Clinical trials: Mental Stress
Treatment Resistant Depression, Substance Use Disorders
Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder
The goal of this clinical trial is to learn if a single dose of psilocybin (5mg Vs 10mg Vs 25mg) alongside psychotherapy is safe and can help treat treatment resistant depression (TRD) with co-occurring substance use disorder…
- Trial name
- NCT07499583
- Testing
- Psilocybin
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Indiana University
Sleep Quality, Sleep Disorders
Plant Protein With Ashwagandha-Rhodiola for Sleep Quality
This study evaluates whether a combination of plant protein with adaptogenic herbs (ashwagandha and rhodiola) can improve sleep quality in middle-aged adults with sleep disturbances.
- Conditions
- Sleep Quality, Sleep Disorders, Insomnia
- Trial name
- TECOS (NCT07461402)
- Testing
- Plant Protein Supplement, Rhodiola rosea Extract, Ashwagandha KSM-66
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Universidad Pablo de Olavide
Post-Traumatic Stress Disorders
To Evaluate the Efficacy of EEG-guided Magnetic Resonant Therapy in War Veterans With Posttraumatic Stress Disorder
After 13 years of war, PTSD has become pervasive in service members. Traditionally it is evaluated by PTSD Checklist Military Version (PCL-M) and treated with cognitive processing therapy, prolonged exposure therapy and…
- Trial name
- NCT02824445
- Testing
- individualized Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- 72nd Medical Group, Tinker Air Force Base
PTSD
Acceptability and Feasibility of Apollo in Veterans With a History of PTSD
The proposed investigation is an open label pilot study intended to establish the acceptability and feasibility of the Apollo in a population of Veterans. Exploratory data regarding biological signatures will also be collected.
- Trial name
- Apollo PTSD (NCT05019651)
- Testing
- Apollo Wearable System
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Lisa Brenner
Mild Cognitive Impairment, Caregivers
iMeditate at Home for Older Adults With Mild Cognitive Impairment and Caregivers
Individuals diagnosed with mild cognitive impairment (MCI) are at a high risk of developing dementia and are an important target population for interventions that may reduce the risk of cognitive decline.
- Trial name
- NCT04184037
- Testing
- Mindfulness meditation delivered via a mobile app
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Baycrest
Violence, Non-accidental, Posttraumatic Stress Disorder
Addressing Traumatic Stress Symptoms in Children
The objective of this study is to evaluate the effectiveness of the Child and Family Traumatic Stress Intervention (CFTSI), provided soon after a violent traumatic event, in producing significant and sustained reduction in PTSS…
- Conditions
- Violence, Non-accidental, Posttraumatic Stress Disorder, Parent-Child Relations, Assault
- Trial name
- NCT03334942
- Testing
- Child and Family Traumatic Stress Intervention
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Children's Hospital of Philadelphia
Post Traumatic Stress Disorder
Use of CBD Oil in the Treatment of Posttraumatic Stress Disorder
The overarching objective of the proposed project is to test the clinical efficacy of CBD in the treatment of post-traumatic stress disorder using a rigorous double-blind randomized clinical trial methodology.
- Trial name
- NCT04197102
- Testing
- CBD Isolate, CBD Broad Spectrum
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Texas at Austin
Anxiety, Stress
Virtual Reality on Anxiety, Stress, Pain and Patient's Satisfaction Among Patients Undergoing Colonoscopy
The goal of this randomized controlled trial was to investigate the effect of Virtual Reality (VR) on anxiety, stress, pain, and patient satisfaction among Palestinian patients undergoing colonoscopy.
- Conditions
- Anxiety, Stress, Pain, Patient Satisfaction
- Trial name
- VR/RCT (NCT07145203)
- Testing
- Meta Quest 2 VR headset
- Where
- Palestinian Territories
- Volunteers
- 150 people
- Sponsor
- Cairo University
Anxiety Disorders, Depression
Hot Water Immersion Therapy for Mental Health
In 2016, it was estimated that nearly 1 billion people worldwide were affected by a mental or addictive disorder, and were associated with considerable excess mortality. Acute heat therapy sessions (e.g.
- Conditions
- Anxiety Disorders, Depression, Post-traumatic Stress Disorder, Heat
- Trial name
- WITHME (NCT04793542)
- Testing
- lower-limb hot water immersion
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Lakehead University
SCHIZOPHRENIA 1 (Disorder), Schizotypal Disorder
PS-Trauma - Development of Trauma Treatment for Patients With Co-morbid Psychotic Disorders and Traumas
Overview: People with psychotic disorders frequently have a history of traumatic events such as neglect, bullying, or physical and sexual abuse.
- Conditions
- SCHIZOPHRENIA 1 (Disorder), Schizotypal Disorder, Post Traumatic Stress Symptoms
- Trial name
- PS-Trauma (NCT07242586)
- Testing
- Prolonged Exposure, EMDR
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Nikolai Albert
Psychological Distress, Life Stress
The Effects of Mindfulness-based Training in Undergraduate Students of Translation and Interpreting
The Faculty of Translation and Interpreting of the University of Granada (UGR) has been leading the lists of the best faculties in this area in Spain and abroad for years.
- Conditions
- Psychological Distress, Life Stress, Anxiety, Perfectionism
- Trial name
- CRAFTftiugr (NCT04392869)
- Testing
- The CRAFT program (adapted due to COVID-19), The MBSR program (adapted due to COVID-19)
- Where
- Spain
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Sleep Deprivation, Cold Exposure
Modafinil to Optimize the Performance of Cold-Stressed Sleep-Deprived Personnel
Environmental and workplace stressors are common and often unavoidable in military operations. Two critical stressors are cold stress and sleep loss. They both can substantially degrade operational effectiveness.
- Trial name
- NCT07830056
- Testing
- Modafinil (M), 200 mg Microcrystalline Cellulose
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Intellectual Disabilities With Other Behavioral Symptoms, Acceptance Processes
Evaluation of an ACT and PBS Group for Parents and Education Staff
Parents and education staff who work with children with intellectual disabilities (ID) are known to be at a higher risk of experiencing psychological distress.
- Conditions
- Intellectual Disabilities With Other Behavioral Symptoms, Acceptance Processes, Psychological Distress, Burnout, Professional
- Trial name
- NCT03917329
- Testing
- ACT and PBS group workshop
- Where
- 2 sites in United Kingdom
- Volunteers
- 37 people
- Sponsor
- University of Edinburgh
Psychological Stress, Psychological Well-Being
DivAirCity Social Health Survey
To reduce stress among urban residents, the consortium members of the European Council Horizon 2020 research program DivAirCity install different stress reducing, noise reducing and air quality improving means in the five cities…
- Conditions
- Psychological Stress, Psychological Well-Being, Pollution; Exposure
- Trial name
- DivAirCitySH (NCT06274229)
- Testing
- Air pollution and noise reducing installations
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Post-Traumatic Stress Disorder
Brief Cognitive-Behavioral Treatment for Victims of Mass Violence
The objective of this randomized control trial is to compare the effectiveness of Stress Inoculation Training (SIT), a well researched psychological treatment for Post Traumatic Stress Disorder (PTSD), to that of the non-specific…
- Trial name
- NCT00495027
- Testing
- Internet-delivered Stress Innoculation Training
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Boston University
Vision Disorders, Stress, Psychological
Effectiveness of a Cognitive-behavioral Program of Coping With Psychological Stress in People With Retinitis Pigmentosa
The aim of this study is to evaluate the efficacy of cognitive - behavioral therapy for the control of psychopathological stress and the disease of people with Retinitis Pigmentosa (RP).
- Conditions
- Vision Disorders, Stress, Psychological, Psychopathy, Self Efficacy
- Trial name
- RCT (NCT03368027)
- Testing
- A cognitive-behavioral intervention program, Standard intervention
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad de Granada
Post Traumatic Stress Disorder
MDMA-Assisted Massed Exposure Therapy for PTSD
The goal of this clinical trial is to investigate the efficacy of 3,4-methylenedioxy-methamphetamine hydrochloride (MDMA) combined with Massed Prolonged Exposure (PE) therapy for the treatment of posttraumatic stress disorder…
- Trial name
- NCT07288151
- Testing
- 3,4-Methylenedioxymethamphetamine (MDMA), Massed Prolonged Exposure (PE)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Emory University
Stroke, Intracerebral Hemorrhage
ACT-group for Stroke Survivors (Pilot Study)
The goal of this clinical pilot trial is to test the feasibility, acceptance and preliminary efficacy of an adapted group psychotherapy manual in stroke survivors with psychological stress.
- Conditions
- Stroke, Intracerebral Hemorrhage, Depressive Symptoms, Anxiety
- Trial name
- NCT06282029
- Testing
- Group Therapy
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Bielefeld University
Fibromyalgia
Tailored Treatments of Fibromyalgia
This study will evaluate the effects of matching treatments to people with fibromyalgia syndrome (FMS) on the basis of their psychosocial and behavioral characteristics.
- Trial name
- NCT00000422
- Testing
- Cognitive-behavioral psychotherapy and physical exercise
- Where
- United States
- Volunteers
- 312 people
- Sponsor
- University of Washington
Psychological Stress, Perceived Stress
A Persian AI-Based CBT Chatbot and Voice Analysis System for Managing Perceived Stress
This pilot randomized controlled trial aims to evaluate a Persian-language artificial intelligence (AI)-based cognitive behavioral therapy (CBT) chatbot designed to support adults in managing perceived stress.
- Trial name
- PersianAI-CBT (NCT07840469)
- Testing
- Persian AI-Based CBT Chatbot, Active Mental Health Content
- Where
- Iran
- Volunteers
- 120 people
- Sponsor
- Hamid Reza Marateb
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