Clinical trials: Metabolic Complication
Type 2 Diabetes Mellitus, Vascular Complications
Platelet Indices and Blood Groups in Type 2 Diabetes Vascular Complications
This cross-sectional study aims to evaluate the association of platelet indices and ABO blood groups with vascular complications in patients with type 2 diabetes mellitus.
- Trial name
- NCT07847099
- Volunteers
- 100 people
- Sponsor
- Assiut University
Dehydration
Efficacy of a Smart Water Bottle Intervention to Increase Fluid Consumption in College Students
Approximately 60% of males and 40% of females do not meet current fluid intake recommendations, which is associated with adverse health consequences such as obesity, diabetes, and chronic kidney disease.
- Trial name
- NCT06259799
- Testing
- Smart Water Bottle
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kennesaw State University
Diabetes, Diabetic Kidney Disease
Effect of Acute Hypoxia on Renal Hemodynamic in Healthy Volunteers, Patients With Diabetes and Patients With Diabetes and Kidney Disease
Diabetes mellitus is a non-transmissible disease whose incidence is growing worldwide . This pathology is defined by a chronic hyperglycaemia linked to a deficiency of either insulin secretion or its action or both.
- Conditions
- Diabetes, Diabetic Kidney Disease, Hypoxia, Healthy Volunteer
- Trial name
- DIAKIPOX (NCT06846034)
- Testing
- Hypoxia administration study group, Renal clairance study
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Anovulation, Obesity
An RCT of Metformin Vs Orlistat in Obese Anovulatory Women
This study aims to investigate the role of the weight reduction agent, Orlistat compared to the Metformin for the management of women who are obese and do not ovulate or have difficulty conceiving.
- Trial name
- NCT00292799
- Testing
- Orlistat Vs Metformin
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Chronic Kidney Diseases, High Cholesterol
Evolocumab In Advanced Chronic Kidney Disease Trial
110 individuals with stage 4-5 Chronic Kidney Disease (CKD) will be randomized to 1-year of blinded Evolocumab or placebo. Subjects will undergo evaluation of circulating lipids at baseline and end of study.
- Trial name
- EVO-CKD (NCT04510844)
- Testing
- Evolocumab
- Where
- 2 sites in United States
- Sponsor
- NYU Langone Health
Fetal Growth Restriction, Gut Microbiota
Gut Microbiota, SCFAs and Glucolipid Metabolism in Pregnant Women With Abnormal Fetal Size and Their Newborns
Abnormal fetal size includes fetal growth restriction and fetal macrosomia. Onset is closely related to maternal nutrition metabolism.
- Conditions
- Fetal Growth Restriction, Gut Microbiota, Fetal Macrosomia, Glucolipid Metabolism
- Trial name
- NCT04399434
- Testing
- test gut microbiota, SCFAs and glucolipid metabolism and insulin sensitivity
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
X Linked Hypophosphatemia
Burden of Disease and Functional Impairment in XLH
Observational study comprising prospective follow up as well as retrospective chart review in order to evaluate the longitudinal course of the disease in XLH patients with a specific focus on functional impairment, physical…
- Trial name
- IdeFIX (NCT04946409)
- Testing
- no intervention
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Wuerzburg University Hospital
Gestational Diabetes, Cardiovascular Risk Factors
Autonomic Nervous System and Exercise In Gestational Diabetes
The focus of this study is on individualized exercise prescription on primary prevention of cardiovascular diseases (CVD). Special attention is set on autonomic nervous system function and inflammation.
- Trial name
- ANS-EXE (NCT01675271)
- Testing
- individual exercise, general exercise
- Where
- Finland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Polycystic Ovary Syndrome
Effect of Exercise on Cardiometabolic Profile in Women With Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS) is a complex hormonal and metabolic disorder that has been shown to affect women's fertility. It can also share many symptoms with pre-diabetes, and women with PCOS often have an increased risk…
- Trial name
- NCT03678714
- Testing
- Exercise Intervention, Lifestyle Physical Activity
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Sheffield Hallam University
Diabetic Nephropathy
To Assess the Accuracy of the eZscan Study in the Screening for Diabetic Nephropathy
Diabetes mellitus (DM) is a metabolic disorder commonly encountered by the healthcare professionals. Diabetic nephropathy is one of its complications, which is becoming the most common cause of end-stage renal failure in Hong…
- Trial name
- NCT01163591
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Secondary Hyperparathyroidism, Chronic Kidney Disease-Mineral and Bone Disorder
Injection of Teriparatide to Prevent Hypocalcemia After Parathyroidectomy in Dialysis Patients (TeriCa).
This is a pilot randomized controlled trial aimed to evaluate the effect of teriparatide on the clinical course of hypocalcemia after parathyroidectomy for secondary hyperparathyroidism in dialysis-dependent patients.
