Clinical trials: Metabolic Evaluation
Overweight, Obesity
Exploratory Study to Evaluate Various Pharmacodynamic Effects of Subcutaneously Infused or Injected Pramlintide in Obese Subjects
This exploratory study is designed to evaluate various pharmacodynamic effects of subcutaneously (SC) infused or injected pramlintide in obese, nondiabetic male and postmenopausal female (not on hormone replacement therapy)…
- Trial name
- NCT00444561
- Testing
- pramlintide acetate
- Where
- 10 sites in United States
- Volunteers
- 184 people
- Sponsor
- AstraZeneca
Renal Impairment, Type 2 Diabetes Mellitus
Effect of Renal Impairment on the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Ertugliflozin in Participants With Type 2 Diabetes Mellitus (MK-8835-009)
This is a study to evaluate the effect of renal impairment on the pharmacokinetics, pharmacodynamics, safety and tolerability of ertugliflozin in participants with type 2 diabetes mellitus (T2DM) and in healthy participants with…
- Trial name
- NCT01948986
- Testing
- Ertugliflozin
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Malnutrition
Investigation of the Effectiveness and Efficiency of a Structural Clinical Nutrition Support
The purpose of this study is to investigate the effectiveness and efficiency of a structural clinical nutrition support by an interdisciplinary Nutrition Support Team.
- Trial name
- NCT02200874
- Where
- Germany
- Volunteers
- 840 people
- Sponsor
- University of Hohenheim
Breast Cancer, Endocrine Therapy
Relationship Between Body Composition, Food Consumption, and Micro and Macronutrients With Gene Expression in Breast Cancer
The protocol involves measurement of 25 hidroxy vitamin D, gene expression of cytochrome and vitamin D receptor , endoxifen, tamoxifen, exemestane, and other metobolites related to nutrition and endocrine metabolism.
- Conditions
- Breast Cancer, Endocrine Therapy, Endocrine Therapy Adverse Reaction, Vitamin D Deficiency
- Trial name
- NUTRIBREAST (NCT04389424)
- Testing
- Tamoxifen, Exemestane, Anastrozole
- Where
- Mexico
- Volunteers
- 300 people
- Sponsor
- Instituto Jalisciense de Cancerologia
Colorectal Neoplasms, Hereditary Nonpolyposis
Implementation of Guidelines on Hereditary or Familial Colorectal Cancer
The aim of this study is to improve clinicians' calculation, interpretation and communication of familial colorectal cancer risk, as well as patients' risk perception and uptake of referral for genetic counselling or for…
- Trial name
- RISCO (NCT00929097)
- Testing
- Implementation aids, Control
- Volunteers
- 300 people
- Sponsor
- ZonMw: The Netherlands Organisation for Health Research and Development
Obesity, Gastroesophageal Reflux
Ultrasound Assessment for Comparison of Gastric Residual Volume After Ingestion of Carbohydrate Drink and Water in Obesity Class II and III Volunteers at Risk of Aspiration
The goal of this clinical trial is to compare gastric residual volume between drinking a carbohydrate drink and water in obesity class II and III volunteers at risk of aspiration.
- Trial name
- CarbDrinkUltra (NCT06941623)
- Testing
- Ultrasonography of gastric residual volume, Point-of-care testing of glucose, Hunger numeric rating scale
- Where
- Thailand
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Overweight, Obesity
Safety & Efficacy of Omega-3 Fish Oil in Overweight Children & Adolescents
Children with an excess in body weight, increase the risk of obesity-related co-morbidities and cardiovascular diseases. Childhood obesity may be due to diets laden with fat and lack of physical activity.
- Trial name
- NCT00447291
- Testing
- Supplement: Omega-3 Fish Oil, Multi-Disciplinary Nutrition & Exercise program
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Heart Center
Type 2 Diabetes
A Trial of INS068 in Patients With Type 2 Diabetes Not Adequately Controlled With One or Two Oral Antidiabetics
The study is being conducted to evaluate the efficacy and safety of IND068 once daily (QD) in subjects with type 2 diabetes not adequately controlled with one or two oral antidiabetics compared to insulin degludec QD for 16 weeks.
- Trial name
- NCT04663282
- Testing
- INS068 injection, Insulin Degludec
- Where
- 35 sites in United States, Australia and 1 more
- Volunteers
- 179 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Diabetes
Three-day, In-clinic Evaluation of the BD 2nd Generation Continuous Glucose Sensor Device in Type 1 Diabetics
The purpose of this study is to investigate the accuracy and performance of a new subcutaneous continuous glucose monitor (BD-CGM, Becton Dickinson) in hyperglycemic (high blood sugar) and hypoglycemic (low blood sugar) "clamp"…
- Trial name
- NCT01645696
- Testing
- BD CGM with Outer Layer, BD CGM without Outer Layer, Medtronic iPro2 Professional CGM
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Becton, Dickinson and Company
HIV-1
Nutritional and Metabolic Disorders in HIV Infected Children and Adolescent
The advent of highly active antiretroviral treatment has resulted in the survival into adolescence of an increasing proportion of infants and children with perinatal HIV infection in Senegal.
