Clinical trials: Mesenchymal Stem Cells
Mesenchymal Stem Cell-derived Bioactivator for Treating Chronic Wounds
Mesenchymal Stem Cell-derived Pleiotropic Factor in Treating Non-healing Wounds
Chronic wounds do not heal for prolonged periods of time with the significant financial burden on the healthcare system. It has become increasingly essential to improve our clinical treatments.
- Trial name
- NCT04235868
- Testing
- Stem cell-derived derived pleiotropic factor, fibroblast growth factor
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Lupus Nephritis, Mesenchymal Stem Cells
Allogeneic Amniotic Mesenchymal Stem Cell Therapy for Lupus Nephritis
This study would further evaluate the safety and efficacy of human amniotic mesenchymal stem cell (hA-MSC) for the treatment of lupus nephritis (LN).
- Trial name
- NCT04318600
- Testing
- human amniotic mesenchymal stem cell
- Volunteers
- 16 people
- Sponsor
- Yan'an Affiliated Hospital of Kunming Medical University
Cardiovascular Diseases, Heart Failure
Randomized Study of Coronary Revascularization Surgery With Injection of WJ-MSCs and Placement of an Epicardial Extracellular Matrix
Ischemic heart disease is one of the most important causes of mortality and morbidity in the Western world and is a public health problem.
- Conditions
- Cardiovascular Diseases, Heart Failure, Coronary Artery Disease, Mesenchymal Stem Cell Transplantation
- Trial name
- scorem-cells (NCT04011059)
- Testing
- Wharton's jelly-derived mesenchymal cells
- Where
- Colombia
- Volunteers
- 40 people
- Sponsor
- Hospital San Vicente Fundación
Tracheal Stenosis, Laryngeal Stenosis
Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells
The trial evaluates the safety and efficacy of the olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis
- Conditions
- Tracheal Stenosis, Laryngeal Stenosis, Mesenchymal Stem Cells
- Trial name
- NCT03130374
- Testing
- Olfactory mucosa-derived mesenchymal stem cells
- Where
- 2 sites in Belarus
- Volunteers
- 12 people
- Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology
Intracranial Hemorrhages, Mesenchymal Stem Cells
Follow-Up Study of Safety of Pneumostem® in Premature Infants With Intraventricular Hemorrhage
This is a follow-up study of the open label, single-center, phase I clinical trial to evaluate the safety of Pneumostem® in premature infants with Intraventricular hemorrhage.
- Conditions
- Intracranial Hemorrhages, Mesenchymal Stem Cells, Newborn Infant
- Trial name
- NCT02673788
- Testing
- observation without intervention in this follow up study
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Samsung Medical Center
Mesenchymal Stem Cell Transplantation
Intraosseous Administration of Mesenchymal Stromal Cells for Patients With Graft Failure After Allo-HSCT
Multipotent mesenchymal stromal cells (MSCs) participate in the formation of bone marrow niches for hematopoietic stem cells. Donor MSCs can serve as a source of recovery for niches in patients with graft failure (GF) after…
- Trial name
- NCT03389919
- Testing
- MSC administration (intraosseal)
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- National Research Center for Hematology, Russia
Mesenchymal Stem Cells
Adipose-tissue Derived Stem Cells in Flaps Versus Liposuction
The aim of the study is to evaluate a physiological concentration of adipose tissue-derived stem cells (ASC) in excised fat versus fat harvested by liposuction.
- Trial name
- NCT03105284
- Testing
- Liposuction
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Mesenchymal Stem Cells, Chronic Kidney Diseases
Treatment of Chronic Renal Failure With Adipose Tissue-derived Mesenchymal Stem Cells
To investigate the biological characteristics of adipose tissue-derived mesenchymal stem cells(AMSCs) and its treatment effects on chronic renal failure.
- Conditions
- Mesenchymal Stem Cells, Chronic Kidney Diseases, Renal Interstitial Fibrosis
- Trial name
- NCT03321942
- Testing
- Treatment group, Control group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Osteoblast, Adipocytes
Effect of Thiazolidinediones on Human Bone
We will prospectively study 2 groups of diabetic patients treated with pioglitazone or placebo for 26 weeks. Bone marrow aspirates will be obtained from these patients at baseline and after 26 weeks of treatment, and hBMCs will…
- Conditions
- Osteoblast, Adipocytes, Bone Density, Osteocalcin
- Trial name
- NCT00927355
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Liver Failure, Mesenchymal Stem Cells
Safety and Efficacy of Human Mesenchymal Stem Cells for Treatment of Liver Failure
Liver failure (LF) is a dramatic clinical syndrome with massive necrosis of liver cells. and liver transplantation is the only available therapeutic option for patients suffering with this condition.
- Trial name
- NCT01218464
- Testing
- Conventional plus MSC treatment, Conventional plus pacebo treatment
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Beijing 302 Hospital
Mesenchymal Stem Cells
Cartilage Tissue Engineering
In this study, the investigators explored the hypothesis that osteoarthritic cartilage fragments can promote chondrogenesis of MSCs.
