Clinical trials: Metabolic Evaluation
Aging
CALERIE (Washington University): Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy
This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet increases the length of life and prevents some age-related chronic diseases such as cancer, diabetes, and…
- Trial name
- NCT00099138
- Testing
- Caloric Restriction (CR), Exercise
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Obesity, Overweight
Impact of Satiating Compounds and Hypocaloric Diet on Weight, Cardiometabolic and Osteoarticular Health in Obesity
The main objective of this intervention study is to evaluate the effect of satiating protein and/or fiber bar consumption on weight loss and other osteoarticular and cardiometabolic parameters related to excess weight in subjects…
- Trial name
- COGLUBOCO (NCT07165548)
- Testing
- Experimental Bar (Formulation 1) + Hypocaloric diet (10% energy restriction), Experimental Bar (Formulation 2) + Hypocaloric diet (10% energy restriction), Experimental Bar (Formulation 3) + Hypocaloric diet (10% energy restriction)
- Where
- Spain
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Diabetic Retinopathy, Diabetes Mellitus, Type 2
Confronting Unequal Eye Care in Pennsylvania
Pt. 1 Diabetic retinopathy is a common eye condition among diabetic adults and can lead to severe vision impairment and even blindness.
- Conditions
- Diabetic Retinopathy, Diabetes Mellitus, Type 2, Glaucoma
- Trial name
- NCT01179555
- Testing
- Behavioral Activation, Supportive Therapy
- Where
- 3 sites in United States
- Volunteers
- 206 people
- Sponsor
- Wills Eye
Obese Adults
Evaluation of the Effects of Systemic Vibration Therapy on Thermogenesis, Cardiovascular Parameters, Endocrine-inflammatory Markers, and Physical-functional Performance in Adults With Obesity.
The goal of this clinical trial was to evaluate the effects of Systemic Vibration Therapy (SVT) on thermogenesis, cardiovascular health, endocrine-inflammatory markers, and physical performance in adults (men and women, aged…
- Trial name
- SVT (NCT07729215)
- Testing
- Systemic vibratory therapy, Systemic vibration therapy
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Laboratorio de Vibraçoes Mecanicas e Praticas Integrativas
Overweight,Obesity
Dose-escalation and Food Effect Study of ZT006 in Healthy, Overweight and Obese Participants
ZT006 is an oral, long-acting glucagon-like peptide-1. This first-in-human study is designed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of ZT006 in healthy, overweight and obese participants.
- Trial name
- NCT07307638
- Testing
- ZT006
- Where
- China
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Beijing QL Biopharmaceutical Co.,Ltd
Hypercholesterolemia, Atherosclerosis
Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) as Add-on to Ezetimibe Therapy in Patients With Elevated LDL-C (CLEAR Tranquility)
The purpose of this study is to determine if bempedoic acid (ETC-1002) added-on to ezetimibe therapy is effective and safe versus placebo in patients with elevated LDL cholesterol.
- Conditions
- Hypercholesterolemia, Atherosclerosis, Statin Adverse Reaction
- Trial name
- NCT03001076
- Testing
- Bempedoic acid, Ezetimibe
- Where
- United States
- Volunteers
- 269 people
- Sponsor
- Esperion Therapeutics, Inc.
Type 1 Diabetes (T1D)
"Perception, Knowledge, and Attitudes of Educational Staff Regarding the Care of Children With Type 1 Diabetes: Evaluation of the Educational Program"
Type 1 diabetes is a chronic autoimmune disease that requires continuous monitoring and regulation of glycemia. Children with type 1 diabetes face challenges that can disrupt their daily routines in school and kindergarten.
- Trial name
- PKA-T1D-EDU (NCT07148076)
- Testing
- Education Program
- Where
- 2 sites in Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sibenik University of Applied Sciences
Diabetes Mellitus, Type 1, Periodontal Diseases
Periodontal and Salivary Evaluation of Type 1 Diabetes Mellitus Patients
Diabetes Mellitus is a risk factor for periodontal disease increasing its prevalence, extension and severity. Periodontal disease is considered the sixth complication of diabetes.
- Trial name
- NCT02935868
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Dyslipidemia, Type 2 Diabetes
Evaluate the Efficacy and Safety of CMG190303 in Patients With Type 2 Diabetes and Dyslipidemia
The goal of this clinical trial is to learn if drug CMG190303 to treat Type 2 Diabetes and Dyslipidemia in adults. It will also learn about the safety of CMG190303.
