Clinical trials: Metabolic Disturbances
Insulin Resistance, Diabetes Mellitus Type 2
Insulin Sensitivity, Irisin and Adipokines as Outcome Parameters in Patients Undergoing Cardiac Surgery
BACKGROUND: Surgical injury and inflammation provoke a stereotypical stress response. Insulin resistance plays an intriguing role in these metabolic alterations and depends on the intensity of injury.
- Conditions
- Insulin Resistance, Diabetes Mellitus Type 2, Other Functional Disturbances Following Cardiac Surgery
- Trial name
- NCT02258698
- Testing
- Cardiac surgery
- Where
- Switzerland
- Volunteers
- 348 people
- Sponsor
- University Hospital, Basel, Switzerland
Overweight or Obesity, Pregnancy Related
Better Lifestyle Counseling for African American Women During Pregnancy
The purpose of this randomized controlled trial is to establish the effectiveness of a culturally targeted and individually tailored behavioral intervention to promote maternal glucose metabolism in African American women.
- Conditions
- Overweight or Obesity, Pregnancy Related, Sleep Disturbances, Sleep Hygiene
- Trial name
- BETTER (NCT05234125)
- Testing
- Better, Birth Prep
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Illinois Chicago
Morbid Obesity, Endometrial Pathology
Study of Menstrual Irregularities and Endometrial Pathology in Women Undergoing Bariatric Surgery
Objectives: Given the profound impact of obesity on the genesis of endometrial cancer, this study proposes to prospectively evaluate the baseline prevalence of menstrual irregularities and endometrial pathology in morbidly obese…
- Conditions
- Morbid Obesity, Endometrial Pathology, Menstrual Irregularities
- Trial name
- NCT01473186
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome
Impact of Metformin in Teens With Polycystic Ovary Syndrome (PCOS) on Oral Contraceptive Therapy
Oral contraceptives are known to improve menstrual cycles and symptoms in PCOS, however may increase cholesterol. Metformin, a drug to improve insulin resistance, may benefit metabolic state.
- Trial name
- NCT00283816
- Testing
- Metformin, Oral Contraceptive Pill, Lifestyle Management Program
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Precursors to PCOS
Research Study for Children With a Mother or Sister With Polycystic Ovary Syndrome
In this study, we want to find out more about polycystic ovary syndrome(PCOS). This is a common problem in about 7% of teenage girls. Problems may include irregular periods, extra hair on the face, chest and back areas.
- Trial name
- PCOS (NCT00559390)
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Reproductive Age, PCOS (Polycystic Ovary Syndrome)
Pro- and Anti-inflammatory Cytokines in PCOS
The study will involve measurements and comparisons of the concentrations of pro-inflammatory cytokines: IL-6, TNF-α, IL-18, as well as anti-inflammatory cytokine IL-4 in women with polycystic ovary syndrome (PCOS) and insulin…
- Trial name
- NCT06793085
- Testing
- Measurement of interleukin-6 (il-6) concentration in blood serum, Measurement of fasting tumor necrosis factor α (TNF-α) concentration, Measurement of interleukin-18 (il-18) concentration
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Osteoporosis, Osteopenia
The Impact of Hormonal Contraceptive Use and Lifestyle Factors on Fracture Risk and Bone Quality in Young Female Adults
The study on hand is based on a cross-sectional design and aims to acquire 1) descriptive data on the physical state and health condition of female soldiers in the German armed forces.
- Conditions
- Osteoporosis, Osteopenia, Fracture Reduction, Body Composition
- Trial name
- FH (NCT06608862)
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Bundeswehr University Munich
Central Blood Pressure, Obesity
Blood Pressure and Central Vascular Stiffness in Obese Children. Relationship to Metabolic Disturbances and Subclinical Cardiovascular Damage. Effect of Weight Reduction
The global epidemic of obesity in childhood continues to evolve and threaten future health and life expectancy primarily due to the increased incidence of cardiovascular disease.
- Conditions
- Central Blood Pressure, Obesity, Subclinical Organ Damage, Children
- Trial name
- AORTA (NCT01310088)
- Testing
- Lifestyle intervention
- Where
- 2 sites in Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Stress Hyperglycemia, Diabetes Mellitus
Diabetes Mellitus After Intensive Care Admission
Stress hyperglycaemia is commonly observed during hospitalization in the intensive care unit (ICU) and has been shown to adversely influence outcome.
