Clinical trials: Mental Processes
Major Depression, End Stage Renal Disease
Bupropion for Depression in ESRD Patients on Hemodialysis
The proposed study will evaluate the response and remission rates for major depressive disorder (MDD) in end-stage renal disease (ESRD) patients undergoing maintenance hemodialysis (HD) treated with bupropion or fluoxetine for 12…
- Trial name
- NCT02238977
- Testing
- Fluoxetine, Bupropion
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Arkansas
Alzheimer Disease, Parkinson Disease
The Relationship Between Neuropsychological Testing and MRI, PET and COBRE - Project 1: AIM 2 (GE-180)
The complex pathological cascades leading to both Alzheimer's disease (AD) and Parkinson's disease (PD) involve, at various points, inflammation.
- Conditions
- Alzheimer Disease, Parkinson Disease, Inflammation
- Trial name
- NCT03702816
- Testing
- GE180 PET Scan
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aaron Ritter, MD
Alcohol Use Disorder, Substance Use
Emergency Department Initiated Extended-Release Naltrexone and Case Management for the Treatment of Alcohol Use Disorder
This is a phase 4, open-label, feasibility study of extended release naltrexone (Vivitrol, Alkermes Pharmaceutical) and case management for treatment of alcohol use disorders in the ED.
- Conditions
- Alcohol Use Disorder, Substance Use, Alcohol Abuse or Dependence
- Trial name
- NCT04094584
- Testing
- Vivitrol (Extended Release Naltrexone)
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- University of California, San Francisco
Post Operative Pain
Parent Nurse Controlled Analgesic in Pediatric Patients With Developmental Delay
The purpose of this study is to compare, the safety, efficacy and level of parent and nurse satisfaction with three methods of opioid administration post-operatively in children (4-18 years of age) with developmental delay.
- Trial name
- PNCA (NCT00743730)
- Testing
- Pain and standard side effect management for PNCA with basal method., Pain and standard side effect management with PNCA without basal, Pain and standard side effect management with IV on an as needed basis method.
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Medical College of Wisconsin
Hepatitis C, Medication Adherence
Intensive Models of HCV Care for Injection Drug Users
Injection drug users (IDUs) constitute 60% of the approximately 5 million people in the U.S. infected with hepatitis C virus (HCV). HCV treatment leading to sustained viral response (SVR) is associated with increased survival.
- Trial name
- NCT01857245
- Testing
- Intensive Models (mDOT and CGT) of HCV Care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Prisma Health-Upstate
Anxiety, Anxiety Disorders
Anxiety, Inflammation, Stress, and Cannabinoids
This study investigates whether the anxiolytic effects and anti-inflammatory properties of cannabis vary as a function of the ratio of CBD to THC, with the goal that these effects may shed light on the mixed data linking cannabis…
- Conditions
- Anxiety, Anxiety Disorders, Anxiety Generalized, Anxiety Chronic
- Trial name
- NCT03491384
- Testing
- Cannabis (smoked flower, ingested edible)
- Where
- United States
- Volunteers
- 361 people
- Sponsor
- University of Colorado, Boulder
Chronic Obstructive Pulmonary Disease, Insomnia
Internet-based Cognitive-behavioral Treatment for Insomnia in COPD Patients Undergoing Pulmonary Rehabilitation
This study is a randomized controlled trial (RCT) to compare sleep and health-related functioning in Veterans with chronic obstructive pulmonary disease (COPD) and insomnia receiving an Internet-based behavioral treatment for…
- Trial name
- NCT04700098
- Testing
- Internet-based behavioral treatment for insomnia, Online insomnia patient education
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- VA Office of Research and Development
Critical Illness
Improving Outcomes After PICU Admission: A Pilot Study
1. Evaluate the feasibility and acceptability of an information based intervention delivered to parents following their child's admission to paediatric intensive care; 2.
