Clinical trials: Metabolic Control, open to volunteers
Postmenopause, Overweight
Spirulina Supplementation in Postmenopausal Women
The purpose of this study is to investigate the effects of spirulina supplementation on weight gain associated with menopause, changes in metabolic parameters, sleep quality, and markers of depression in mildly overweight…
- Trial name
- NCT07718399
- Testing
- Spirulina
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Halic University
Postoperative Delirium
Effects of Different Preoperative Oral Rehydration Protocols in Undergoing Thoracoscopic Radical Lung Cancer Surgery
This study aims to compare the new preoperative oral rehydration protocol (administering 50-100 mL of clear fluids or carbohydrate-rich beverages orally every hour until the patient arrives at the operating room) with the…
- Trial name
- NCT07042503
- Volunteers
- 420 people
- Sponsor
- Fujian Medical University Union Hospital
Chronic Kidney Disease, Type II Diabetes
Heart-Kidney-Diabetes Multidisciplinary Care MOdels for CardiovascuLar Health In Patients With Chronic Kidney DiSease and Diabetes: A PragmaTIC Cluster Randomized Controlled Trial (HOLISTIC)
Our overarching goal of this study is to provide rigorous evidence for using an accelerated risk-based approach to implementing guideline directed medical therapies (GDMT) using a multidisciplinary care model (MCM) versus a usual…
- Trial name
- HOLISTIC (NCT07811427)
- Testing
- The intervention with the MCM is Kidney-Heart GDMT initiation and titration for dose optimization (as clinically tolerated), within 4 months of enrollment in the study.
- Volunteers
- 570 people
- Sponsor
- Baim Institute for Clinical Research
Irritable Bowel Syndrome
Effect of Chronic Feeding of Inulin And Methylcellulose on Colonic Fermentation
To determine the effect on tolerance and gas production from chronic feeding of fermentable fibre (inulin) incorporated into a gel forming fibre (methylcellulose) compared with placebo (maltodextrin)
- Trial name
- CINNAMON (NCT06551961)
- Testing
- methylcellulose, inulin, maltodextrin
- Where
- 2 sites in United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Type 2 Diabetes
Regimen Transition After Short-Term Intensive Insulin Therapy in Type 2 Diabetes
Failure of oral antidiabetic drugs (OADs) is a frequent challenge in patients with type 2 diabetes mellitus (T2DM), and inadequate long-term glycemic control substantially increases the risk of diabetic complications.
- Trial name
- NCT07173712
- Testing
- CSII, Insulin glargine /lixisenatide Fixed Ratio Combination, Insulin Degludec and Insulin Aspart Injection
- Volunteers
- 324 people
- Sponsor
- Yanbing Li
Heart Failure With Preserved Ejection Fraction, Iron Deficiencies
The Effects of Ferric Derisomaltose in Patients With Acute Heart Failure and Iron Deficiency on Exercise Capacity and Quality of Life
This study will address whether the additional use of Ferric Derisomaltose on top of standard care will improve exercise capacity and quality of life in patients with acute heart failure and iron deficiency.
- Conditions
- Heart Failure With Preserved Ejection Fraction, Iron Deficiencies, Acute Heart Failure
- Trial name
- COREVIVE-HFpEF (NCT05991128)
- Testing
- Ferric derisomaltose
- Where
- China
- Volunteers
- 170 people
- Sponsor
- China-Japan Friendship Hospital
Metabolic Syndrome, Inactivity/Low Levels of Exercise
Impact of Lifestyle on Health Maintenance: A Randomized Controlled Trial
This study aims to evaluate the impact of public health interventions on changes in healthy lifestyle habits over time and their subsequent effects on health outcomes.
- Conditions
- Metabolic Syndrome, Inactivity/Low Levels of Exercise, Unhealthy Diet, Unhealthy Alcohol Use
- Trial name
- LifeHealth-RCT (NCT07314957)
- Testing
- Intervention of physical activity, Mediterranean Diet Education, Behavioral: Stress-Resilience Training
- Where
- Croatia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Zadar
Amnestic Mild Cognitive Impairment - aMCI, AD-MCI
Temporal Interference Stimulation Treatment in Patients With Cognitive Impairment
This study aims to evaluate the efficacy and safety of temporal interference stimulation (TIS), a non-invasive neuromodulation technique, in improving cognitive function in patients with cognitive impairment.
- Conditions
- Amnestic Mild Cognitive Impairment - aMCI, AD-MCI, AD - Alzheimer's Disease, FTD
- Trial name
- TIS (NCT07643363)
- Testing
- Temporal Interference Stimulation, Targeted Cognitive Training, General Cognitive Training
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tianjin Huanhu Hospital
Melanocortin Obesity Syndrome, MCOS
Atomoxetine in Melanocortin Obesity Syndrome
This is a phase 2 randomized placebo-controlled crossover trial to determine the safety and efficacy of atomoxetine for treating obesity caused by loss-of-function variants in the melanocortin-4 receptor (MC4R), the most common…
- Trial name
- MCOS (NCT06899178)
- Testing
- Atomoxetine
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Obesity, Liver Diseases
Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. While weight loss through lifestyle modification is the standard treatment, most patients regain weight limiting…
- Conditions
- Obesity, Liver Diseases, Liver Fibrosis, Liver Fat
- Trial name
- NCT06138821
- Testing
- ESG + lifestyle modification, Lifestyle modification
- Where
- 2 sites in United States
- Volunteers
- 132 people
- Sponsor
- Pichamol Jirapinyo, MD, MPH
Obesity
Intervention Study on Weight Loss in Patients With Obesity
The goal of this clinical trial is to evaluate the feasibility of using Socratic questioning as an alternative method for weight loss in adult patients with obesity (aged 18 to 65) in a primary care setting.
- Trial name
- NCT07124832
- Testing
- Socratic Questioning Method
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Sıdıka Ece Yokuş
Pediatric Fractures, Hypovitaminosis D
Bone Outcomes, Obesity, Sunlight, and Trauma in Children
Prospective case-control study of children (3-15 years) after low-energy trauma. We compare serum bone metabolic markers (25OHD, PTH, ALP, calcium, phosphate), BMI/percentile, and dietary calcium intake between fracture and…
- Conditions
- Pediatric Fractures, Hypovitaminosis D, Obesity and Overweight
- Trial name
- BOOST (NCT07143552)
- Where
- 2 sites in Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Paracelsus Medical University
Type 2 Diabetes
Continuous Glucose Monitoring Systems in People With Type 2 Diabetes Not Treated With Insulin
The aim of the study is to assess the influence of continuous glucose monitoring (CGM) systems on metabolic control and quality of life in people with type 2 diabetes and overweight/obesity who are not treated with insulin.
- Trial name
- NCT07919236
- Testing
- Continuous glucose monitoring, Self-monitoring of blood glucose
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Bialystok
Child Malnutrition
The Impact of Community Health Workers on Child Malnutrition in the Philippines
This study will focus on a new community health worker (CHW) program called 'Flourish', which is implemented by Philippine non-governmental organization (NGO) International Care Ministries (ICM).
- Trial name
- NCT05774314
- Testing
- Community Health Worker Intervention
- Where
- 4 sites in Philippines
- Volunteers
- 7,650 people, healthy volunteers welcome
- Sponsor
- International Care Ministries, Philippines
Obesity or Overweight, Type 2 Diabetes Mellitus
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes
The purpose of this study is to assess the efficacy and safety of enicepatide, a dual glucagon-like peptide-1 (GLP-1)/glucose-dependent insulinotropic polypeptide (GIP) receptor agonist (RA), at multiple doses compared with…
- Trial name
- Enith2 (NCT07351058)
- Testing
- Enicepatide
- Where
- 210 sites in United States, Argentina and 19 more
- Volunteers
- 1,600 people
- Sponsor
- Hoffmann-La Roche
Osteoporosis, Inflammation
Synbiotic to Attenuate Resorption of the Skeleton
This randomized, double blind, placebo controlled clinical trial will test the efficacy of a probiotic/prebiotic combination ("synbiotic") on the skeleton in older women.
- Conditions
- Osteoporosis, Inflammation, Aging
- Trial name
- STARS (NCT06389539)
- Testing
- SBD111 medical food
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Obesity, Obesity, Abdominal
Acupoint Catgut Embedding With Laser Acupuncture for Weight Loss in Adults With Obesity
Acupoint catgut embedding and laser acupuncture have each been studied as treatments for obesity in adults, but the two have not been evaluated in combination, and few trials have measured anthropometric, biochemical, and blood…
- Conditions
- Obesity, Obesity, Abdominal, Overweight
- Trial name
- NCT07770893
- Testing
- Acupoint catgut embedding, Active laser acupuncture, Dietary and exercise counseling
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei City Hospital
Amyotrophic Lateral Sclerosis
A Study of LTX-002 in Adult Participants With Amyotrophic Lateral Sclerosis
This study will examine what happens when patients with amyotrophic lateral sclerosis (ALS) are given an investigational medication (study drug) known as LTX-002.
- Trial name
- NeurALS (NCT07660614)
- Testing
- LTX-002
- Where
- 5 sites in Germany, Italy and 2 more
- Volunteers
- 56 people
- Sponsor
- Leal Therapeutics, Inc
Heathly Volunteers
Role of a Mitochondrial Receptor in Blood Sugar Regulation
The goal of this clinical trial is to learn whether a single dose of XBD173, a medicine that binds to a protein called the 18 kiloDalton Translocator Protein (TSPO), affects how the body processes glucose in healthy volunteers…
- Trial name
- G-TSPO (NCT07682233)
- Testing
- XBD173
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention
Efficacy of Lipid-Lowering Therapy Based on Apolipoprotein B Versus LDL-Cholesterol Levels in Patients Undergoing Percutaneous Coronary Intervention
This multicenter randomized trial is designed to assess the efficacy of lipid-lowering therapy in patients undergoing percutaneous coronary intervention, comparing an Apolipoprotein B-targeted approach with a Low-Density…
- Conditions
- Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention, LDL-cholesterol, Lipid Metabolism Disorders
- Trial name
- ApoB-guidedLLT (NCT06626126)
- Testing
- ApoB-guided-LLT, LDL-C-guided-LLT
- Where
- Vietnam
- Volunteers
- 1,448 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
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