Clinical trials: Mental Stress
Posttraumatic Stress Disorder, PTSD
D-cycloserine Adjunctive Treatment for Posttraumatic Stress Disorder (PTSD) in Adolescents
The purpose of this study is to show whether D-cycloserine in combination with cognitive behavioral therapy (CBT) is more effective than CBT plus placebo to reduce symptoms of posttraumatic stress disorder (PTSD) in 13-18…
- Trial name
- NCT01157429
- Testing
- D-cycloserine, CBT
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Tulane University School of Medicine
Alzheimer's Disease and Related Dementias
Pilot Testing Dementia-Enhanced Training and Tool for Home Hospice Clinicians
The purpose of this study is to pilot test the feasibility, acceptability, and preliminary efficacy of a clinically useful, inclusive dementia-enhanced training and tool for use by home hospice clinicians to improve care and…
- Trial name
- EDITH-HC (NCT05719077)
- Testing
- EDITH-HC
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Post Traumatic Stress Disorder, Opioid-use Disorder
Prolonged Exposure Therapy for PTSD and Opioid Use Disorder
Among patients with opioid use disorder (OUD), 90% report lifetime trauma exposure and 33% meet criteria for posttraumatic stress disorder (PTSD).
- Trial name
- NCT04104022
- Testing
- Prolonged Exposure Therapy, Attendance-based monetary incentives
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Vermont
Cognition, Brain Injuries
Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator
Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are common combat-related conditions that can result in impairments in cognition, including memory, attention and multi-tasking.
- Conditions
- Cognition, Brain Injuries, Stress Disorders, Post-Traumatic
- Trial name
- NCT07414537
- Testing
- Transcranial direct current stimulation (tDCS), Cognitive training
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- VA Office of Research and Development
Specific Phobia
Effects of Stress on Exposure Therapy
This study investigates whether stress can augment exposure therapy outcome in patients with specific phobia (spider phobia).
- Trial name
- NCT03505437
- Testing
- Cold water condition, Warm water condition
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Ruhr University of Bochum
Chronic Post-Traumatic Stress Disorder
Theta-Burst Neuromodulation for PTSD
The purpose of the proposed study is to evaluate initial feasibility and efficacy of Theta Burst Transcranial Magnetic Stimulation (TBS) as an adjunct treatment for Veterans with PTSD.
- Trial name
- TBS (NCT02769312)
- Testing
- Theta burst stimulation
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- VA Office of Research and Development
PTSD
Brief Treatment for Posttraumatic Stress Disorder
The primary goal of this study is to examine whether a brief treatment approach for PTSD is equally efficacious in the treatment of active duty service members relative to a first line treatment approach that requires much…
- Trial name
- NCT03033602
- Testing
- written exposure therapy, CPT, cognitive only
- Where
- 2 sites in United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Boston VA Research Institute, Inc.
Posttraumatic Stress Disorder
Mindfulness and Present Centered Therapies for PTSD: Efficacy and Mechanisms
This project will study whether a new therapy that includes the practice of forms of meditation is helpful for combat veterans returning from deployments in Iraq or Afghanistan suffering with posttraumatic stress disorder (PTSD).
- Trial name
- NCT01347749
- Testing
- Mindfulness & Compassion Meditation-based Exposure Therapy, Present Centered Therapy for PTSD
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- University of Michigan
Psychological Burnout, Stress, Psychological
A Virtual Reality Relaxation Intervention for Clinical Staff
Clinical staff working in mental health services experience high levels of work-related stress, burnout and poor wellbeing. They may work long hours, experience stress directly related to the emotional demands of the role and…
- Conditions
- Psychological Burnout, Stress, Psychological, Mental Health Burden
- Trial name
- NCT05601908
- Testing
- Virtual Reality Relaxation
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- King's College London
Posttraumatic Stress Disorders
PTSD Symptom Reduction by Propranolol Given After Trauma Memory Activation
This study is a randomized, double-blind, placebo-controlled clinical trial of propranolol combined with trauma memory reactivation, to determination if this approach is effective in treating PTSD symptoms.
- Trial name
- NCT00645450
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Office of Research and Development
Caregiving Stress, Dementia
Providing Evidence-Based Approaches for Caregiver Stress Study
The purpose of this preliminary study is to examine the effects of adult day service use on subjective and physiological measures of stress in 50 Black informal caregivers for individuals with dementia (IWD).
- Trial name
- PEACE (NCT06451250)
- Testing
- Adult Day Service use for family member with dementia
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Tardive Dyskinesia
Melatonin Treatment for Tardive Dyskinesia in Schizophrenia
This is a double-blind, randomized, placebo-controlled trial of melatonin as an add-on therapy to antipsychotics will be performed to examine the effects of melatonin on tardive dyskinesia symptoms and cognitive deficits in 120…
- Trial name
- NCT01391390
- Testing
- Melatonin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing HuiLongGuan Hospital
Post Traumatic Stress Disorder
Written Exposure Therapy for Post-traumatic Stress Syndrome
To investigate if written exposure therapy is feasible for patients with post-traumatic stress disorder
- Trial name
- NCT04328935
- Testing
- WET
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Karolinska Institutet
Anxiety, Depression
Quality of Dying in the Intensive Care Unit: Validation of the CAESAR Scale
The purpose of the study is to evaluate the quality of the dying process in french ICUs (assessed by the CAESAR scale) and to compare physicians', nurses' and relatives perceptions and experiences, with a one-year follow-up of…
- Conditions
- Anxiety, Depression, Posttraumatic Stress Disorder
- Trial name
- CAESAR (NCT01549197)
- Where
- 47 sites in France
- Volunteers
- 475 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Burnout, Mental Health
Mindful Hand Hygiene for Healthcare Workers
The purpose of this study is to test an intervention focused towards promoting mindfulness among VA physicians and nurses. Mindfulness is a tool that can help people focus. It helps clear the mind of distractions and biases.
- Trial name
- NCT05261282
- Testing
- Mindful Hand Hygiene
- Where
- 2 sites in United States
- Volunteers
- 343 people
- Sponsor
- VA Office of Research and Development
Mild Traumatic Brain Injury
Quetiapine to Reduce Post Concussive Syndrome After Mild Traumatic Brain Injury (mTBI)
A two site, 2-arm, Phase III randomized pragmatic clinical trial evaluating the effectiveness of quetiapine monotherapy in comparison to Treatment As Usual (TAU) medication management for symptoms experienced by veterans…
- Trial name
- NCT06333990
- Testing
- Quetiapine Fumarate, TAU
- Where
- 2 sites in United States
- Volunteers
- 146 people
- Sponsor
- Foundation for Advancing Veterans' Health Research
Hemodialysis, Stress
Mindfulness Meditation in Hemodialysis Patients
This randomised controlled study aims to evaluate the effects of mindfulness meditation on sleep quality, perceived stress and symptoms levels ion hemodialysis patients.
- Conditions
- Hemodialysis, Stress, Sleep Quality, Symptom
- Trial name
- MIND-HD (NCT07620990)
- Testing
- Mindfulness Meditation Program, Routine Care
- Where
- 4 sites in Cyprus
- Volunteers
- 50 people
- Sponsor
- Cyprus Aydin University
Cardiovascular Disease, Post Traumatic Stress Disorder
Cardiovascular Risk Markers in Veterans With Post Traumatic Stress Disorder
This is an observational study designed to determine whether veterans with PTSD have a higher risk of heart disease than those without PTSD.
- Trial name
- CVMarkers (NCT01650220)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium
Quality of Life
Medical Affairs Pharmaceutical Physician Work-related Quality of Life (MAPPWrQoL) Instrument Development and Patient Registry (MAPPWrQoLReg)
Existing evidence has shown that medical affairs pharmaceutical physicians (MAPPs), are a core function within the pharmaceutical industry.
- Trial name
- NCT05123846
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Medialis Ltd.
Stress Disorders, Post-Traumatic
A fMRI Study of the Treatment of Danish Veterans With PTSD With Prolonged Exposure Therapy
In this article, the investigators report the design and protocol of a functional magnetic resonance imaging study (fMRI) of the treatment of Danish veterans with PTSD with Prolonged Exposure Therapy (PE).
- Trial name
- NCT02519296
- Testing
- Prolonged Exposure Therapy, Observation, fMRI
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
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