- Trial name
- NCT01301664
- Testing
- total knee / hip replacement
- Sponsor
- Chin-Hung Chang
Stem Cell Transplantation, Hematopoietic, Mesenchymal Stem Cells
Mesenchymal Stem Cells for Treatment of Poor Graft Function After Allogeneic Hematopoietic Stem Cell Transplant
The purpose of this study is to evaluate the utility of treating patients experiencing poor graft function after allogeneic hematopoietic stem cell transplantation with ex-vivo-expanded BM-drived mesenchymal stem cells from…
- Conditions
- Stem Cell Transplantation, Hematopoietic, Mesenchymal Stem Cells, Poor Graft Function, Hematological Diseases
- Trial name
- NCT01763086
- Testing
- Mesenchymal stem cells
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Hematopoietic Stem Cell Transplantation, Mesenchymal Stem Cells
Mesenchymal Stem Cells Combined With Cord Blood for Treatment of Graft Failure
The purpose of this study is to evaluate the utility of treating patients experiencing graft failure after autologous hematopoietic stem cell transplantation with ex-vivo-expanded BM-drived mesenchymal stem cells from third-party…
- Conditions
- Hematopoietic Stem Cell Transplantation, Mesenchymal Stem Cells, Umbilical Cord Blood, Graft Failure
- Trial name
- NCT01763099
- Testing
- Mesenchymal stem cells, Mesenchymal stem cells and cord blood
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Liver Failure, Mesenchymal Stem Cells
Therapeutic Effects of Liver Failure Patients Caused by Chronic Hepatitis B After Autologous MSCs Transplantation
The study aimed to investigate the short-term efficacy and long-term prognosis of liver failure patients caused by hepatitis B after single transplantation with autologous marrow mesenchymal stem cells (MMSCs).
- Trial name
- NCT00956891
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Sun Yat-sen University
Liver Cirrhosis, Radiology
Umbilical Cord Mesenchymal Stem Cells Infusion Via Hepatic Artery in Cirrhosis Patients
The purpose of this study is to investigate the efficacy of umbilical cord mesenchymal stem cells (MSCs) infusion via hepatic artery in the treatment of liver cirrhosis.
- Conditions
- Liver Cirrhosis, Radiology, Mesenchymal Stem Cells, Umbilical Cord
- Trial name
- NCT01224327
- Testing
- umbilical cord Mesenchymal Stem Cells, Conserved therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Qingdao University
Ulcerative Colitis, Mesenchymal Stem Cells
Umbilical Cord Mesenchymal Stem Cells Infusion for Ulcerative Colitis
The purpose of this study is to determine whether umbilical cord Mesenchymal Stem Cells of treatment for ulcerative colitis is safe and effective.
- Conditions
- Ulcerative Colitis, Mesenchymal Stem Cells, Umbilical Cord
- Trial name
- NCT01221428
- Testing
- Umbilical Cord Mesenchymal Stem Cells
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Qingdao University
Diabetic Foot, Critical Limb Ischemia
Umbilical Cord Mesenchymal Stem Cells Injection for Diabetic Foot
The purpose of this study is to determine whether umbilical cord Mesenchymal Stem Cells of treatment for diabetic foot is safe and effective in the management of diabetic foot ischemia, the therapeutic effect of stem cells is…
- Conditions
- Diabetic Foot, Critical Limb Ischemia, Mesenchymal Stem Cells, Umbilical Cord
- Trial name
- NCT01216865
- Testing
- umbilical cord mesenchymal stem cells, Standard Therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Qingdao University
Diabetes Mellitus, Diabetes Mellitus, Type 1
Umbilical Cord Mesenchymal Stem Cells Infusion for Initial Type 1 Diabetes Mellitus
The purpose of this study is to determine whether umbilical cord Mesenchymal Stem Cells of treatment for initial type 1 diabetes is safe and effective.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Mesenchymal Stem Cells, Umbilical Cord
- Trial name
- NCT01219465
- Testing
- umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Qingdao University
Sjogren's Syndrome, Mesenchymal Stem Cells
Allogeneic Mesenchymal Stem Cells Transplantation for Primary Sjögren's Syndrome (pSS)
This study will explore safety and efficacy of allogeneic mesenchymal stem cells transplantation (MSCT) to treat patients with diagnosis of primary Sjögren's Syndrome (pSS) who have been resistant to multiple standard treatments.
- Trial name
- NCT00953485
- Testing
- Allogeneic Mesenchymal Stem Cells (AlloMSC)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Systemic Sclerosis, Mesenchymal Stem Cells
Allogeneic Mesenchymal Stem Cells Transplantation for Systemic Sclerosis (SSc)
This study will explore safety and efficacy of allogeneic mesenchymal stem cells transplantation (MSCT) to treat patients with diagnosis of systemic sclerosis(SSc) who have been resistant to multiple standard treatments.
- Trial name
- NCT00962923
- Testing
- Allogeneic Mesenchymal Stem Cells (AlloMSC)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School