Clinical trials: Mental Stress
Bereavement, Prolonged Grief Disorder
Cognitive Behavioural Therapy for Complicated Grief Reactions in Old Age
While most bereaved individuals cope adaptively with the loss of a loved one, a significant minority experiences more severe and complicated grief reactions.
- Conditions
- Bereavement, Prolonged Grief Disorder, Depression, Anxiety
- Trial name
- NCT04694807
- Testing
- Group-based Cognitive Behavioural Therapy for Complicated Grief Reactions, Individually delivered Cognitive Behavioural Therapy for Complicated Grief Reactions
- Where
- Denmark
- Volunteers
- 113 people
- Sponsor
- University of Aarhus
Parkinson Disease
The UPbeating GReek Application of DancE in Parkinson's Disease Clinical Trial
Dance for Parkinson's Disease® (DfPD®) is a specially designed dance program for individuals with PD. This study assesses the efficacy, safety and feasibility of a culturally adapted DfPD® program offered both live and online in…
- Trial name
- UPGRADE-PD (NCT06220084)
- Testing
- Dance for PD®
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- University of West Attica
Posttraumatic Stress Disorder
Study of 3,4-Methylenedioxymethamphetamine-assisted Psychotherapy in People With Posttraumatic Stress Disorder
This study will examine MDMA-assisted psychotherapy in individuals aged 18 years or older diagnosed with PTSD, with PTSD symptoms not improving after trying at least one treatment.
- Trial name
- NCT00353938
- Testing
- 3,4-methylenedioxymethamphetamine (125 mg), 3,4-methyelendioxymethamphetamine (25 mg), Therapy
- Where
- Switzerland
- Volunteers
- 14 people
- Sponsor
- Resilient Pharmaceuticals
Traumatic Brain Injury, PTSD
Structural and Functional Neuroimaging Studies of Combat Veterans
Background: Studies have shown that some people develop post-traumatic stress disorder (PTSD) after being exposed to the trauma of military combat.
- Trial name
- NCT01296126
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Alcohol Use Disorder
Orexin Receptor Antagonism for the Treatment of Alcohol Use Disorder and Stress-Related Drinking
The goal of this clinical trial is to learn if, how, and for whom suvorexant (SUV) works to treat alcohol use disorder (AUD). The main questions it aims to answer are: Is SUV effective for AUD? Does SUV dampen stress reactivity?…
- Trial name
- NCT07214207
- Testing
- Suvorexant 10 mg
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Ohio State University
Mental Health, Stress
Psychosocial Counseling in Afghanistan
The assessment intends to investigate the efficacy of psychosocial counseling for the treatment of help seeking individuals with psychosocial problems in Mazar-e-Sharif, Afghanistan.
- Trial name
- NCT01155687
- Where
- Afghanistan
- Volunteers
- 61 people
- Sponsor
- University of Konstanz
Stress Disorders, Post-Traumatic
Post Traumatic Stress Disorder (PTSD) Hyperarousal Symptoms Treated With Physiological Stress Management
Hyperarousal is a key symptom of PTSD. Even after receiving trauma-focused therapy, PTSD patients may continue to suffer from hyperarousal.
- Trial name
- BaRT (NCT00855816)
- Testing
- Breathing training
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Alcoholism, Alcohol Dependence
The Effect of NK1R Antagonism on Alcohol Craving and PTSD Symptoms in Alcohol Dependent Patients With PTSD
Objective: Alcoholism is highly co-morbid with post traumatic stress disorder (PTSD). Since stress and negative affective states are major relapse triggering factors for alcohol use, the negative symptoms associated with PTSD are…
- Conditions
- Alcoholism, Alcohol Dependence, Posttraumatic Stress Disorder
- Trial name
- NCT00896038
- Testing
- Aprepitant
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Mental Stress, Hypertension
Impact of a Health and Mental Health Promotion Intervention Among Jordanians and Syrians.
Given the heightened risk of NCDs and mental health issues, it is critical for Jordanians and Syrian refugees to have access to prevention based health services.
- Conditions
- Mental Stress, Hypertension, Diabetes
- Trial name
- NCT03721848
- Testing
- Healthy community clinic NCD+MH, Healthy community clinic NCD
- Where
- Jordan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Stress Disorders, Post-Traumatic, Bulimia Nervosa
Effectiveness of Prazosin in Bulimic Patients Experiencing Nightmares Due to PTSD
This research is being done to find out how effective Prazosin is in the treatment of bulimic patients experiencing distressing nightmares using subjective and objective measures.
- Trial name
- NCT02382848
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Milton S. Hershey Medical Center
COVID-19 Pandemic, Stressor, Psychological
Stress and Coping, Resilience, and Compassion Fatigue of Front-line Nurses During COVID-19 Pandemic
This is a cross-sectional research. The investigators plan to recruit about 250 front-line nurses who provided direct care to COVID-19 confirmed cases in a medical center in Taiwan.