- Trial name
- DIAFIC (NCT02180555)
- Testing
- Oral glucose tolerance test
- Where
- Belgium
- Volunteers
- 400 people
- Sponsor
- Christophe De Block
Frontotemporal Dementia
Serotonergic Function and Behavioural and Psychological Symptoms of Frontotemporal Dementia
Frontotemporal lobar degeneration(FTLD) is a common cause of early-onset dementia. FTLD is characterized multiple behavioral symptoms including mental rigidity, irritability, emotional blunting, disinhibition, apathy, and…
- Trial name
- NCT00376051
- Testing
- Citalopram
- Where
- 2 sites in Canada
- Volunteers
- 22 people
- Sponsor
- Sunnybrook Health Sciences Centre
Sodium-glucose Transport Protein Two Inhibitor (SGLT2),Metabolic Deficits Caused by Antipsychotics
Empagliflozin Addition in Modulating Metabolic Disturbances Associated With Olanzapine in Schizophrenia Patients
Olanzapine is a thieno-benzodiazepine derivate that is effective managing the symptoms of schizophrenia and reducing the psychopathological symptoms of psychosis.
- Trial name
- NCT05669742
- Testing
- Empagliflozin, olanzapine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Menorrhagia, Dysmenorrhea
Menorrhagia, Dysmenorrhea and Iron Deficiency Among Young Women Soldiers and Effect on Activity
As combat women soldiers are required to more intensive daily activity the investigators believe that the impact of menorrhagia, dysmenorrhea and its clinical consequence (as characterized by, anemia iron deficiency and reduced…
- Conditions
- Menorrhagia, Dysmenorrhea, Iron Deficiency Anemia
- Trial name
- NCT02685501
- Testing
- no intervention
- Where
- 2 sites in Israel
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Schizophrenia, Antipsychotics
The Study of Atypical Antipsychotics-induced Metabolic Disturbances
Schizophrenia is one of the most severe mental illnesses. The antipsychotic drugs, introduced in early 1950s, have revolutionized the treatment of schizophrenia.
- Trial name
- NCT00937755
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Medical University Hospital
Mood Disorders
Development of Systems and Precision Medicine - Take Mood Disorder as an Example.
Precision medicine is to achieve individual optimal health care, given the biological mechanisms, genetic variants, and environmental measurements.
- Trial name
- NCT04483661
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Cheng-Kung University Hospital
Cerebral Palsy Infantile
Outcome of Very Preterm Infants With Glucose Level Disturbances
The hypothesis of this prospective, cohort study is that hyperglycemia, hypoglycemia and unstable glucose levels in the first seven days of life in infants born very preterm and at very low birth weights can harm long-term…
- Trial name
- NCT03530189
- Testing
- 10% dextrose, bolus of dextrose, reducing the glucose infusion, insulin
- Where
- Croatia
- Volunteers
- 150 people
- Sponsor
- University Hospital Rijeka
Stroke, Sleep Apnea Syndromes
The Impact of Ergonomic Circadian Light on Hospitalized Stroke Patients in a Rehabilitation Unit
The purpose of this study is to investigate the impact of exposure to ergonomic circadian light on physiological and mental parameters in stroke patients admitted for rehabilitation.
- Conditions
- Stroke, Sleep Apnea Syndromes, Depression, Anxiety
- Trial name
- NCT02186392
- Testing
- Circadian Light luminaries
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Hypoparathyroidism, Hypoparathyroidism Postprocedural
Evaluation of iMmune Function in Post-surgical and AuToimmune HYpoparathyroidism (EMPATHY)
This is an observational pilot study for the evaluation of immune function, infectious diseases, psychometric status and quality of life in patients with hypoparathyroidism compared to healthy controls.
- Conditions
- Hypoparathyroidism, Hypoparathyroidism Postprocedural, Hypoparathyroidism Due to Impaired Parathormone Secretion
- Trial name
- EMPATHY (NCT04059380)
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Acromegaly
PegvisOMant and the Immune SystEm (PROMISE)
This is a prospective observational pilot study for the evaluation of immune cells phenotype in acromegalic patients in comparison with a control population and to investigate the impact of disease control and different medical…
- Trial name
- NCT05069324
- Where
- Italy
- Volunteers
- 62 people
- Sponsor
- University of Roma La Sapienza
Amenorrhea, Bone Loss
Bone Mass Accrual in Adolescent Athletes
The adolescent and young adult years are a critical window in time for bone mineral accrual. More than 90% of peak bone mass is achieved by 18 years, and data indicate that insults sustained during adolescence and young adulthood…
- Trial name
- 838 (NCT00827151)
- Testing
- Estrogen
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Polycystic Ovary Syndrome, Hirsutism
Combination Therapy With Myo-inositol and Folic Acid Versus Myo-inositol Alone
Previous studies have demonstrated that Myo-inositol is capable of restoring spontaneous ovarian activity, and consequently fertility, in most patients with PCOS.
- Conditions
- Polycystic Ovary Syndrome, Hirsutism, Menstrual Irregularity
- Trial name
- NCT01555190
- Testing
- myo-inositol 1500 gr, myo-inositol 2000 gr + folic acid 200 mcg
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart