Clinical trials: Meropenem
Enterobacteriaceae Infections
Effect of Imipenem and Meropenem on the Digestive Microbiota and the Emergence and Carriage of Multidrug-resistant Bacteria
Among enterobacteria, ESBL production is the leading cause of multidrug resistance. The first cases of ESBL-producing Enterobacteriaceae (EBLSE) infections were described in the 1980s and subsequently spread worldwide.
- Trial name
- MERIMI (NCT05516433)
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Pulmonary Tuberculosis
Study to Evaluate EBA, Safety and Tolerability of Carbapenems in Adults With Pulmonary Tuberculosis
The goal of this single-center, open-labelled, clinical trial in two groups aims to proof that a specific group of antibiotics (carbapenems) can be used to treat pulmonary tuberculosis if it is combined with another antibiotic…
- Trial name
- NCT05896930
- Testing
- Meropenem 6g IV over 6 hours, Ertapenem 1g IM, Meropenem 3g IV
- Where
- South Africa
- Volunteers
- 134 people
- Sponsor
- TASK Applied Science
Predictors and Outcomes of Meropenem Treatment Failure
Predictors and Outcomes of Meropenem Treatment Failure Among Patients With Septic Shock in Intensive Care Unit
Lately, the inappropriate used of Meropenem in critically ill patient were increased. Therefore, increased development of drug resistance bacteria towards Meropenem.
- Trial name
- Meropenem (NCT04042662)
- Testing
- no intervention
- Volunteers
- 400 people
- Sponsor
- Universiti Sains Malaysia
Complicated Intra-abdominal Infection
Safety and Efficacy Study to Compare IV CXA 101/Tazobactam and Metronidazole With Meropenem in Complicated Intraabdominal Infections
A Phase 2, multicenter, prospective, randomized, double-blind study of CXA-101/ tazobactam (1000/500 mg q8h) and metronidazole (500 mg q8h) IV infusion vs.
- Trial name
- NCT01147640
- Testing
- CXA-101/ tazobactam and metronidazole
- Where
- 33 sites in United States, Argentina and 3 more
- Volunteers
- 122 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Complicated Intra-abdominal Infections
Prospective Multicenter Doubleblind Randomized Study of NXL104/Ceftazidime + Metronidazole vs. Meropenem in Treatment of Complicated Intra-abdominal Infections
The purpose of this study is to determine whether NXL104 plus ceftazidime is effective in the treatment of complicated intra-abdominal infections as compared to a comparator group.
- Trial name
- NCT00752219
- Testing
- ceftazidime/NXL104 + metronidazole, meropenem
- Where
- 45 sites in United States, Bulgaria and 6 more
- Volunteers
- 204 people
- Sponsor
- Pfizer
Urinary Tract Infections, Acute Pyelonephritis
Safety and Efficacy Study of Cefepime/VNRX-5133 in Patients With Complicated Urinary Tract Infections
This study will assess the safety and efficacy of cefepime/VNRX-5133 compared with meropenem in both eradication of bacteria and in symptomatic response in patients with cUTIs.
- Trial name
- CERTAIN-1 (NCT03840148)
- Testing
- Cefepime/VNRX-5133 (taniborbactam), Meropenem
- Where
- 78 sites in United States, Argentina and 13 more
- Volunteers
- 661 people
- Sponsor
- Venatorx Pharmaceuticals, Inc.
Pharmacokinetics, Amoxicillin-clavulanate
Antibiotic Dosing in Pediatric Intensive Care
Pharmacokinetics of antibiotics in critically ill neonates, infants and children
- Conditions
- Pharmacokinetics, Amoxicillin-clavulanate, Piperacillin-tazobactam, Vancomycin
- Trial name
- ADIC (NCT02456974)
- Testing
- blood sampling in patients receiving amoxicillin-clavulanate as part of routine clinical care, blood sampling in patients receiving piperacilline-tazobactam as part of routine clinical care., blood sampling in patients receiving vancomycin as part of routine clinical care.
- Where
- Belgium
- Volunteers
- 640 people
- Sponsor
- University Hospital, Ghent
Bloodstream Infections
Trial of Meropenem Versus Piperacillin-Tazobactam on Mortality and Clinial Response
Infections of the blood are extremely serious and require intravenous antibiotic treatment. When the infection results from antibiotic resistant bacteria, the choice of antibiotic is an extremely important decision.
- Trial name
- MERINO II (NCT02437045)
- Testing
- Meropenem, Piperacillin-tazobactam combination product
- Where
- 6 sites in Australia, Singapore
- Volunteers
- 100 people
- Sponsor
- The University of Queensland
Beta Lactam Resistant Bacterial Infection, Enterobacteriaceae Infections
PipEracillin/Tazobactam Versus mERoPENem for Treatment of AmpC Producing Blood Stream Infections
Data regarding optimal treatment for extended-spectrum beta-lactamase (ESBL) producing Enterobacterales bloodstream infection are lacking.
- Conditions
- Beta Lactam Resistant Bacterial Infection, Enterobacteriaceae Infections, Bacteremia
- Trial name
- SPICE-M (NCT05355350)
- Testing
- Piperacillin / Tazobactam Injection, Meropenem
- Where
- 4 sites in Israel
- Sponsor
- Rambam Health Care Campus
Infections
Validation of Betalactam ML Prediction Models - TDMAide
The goal of this study is to learn about the real wold behavior of developed machine learning models that predict the plasma concentration of piperacillin-tazobactam and meropenem in critically ill patients admitted to the…
- Trial name
- TDMAide (NCT06026852)
- Testing
- Prediction of plasma concentration of piperacillin-tazobactam or meropenem, Determination of plasma concentration of piperacillin-tazobactam or meropenem, Daily short questionnaire
- Where
- Belgium
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Allogenic Blood Stem Cell Transplantation, Febrile Neutropenia
Meropenem Versus Meropenem Plus Glycopeptide in Patients With Febrile Neutropenia After Allogenic Blood Stem Cell Transplantation
Observational study to compare the treatment in neutropenic patients after allogenic blood stem cell transplantation, with meropenem or meropenem plus glycopeptide.
- Trial name
- MERONEM (NCT00462878)
- Testing
- Meropenem, Vancomycin, Teicoplanin
- Where
- 64 sites in Spain
- Volunteers
- 392 people
- Sponsor
- PETHEMA Foundation
Peritoneal Dialysis-associated Peritonitis, Peritoneal Dialysis (PD)
Pharmacokinetics of Intraperitoneal and Intravenous Meropenem, Ampicillin, Aztreonam and Ciprofloxacin in Automated Peritoneal Dialysis Patients Without Peritonitis
This study aims to investigate the pharmacokinetics (PK) and pharmacodynamic (PD) profiles of four commonly used antibiotics - meropenem, ampicillin, aztreonam, and ciprofloxacin - administered via intravenous (i.v.) and…
- Conditions
- Peritoneal Dialysis-associated Peritonitis, Peritoneal Dialysis (PD), Pharmacokinetics, Intravenous Administration
- Trial name
- NCT07113587
- Testing
- Application of intraperitoneal and intravenous meropenem in in automated peritoneal dialysis patients without peritonitis, Application of intraperitoneal and intravenous ampicillin in automated peritoneal dialysis patients without peritonitis, Application of intraperitoneal and intravenous aztreonam in automated peritoneal dialysis patients without peritonitis
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Karl Landsteiner Insitute for Nephrology and Haemato-Oncology
Melioidosis
A Randomized Double Blinded Comparison of Ceftazidime and Meropenem in Severe Melioidosis
Melioidosis, an infection caused by the bacterium Burkholderia pseudomallei, is a major cause of community-acquired septicaemia in northeast Thailand.
- Trial name
- ATOM (NCT00579956)
- Testing
- Meropenem, Ceftazidime
- Where
- 2 sites in Thailand
- Volunteers
- 750 people
- Sponsor
- University of Oxford
Nephrotoxicity, Bacterial Infections
Differentiating True Nephrotoxicity From Pseudo-nephrotoxicity: A Prospective Comparative Study of Vancomycin Plus Piperacillin-Tazobactam vs. Meropenem Using Serum Creatinine and Cystatin-C
This prospective comparative observational study will compare the incidence of true nephrotoxicity in adult patients receiving vancomycin in combination with either piperacillin-tazobactam or meropenem.
- Conditions
- Nephrotoxicity, Bacterial Infections, Acute Kidney Injury, Renal Impairment
- Trial name
- NCT07818265
- Where
- Saudi Arabia
- Volunteers
- 304 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Extensively Drug-Resistant Typhoid Fever, Typhoid Fever
This Randomized Controlled Trial Evaluates the Comparative Efficacy of Intravenous Meropenem Alone Versus Intravenous Meropenem Combined With Oral Azithromycin in Children Aged 6 Months to Under 5 Years Diagnosed With Blood Culture-confirmed Extensively Drug-resistant Uncomplicated Typhoid Fever
This randomized controlled trial evaluates the comparative efficacy of intravenous meropenem alone versus intravenous meropenem combined with oral azithromycin in children aged 6 months to under 5 years diagnosed with blood…
- Conditions
- Extensively Drug-Resistant Typhoid Fever, Typhoid Fever, Salmonella Typhi Infection
- Trial name
- XDR-TY (NCT07445282)
- Testing
- Meropenem, Azithromycin + Metronidazole
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Sheikh Zayed Medical College
Late Onset Neonatal Sepsis
Bolus Versus Prolonged Infusion of Meropenem in Newborn With Late Onset Sepsis
Newborns in the neonatal intensive care unit (NICU), especially premature ones with immature organ systems, frequently suffer nosocomial infections caused by microorganisms resistant to narrow-spectrum antibiotics like ampicillin…
- Trial name
- BVPIMNBLOS (NCT02503761)
- Testing
- Meropenem.
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Ventilator-associated Bacterial Pneumonia
Trial of Colistin Versus Meropenem in Ventilator-associated Pneumonia (VAP) (CR-GNB)
1. To demonstrate that colistin iv. is not inferior to meropenem in empiric treatment of VAP regarding the final point of primary efficacy: mortality in the 28 subsequent days and clinical healing in patients clinically…
- Trial name
- MagicBullet (NCT01292031)
- Testing
- Colistin, Meropenem
- Where
- 33 sites in Greece, Italy and 1 more
- Volunteers
- 232 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Pancreatitis, Acute Necrotizing
A Study to Determine if Antibiotics Prevent Infection in the Pancreas of Patients Where Part of the Pancreas Has Died
This is a research study in patients having a condition known as necrotizing pancreatitis. This is inflammation of the pancreas (an intestinal organ which assists with digestion) that has resulted in the damage and death of some…
- Trial name
- NCT00061438
- Testing
- meropenem
- Where
- 11 sites in United States, Canada
- Volunteers
- 240 people
- Sponsor
- Pfizer
Urinary Tract Infections, Enterobacteriaceae Infections
Piperacillin/Tazobactam Versus Carbapenems in Non-bacteremic UTI Due to -ESBL-producing Enterobacteriaceae
This study evaluates the efficacy in achieving clinical cure in non-bacteremic urinary tract infections (UTI) caused by Escherichia coli or Klebsiella pneumoniae producers of extended-spectrum β-lactamases (ESBL) in adult…
- Conditions
- Urinary Tract Infections, Enterobacteriaceae Infections, Infection Due to ESBL Bacteria, Carbapenem
- Trial name
- CAPITIS (NCT03891433)
- Testing
- Meropenem, Ertapenem 1000 MG, Piperacillin, Tazobactam 4-0.5G Solution for Injection
- Where
- Colombia
- Volunteers
- 198 people
- Sponsor
- Universidad del Norte
Complicated Intra-abdominal Infections
Ceftolozane/Tazobactam (MK-7625A) Plus Metronidazole Versus Meropenem for Participants With Complicated Intra-abdominal Infection (MK-7625A-015)
This study aims to evaluate the efficacy of ceftolozane/tazobactam (MK-7625A) plus metronidazole versus meropenem in adults diagnosed with complicated intra-abdominal infection (cIAI).
- Trial name
- 7625ACNPhase3 (NCT03830333)
- Testing
- Ceftolozane/Tazobactam, Metronidazole, Meropenem
- Where
- 25 sites in China
- Volunteers
- 268 people
- Sponsor
- Merck Sharp & Dohme LLC