Clinical trials: Mesenchymal Stem Cell
Osteoarthritis
The Safety and Efficacy of XytriX (Umbilical Cord-Derived Mesenchymal Stem Cells) in the Treatment of Knee Osteoarthritis
This study aims to study the safety and efficacy of XytriX, an umbilical cord-derived stem cell product, in the treatment of Grade I-IV knee osteoarthritis.
- Trial name
- NCT07487766
- Testing
- Mesenchymal Stem Cell Injection
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- TricelX Inc.
Critical Limb Ischemia
Cell Therapy in Critical Limb Ischemia
Study drug and dosage form : Umbilical cord-derived mesenchymal stem cells (HB-MSC1) Dose and route of administration : 60 × 106 cells or 120 x 106 cells to be injected as 30 individual intramuscular injections, once at V0 within…
- Trial name
- CLI (NCT03994666)
- Testing
- allogeneic umbilical cord-derived mesenchymal stem cells
- Where
- France
- Volunteers
- 30 people
- Sponsor
- CHU de Reims
Chronic Kidney Diseases, Diabetes Mellitus
Inflammation and Stem Cells in Diabetic and Chronic Kidney Disease
The proposed studies will examine the effect of fisetin on adipose tissue-derived mesenchymal stem/stromal cell function, kidney function, markers of inflammation, and physical function in individuals with advanced chronic kidney…
- Conditions
- Chronic Kidney Diseases, Diabetes Mellitus, Diabetic Nephropathies
- Trial name
- NCT03325322
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Multiple Sclerosis
Mesenchymal Stem Cell Transplantation in MS
The study is a randomized Phase II study, masked and crossed-over with placebo to evaluate the safety and tolerability of autologous mesenchymal stem cell transplantation in patients with active multiple sclerosis
- Trial name
- CMM-EM (NCT01228266)
- Testing
- autologous mesenchymal stem cells
- Where
- Spain
- Volunteers
- 9 people
- Sponsor
- Albert Saiz
Osteoarthritis
Comparing Mesenchymal Stem Cell Counts in Unilateral vs. Bilateral Posterior Superior Iliac Spine Bone Marrow Aspiration
Musculoskeletal conditions are common sources of pain. Specifically, osteoarthritis affects nearly 27 million people in the United States.
- Trial name
- NCT03014037
- Testing
- Unilateral Bone Marrow Procurement, Bilateral Bone Marrow Procurement
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Emory University
Systemic Lupus Erythematosus
Umbilical Cord Derived Mesenchymal Stem Cells Transplantation for Active and Refractory Systemic Lupus Erythematosus
This study will explore safety and efficacy of allogeneic umbilical cord (UC) derived mesenchymal stem cells transplantation (MSCT) to treat patients with active and refractory systemic lupus erythematosus (SLE) who have been…
- Trial name
- NCT01741857
- Testing
- human umbilical cord derived MSC transplantation for SLE
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
COVID-19, SARS-CoV 2
Efficacy and Safety Evaluation of Mesenchymal Stem Cells for the Treatment of Patients With Respiratory Distress Due to COVID-19
Randomized, double-blind, parallel, two-arms clinical trial to assess the efficacy and safety of 2 infusions of Wharton-Jelly mesenchymal stromal cells (day 1 and day 3, endovenously at 1E6cells/Kg per dose) in patients with…
- Conditions
- COVID-19, SARS-CoV 2, Adult Respiratory Distress Syndrome
- Trial name
- COVIDMES (NCT04390139)
- Testing
- XCEL-UMC-BETA
- Where
- 5 sites in Spain
- Volunteers
- 26 people
- Sponsor
- Banc de Sang i Teixits
Hypoxic-Ischemic Encephalopathy, Neonatal, Brain Injuries, Hypoxic-Ischemic
Mesenchymal Stem Cells With Cooling Therapy for Infants With Hypoxic-Ischemic Encephalopathy
Hypoxic-ischemic encephalopathy (HIE) is a serious condition in newborns caused by lack of oxygen and blood flow around the time of birth.
- Trial name
- SiSTEM-NEO (NCT07018739)
- Testing
- Wharton's jelly-derived mesenchymal stem cells, 0.9 % Normal Saline
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Osteoarthritis, Spinal Arthritis
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cells for OA
This trial will study the safety and efficacy of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells delivered intravenously and intraarticularly for the treatment of Osteoarthritis.
- Trial name
- NCT05147675
- Testing
- AlloRx
- Where
- 2 sites in United States, Greece
- Volunteers
- 92 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Cartilage Diseases, Osteoarthritis
Human Umbilical Cord Mesenchymal Stem Cell Transplantation in Articular Cartilage Defect
The purpose of this study is to evaluate the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC) for articular cartilage defect of knee.
- Trial name
- NCT02291926
- Testing
- Human umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Hornetcorn Bio-technology Company, LTD
Chronic Pancreatitis, Mesenchymal Stem Cells
Autologous Mesenchymal Stromal Cells and Islet Co-transplantation in TP-IAT
This is a clinical trial for chronic pancreatitis (CP) patients undergoing total pancreatectomy with islet autotransplantation (TP-IAT).
- Trial name
- NCT05095532
- Testing
- Bone marrow-derived mesenchymal stem cells
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Medical University of South Carolina
Asthma
Allogeneic Human Cells (hMSC) Via Intravenous Delivery in Patients With Mild Asthma
A Phase 1 investigation will be performed to test the safety of two doses of bone marrow-derived MSCs (20,000,000 and 100,000,000) administered via peripheral intravenous infusion.
- Trial name
- ASTEC (NCT03137199)
- Testing
- hMSCs
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Marilyn Glassberg
Liver Failure, Mesenchymal Stem Cell
MSC-EVs in Acute/ Acute-on-Chronic Liver Failure After Liver Transplantation
Acute liver failure (ALF) refers to a potentially reversible disorder that was the result of severe liver injury, with an onset of encephalopathy within 8 weeks of symptom appearance and in the absence of pre-existing liver…
- Conditions
- Liver Failure, Mesenchymal Stem Cell, Extracellular Vesicles
- Trial name
- NCT06825572
- Testing
- MSC-EVs
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Crohn's Disease, Fistula
Dose-escalating Therapeutic Study of Allogeneic Bone Marrow Derived Mesenchymal Stem Cells for the Treatment of Fistulas in Patients With Refractory Perianal Crohn's Disease
In a dose escalation study we will determine the safety and preliminary efficacy of allogeneic bone marrow mesenchymal stem cells (bmMSCs) in the induction of response for active fistulizing Crohn's Disease (CD).
- Trial name
- NCT01144962
- Testing
- Localization, curettage of the fistulous tract and closure of the internal opening without MSC injection., Localization, curettage of the fistulous tract and closure of the internal opening with local MSC injection.
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Leiden University Medical Center
Human Immunodeficiency Virus, Disorder of Immune Reconstitution
Umbilical Cord Mesenchymal Stem Cells for Immune Reconstitution in HIV-infected Patients
HIV-1 infection is characterized by progressive depletion of CD4+ T cells that eventually leads to clinically significant immunodeficiency.
- Trial name
- NCT01213186
- Testing
- high dose of MSC, low dose of MSC treatment
- Where
- 3 sites in China
- Volunteers
- 72 people
- Sponsor
- Fu-Sheng Wang
Systemic Lupus Erythematosus
Phase 2 Trial of Mesenchymal Stem Cells in Systemic Lupus Erythematosus (MiSLE)
The purpose of this study is to evaluate the efficacy and safety of mesenchymal stem cells (MSCs) obtained from umbilical cords for the treatment of adults with systemic lupus erythematosus (SLE).
- Trial name
- NCT02633163
- Testing
- Low Dose Mesenchymal Stem Cells (MSCs), High Dose Mesenchymal Stem Cells (MSCs)
- Where
- 9 sites in United States
- Volunteers
- 81 people
- Sponsor
- Medical University of South Carolina
Diabetes
Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for Diabetes
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord derived mesenchymal stem cells for the treatment of Diabetes
- Trial name
- NCT05003908
- Testing
- AlloRx
- Where
- 2 sites in Antigua and Barbuda, Argentina
- Volunteers
- 2 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Alcoholic Cirrhosis
Clinical Trial to Evaluate the Efficacy and Safety of Cellgram-LC Administration in Patients With Alcoholic Cirrhosis
The goal of this clinical trial is to evaluate the efficacy and safety of Cellgram-LC in patients with alcoholic cirrhosis. The main questions it aims to answer are: Is Cellgram-LC superior to best supportive care (BSC) in…
- Trial name
- Cellgram-LC (NCT04689152)
- Testing
- Cellgram-LC, Best Supportive Care (BSC)
- Where
- 15 sites in South Korea
- Volunteers
- 200 people
- Sponsor
- Pharmicell Co., Ltd.
Renal Transplantation, Mesenchymal Stem Cells
Mesenchymal Stromal Cells in Living Donor Kidney Transplantation
Kidney transplantation is a good treatment option for people with kidney disease. However, there is still much to learn about how to best care for the transplanted kidney and keep it functioning for a long time.
- Trial name
- NCT03478215
- Testing
- Mesenchymal Stromal Stem Cells (MSCs) Infusion
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The Methodist Hospital Research Institute
Sjorgren's Syndrome
Intraglandular Treatment With Adipose-derived Mesenchymal Stem Cells in Patients With Xerostomia Due to Sjögren's Disease
Living with dry mouth significantly impacts daily life, causing constant discomfort. It makes it harder to talk, eat solid food (increasing the risk of malnutrition), swallow, and sleep well.
- Trial name
- ASSIX (NCT06805448)
- Testing
- MSC, Saline Water (Control)
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet