Clinical trials: Metabolic Disorder, Glucose
Type 2 Diabetes
Effects of Modulators of Gluconeogenesis, Glycogenolysis and Glucokinase Activity
It has been shown that individuals with type 2 diabetes have higher blood sugar throughout the night than individuals without type 2 diabetes.
- Trial name
- NCT05098470
- Testing
- Metformin, Insulin Glargine, Dorzagliatin
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Obesity
Banded Sleeve Gastrectomy Versus Banded Ring Gastric Bypass in Morbidly Obese Patients
Obesity is a multifactorial disease that affects millions of people worldwide. It is the main independent risk factor for developing type 2 diabetes mellitus (T2DM).
- Trial name
- NCT00873405
- Testing
- Silastic® ring sleeve gastrectomy, Silastic® ring gastric bypass
- Where
- Brazil
- Volunteers
- 65 people
- Sponsor
- Federal University of Espirito Santo
Type 2 Diabetes
Nationwide Assessment of Cardiovascular Risk Factors: in Chinese Patients With Type 2 Diabetes
The objective of this study is to evaluate the level of control of cardiovascular disease risk factors, including blood pressure, blood lipid, and blood glucose, in out patients with type 2 DM in 6 representative regions in…
- Trial name
- 3B (NCT01128205)
- Where
- China
- Volunteers
- 25,000 people
- Sponsor
- China Cardiometabolic Registries
Overweight, Hypertriglyceridemic Waist
Effect of Arginine Supplementation in the Metabolic Syndrome
The purpose of this study is to determine whether oral supplementation with one form of arginine improves vascular endothelial function in healthy subjects with risk factors associated with the metabolic syndrome
- Trial name
- NCT02354794
- Testing
- One form of arginine
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Diabetes Mellitus
Aspirin Twice Daily in Diabetic Patients With Coronary Artery Disease
The aim of the study is to evaluate platelet function variations according to the delay since last aspirin intake (12 vs 24 hours)in a population of diabetic patients with previous Coronary Artery Disease.
- Trial name
- NCT01617031
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Hopital Lariboisière
Diabetes Mellitus, Type 2
Dose-Ranging Study in Treatment Naive Type 2 Diabetes Mellitus(T2DM)
This is a dose-ranging study that will evaluate the efficacy, safety and tolerability of a range of doses of investigational product and pioglitazone, compared to placebo, administered as monotherapy over 12 weeks in treatment…
- Trial name
- NCT00500331
- Testing
- GSK189075, pioglitazone
- Where
- 136 sites in United States, Argentina and 17 more
- Volunteers
- 334 people
- Sponsor
- GlaxoSmithKline
Insulin Resistance, Type2 Diabetes Mellitus
High-fat Overfeeding, Hepatokines and Appetite Regulation
The present study will investigate the effect of high-fat overfeeding on a group of liver-secreted proteins linked to worsened blood sugar control, as well as proteins involved in appetite control.
- Conditions
- Insulin Resistance, Type2 Diabetes Mellitus, Non-Alcoholic Fatty Liver Disease, Obesity
- Trial name
- OVEREAT (NCT03369145)
- Testing
- High-fat diet
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Diabetes Mellitus, Type 2
Metformin's Effect on Drug Metabolism in Patients With Type 2 Diabetes
Type 2 diabetes is a major public health concern. It is widely established that type 2 diabetes in linked to activated innate immunity and increased levels of C-reactive protein and interleukin-6 (IL-6) in plasma.
- Trial name
- NCT04504045
- Testing
- Metformin, Caffeine, Efavirenz
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Southern Denmark
Type 2 Diabetes
Pilot RCT Evaluating Clinical Outcomes of Using Undermyfork Mobile App With Dexcom G7
This study aims to determine if adding using a mobile diabetes-related health application with CGM device yields significant benefits, contributing to our understanding of the potential advantages and informing future diabetes…
- Trial name
- NCT06501612
- Testing
- Continuous Glucose Monitor and Undermyfork App, Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Scripps Whittier Diabetes Institute
Type 1 Diabetes, Hypoglycemia
Micro Glucagon During Exercise in Type 1 Diabetes
This proof-of-principle study to assess effects of different doses (mini and micro) of subcutaneous glucagon analog Dasiglucagon (Zealand Pharma, Copenhagen, Denmark) on the change in blood glucose concentration during…
- Trial name
- NCT04192019
- Testing
- Micro-glucagon, Mini-glucagon
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Type 2 Diabetes, Obese Diabetics
The Role of CYP8B1 Polymorphisms in Modulating the Biochemical Pathways Affected by SGLT2 Inhibitors in T2DM and Obesity
This study explores the long-term effects of dapagliflozin and empagliflozin on CYP8B1 gene expression and a range of metabolic, oxidative, and inflammatory biomarkers in obese patients with Type 2 Diabetes Mellitus (T2DM).