- Trial name
- NCT01771562
- Where
- 2 sites in Senegal
- Volunteers
- 330 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Body Weight, Metabolic Syndrome
Evaluation of the Body Slimming Effect of TCI904
To assess the efficacy of Lactobacillus delbrueckii ssp. bulgaricus TCI904 on body slimming
- Trial name
- NCT05805488
- Testing
- TCI904 sachet
- Where
- Taiwan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Diabetes
Improving Diabetes Care Via Telephone Assessment and Patient Education
The purpose of this study is to improve the quality of VA diabetes care using an automated telephone disease management (ATDM) system that administers patient assessments and targeted self-care education between clinic visits.
- Trial name
- NCT00012649
- Where
- 4 sites in United States
- Volunteers
- 480 people
- Sponsor
- US Department of Veterans Affairs
Type 2 Diabetes Mellitus
Study to Evaluate the Efficacy and Safety of ORMD-0801 in Subjects With Type 2 Diabetes Mellitus
In this randomized, double-blind, double-dummy, placebo-controlled study, approximately 675 eligible subjects with type 2 diabetes and inadequate control on at least one and up to 3 oral glucose-lowering agents will undergo an…
- Trial name
- NCT04606576
- Testing
- ORMD-0801 QD, ORMD-0801 BD
- Where
- United States
- Volunteers
- 710 people
- Sponsor
- Oramed, Ltd.
Cystinosis, Native Kidney
Cystinosis and Mitochondrial Metabolism
Cystinosis is a monogenic autosomal recessive lysosomal storage disease with complete penetrance, caused by a biallelic mutation in the CTNS gene (17p13.2) encoding cystinosin, a ubiquitous membrane protein whose role is to clear…
- Trial name
- CYSTI-MITO (NCT07319091)
- Testing
- Mitochondrial metabolism
- Where
- 9 sites in France
- Volunteers
- 25 people
- Sponsor
- Hospices Civils de Lyon
Type 1 Diabetes Mellitus
Group Education Curriculum for Older Teens With Type 1 Diabetes
SMART T1D is a research study that offers interactive diabetes education for teens with type 1 diabetes in peer groups led by diabetes nurse educators.
- Trial name
- SMART T1D (NCT03147274)
- Testing
- Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Children's Hospital
Asthma
Study to Evaluate the Effects of Weight Loss on Airway Inflammation and Mechanics in Subjects With Asthma (Asthma-Bariatric Surgery Study)
Current research shows that obesity greatly increases the risk of developing asthma. Although the two conditions are clearly related, experts do not fully understand why they are linked.
- Trial name
- NCT00615498
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Emory University
RED S, Eating Disorders
Relative Energy Deficiency in Sports (REDs) in Swedish Athletes
Background: Relative Energy Deficiency in Sport (REDs) describes impairment of health and performance due to problematic (long-term/severe) low energy availability (LEA), with or without eating disorders.
- Trial name
- REDs-Sweden (NCT06371963)
- Where
- Sweden
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Linnaeus University
Prader-Willi Syndrome
Follow-up of Prader Willi Syndrome Infants Treated by Oxytocin and Comparison With Not-treated Infants.
The objective of this study is to collect data on tolerance and effects of early treatment with oxytocin in children with Prader Willi Syndrome aged from 3 to 4 years and to compare these infants with not treated age-matched…
- Trial name
- OT2SUITE (NCT03081832)
- Testing
- Oxytocin, Control
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Toulouse
Overweight or Obesity
The Effect of AMG 133 on Gastric Emptying
The primary objective of the trial is to evaluate the effect of AMG 133 versus placebo on acetaminophen pharmacokinetics (PK), a marker for gastric emptying, in participants living with overweight or obesity.
- Trial name
- NCT07429032
- Testing
- AMG 133, Acetaminophen
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Amgen
Healthy
Study to Assess the Pharmacokinetics, Pharmacodynamics, and Safety of Canagliflozin (JNJ-28431754) in Otherwise Healthy Obese Volunteers
The purpose of this study is to assess the pharmacokinetics (ie, how the body affects the drug) and pharmacodynamics (ie, how the drug affects the body) of increasing doses of canagliflozin (JNJ-28431754) in healthy obese…
- Trial name
- NCT01756404
- Testing
- Canagliflozin (JNJ-28431754)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.