- Conditions
- COVID-19 Pandemic, Stressor, Psychological, Mental Health Issue
- Trial name
- NCT05205564
- Testing
- This is a cross-sectional research design.
- Where
- 3 sites in Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Taiwan University
Moral Injury, TEPT
A Comprehensive Group Intervention for Psychosocial Personnel at Risk of Stress and Moral Injury
The objective of this randomized controlled trial is to evaluate the effectiveness of the CARE-MI group intervention in reducing symptoms of post-traumatic stress and moral injury in support staff working with individuals…
- Trial name
- CARE-MI-PsychS (NCT07140263)
- Testing
- CARE MI, TAU: Treatment as usual
- Where
- Spain
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Stress Disorders, Post Traumatic
Treatment of Post-traumatic Stress Disorder With High Doses of Escitalopram
The study evaluates the hypothesis that large doses of Escitalopram will reduce symptoms of chronic post-traumatic stress disorder (PTSD) in adult civilian survivors of traumatic events.
- Trial name
- NCT00736021
- Testing
- Escitalopram
- Where
- Israel
- Volunteers
- 38 people
- Sponsor
- Hadassah Medical Organization
Post-traumatic Stress Disorder (PTSD), Anxiety Symptoms
The Impact of Playing Tetris on Migrants' Mental Health
This study examines if playing Tetris prevents the development of Post-traumatic stress disorder or related anxiety and depressive symptoms. The investigators recruit 300 participants in total in Greece and in the Netherlands.
- Conditions
- Post-traumatic Stress Disorder (PTSD), Anxiety Symptoms, Depression Symptoms
- Trial name
- NCT06773338
- Testing
- Tetris, No intervention
- Where
- 2 sites in Greece, Netherlands
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tilburg University
Symptoms of Depression and Anxiety
The Feasibility of Chatbot-based Stress Management Intervention STARS for Youth in Lithuania
The study aims to assess the feasibility of a chatbot-based stress management intervention among youth in Lithuania.
- Trial name
- NCT06651411
- Testing
- STARS (Scalable Technology for Adolescents and youth to Reduce Stress), Basic psychoeducation
- Where
- Lithuania
- Volunteers
- 80 people
- Sponsor
- Vilnius University
Chronic Pain, Post-traumatic Stress Disorder
Treatment of Post-Traumatic Stress Disorder (PTSD) and Chronic Pain After Traumatic Orthopedic Injury
The purpose of this study is to examine the efficacy of multiple treatment options in addressing the co-morbidity between pain and PTSD symptoms.
- Trial name
- NCT00957164
- Testing
- Brief Prolonged Exposure Protocol, Chronic Pain Management Treatment, Self-Care
- Where
- 4 sites in United States
- Volunteers
- 51 people
- Sponsor
- The University of Texas at Arlington
Mental Health Issue, Trauma, Psychological
R34 Family Navigator Enhancing Early Engagement
For the current study, the investigators will develop, implement, and evaluate web-based and consultative training for Family Advocates employed at Children's Advocacy Centers (CACs) across the United States to enhance children's…
- Trial name
- NavE3 (NCT04221633)
- Testing
- Enhancing Early Engagement (E3) webinar, Consultation for E3 training
- Where
- 2 sites in United States
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Post-traumatic Stress Disorder
An Advanced Digital Phenotype System Among People Suffering From Post-traumatic Stress Disorder
Psychiatric diagnosis is based mainly on questioning the patient and subjective impression rather than a quantitative assessment.
- Trial name
- NCT03788278
- Testing
- BioBeat
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nadav Goldental
Marital Transgression, Marital Relationship
Efficacy of Islamic Integrated Forgiveness Therapy (IIFT) in Marital Relationship
The aim of the study was to test the indigenously developed and Islamic Integrated forgiveness therapy to deal the symptoms of depression, anxiety, stress, anger and ruminations after the occurrence of marital transgression.
- Conditions
- Marital Transgression, Marital Relationship, Forgiveness, Depression
- Trial name
- IIFT (NCT07869433)
- Testing
- Islamic Integrated Forgiveness Therapy (IIFT), Enright's Forgiveness Therapy (EFT)
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- University of the Punjab
Depressive Disorder, Major, Post Traumatic Stress Disorder
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot Trial
The proposed study will assess the combined effect of perampanel and ketamine on the anti-depressant response in individuals with treatment resistant depression.
- Conditions
- Depressive Disorder, Major, Post Traumatic Stress Disorder, Bipolar Disorder
- Trial name
- NCT03367533
- Testing
- Ketamine, Perampanel
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Yale University
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