Clinical trials: Metabolic Disorder, Glucose
Pre-diabetes
The Role of Cholinergic Signaling for Mediating the Effects of GIP and/or Xenin-25 on Insulin Secretion
Glucose-dependent insulinotropic polypeptide (GIP) is a hormone produced in the intestine. It is released immediately after meal ingestion and increases insulin release. This, in turn, helps reduce blood glucose levels.
- Trial name
- NCT01951729
- Testing
- Control, Xenin-25 without atropine, GIP without atropine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Cardiopathy, Diabetes
Diabetic/Metabolic Cardiomyopathy: Prevalence and Phenotype
"Little is known about the prevalence, determinants and phenotypes of the cardiomyopathy associated with diabetes and/or metabolic syndrome.
- Conditions
- Cardiopathy, Diabetes, Metabolic Syndrome
- Trial name
- METAB-HEART (NCT05181631)
- Testing
- Biobanking
- Volunteers
- 1,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Failure, Chronic, Diabetes Mellitus, Type 1
Vascular Reactivity in Kidney Disease Patients
Dialysis patients suffer from many problems with blood vessels and this is even more so for patients with the added complication of diabetes.
- Conditions
- Kidney Failure, Chronic, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT00226902
- Testing
- Changing hemoglobin concentration
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- Melbourne Health
Prediabetes
The Prevalence of Metabolic Syndrome and Its Associated Factors in an Urban City
The secondary objective is to evaluate the agreement between these criteria and the prevalence of concordant and discordant according to different criteria.
- Trial name
- NCT00308672
- Where
- Taiwan
- Volunteers
- 3,000 people
- Sponsor
- China Medical University Hospital
Diabetes, Hypertension
Take Charge of Your Diabetes
The investigator plans to assess enrollment rates among two different enrollment methods, while providing a behavioral economic intervention to enhance the uptake of home-health monitoring devices to lower hemoglobin A1C among…
- Trial name
- NCT01977495
- Testing
- Financial Incentive: Fixed Lottery
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- University of Pennsylvania
Diabetes Mellitus, Type 2
A Research Study Looking at How Victoza® Works in People With Type 2 Diabetes in Iran, Followed in Local Clinical Routine
The purpose of the study is to collect information on how the medicine Victoza® (liraglutide) works in people with Type 2 diabetes in Iran. Patients will get Victoza® as prescribed to them by their study doctor.
- Trial name
- VIEW-Iran (NCT03888157)
- Testing
- Liraglutide
- Where
- 16 sites in Iran
- Volunteers
- 839 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes, Healthy Lifestyle Behaviors
Harnessing Human Potential and Improving Health Span in Women and Their Children
Women with Gestational Diabetes Mellitus (GDM) are 12-times more likely to develop Type 2 Diabetes (T2D) 4-6 years after delivery than women without GDM.
- Conditions
- Type 2 Diabetes, Healthy Lifestyle Behaviors, Gestational Diabetes
- Trial name
- HAPPY (NCT05949957)
- Testing
- LvL UP App, HAPPY App, Oura Ring And Oura App
- Where
- Singapore
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Cystic Fibrosis-related Diabetes
EnVision CF Multicenter Study of Glucose Tolerance in Cystic Fibrosis
Cystic Fibrosis Related Diabetes has been identified by the CF community as one of the top ten priorities for CF research. In CF clinical decline due to dysglycemia begins early, prior to diagnosis of diabetes and increases…
- Trial name
- NCT03650712
- Testing
- Oral glucose tolerance test, Continuous glucose monitoring, Dexa scan
- Where
- 4 sites in United States
- Volunteers
- 317 people
- Sponsor
- Katie Larson Ode
Type 2 Diabetes Mellitus
Quadruple Oral Combination Therapy for Type 2 Diabetes Mellitus : Glycemic Control by Thiazolidinedione (TZD) or Sodium Glucose Co-transporter 2 (SGLT-2) Inhibitor as an add-on Therapy in Type 2 Diabetes Mellitus After Failure of an Oral Triple Antidiabetic Regimen
In the treatment of type 2 diabetes (T2D), the number of patients requiring combination therapy of oral antidiabetic agents (OADs) is more than 70%.
- Trial name
- NCT04013581
- Testing
- TZD group, SGLT-2 group
- Where
- South Korea
- Volunteers
- 121 people
- Sponsor
- Yonsei University
Type 1 Diabetes
The Management of Glucose Control and Hypoglycemic Prevention Using Continuous Glucose Monitoring System in Patients With Type 1 Diabetes
This study was designed to evaluate the glucose control and hypoglycemic prevention effect of using continuous glucose monitoring system(CGMS) in patients with type 1 diabetes.
- Trial name
- NCT04684030
- Testing
- Continuous glucose monitoring system(CGMS), Self-monitoring of blood glucose (conventional fingerpricking method)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Type 2 Diabetes
GALLANT 8 Tesaglitazar Add-on to Metformin
This is a 24-week randomized double-blind, parallel-group, multi-center, placebo-controlled study of tesaglitazar (0.5 mg and 1 mg) given as add-on therapy to metformin in patients with type 2 diabetes, not adequately controlled…
- Trial name
- NCT00251953
- Testing
- Tesaglitazar, Metformin
- Where
- 107 sites in Australia, Canada and 9 more
- Volunteers
- 555 people
- Sponsor
- AstraZeneca
Spinal Cord Injuries, Obesity
Telenutrition for Individuals With SCI
This study will provide nutrition counseling via FaceTime on an iPad to persons with traumatic spinal cord injury (SCI) who are overweight or obese and are at least one-year post-injury.
- Conditions
- Spinal Cord Injuries, Obesity, Cardiometabolic Syndrome
- Trial name
- NCT05468437
- Testing
- Telenutrition
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Santa Clara Valley Health & Hospital System
Diabetes Mellitus Type 2
Evaluating the Impact of Year Long, Augmented Diabetes Self Management Support
Improving diabetes social support is associated with health improvement benefits. This study is a prospective randomized controlled trial comparing the effects of telephone-based diabetes self-management support (DSMS) compared…
- Trial name
- NCT02160639
- Testing
- diabetes self management support
- Where
- 4 sites in United States
- Volunteers
- 449 people
- Sponsor
- American Association of Diabetes Educators
Diabetes Mellitus Type 2, Social Determinants of Health (SDOH)
Re-Engineered Discharge for Diabetes Care Transitions
The goal of this project is to test a novel bedside SDOH screening intervention coupled with post-discharge navigation for hospitalized patients with a diabetes diagnosis to reduce unmet social needs, compared to usual care.
- Conditions
- Diabetes Mellitus Type 2, Social Determinants of Health (SDOH), Hospital Readmission
- Trial name
- REDDCAT2 (NCT06869057)
- Testing
- REDDCAT2 Post-Discharge Navigation, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 412 people
- Sponsor
- University of Massachusetts, Worcester
Type 1 Diabetes
COVID-19 Pandemic Lockdown Effect in Adolescents and Young Adults With Type 1 Diabetes: Positive Results of an Unpreceded Challenge for Telemedicine and Patient Self-management
Lockdown resulting from the COVID-19 pandemic was an unpreceded model of the impact of lifestyle on chronic diseases, especially for adolescents and young adults with type 1 diabetes (T1D) whose lifestyle is known to strongly…
- Trial name
- COVIDIABADO (NCT04669912)
- Testing
- glucose control and sensor usage
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Centre Hospitalier Sud Francilien
Type 1 Diabetes
Feasibility Study to Evaluate the Hybrid-Logic Closed Loop System in Type 1 Diabetes The DREAMED Trail
Closed loop technology has been shown to reduce both hypoglycemia and hyperglycemia, as well as reduce glycemic variability. Several groups around the world investigate efforts in developing closed-loop systems.
- Trial name
- NCT02651181
- Testing
- HLCL- Hybrid Logic Closed Loop System
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Rabin Medical Center
Metabolic Disease
Husk Fiber Intervention on Metabolic Health of Centrally Obese School Teachers
A group of 120 school teachers (male=60, female=60) was divided into four subgroups for sixteen weeks of an interventional study. One group was kept in control while the other three groups were assigned intervention.
- Trial name
- NCT06188728
- Testing
- effect of 10 gm psyllium husk fiber twice a day, 30 minutes before breakfast and dinner, Effect of life style modification (Diet, Behavior and physical activity), Combined effect of 10 gm Psyllium husk fiber and lifestyle modification
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Peshawar
Cardiovascular Disease, Insulin Resistance
A Trial of Tadalafil and Glycemic Traits
The purpose of this study is to find out if tadalafil can help overweight and obese people metabolize blood sugar more efficiently.
- Conditions
- Cardiovascular Disease, Insulin Resistance, Glucose Intolerance, Obesity
- Trial name
- NCT01444651
- Testing
- Tadalafil
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Thomas J. Wang, MD
Type 2 Diabetes
Hope Theory as Ability Determinant to Permanently Change the Adapted Physical Activity (APA) in Type 2 Diabetic Patients
The control of diabetes is related both to food, treatment but also to physical activity. Despite these recommendations and these positive findings, patients are always sedentary because of brakes in the practice of a regular…
- Trial name
- APADIAB-ESPOIR (NCT02733302)
- Testing
- Hope theory
- Where
- France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Angers
Type 2 Diabetes Mellitus (T2DM), Cardiovascular Diseases
Cardioprotective Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Korean Patients With Type 2 Diabetes
This observational study will evaluate the cardiovascular effects of sodium-glucose cotransporter-2 inhibitors (SGLT2 inhibitors) and glucagon-like peptide-1 receptor agonists (GLP-1 receptor agonists) in Korean adults with type…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Cardiovascular Diseases, Stage B Heart Failure
- Trial name
- NCT07770737
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Dongtan Sacred Heart Hospital
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