Clinical trials: Metabolic Disorder, Glucose
Diabetes Mellitus, Type 1, Ischemia
Non-enhanced Magnetic Resonance Angiography of Diabetic Ischemic Lower Limbs
Diabetic foot ulcers often progresses after many years of diabetes where the patients system is so damaged that normal heeling of ulcers cannot happen.
- Conditions
- Diabetes Mellitus, Type 1, Ischemia, Foot Ulcer
- Trial name
- NCT01614379
- Where
- 2 sites in Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Type 2 Diabetes Mellitus
Effects of Linagliptin in Addition to Empagliflozin on Islet Cell Physiology
The primary aim of this exploratory mechanistic study is to investigate the effects of Empagliflozin and Linagliptin on alpha- and beta cell physiology in T2DM patients.
- Trial name
- NCT02401880
- Testing
- Linagliptin, Empagliflozin
- Where
- 2 sites in Germany
- Volunteers
- 89 people
- Sponsor
- Profil Institut für Stoffwechselforschung GmbH
Telenursing, Adolescent
Tele Nursing Application For Type 1 Diabetes Mellitus Adolescents
Studies have shown that tele-nursing practice is effective in children with Type 1 Diabetes Mellitus, but the number of studies conducted is very few.
- Conditions
- Telenursing, Adolescent, Type 1 Diabetes Mellitus
- Trial name
- NCT05211479
- Testing
- educational intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people
- Sponsor
- University of Yalova
Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD)
A Study of REGEND003 on Patients With Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD)
REGEND003, which consists of human kidney progenitor cells, demonstrates promising potential in repairing kidney injury. The purpose of this study is to assess the saftey and tolerability of REGEND003 on patients with Type 2…
- Trial name
- NCT07275788
- Testing
- REGEND003
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Regend Therapeutics
Foot Ulcer, Diabetic Foot
A Study on the Efficacy and Safety of Long-Term Treatment and Re-Treatment of Lower Extremity Diabetic Ulcers With REGRANEX
The purpose of this study is to evaluate the efficacy and safety of REGRANEX® Gel compared with placebo when applied for up to 52 consecutive weeks to recurring or non-healing ulcers of the ankle or foot related to diabetes.
- Conditions
- Foot Ulcer, Diabetic Foot, Skin Ulcer, Diabetic Neuropathies
- Trial name
- NCT00034788
- Testing
- Becaplermin
- Volunteers
- 84 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Obesity, Diabetes Mellitus Type 2
Mode of Action of Topiramate in the Treatment of Obese Patients With and Without Type 2 Diabetes Mellitus
The purpose of this study is to explore the mode of action of topiramate in the treatment of obese and diabetic patients by testing association between genetic variations within candidate genes or chromosomes (thread like…
- Trial name
- NCT00304603
- Testing
- No intervention
- Volunteers
- 1,145 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Elevated Body Mass Index
Effect of LIK066 on Body Weight in Patients With Elevated Body Mass Index
A 12-week study to assess LIK066 effect on body weight in diabetics, prediabetics and normoglycemic patients with elevated body mass index (BMI)
- Trial name
- NCT02470403
- Testing
- LIK066
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- Novartis Pharmaceuticals
Insulin Sensitivity
Modulation of Insulin Sensitivity by Betaine Upregulation of FGF21
People with poor insulin sensitivity do not respond normally to elevations in blood sugar. This may increase their risk of developing diabetes in the future.
- Trial name
- NCT02118142
- Testing
- Betaine, Dextrose
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- UNC Nutrition Research Institute
Metabolic Syndrome
The Effect of Fluvastatin XL® Treatment in Patients With Metabolic Syndrome
This study evaluated safety, tolerability and efficacy of Fluvastatin XL® -extended release (80 mg once daily) in patients with metabolic syndrome
- Trial name
- NCT00664742
- Testing
- Fluvastatin XL®
- Where
- Turkey (Türkiye)
- Volunteers
- 614 people
- Sponsor
- Novartis
Type 2 Diabetes Mellitus
Effects Of Resistive Exercise or Proprioceptive Exercise Training Among Patients With Type 2 Diabetes Mellitus
The aim of the study is to investigate proprioceptive exercises training combined with aerobic exercises and resistive exercises training combined with aerobic exercises on dynamic balance and superficial sense.
- Trial name
- NCT03363386
- Testing
- Proprioceptive Exercises, Resistive Exercises, Aerobic Exercise
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Diabetes Mellitus, Type 2
Efficacy of Black Seed Oil in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to determine the effect of black seed oil on markers of endothelial dysfunction in patients with type 2 diabetes mellitus .Also, to investigate its effect on glycemic control ,lipid profile and…
- Trial name
- NCT03959306
- Testing
- Black Seed Oil, Anti-Diabetics
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Diabetes, Healthy
Investigating the Pharmacokinetics of Subcutaneous Injections With 1 mg/mL, 3 mg/mL, and 10 mg/mL Semaglutide Strengths and the Absolute Bioavailability of Semaglutide
This trial is conducted in Europe. The aim of this trial is to investigate the pharmacokinetics (the exposure of the trial drug in the body) of subcutaneous injections of three different strengths of semaglutide and the absolute…
- Trial name
- NCT02231684
- Testing
- semaglutide
- Where
- Germany
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2, Exercise
Compliance to HIT-program at Home With the Use of Technology
High-intensity training (HIT) has showed beneficial effects in type 2 diabetics such as improved glycemic control, improved bloodpressure and more.
- Conditions
- Diabetes Mellitus, Type 2, Exercise, Technology
- Trial name
- NCT03166852
- Testing
- Home-training
- Volunteers
- 21 people
- Sponsor
- University College of Northern Denmark
Osteomyelitis - Foot
Comparison Between Two Durations of Antibiotherapy for Non-surgically-treated Diabetic Foot Osteomyelitis (CHRONOS-2)
The aim of this clinical study is to compare the efficacy and tolerance of 3 versus 6 weeks of antibiotherapy in patients with diabetic foot osteomyelitis treated medically.
- Trial name
- CHRONOS-2 (NCT05074147)
- Testing
- Reduction in the duration of antibiotic therapy 3 weeks or 6 weeks
- Where
- 18 sites in France
- Sponsor
- Tourcoing Hospital
Type 1 Diabetes, Type 2 Diabetes
Efficacy, Safety and Satisfaction of the New Pen Needle 33 Gauge x 4 mm.
During the last years, even more little needles are used for the injection of sub cutaneous insulin, for the diabetes therapy. The aim of this study is to evaluate the non inferiority of a new needle, smaller than another needle…
- Trial name
- AGO01 (NCT01745549)
- Testing
- Needle for insulin pen, 4 mm long and with a diameter of 33 gauge, Needle for insulin pen, 4 mm long and with a diameter of 32 gauge
- Where
- 4 sites in Italy
- Volunteers
- 87 people
- Sponsor
- Consorzio Mario Negri Sud
Type 2 Diabetes
Long-term Safety Study of Vildagliptin in Patients With Type 2 Diabetes
This study is designed to demonstrate the long-term safety of vildagliptin in patients with type 2 diabetes. This study will study vildagliptin as add-on therapy with metformin, thiazolidinedione, α-glucosidase inhibitor (α-GI)…
- Trial name
- NCT01159249
- Testing
- Vildagliptin
- Where
- 24 sites in Japan
- Volunteers
- 245 people
- Sponsor
- Novartis Pharmaceuticals
Diabetes Mellitus, Insulin-Dependent, Diabetes
The RADAR Study - Wearable-Based Dysglycemia Detection and Warning in Diabetes
The study RADAR aims at developing a wearable based dysglycemia detection and warning system for patients with diabetes mellitus using artificial intelligence.
- Trial name
- RADAR (NCT04689685)
- Testing
- Wearing smartwatch and continous glucose sensor
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetes Mellitus Type 2
A Study of Aleglitazar in Combination With Metformin in Patients With Type 2 Diabetes Mellitus Who Are Inadequately Controlled With Metformin Monotherapy
This multicenter, randomized, double-blind, placebo-controlled study will evaluate the efficacy, safety and tolerability of aleglitazar in combination with metformin in patients with Type 2 diabetes mellitus who are inadequately…
- Trial name
- NCT01871415
- Testing
- aleglitazar, metformin
- Where
- 7 sites in China, South Korea
- Volunteers
- 7 people
- Sponsor
- Hoffmann-La Roche
Infant Conditions, Glucose Intolerance
Monitoring of Postprandial Glycemic Variability in Healthy Young Infants
To measure and quantify the postprandial glucose variations in response to a meal in the healthy 6-12 months old child and correlate this response with the composition of this meal.
- Trial name
- IGVM (NCT03819725)
- Testing
- Glucose monitoring
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Diabetes Mellitus, Type 2
Study Evaluating the Efficacy and Safety of Simvastatin Alone Compared With Simvastatin Plus Ezetimibe in Type 2 Diabetic Patients (0653-021)(COMPLETED)
The purpose of this study is to determine if the addition of ezetimibe 10 mg daily to ongoing 20 mg simvastatin daily will reduce LDL Cholesterol to a greater extent than increasing the dose of simvastatin to 40 mg daily in Type…
- Trial name
- NCT00551876
- Testing
- MK0653, ezetimibe / Duration of Treatment: 30 Weeks, Comparator : ezetimibe (+) simvastatin / Duration of Treatment: 30 Weeks
- Volunteers
- 214 people
- Sponsor
- Organon and Co
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