Clinical trials: Mental and Behavioral Disorders
Borderline Personality Disorder
Long Term Follow-up of Mentalization-Based Treatment: Exploring Variability in Outcomes, Long-term Value and Experiences 10+ Year After Receiving MBT Day Hospital or MBT Intensive Outpatient
This study is a long-term follow-up study of a previous multicenter randomized controlled trial, in which n=114 participants were included.
- Trial name
- MBT-EVOLVE (NCT07509216)
- Where
- 2 sites in Netherlands
- Volunteers
- 113 people
- Sponsor
- De Viersprong
Interpersonal Psychotherapy, Family Caregivers
Application of Group Interpersonal Psychotherapy (IPT-G) to Family Members Caring for Patients With Schizophrenia
The goal of this re-measured quasi-experimental study is to evaluate the effect of Group Interpersonal Psychotherapy (IPT-G) intervention given to caregiver family members of people with schizophrenia on caregiver burden…
- Trial name
- IPT-G (NCT05870384)
- Testing
- Group Interpersonal Psychotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Inflammation, Depression Disorder
Inflammatory Pathways Modulated by Prenatal Mindfulness: A Route to Improve Maternal Child Emotional Well Being and Whole Person Health
The goal of this study is to investigate inflammation as the biological mechanism by which mindfulness based cognitive therapy for perinatal depression (MBCT-PD) administered during pregnancy improves women's emotional well-being…
- Conditions
- Inflammation, Depression Disorder, Mindfulness, Emotional Well-being
- Trial name
- NCT07892326
- Testing
- Mindfulness-based cognitive therapy for perinatal depression, Pregnancy Health Group
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Oregon Health and Science University
Obsessive-compulsive Disorder
Booster as an Adjunct to Internet-based Cognitive Behavior Therapy (CBT)
In this trial, we test if adding an Internet-based booster program to regular Internet-based cognitive behavior therapy (ICBT) is effective for patients with obsessive-compulsive disorder (OCD).
- Trial name
- NCT01525576
- Testing
- Booster
- Where
- Sweden
- Volunteers
- 98 people
- Sponsor
- Karolinska Institutet
Schizophrenia
A Study to Evaluate the Effects of Once Daily Doses of AQW051 on Cognition, in Stable Schizophrenia Patients
This is a study in chronic stable Schizophrenia with the purpose to answer the question of whether agonism of the nicotinic alpha7 receptor is capable of enhancing cognition in a well defined chronic stable patient population…
- Trial name
- NCT01730768
- Testing
- AQW051
- Where
- 13 sites in United States
- Volunteers
- 147 people
- Sponsor
- Novartis Pharmaceuticals
Bipolar Disorder, Depression
A Study Of Kappa Opioid Receptor Occupancy Of PF-04455242, Using PET (Positron Emission Tomography)
This is a subject blind, investigator and sponsor open, randomized study consisting of 2 parts. Up to 15 healthy subjects will be included in the study.
- Trial name
- NCT00939887
- Testing
- PF-04455242
- Where
- 3 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Depressive Disorder, Major
A Study Of A New Medicine (GW597599B) For The Treatment Of Major Depressive Disorder
A Placebo Controlled Study Evaluating Efficacy And Safety of Medication In Patients With Major Depressive Disorder (MDD)
- Trial name
- NCT00048204
- Testing
- GW597599B, paroxetine
- Volunteers
- 372 people
- Sponsor
- GlaxoSmithKline
Primary Insomnia
The Effects of Modafinil on Waking Function and on Sleep in Individuals With Primary Insomnia
This study examines how treatment with the drug modafinil, by itself or in combination with cognitive behavioral treatment for insomnia (CBT-I), may improve daytime functioning and/or diminish the severity of insomnia.
- Trial name
- NCT00124384
- Testing
- CBT-I, modafinil
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Internalizing Psychopathologies (IPs) Depression and Anxiety
Negative Valence Brain Targets and Predictors of Anxiety and Depression Treatment
Internalizing psychopathologies (IPs) involving depression and anxiety are among the most prevalent, costly and disabling illnesses.
- Trial name
- NCT01903447
- Testing
- SSRI, CBT
- Where
- United States
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Major Depressive Disorder, Coronary Artery Disease
Vortioxetine in Patients With Major Depressive Disorder and Coronary Artery Disease
This is a preliminary, open-label, clinical trial designed to assess the efficacy, safety, and tolerability of vortioxetine for the treatment of major depressive disorder in patients with coronary artery disease.
- Trial name
- NCT02454426
- Testing
- Vortioxetine
- Where
- United States
- Sponsor
- Thomas Jefferson University
Substance Use Disorders, Insomnia
Feasibility of Brief Behavioral Therapy for Insomnia (BBTI) in SUD Recovery
The goal of this clinical study is to learn whether treating sleep problems is helpful in people with substance abuse problems who are living in a residential treatment program.