- Conditions
- Type 2 Diabetes, Obese Diabetics, Obese Patients (BMI ≥ 30 kg/m²)
- Trial name
- CYP8B1-SGLT2-T (NCT07120828)
- Testing
- Empagliflozin (oral), Dapagliflozin (DAPA), Metfomin
- Where
- Iraq
- Volunteers
- 260 people
- Sponsor
- Erbil Polytechnic University
Metabolic Syndrome, Prostate Cancer
Effect of TyG Index on Outcomes of Radical Prostatectomy
We investigate the association between Triglyserid-Glucose(TyG) index and prostate cancer in patients undergoing radical prostatectomy.
- Conditions
- Metabolic Syndrome, Prostate Cancer, Insulin Resistance
- Trial name
- TyG-PCa (NCT03447028)
- Volunteers
- 200 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Diabetes Mellitus, Type 1
The PSIQS Study - User Experience With Pro-Set
Open label, randomized 2-period cross-over study comparing two continuous subcutaneous insulin infusion sets ; MiniMed® Pro-set® with BD FlowSmart™ technology and MiniMed® Quick-set®
- Trial name
- NCT03242005
- Testing
- MiniMed® Pro-set®, MiniMed® Quick-set®
- Sponsor
- Becton, Dickinson and Company
Gestational Diabetes Mellitus
Gestational Diabetes: Insulin or Oral Hypoglycemic Agents?
Gestational diabetes mellitus takes place in 2 steps. First, it is the consequence of insulin resistance due to the modifications of the pregnancy hormonal environment, and second, of the deficiency of the beta cells of the…
- Trial name
- DG5 (NCT01215331)
- Testing
- Insulin, Metformin, glyburide and insulin
- Where
- Canada
- Volunteers
- 73 people
- Sponsor
- Université de Sherbrooke
Type 2 Diabetes
Evidence-based Text Messages to Target Diet and Physical Activity
This research aims to develop a bank of text messages based on behaviour change techniques targeting specific diet and physical activity behaviours in people with type 2 diabetes
- Trial name
- NCT05641402
- Testing
- Text messages
- Where
- United Kingdom
- Volunteers
- 148 people
- Sponsor
- University of Manchester
PreDiabetes, Metabolic Syndrome
Does Co-administration of Lactate to an Oral Glucose Tolerance Test Lower the Glucose Response?
To investigate whether co-administration of lactate with a glucose load affects postprandial glucose levels/handling, gastrointestinal hormones, gastric emptying, and appetite sensations in individuals with pre-diabetes when…
- Conditions
- PreDiabetes, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT06265337
- Testing
- Lactate
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Lifestyle Factors, Overweight and Obesity
Effect of Sleep Extension on Ceramides in People With Overweight and Obesity
The overall goal is to determine how a sleep extension intervention (increasing time in bed) in individuals who maintain less than 6.5 hours sleep per night affects their plasma ceramides and insulin sensitivity.
- Conditions
- Lifestyle Factors, Overweight and Obesity, Insulin Sensitivity, Eating Habit
- Trial name
- NCT06180837
- Testing
- Sleep Extension Intervention
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Utah
Type 2 Diabetes
Effects of Colesevelam on How the Body Responds to Insulin in Patients With Type 2 Diabetes
This study is designed to assess the potential mechanism of action by which WelChol® (colesevelam) may improve blood glucose control in patients with type 2 diabetes
- Trial name
- NCT00147745
- Testing
- Colesevelam, Insulin glargine (Lantus)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Daiichi Sankyo
Diabetes, Pregnancy
Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy (MOMPOD)
Purpose: The objective of this proposal is to study the safety and efficacy of metformin added to insulin for treatment of type 2 diabetes mellitus (T2DM) among pregnant women.
- Trial name
- MOMPOD (NCT02932475)
- Testing
- Metformin
- Where
- 10 sites in United States
- Volunteers
- 831 people
- Sponsor
- University of North Carolina, Chapel Hill
Insulin Resistance - Type A, Insulin Resistance - Type B
A Study of Empagliflozin in Patients With Refractory Diabetes Mellitus With Insulin Resistance
A multicenter, open-label, single-arm study with regard to the efficacy and safety of empagliflozin in patients with refractory diabetes mellitus with insulin resistance
- Conditions
- Insulin Resistance - Type A, Insulin Resistance - Type B, Lipoatrophic Diabetes Mellitus, Insulin Resistance Syndrome
- Trial name
- EMPIRE-01 (NCT04018365)
- Testing
- Empagliflozin Tablets
- Where
- 5 sites in Japan
- Volunteers
- 8 people
- Sponsor
- Kobe University
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