Clinical trials: Metabolic Disturbance
Cardiovascular Diseases, Acute Myocardial Infarction
Metabolic Substrate of Patients With Myocardial Infarction With and Without Modifiable Cardiovascular Risk Factors
Coronary heart disease (CHD) is the leading cause of mortality worldwide. Every year, millions of people suffer its most adverse manifestation, an acute myocardial infraction (AMI).
- Conditions
- Cardiovascular Diseases, Acute Myocardial Infarction, Acute Coronary Syndrome, Metabolic Disturbance
- Trial name
- Meta-SMuRF (NCT05494151)
- Testing
- Investigation of the metabolic substrate
- Sponsor
- Aristotle University Of Thessaloniki
PCOS, Offspring, Adult
Offspring Born to Mothers With Polycystic Ovary Syndrome in Guangzhou Cohort Study
The Offspring Born to Mothers with Polycystic Ovary Syndrome in Guangzhou Cohort study (PCOS-BIG) was established to investigate the short- and long-term effects of intrauterine exposure to maternal PCOS on the health of…
- Conditions
- PCOS, Offspring, Adult, Hyperandrogenism, Epigenetics
- Trial name
- PCOS-BIG (NCT03742011)
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Noise Exposure, Sleep Disturbance
Low Particle Emission and Low Noise Tyres
This study will investigate the biological mechanisms linking sleep disruption by noise and the development of disease. In a laboratory sleep study, the investigators will play synthesised automotive tyre sounds, investigating…
- Conditions
- Noise Exposure, Sleep Disturbance, Sleep Hygiene, Metabolic Disturbance
- Trial name
- LEON-T (NCT05611619)
- Testing
- Tyre noise - continuous flow, Tyre noise - discrete events, High noise level
- Where
- Sweden
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Göteborg University
The Patients Suffered With Sellar Diseases, The Fluid and Electrolyte Imbalance Happened After Surgery
Disturbance of Water and Sodium Metabolism After Surgery of Sellar Lesions, and Correspond Clinical Strategy
The fluid and electrolyte imbalance (FEI) is pretty common encountered during the clinical process of patients suffered sellar lesions.
- Trial name
- NCT01406041
- Testing
- Chemical and physical detection
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Southern Medical University, China
Obesity, Hormone Disturbance
Bariatric Surgery, Hormones, and Quality of Life
The purpose of this study is to characterize the hormonal status in fertile women undergoing laparoscopic gastric bypass, pre- and postoperatively, and evaluate if there is a correlation between health-related quality of life and…
- Conditions
- Obesity, Hormone Disturbance, Quality of Life, Hyperandrogenism
- Trial name
- OBLIV (NCT03188640)
- Testing
- Laparoscopic gastric-bypass surgery
- Volunteers
- 68 people
- Sponsor
- Linkoeping University
Schizophrenia
Berberine Effect on Cytokine, CRP, Metabolic Disturbance as an Adjunctive Therapy in Schizophrenia Patients
The etiology and pathogenesis of schizophrenia remains unclear. Immune dysfunction hypothesis for schizophrenia has attracted increasing attention of the researchers, substantial evidences suggested the levels of C-reaction…
- Trial name
- NCT02936414
- Testing
- Berberine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tianjin Anding Hospital
Mental Disorder, Metabolic Disturbance
Is Saxenda® a Viable Treatment of Obese Patients in Forensic Psychiatry?
An open-label, multi-centre, 26-weeks clinical feasibility study. The objective is to explore whether Saxenda could be a feasible choice in the treatment of overweight, obesity and weight-related medical problems, in patients…
- Conditions
- Mental Disorder, Metabolic Disturbance, Feasibility, Overweight and Obesity
- Trial name
- NCT04781998
- Testing
- liraglutide 3 mg (Saxenda®) once-daily
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Diabetes Mellitus, Type 2, Metabolic Cardiomyopathy
Cardiac Rest and Stress Metabolism in Patients With Type 2 Diabetes
The number of people with diabetes is rising. One of the major causes of premature death in diabetes is heart failure (HF). This is when the heart cannot pump blood effectively, and this may be related to abnormalities in energy…
- Conditions
- Diabetes Mellitus, Type 2, Metabolic Cardiomyopathy, Metabolic Disturbance, Fatty Acid Oxidation Disorder
- Trial name
- CardioMET (NCT04009642)
- Testing
- Surely observational based on disease state
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- University of Leicester
Metabolic Disturbance
Concurrent Training and Prediabetes Control
Despite exercise training decrease blood fasting glicaemy in 'average' terms, there is a wide inter-individual variability after exercise training explored mainly in adults but not in adults with prediabetes comorbidities.
- Trial name
- NCT03502304
- Testing
- Endurance training plus resistant training
- Where
- Chile
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Santo Tomas
Dietary Exposure, Metabolic Disturbance
Influence of Tart Cherry Juice Intervention on Vascular Function
Diets containing fruit rich in anthocyanins have been shown (in meta-analyses) to be beneficial for health, but intervention trials have shown inconsistent results.
- Trial name
- NCT04840160
- Testing
- Cherry juice
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Ileostomy; Functional Disturbance, Healthy
Carotenoid Absorption and Metabolism From Green-leafy Vegetable Matrices
Absorption and metabolism of carotenoids from two types of spinach preparations will be investigated in two study groups, short bowel/ileostomy and healthy, respectively.
- Trial name
- Popeye (NCT02450227)
- Testing
- Spinach - Whole leaf (10 mg lutein), Spinach - Minced (10 mg/lutein)
- Where
- 2 sites in Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Metabolic Disturbance, Protein Deficiency
Biological Signatures Resulting From Occupational Exposure to Complex Mixtures of PAHs
This research project aims at better understanding the early biological effects resulting from occupational exposure to complex Polycyclic Aromatic Hydrocarbon (PAH) mixtures.
- Conditions
- Metabolic Disturbance, Protein Deficiency, Genotoxicity
- Trial name
- PAH-ProMetGen (NCT05679544)
- Testing
- Characterization of early biological effects following exposure to PAHs
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Obesity, Childhood, Cognition
NiPPeR Randomised Trial - Child Follow Up Study
There is an increasing focus on the need to optimise nutrition, lifestyle and metabolism of parents before and during pregnancy and of the infant after birth, but as yet there is limited understanding of the specific influences…
- Conditions
- Obesity, Childhood, Cognition, Neurobehavioral Manifestations, Metabolic Disturbance
- Trial name
- NiPPeR Child (NCT05934422)
- Testing
- Intervention (Study Nutritional Drink), Control (Standard Nutritional Drink)
- Where
- 3 sites in New Zealand, Singapore and 1 more
- Volunteers
- 461 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Fasting, Metabolic Disturbance
Physiological and Sensory Responses to Prolonged Fasting in Humans
This study aims to establish the metabolic/molecular response in both adipose tissue and skeletal muscle as well as sensory experiences (pain, fatigue, drive) to prolonged fasting of 3 days duration.
- Conditions
- Fasting, Metabolic Disturbance, Energy Supply; Deficiency, Adiposity
- Trial name
- PRO-FAST (NCT05977569)
- Testing
- Prolonged Fasting
- Where
- United Kingdom
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Bath
Metabolic Disturbance, Glucose Intolerance
A Nutrient Cocktail to Protect Against Physical Inactivity
This experiment consists on a 20-day reduction in daily step in free-living active individuals to induce physical inactivity. This will be used to test the efficacy of the anti-oxidant cocktail we aim to test as a new…
- Conditions
- Metabolic Disturbance, Glucose Intolerance, Physical Inactivity, Glucose Metabolism Disorders
- Trial name
- NCT03313869
- Testing
- XXS-2A + Omega-3 + Vitamin E + Selenium, control diet
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Sleep Deprivation, Metabolic Disturbance
Biorhythms in Metabolic Tissues
Metabolism is increasingly recognized as being highly regulated by anticipatory biological rhythms (circadian rhythms or "biorhythms"), which are driven by molecular feedback loops, and which are approximately 24 hours long…
- Conditions
- Sleep Deprivation, Metabolic Disturbance, Biological Clocks, Healthy
- Trial name
- NCT03276442
- Testing
- Low-fat dietary intervention, High-fat dietary intervention
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Sedentary Behavior, Affect
Effects of Multi-day Interruptions in Sitting on Type 2 Diabetes-relevant Outcomes in Children
The overall objective of this in-lab randomized controlled trial is to test the efficacy of multi-day interruptions in sedentary behavior vs.
- Conditions
- Sedentary Behavior, Affect, Metabolic Disturbance, Anxiety
- Trial name
- NCT04469790
- Testing
- SIT+WALK, EX
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Irritable Bowel Syndrome
Curcumin (Tumeric) in the Treatment of Irritable Bowel Syndrome: A Randomized-Controlled Trial
Evidence exists to support low-grade inflammation as the inciting factor leading to visceral hypersensitivity and alteration in motility in irritable bowel syndrome.In the medical literature,there is ample in vitro and in vivo…
- Trial name
- CuTIBS (NCT00779493)
- Testing
- curcumin
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Post-COVID-19 Syndrome, Long-COVID-19 Syndrome
Fat Oxidation Capacity in Patients With Post Covid-19 Syndrome
Post-COVID-19 Syndrome (PCS) is characterized by symptoms, including fatigue, reduced physical performance, dyspnea, cognitive impairment, and psychological distress.
- Trial name
- NCT06468722
- Testing
- Exercise-based rehabilitation
- Where
- Germany
- Volunteers
- 187 people
- Sponsor
- University of Witten/Herdecke
Alzheimer Disease, Mild Cognitive Impairment
Brain Energy Metabolism and Sleep in Adults
The three primary goals of this pilot will be followed by a secondary goal to test if dental intervention improves brain health in terms of sleep and cognition. The primary and secondary goals are 1.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Cognitive Change, Energy Metabolism
- Trial name
- NCT03929302
- Testing
- MyTAP oral appliance plus mouth shield
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- The University of Texas at Dallas