- Trial name
- BBTI_SUDs (NCT05935735)
- Testing
- Brief Behavioral Therapy for Insomnia (BBTI)
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Attention-deficit/Hyperactivity Disorder
The Metabolome Profiling and Pathway Analysis of ADHD
The purpose of this study is to understand the pathophysiological mechanisms of ADHD, especially the metabolomic pathway related to the behavioral/neuropsychological deficits of ADHD.
- Trial name
- NCT02942225
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Disruptive Behavior Disorders
The Parenting Young Children Check-up: Proof-of-Concept Trial
The Parenting Young Children Check-up (PYCC) is a 3-part system for parents of children with Disruptive Behavior Problems (DBPs).
- Trial name
- NCT04113304
- Testing
- Parenting Young Children Check-up (PYCC)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Wayne State University
Bipolar Disorder, Bipolar Depression
Seroquel in Bipolar Depression Versus SSRI
The purpose of this study is to determine whether quetiapine is effective and safe in the acute treatment of bipolar depression and whether the effect is maintained when treatment is continued.
- Conditions
- Bipolar Disorder, Bipolar Depression, Depression
- Trial name
- EMBOLDEN II (NCT00119652)
- Testing
- quetiapine fumarate (Seroquel), paroxetine, mood stabilizing activity
- Where
- 55 sites in United States, Australia and 9 more
- Volunteers
- 676 people
- Sponsor
- AstraZeneca
Multiple Sclerosis, Anxiety
Evaluating the Feasibility and Effectiveness of an Online Psychological Intervention Targeting Problem-Solving and Coping Strategies in People With Multiple Sclerosis
Multiple Sclerosis (MS) is a chronic autoimmune disease that affects the brain and spinal cord, often leading to unpredictable symptoms and significant emotional distress.
- Conditions
- Multiple Sclerosis, Anxiety, Problem Solving, Depression Anxiety Disorder
- Trial name
- NCT07507149
- Testing
- Problem-Solving Coping Strategies (PCS) Intervention, Treatment as usual (TAU)
- Where
- Lebanon
- Volunteers
- 30 people
- Sponsor
- American University of Beirut Medical Center
Pain Dysfunction, Sleep Disturbance
Cognitive Behavioral Therapy for Arthritis Pain and Insomnia in Older Adults
This study compares the efficacy of three group interventions for people with co-morbid osteoarthritis (OA) and insomnia to help them manage their OA symptoms.
- Conditions
- Pain Dysfunction, Sleep Disturbance, Osteoarthritis
- Trial name
- Lifestyles (NCT01142349)
- Testing
- Lifestyles A, Lifestyles B, Lifestyles C
- Where
- 2 sites in United States
- Volunteers
- 367 people
- Sponsor
- University of Washington
Case Management, Managed Care Program
San Francisco Health Plan Care Support Trial
This study will expand and evaluate an existing pilot program to improve care for frequent users of acute emergency and inpatient services by providing care coordination and management for eligible San Francisco Health Plan…
- Trial name
- SFHP_CBCM (NCT02463838)
- Testing
- Care Support Intervention
- Where
- United States
- Volunteers
- 292 people
- Sponsor
- University of California, San Francisco
Subthreshold Depression, Exercise
The Effect of Exercise on Cognition and Preventing Depression in Young People
It is estimated that approximately 30% of child and adolescents manifest subthreshold depression (including other specified depressive disorder and unspecified depressive disorder), which can further develop into major depression…
- Conditions
- Subthreshold Depression, Exercise, Clinically-well, Cognitive Change
- Trial name
- NCT04816617
- Testing
- Aerobic exercise intervention, Psycho-education
- Where
- China
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital
Suicide, Trauma, Psychological
Wakȟáŋyeža (Little Holy One)
The overall goal of this study is to develop, adapt and evaluate an intergenerational prevention intervention, named "Wakȟáŋyeža (Little Holy One)," with Native American caregivers on a Northern Plains reservation and the…
- Conditions
- Suicide, Trauma, Psychological, Parenting
- Trial name
- NCT04201184
- Testing
- Newly created cultural components, adapted Family Spirit lessons, adapted CETA modules, Active nutrition control
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Autism Spectrum Disorder
The Effect of the Low Fodmap Diet in Children With Autism Spectrum Disorders
This study assesses the effect of the low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diet on gastrointestinal (GI) and behavioral problems in children with autism spectrum disorder (ASD).
- Trial name
- NCT04054349
- Testing
- Low FODMAP diet
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Ohio State University
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