Clinical trials: Mesh Infection
Hernia, Ventral Hernia
Prospective Clinical Evaluation of High-Purity Type I Collagen in Select High-Risk Hernia Repair Scenarios
This prospective, single-arm clinical study evaluates the safety, feasibility, and early clinical outcomes of High-Purity Type I Collagen (HPTC; Surgicoll-Mesh®) when used as a biologic reinforcement in selected hernia repair…
- Conditions
- Hernia, Ventral Hernia, Incisional Hernia, İnguinal Hernia
- Trial name
- NCT07360691
- Testing
- High-Purity Type I Collagen Mesh
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Incisional Hernia of Anterior Abdominal Wall, Dehiscence Wound
Prevention of Incisional Hernia With Mesh-suture at Umbilical Trocar Site.
Incisional hernia related to the umbilical trocar site is probably the most frequent complication after laparoscopic surgical procedures.
- Conditions
- Incisional Hernia of Anterior Abdominal Wall, Dehiscence Wound, Wound Infection
- Trial name
- INDURATE (NCT06251583)
- Testing
- duramesh suture
- Where
- Spain
- Volunteers
- 124 people
- Sponsor
- Miguel A ngel Garci-a Urena
Parastomal Hernia
Prevention of Parastomal Hernia With a Mesh
Parastomal hernias are randomised to either a conventional stoma formed through the rectus anterior muscle or to the same procedure with the addition of a prophylactic mesh in a sublay position.
- Trial name
- NCT00509054
- Testing
- Prophylactic mesh
- Where
- Sweden
- Volunteers
- 54 people
- Sponsor
- Sundsvall Hospital
Chronic Hepatitis C Virus
Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed-Dose Combination (FDC) With and Without Ribavirin for the Treatment of HCV
The purpose of this study is to evaluate the safety, tolerability, and antiviral efficacy of ledipasvir (LDV)/sofosbuvir (SOF) fixed-dose combination (FDC) tablets with or without ribavirin (RBV) administered for 12 and 24 weeks…
- Trial name
- NCT01701401
- Testing
- LDV/SOF, RBV
- Where
- 88 sites in United States, France and 5 more
- Volunteers
- 870 people
- Sponsor
- Gilead Sciences
Relapsed, Diffuse Large B-cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma
Study of Betalutin for Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma (LYMRIT-37-05)
This study is a phase 1, dose finding, open-label study in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL).
- Trial name
- NCT02658968
- Testing
- Betalutin
- Where
- 10 sites in United States, Germany and 3 more
- Volunteers
- 18 people
- Sponsor
- Nordic Nanovector
Strangulated Hernia
Mesh Hernioplasty Of Strangulated Hernias With Intestinal Resection
Primary suture repair increases the risk for recurrence, the fact of benefit of mesh repair in elective situations is documented, and many studies have reported beneficial outcomes of mesh hernioplasty in emergency situations.
- Trial name
- NCT01411397
- Testing
- SURGERY, mesh repair
- Where
- Egypt
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Surgical Site Infection
Environmental Risk Factors of Mesh Infection After Abdominal Wall Hernia Repair
Mesh infection is the main complication in abdominal hernia repair. In case of infection, a conservative management of mesh is not always possible.
- Trial name
- NCT04174976
- Testing
- wall hernia repair
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Chronic Hepatitis C Virus
Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed-Dose Combination ± Ribavirin in Treatment-Experienced Subjects With Genotype 1 HCV Infection
This study is to evaluate the safety, tolerability, and antiviral efficacy of ledipasvir/sofosbuvir fixed dose combination (FDC) with or without ribavirin (RBV) administered for 12 or 24 weeks in treatment-experienced subjects…
- Trial name
- ION-2 (NCT01768286)
- Testing
- LDV/SOF, RBV
- Where
- 53 sites in United States
- Volunteers
- 441 people
- Sponsor
- Gilead Sciences
Hernia, Inguinal, Chronic Pain
A Comparative Study of 3-point With 1-point Mesh Fixation in TAPP for Gilbert Type III Inguinal Hernia
This study was designed to compare the outcome of 3 point with 1 point lightweight mesh fixation in TAPP surgery for patients with type Ⅲ gilbert inguinal hernia. The main outcome include seroma, chronic pain, recurrence, et al.
- Conditions
- Hernia, Inguinal, Chronic Pain, Seroma, Recurrence
- Trial name
- NCT05929378
- Testing
- Lightweight mesh fixation
- Where
- China
- Volunteers
- 351 people
- Sponsor
- Nanchong Central Hospital
Incisional Hernia, Wound Infection
Prophylactic Sub-lay Non-absorbable Mesh Following Midline Laparotomy: PROMETHEUS (PROphylactic Mesh Trial Evaluation UltraSound)
The aim of the present study is to analyse feasibility, safety and Incisional Hernia rate using a prophylactic sub lay non-absorbable mesh [Parietex Progrip (Medtronic) ] in order to prevent Incisional Hernia following midline…
- Trial name
- PROMETHEUS (NCT04436887)
- Testing
- positioning of polypropylene strips for prophylactic purposes in closing the middle laparotomies to prevent the incisional hernia
- Volunteers
- 200 people
- Sponsor
- Francesco Pizza
Breast Cancer, Breast Implant; Complications, Infection or Inflammation
Randomized Feasibility Trial for Mesh in Pre-Pectoral Reconstruction
Surgical mesh products, particularly acellular dermal matrices (ADM), are now used by the majority of plastic surgeons to assist with the nearly 100,000 prosthetic breast reconstruction procedures in the United States, despite…
- Trial name
- NCT05190978
- Testing
- Acellular Dermal Matrix, Reconstruction without ADM
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
Peritonitis, Incisional Hernia
Prophylactic Mesh Implantation in Patients With Peritonitis for the Prevention of Incisional Hernia
In patients undergoing laparotomy, the incidence of abdominal wall related complications such as incisional hernia is very high.
- Conditions
- Peritonitis, Incisional Hernia, Surgery
- Trial name
- PerProMe (NCT01802164)
- Testing
- A non-absorbable composite mesh (Ethicon Physiomesh)
- Where
- Switzerland
- Volunteers
- 5 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Colorectal Cancer, Wound Infection
Comparing PP and PVDF Meshes in Midline Laparotomy Closure for High-risk Colorectal Surgery. Impact on Incisional Hernia and Surgical Wound Infection.
In the latest guidelines for abdominal wall closure in emergency surgery published in the World Journal of Emergency Surgery (WJES) in 2023, no specific recommendations are made in this regard.
- Conditions
- Colorectal Cancer, Wound Infection, Hernia Incisional
- Trial name
- PROFIMESH (NCT06220045)
- Testing
- Polyvinylidene fluoride mesh, Prophylactic polypropylene mesh
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Hernia, Ventral
Complex Ventral Hernia Repair Using Biologic or Synthetic Mesh
Hernias are often treated using a prosthetic mesh to add support to the healing wound. Prosthetic meshes have been used for decades to repair ventral hernias, level 1 data regarding which type of mesh to use is limited.
- Trial name
- CVHR (NCT02041494)
- Testing
- Ventralight, Strattice
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Hobart Harris
Cardiac Implantable Electronic Device Infection
TYRX™ Envelope for Prevention of Infection Following Replacement With a CRT or ICD
The purpose of this study is to compare the incidence of cardiac implantable electronic device (CIED) infection and CIED mechanical complication after CIED replacement with a high-power cardiac implantable electronic device…
- Trial name
- Centurion (NCT01043705)
- Where
- 52 sites in United States
- Volunteers
- 1,262 people
- Sponsor
- TYRX, Inc.
Patients Undergoing Open Hernia Repair, Patients Undergoing Ventral or Inguinal Hernia Repair
Reducing Mesh Infections in Open Hernia Repairs
Soaking meshes in a vancomycin solution just prior to their use in open hernia repairs will decrease rates of mesh infection
- Trial name
- NCT01860469
- Testing
- vancomycin-soaked mesh, plain mesh
- Where
- Canada
- Sponsor
- University of Saskatchewan
Incisional Hernia, Ventral Hernia
Risk Factors for Mesh Infection After Abdominal Wall Reconstruction
Abdominal wall reconstruction (AWR) with mesh is the standard repair for ventral, incisional, parastomal and complex abdominal wall defects, but mesh-related infection remains one of its most serious complications - prolonging…
- Conditions
- Incisional Hernia, Ventral Hernia, Parastomal Hernia, Abdominal Wall Defect
- Trial name
- NCT07725718
- Where
- Egypt
- Volunteers
- 420 people
- Sponsor
- Minia University
Colorectal Cancer, Incisional Hernia
Comparing Polypropylene Mesh and "Small Bites" Technique in Emergency Colorectal Surgery's Midline Laparotomy Closure. Study for Incisional Hernia Prevention.
The 2023 World Journal of Emergency Surgery guidelines couldn't provide a recommendation for emergency abdominal wall closure due to insufficient consensus (>80% required).
- Conditions
- Colorectal Cancer, Incisional Hernia, Wound Infection
- Trial name
- BITEME (NCT06220058)
- Testing
- Closure of the midline laparotomy using the "small bites" technique, Closure of the midline laparotomy using the "small bites" technique with an absorbable PP mesh
- Where
- Spain
- Volunteers
- 148 people
- Sponsor
- Fernandez Zamora
Ventral Hernia, Incisional Hernia
Comparison of Sublay and Onlay Mesh Repair in Ventral Hernia
This study is designed to compare two different surgical methods for repairing ventral abdominal wall hernias: sublay mesh repair and onlay mesh repair.
- Trial name
- NCT07140471
- Testing
- Onlay Mesh Repair, Sublay Mesh Repair
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Sana Ehsan ullah
Ventral Hernia
Cost-effectiveness Analysis Between Biosynthetic and Biological Parietal Prostheses
Eventration corresponds to the dehiscence of the abdominal wall, with passage of peritoneum and / or intra-abdominal viscera, through an acquired orifice of the abdominal wall.
- Trial name
- NCT03590184
- Where
- France
- Volunteers
- 114 people
- Sponsor
- University Hospital, Strasbourg, France