Clinical trials: Meropenem
Complicated Urinary Tract Infection, Acute Pyelonephritis
Study of Cefepime-tazobactam (FEP-TAZ) in Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)
This is a Phase III, randomized, double-blind, multicenter, non-inferiority study to evaluate the efficacy, safety, and tolerability of FEP-TAZ vs. meropenem in the treatment of hospitalized adults with cUTI or AP.
- Trial name
- NCT03630081
- Testing
- WCK 4282 (FEP-TAZ) 4 g, Meropenem, ciprofloxacin 500 mg Optional Oral Switch
- Volunteers
- 1,004 people
- Sponsor
- Wockhardt
Urinary Tract Infections
A Study to Investigate the Pharmacokinetics of RO7079901 and Meropenem in Participants With a Complicated Urinary Tract Infection
This is a non-randomized, open-label, one-treatment, one group study in participants with complicated urinary tract infection (cUTI) including pyelonephritis to characterize the pharmacokinetics of RO7079901 co-administered with…
- Trial name
- NCT03174795
- Testing
- RO7079901, Meropenem
- Where
- 14 sites in United States, Hungary and 3 more
- Volunteers
- 20 people
- Sponsor
- Hoffmann-La Roche
Septic Shock
Meropenem and Ciprofloxacin Dosing in Septic Shock
Patients with septic shock may have altered volume of distribution and metabolism of antibiotics which are crucial medications for treating infections.
- Trial name
- NCT02240277
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hospital-Acquired Bacterial Pneumonia, Ventilator-Associated Bacterial Pneumonia
A Study of Meropenem-Vaborbactam Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia
The purpose of this study is to determine the efficacy, safety, tolerability, and pharmacokinetics (PK) of meropenem-vaborbactam compared to piperacillin/tazobactam for 7 to 14 days in the treatment of hospitalized adults who…
- Conditions
- Hospital-Acquired Bacterial Pneumonia, Ventilator-Associated Bacterial Pneumonia, Hospital-Acquired Pneumonia, Ventilator-Associated Pneumonia
- Trial name
- TANGOIII (NCT03006679)
- Testing
- Meropenem-Vaborbactam, Piperacillin/Tazobactam
- Sponsor
- Melinta Therapeutics, Inc.
Cardiac Dysfunction
Population Pharmacokinetics of Teicoplanin, Levofloxacin, Piperacillin/Tazobactam, Meropenem, Vancomycin, Remifentanil, Cefepime, Cefpirome, Sufentanil, Midazolam, Clopidogrel, Ticagrelor, Prasugrel During Veno-arterial Extracorporeal Membrane Oxygenation (VA ECMO)
Extracorporeal membrane oxygenation (ECMO) is the device which increases the supply of oxygen to the body tissues in vitro and to assist in heart and lung function.
- Trial name
- NCT02581280
- Testing
- Residual blood
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yonsei University
Amoxicillin-clavulanate, Piperacillin-tazobactam
Precision Dosing of Beta-lactam Antibiotics in Critically Ill Children
The overall objective of this study is to investigate the impact of early model-informed precision dosing (MIPD) on target attainment of three beta-lactam antibiotics (amoxicillin-clavulanic acid, piperacillin-tazobactam and…
- Conditions
- Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem
- Trial name
- MOMENTUM (NCT06929702)
- Testing
- Beta-lactam antibiotic, Beta-lactam model-informed precision dosing
- Where
- Belgium
- Volunteers
- 58 people
- Sponsor
- University Hospital, Ghent
Infection, Renal Failure
Pharmacokinetics of Meropenem During High-dose CRRT
Assessment of meropenem plasma concentration in critically ill patients who require CRRT (continuous renal replacement therapy). A standard dose of meropenem is administered, i.e. 1 gram every 8 hours.
- Trial name
- NCT03507751
- Testing
- Meropenem, CRRT
- Where
- Poland
- Volunteers
- 19 people
- Sponsor
- Medical University of Lublin
Obesity
Pharmacokinetics of Carbapenem Antibiotics in Obese Patients.
Tissue kinetics of ertapenem and meropenem in fatty tissue, intraperitoneal fluid and plasma.
- Trial name
- NCT01407965
- Testing
- microdialysis catheter
- Where
- 2 sites in Germany
- Volunteers
- 13 people
- Sponsor
- University of Ulm
Lower Respiratory Tract Infection
Meropenem Dosage Strategy Based on PPK Model
To evaluate the clinical and economical benefits of a meropenem dosage strategy based on a population pharmacokinetic(PPK)-pharmacodynamic(PD) model in lower respiratory tract infection patients.
- Trial name
- NCT01944319
- Testing
- Routine meropenem therapy, Meropenem therapy based on a PPK and PD model
- Where
- China
- Volunteers
- 79 people
- Sponsor
- Qingtao Zhou
Nosocomial Pneumonia (NP), Ventilator-associated Pneumonia (VAP)
A Study Comparing Ceftazidime-Avibactam Versus Meropenem in Hospitalized Adults With Nosocomial Pneumonia
The purpose of the study is to evaluate the effects of Ceftazidime-Avibactam compared to Meropenem for treating hospitalized adults with nosocomial pneumonia including ventilator-associated pneumonia
- Trial name
- NCT01808092
- Testing
- ceftazidim-avibactam (CAZ-AVI, experimental product), meropenem (active comparator)
- Where
- 123 sites in Argentina, Brazil and 24 more
- Volunteers
- 969 people
- Sponsor
- Pfizer
Pancreatitis
Evaluation of Pancreatic Tissue Penetration of Meronem® in the Prophylaxis of Septic Complications in Severe Pancreatitis
To measure meropenem pancreatic tissue penetration in subjects with severe pancreatitis requiring surgery between 30 to 60 minutes after a bolus of 1 g IV meropenem given during the induction period of anesthesia.