- Trial name
- NCT01737021
- Testing
- Psycho-education
- Volunteers
- 31 people
- Sponsor
- Imperial College London
Advanced Cancers
Sublingual Fentanyl for the Management of Breakthrough Pain
The goal of this clinical research study is to learn if an investigational dose of fentanyl sublingual spray (FSS) can help to control pain in patients with advanced cancer when given in an outpatient and inpatient setting.
- Trial name
- NCT02514252
- Testing
- Fentanyl Sublingual Spray (FSS), Questionnaires, Mental Ability Tests
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- M.D. Anderson Cancer Center
Insomnia, End Stage Renal Disease
Short and Long-Term Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis
Insomnia is a common and distressing symptom for patients on hemodialysis (HD), and there is evidence for a much larger impact on the health of patients.
- Trial name
- Sleep-HD (NCT03534284)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Trazodone
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Washington
Insomnia
Effects of Suvorexant in Patients With Chronic Obstructive Pulmonary Disease (MK-4305-032)
This study will evaluate the safety, tolerability, and effect of multiple doses of suvorexant (MK-4305) on respiratory function in participants with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT01293006
- Testing
- suvorexant
- Volunteers
- 25 people
- Sponsor
- Merck Sharp & Dohme LLC
Pain, Postoperative, Depression, Postpartum
Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery (PREPARE 1)
The purpose of this study is to identify a tolerable dose for postpartum ketamine infusion using a maximum tolerated dose (MTD) 3+3 design.
- Trial name
- NCT05907213
- Testing
- Ketamine (Ketalar) Dose Level 1, Ketamine (Ketalar) Dose Level 2, Ketamine (Ketalar) Dose Level 3
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Endometriosis
Extension to Study on Efficacy and Safety of Linzagolix for the Treatment of Endometriosis-associated Pain (EDELWEISS 6)
The primary objective of this extension study is to assess the maintenance of efficacy of linzagolix administered orally once daily for up to an additional 6 months (for up to 12 months of treatment in total) in women who have…
- Trial name
- NCT04335591
- Testing
- 75 mg linzagolix tablet, 200 mg linzagolix tablet, Add-back capsule (E2 1 mg / NETA 0.5 mg)
- Where
- 47 sites in United States, Austria and 7 more
- Volunteers
- 356 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Intensive Care Unit Survivors, Informal Caregivers (Family and Friends)
Improving Psychological Distress Among Critical Illness Survivors and Their Caregivers
Patients who receive life support in intensive care units commonly suffer from persistent depression, anxiety, and post-traumatic stress disorder (PTSD) symptoms after discharge.
- Trial name
- NCT01983254
- Testing
- coping skills training, education program
- Where
- 4 sites in United States
- Volunteers
- 417 people
- Sponsor
- Duke University
Alzheimer's Disease
Imaging Inflammation in Alzheimer's Disease
This study is being done to learn about inflammation and amyloid in Alzheimer's disease. A type of brain scan called a PET scan is used measure 1) inflammation and 2) abnormal accumulation of a the amount of a certain protein…
- Trial name
- NCT02831283
- Testing
- 11C-PBR28, 18F-Florbetaben, Lumbar puncture (optional)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Patrick Lao
Coronary Artery Disease, Postoperative Cognitive Dysfunction
Cerebral Oximetry and Neurocognitive Functions in Cardiosurgical Patients
It is previously reported that the cerebral oxygen desaturation during cardiac surgery is associated with an increased incidence of cognitive impairment.
- Conditions
- Coronary Artery Disease, Postoperative Cognitive Dysfunction, Neurological Impairment
- Trial name
- NCT00917124
- Testing
- INVOS
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- University of Zagreb
Huntington Disease
A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD)
The primary goal of this study is to evaluate the safety and pharmacodynamic effects of PTC518 compared with placebo in participants with HD.
- Trial name
- NCT05358717
- Testing
- PTC518
- Where
- 28 sites in United States, Australia and 9 more
- Volunteers
- 159 people
- Sponsor
- Novartis Pharmaceuticals