Dose Regimens of CHF 5074 and Exploration of Effects on Potential Markers of Clinical Efficacy in Patients With Mild Cognitive Impairment - Open Label Extension (CT04 OLEP)
The purpose of this study is to evaluate the safety and tolerability of ascending oral doses of CHF 5074 after prolonged administration to patients with mild cognitive impairment.
- Trial name
- NCT01421056
- Testing
- CHF 5074 1x, CHF 5074 2x, CHF 5074 3x
- Where
- 6 sites in United States, Italy
- Volunteers
- 74 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Alzheimer's Disease, Mild Cognitive Impairment
A PET Study of the Effects of p38 MAP Kinase Inhibitor, VX-745, on Amyloid Plaque Load in Alzheimer's Disease (AD)
This study will assess the effects of administration of VX-745 for 12 weeks on amyloid plaque burden in Alzheimer's disease (AD).
- Trial name
- NCT02423122
- Testing
- VX-745
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- EIP Pharma Inc
Memory Impairment, Sleep Disorder
Improving Patient Memory for Treatment for Mild Cognitive Impairment
The main empirical question to be addressed is: What types of memory support are most potent for patients who are experiencing a mild cognitive impairment (MCI) relative to non-MCI patients?
- Trial name
- NCT05668481
- Testing
- Transdiagnostic sleep and circadian intervention (TranS-C)
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
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