- Conditions
- Secondary Hyperparathyroidism, Chronic Kidney Disease-Mineral and Bone Disorder, Dialysis, Hypocalcemia
- Trial name
- TeriCa (NCT04750460)
- Testing
- Teriparatide
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Saint Petersburg State University, Russia
Preterm Birth, Pediatric Cancer
eHealth as an Aid for Facilitating and Supporting Self-management in Families With Long-term Childhood Illness
The overall aim is twofold: 1) to stretch the borderline regarding the present knowledge of clinical and economic cost-effectiveness of eHealth as an aid for facilitating and supporting self-management in families with long-term…
- Conditions
- Preterm Birth, Pediatric Cancer, Hirschsprung Disease, Congenital Malformation
- Trial name
- eChildHealth (NCT04150120)
- Testing
- e-health device with application, Mobile phone text messaging, early detection of cerebral palsy using a mobile phone application
- Where
- 7 sites in Denmark, Ethiopia and 1 more
- Volunteers
- 720 people
- Sponsor
- Lund University
Endometriosis
Effect of Quercetin Supplementation on Endometriosis Outcomes
Quercetin is a polyphenol compound that possesses anti-inflammatory properties and can be found in various food sources like apples, berries, cabbage, and onions.
- Trial name
- NCT05983224
- Testing
- Quercetin
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- National Nutrition and Food Technology Institute
Renal Insufficiency
Pharmacokinetics (PK) and Metabolism of FTY720 in Patients With Severe Renal Impairment and Healthy Matched Subjects.
The purpose of this study is to compare the pharmacokinetics of FTY720 and its metabolites in patients with severe renal insufficiency and in matched, healthy volunteers.
- Trial name
- NCT00731523
- Testing
- fingolimod (FTY720)
- Where
- Russia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Novartis
Polycystic Ovary Syndrome, PCOS
Insulin Differences Between African-American and Caucasian Female Adolescents With Polycystic Ovary Syndrome (PCOS)
The purpose of this research study is to see if there are differences between African-American and Caucasian girls with Polycystic Ovary Syndrome (PCOS) in how their bodies respond to a type of sugar, called glucose, the body's…
- Trial name
- NCT02052479
- Testing
- Frequently Sampled Intravenous Glucose Tolerance Test (FSIVGTT)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Nationwide Children's Hospital
Glucose Metabolism Disorders, Lipid Metabolism Disorders
Metabolic Complications Following Knee Injury in Young and Middle Aged Patients
Introduction This study evaluates the effect on glucose, lipid and bone metabolism following knee orthopedic procedures in healthy and physically active individuals.
- Conditions
- Glucose Metabolism Disorders, Lipid Metabolism Disorders, Sedentary Lifestyle
- Trial name
- OrthoMetKnee (NCT02573662)
- Testing
- Blood and Urine sampling, DXA scan, OGTT
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Haugaard, Steen Bendix, M.D., DMSc
Hirsutism, Type 2 Diabetes
Prospective Study of Patients With Hirsutism
Hirsutism is the presence of terminal hairs in a male-like pattern in females, due to elevated male hormone levels. Females with hirsutism are often overweight and have metabolism disturbances as insulin resistance and impaired…
- Conditions
- Hirsutism, Type 2 Diabetes, Polycystic Ovary Syndrome
- Trial name
- NCT00145288
- Where
- Denmark
- Volunteers
- 340 people
- Sponsor
- Odense University Hospital
Sarcoidosis, Hypercalcemia Due to Sarcoidosis
ACTHAR GEL for Sarcoidosis-Associated Calcium Dysregulation: An Open-label Pilot Study
ACTHAR Gel has activity in sarcoidosis associated hypercalciuria and calcium dysregulation.
- Trial name
- NCT02155803
- Testing
- ACTHAR Gel (adrenocorticotropic hormone)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Albany Medical College
Congenital Adrenal Hyperplasia
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Crinecerfont in Participants With Classic Congenital Adrenal Hyperplasia (CAH) Who Are Less Than 4 Years Old
The main objective of this study is to assess the safety and tolerability of crinecerfont in pediatric participants 3 months to <4 years of age with CAH.
- Trial name
- NCT07536269
- Testing
- Crinecerfont
- Where
- 11 sites in United States
- Volunteers
- 20 people
- Sponsor
- Neurocrine Switzerland GmbH
Diabetic Neuropathies, Diabetes Mellitus, Type 2
A Study To Evaluate The Effect Of Topiramate On Clinical And Electrophysiological Parameters In Subjects With Diabetic Peripheral Polyneuropathy
The purpose of the study is to evaluate the effect of topiramate on clinical and electrophysiological parameters in patients with diabetic peripheral polyneuropathy.
- Conditions
- Diabetic Neuropathies, Diabetes Mellitus, Type 2, Polyneuropathies
- Trial name
- NCT00231673
- Testing
- Topiramate
- Volunteers
- 72 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.