- Trial name
- NCT00318994
- Testing
- Meropenem
- Where
- Colombia
- Volunteers
- 6 people
- Sponsor
- Pfizer
Infections
Antimicrobial De-escalation Strategy in Medical Patients
The purpose of this pilot study is to assess the impact of an antibiotic de-escalation strategy on the clinical outcomes (clinical cure or improvement) of medical patients related to the usage of of broad-spectrum antimicrobial…
- Trial name
- NCT01066013
- Testing
- Antimicrobial de-escalation strategy
- Volunteers
- 100 people
- Sponsor
- Fraser Health
Multi-antibiotic Resistance
Use of New Antibiotics in Sweden
Antibiotic resistance is a growing global health problem of great concern, especially multidrug-resistant Gram-negative bacteria. In recent years some new antibiotics targeting these bacteria have been developed.
- Trial name
- NCT05048693
- Where
- 7 sites in Sweden
- Volunteers
- 41 people
- Sponsor
- Uppsala University
Sepsis, Septic Shock
Monitoring of Piperacillin-Tazobactam and Meropenem Plasmatic Levels in Critical Patients
The aim of this study is to establish the Piperacillin-Tazobactam and Meropenem Plasmatic Levels to know if it´s necessary to make some adjustment in the recommended dose regimen.
- Trial name
- NCT04257838
- Testing
- Piperacillin/tazobactam or Meropenem
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Pseudomonas
Impact of Modifications to the Rendering of the Antibiogram on the Prescriptions of Meropenem in Pseudomonas Bacteremia
Modification of the rendering of the antibiogram at the Strasbourg University Hospital in November 2019 with the appearance of the concept of "standard dose" or "high dose" sensitivity.
- Trial name
- Mero-Pyo (NCT06113107)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
Empirical Antimicrobial Therapy, Critically Ill
Empirical Meropenem Dosing in Critically Ill Patients: Early Assessment of Plasma Exposure and Minimum Inhibitory Concentration Targets
The goal of this prospective cohort study is to characterize meropenem exposure in critically ill adult patients receiving empiric antibiotic treatment in the intensive care unit (ICU).
- Conditions
- Empirical Antimicrobial Therapy, Critically Ill, Meropenem, Pharmacokinetics and Pharmacodynamics
- Trial name
- NCT07681544
- Testing
- Blood extraction
- Where
- Argentina
- Volunteers
- 26 people
- Sponsor
- Hospital Italiano de Buenos Aires
Pediatric Patients Receiving Venoarterial Extracorporeal Membrane Oxygenation
Population Pharmacokinetics of Vancomycin, Meropenem, Milrinone, Dexmedetomidine and Fentanyl in Pediatric Patients During Extracorporeal Membrane Oxygenation
Extracorporeal membrane oxygenation (ECMO) has been used primarily in newborns since it was first successfully implemented in the 1970s, and has recently increased use in infants and young children.
- Trial name
- NCT04701099
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Sepsis
THE ROLE OF PANCREATIC STONE PROTEIN (PSP) AND PSP-GUIDED EARLY MEROPENEM TREATMENT TO MITIGATE SEPSIS RISK AT THE EMERGENCY DEPARTMENT: THE PROMISE DOUBLE BLIND, PHASE III, RANDOMIZED CONTROLLED CLINICAL TRIAL
The goal of this clinical trial is to demonstrate the clinical benefit of early intervention with meropenem in adult patients of both sexes with suspected infection and risk of sepsis.
- Trial name
- PROMISE (NCT07813767)
- Testing
- Meropenem Infusion, Sodium Chloride (NaCl) 0.9 %
- Where
- 10 sites in Greece
- Volunteers
- 398 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
MDR Bacteria
Comparing Efficacy and Safety of (Meropenem + Colistin) Versus (Imipenem/Cilastatin + Tigecycline) on Eradication of Multi-Drug Resistance Bacteria
This study aims to compare the efficacy and safety of two antibiotic combinations (Colistin + Meropenem) vs (Imipenem/cilastatin+ Tigecycline) in the treatment of adults with MDR gram-negative infections.
- Trial name
- NCT07524920
- Testing
- "Imipenem/cilastatin" and "Tigecycline", "colistin" and "meropenem"
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Sepsis, Bacterial Infection
EFFICACY OF PROLONGED INFUSION MEROPENEM IN CRITICALLY ILL PAEDIATRIC INTENSIVE CARE PATIENTS
As a broad-spectrum carbapenem, meropenem is one of the most commonly used antibiotics for critically ill pediatric patients who have severe infections.
- Trial name
- NCT07122596
- Testing
- Meropenem Infusion
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- Pakistan Navy Station Shifa Hospital