- Trial name
- NCT06772168
- Testing
- CMG190303(Dapagliflozin/Rosuvastatin)
- Where
- 24 sites in South Korea
- Volunteers
- 240 people
- Sponsor
- CMG Pharmaceutical Co. Ltd
Schizophrenia, Bipolar Disorder
A 12-weeks Study to Evaluate the Dietary Fiber and Probiotics Treatment in Prevention and Intervention of Weight-gain and Cognitive Impairment of Schizophrenia or Bipolar Disorder
In this study, the investigators will evaluate the efficacy, safety and related mechanism of dietary fiber and probiotics alone and in combination as a add-on treatment in improving the antipsychotic induced weight gain, the…
- Trial name
- NCT03379597
- Testing
- Bifico (Live combined bifidobacterium,Lactobacillus and Enterococcus capsules, Oral), Dietary fiber
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Central South University
Obesity
A Phase 1b Study to Evaluate the Safety of XEN-101
This Phase 1b study will evaluate the effects of XEN-101 in subjects with obesity
- Trial name
- NCT06417697
- Testing
- XEN-101
- Where
- Australia
- Volunteers
- 33 people
- Sponsor
- Xeno Biosciences
Urea Cycle Disorder
UNLOCKED: A Phase 2, Open-label Trial With KB195 in Subjects With a Urea Cycle Disorder
UNLOCKED: A Phase 2 Trial to Evaluate the Efficacy and Safety of KB195 in Subjects with a Urea Cycle Disorder with Inadequate Control on Standard of Care
- Trial name
- UNLOCKED (NCT03933410)
- Testing
- KB195
- Where
- 19 sites in United States, Belgium and 5 more
- Volunteers
- 13 people
- Sponsor
- Kaleido Biosciences
Primary Hypercholesterolemia, Mixed Dyslipidemia
Efficacy and Safety of Extended-Release Niacin/ Laropiprant/Simvastatin Tablets in Participants With Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-143)
This study is being done to find out if tablets containing extended release (ER) niacin, laropiprant, and simvastatin (ERN/LRPT/SIM) are as effective as tablets containing ER niacin and laropiprant taken with simvastatin tablets…
- Trial name
- NCT01335997
- Testing
- ER niacin/laropiprant (ERN/LRPT), ER niacin/laropiprant/simvastatin (ERN/LRPT/SIM), Simvastatin (SIM)
- Volunteers
- 1,139 people
- Sponsor
- Merck Sharp & Dohme LLC
Obesity
Esophageal Manometry and Impedance Study in Obese Patients Before and During Anesthesia
The purpose of this study is to evaluate the effects of anesthesia on the esophageal body in obese patients before and during anesthesia.
- Trial name
- NCT01703897
- Testing
- Manometry and Impedance analysis
- Where
- Sweden
- Sponsor
- Örebro University, Sweden
Healthy
Effect on Blood Chemistry and Inflammatory Marker of Omega-3 Enriched Total Parenteral Nutrition
Fish oil is a rich source of omega-3 fatty acids, especially eicosapentanoic acid and docosahexaenoic acid, and it is not used widely in parenteral nutrition because fish oil emulsions have not been commercially available until…
- Trial name
- NCT02468713
- Testing
- Combiflex® lipid peri, Winuf® peri
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Mild Cognitive Impairment
Impact of Grape Consumption on Brain Metabolism and Neuropsychological Performance Over 1 Year
Constituents of grapes have been studied for their antioxidant, anti-inflammatory, and anticarcinogenic properties. In the past decade, there has been emerging evidence regarding a potential role for grapes in slowing cognitive…
- Trial name
- NCT03361410
- Testing
- Grape Powder
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, Los Angeles
Diabetes Mellitus, Type 2
An Exploratory Investigation to Assess Changes in Quality of Life for Individuals With Type 2 Diabetes After Taking a Meal-replacement Shake.
This is an open-label single-arm observational trial to study the effectiveness of a commercially available meal-replacement shake and its effect on the quality of life in individuals with type 2 diabetes.
- Trial name
- NCT05129735
- Testing
- Meal replacement shake
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Teatis, Inc
Gout
Safety/Efficacy Study to Evaluate of MBX-102 in Combination With Allopurinol in Gout Patients
The purpose of this study is to evaluate the efficacy, safety and tolerability of MBX-102 in combination with allopurinol compared to allopurinol alone when administered orally once a day for four weeks to gout patients with an…
- Trial name
- NCT01399008
- Testing
- Arhalofenate, Allopurinol, Colchicine
- Where
- 24 sites in United States, Canada and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Celiac Disease, Coeliac Disease
MAgnetic Resonance Imaging in COeliac Disease
One in 100 people suffers from coeliac disease. It affects the lining of the bowel and causes many symptoms such as diarrhoea, wind, stomach pain, constipation and nausea.
- Conditions
- Celiac Disease, Coeliac Disease, Celiac Sprue, Gluten Enteropathy
- Trial name
- MARCO (NCT02551289)
- Testing
- Gluten free diet
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Duchenne Muscular Dystrophy, Amyotrophic Lateral Sclerosis
Evaluation of a Mechanical Device During Acute Respiratory Failure in Patients With Neuromuscular Disorders
The hypothesis is that a mechanical insufflation-exsufflation (MI-E) is associated with a decrease in the number of intubations and more rapid clinical improvement in children and adults with neuromuscular disease who are…
- Conditions
- Duchenne Muscular Dystrophy, Amyotrophic Lateral Sclerosis, Neuromuscular Diseases
- Trial name
- Nemucough (NCT00839033)
- Testing
- mechanical insufflation - exsufflation, Standard respiratory physiotherapy
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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